Works about DNA topoisomerase II

Results: 1491

TOP2A Promotes Proliferation, Migration, and Inflammatory Response in M5-Treated Keratinocytes by Binding CTBP1 to Activate Wnt/β-Catenin Signaling.

Published in:

Cell Biochemistry & Biophysics, 2025, v. 83, n. 2, p. 2101, doi. 10.1007/s12013-024-01620-2

By:

Yang, Yuanwen;
Liu, Shumei;
Xiao, Xia

Publication type:

Article

Gepotidacin: The first-in-class triazaacenaphthylene antibiotic approved for the treatment of uncomplicated urinary tract infections.

Published in:

Drug Discoveries & Therapeutics, 2025, v. 19, n. 2, p. 129, doi. 10.5582/ddt.2025.01028

By:

Shasha Hu;
Haizhou Yu;
Jianjun Gao

Publication type:

Article

Spo11: from topoisomerase VI to meiotic recombination initiator.

Published in:

Biochemical Society Transactions, 2025, v. 53, n. 2, p. 383, doi. 10.1042/BST20253019

By:

Harper, Jon A.;
Brown, George G. B.;
Neale, Matthew J.

Publication type:

Article

Pyrazine Linked 1,3,4-Oxadiazoles as DNA Gyrase Inhibitors: In silico Design, Molecular Docking, MM-GBSA Assay, MD Simulations and ADMET Studies.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 8, p. 1063, doi. 10.1142/S2737416525500103

By:

Ranjan, Venkatesh;
Revanasiddappa, B. C.;
Prasanth, S.;
Bhat, Nanditha;
Bidye, Durgesh Paresh;
Dixit, Sheshagiri R.;
Pai, Aravinda

Publication type:

Article

Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights.

Published in:

Microbial Cell Factories, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12934-025-02710-3

By:

Abo El-Souad, Sayed M. S.;
Dawoud, Mohamed A.;
Ibrahim, Mahmoud;
Soliman, Mona M.

Publication type:

Article

Circadian Variation of Topoisomerase II-a in Human Rectal Crypt Epithelium: Implications for Reduction of Toxicity of Chemotherapy.

Published in:

Modern Pathology, 2002, v. 15, n. 11, p. 1191, doi. 10.1097/01.MP.0000032529.68297.B2

By:

Clayton, Frederic;
Tessnow, Kathryn A.;
Fang, John C.;
Holden, Joseph A.;
Moore, John G.

Publication type:

Article

Topoisomerase IIa Expression in Pituitary Adenomas and Carcinomas: Relationship to Tumor Behavior.

Published in:

Modern Pathology, 2002, v. 15, n. 11, p. 1205, doi. 10.1097/01.MP.0000036342.73003.55

By:

Vidal, Sergio;
Kovacs, Kalman;
Horvath, Eva;
Rotondo, Fabio;
Kuroki, Takao;
Lloyd, Ricardo V.;
Scheithauer, Bernd W.

Publication type:

Article

Topoisomerase II-a Expression in Different Cell Cycle Phases in Fresh Human Breast Carcinomas.

Published in:

Modern Pathology, 2002, v. 15, n. 5, p. 486, doi. 10.1038/modpathol.3880552

By:

Viliman, Kenneth;
Ståhl, Elisabeth;
Liljegren, Göran;
Tidefelt, Ulf;
Karlsson, Mats G.

Publication type:

Article

Topoisomerase IIa Expression in Breast Cancer: Correlation with Outcome Variables.

Published in:

Modern Pathology, 2000, v. 13, n. 5, p. 542, doi. 10.1038/modpathol.3880094

By:

Depowski, Peter L.;
Rosenthal, Seth I.;
Brien, Thomas P.;
Stylos, Scott;
Johnson, Rebecca L.;
Ross, Jeffrey S.

Publication type:

Article

Expression of DNA Topoisomerase IIa in Thyroid Neoplasia.

Published in:

Modern Pathology, 2000, v. 13, n. 4, p. 396, doi. 10.1038/modpathol.3880066

By:

Lee, Andrea;
LiVolsi, Virginia A.;
Baloch, Zubair W.

Publication type:

Article

Species-Specific Heterochromatin Prevents Mitotic Chromosome Segregation to Cause Hybrid Lethality in Drosophila.

Published in:

PLoS Biology, 2009, v. 7, n. 10, p. 1, doi. 10.1371/journal.pbio.1000234

By:

Ferree, Patrick M.;
Barbash, Daniel A.

Publication type:

Article

Dual Role of Topoisomerase II in Centromere Resolution and Aurora B Activity.

Published in:

PLoS Biology, 2008, v. 6, n. 8, p. e207, doi. 10.1371/journal.pbio.0060207

By:

Coelho, Paula A.;
Queiroz-Machado, Joana;
Carmo, Alexandre M.;
Moutinho-Pereira, Sara;
Maiato, Helder;
Sunkel, Claudio E.

Publication type:

Article

A New Role for a Long-Studied DNA-Wrangling Enzyme.

Published in:

PLoS Biology, 2008, v. 6, n. 8, p. e218, doi. 10.1371/journal.pbio.0060218

By:

Gross, Liza

Publication type:

Article

First Principle Studies of Electronic Properties, Global Reactivity Descriptors, and Molecular Docking of Olivacine Drug.

Published in:

Macromolecular Symposia, 2024, v. 413, n. 5, p. 1, doi. 10.1002/masy.202400075

By:

Mishra, Abhinav;
Sharma, Dipendra;
Tiwari, Sugriva Nath

Publication type:

Article

Synthesis of Derivatives of the Antibiotic Albicidin: The N‐Terminal Fragment as Key to Control Potency and Resistance Mediated by the Binding Protein AlbA.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 21, p. 1, doi. 10.1002/chem.202500162

By:

Kulike‐Koczula, Marcel;
Hommernick, Kay;
Ghimire, Leela B.;
Kosol, Simone;
Zborovsky, Lieby;
Seidel, Maria;
Sattler, Nicole;
Mainz, Andi;
Weston, John B.;
Ghilarov, Dmitry;
Süssmuth, Roderich D.

Publication type:

Article

Is Simultaneous Binding to DNA and Gyrase Important for the Antibacterial Activity of Cystobactamids?

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 19, p. 1, doi. 10.1002/chem.202303796

By:

Solga, Danny;
Wieske, Lianne H. E.;
Wilcox, Scott;
Zeilinger, Carsten;
Jansen‐Olliges, Linda;
Cirnski, Katarina;
Herrmann, Jennifer;
Müller, Rolf;
Erdelyi, Mate;
Kirschning, Andreas

Publication type:

Article

Reference genes for RT-qPCR studies in Corynebacterium pseudotuberculosis identified through analysis of RNA-seq data.

Published in:

Antonie van Leeuwenhoek, 2014, v. 106, n. 4, p. 605, doi. 10.1007/s10482-014-0231-3

By:

Carvalho, Daiane;
Sá, Pablo;
Castro, Thiago;
Carvalho, Rodrigo;
Pinto, Anne;
Gil, Danilo;
Bagano, Priscilla;
Bastos, Bruno;
Costa, Lilia;
Meyer, Roberto;
Silva, Artur;
Azevedo, Vasco;
Ramos, Rommel;
Pacheco, Luis

Publication type:

Article

Bee Trypanosomatids: First Steps in the Analysis of the Genetic Variation and Population Structure of Lotmaria passim, Crithidia bombi and Crithidia mellificae.

Published in:

Microbial Ecology, 2022, v. 84, n. 3, p. 856, doi. 10.1007/s00248-021-01882-w

By:

Bartolomé, Carolina;
Buendía-Abad, María;
Ornosa, Concepción;
De la Rúa, Pilar;
Martín-Hernández, Raquel;
Higes, Mariano;
Maside, Xulio

Publication type:

Article

The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 5, p. 1125, doi. 10.1007/s00280-011-1587-y

By:

Rao, V.;
Zhang, Jun;
Klein, Sarah;
Espandiari, Parvaneh;
Knapton, Alan;
Dickey, Jennifer;
Herman, Eugene;
Shacter, Emily

Publication type:

Article

Amrubicin for the treatment of neuroendocrine carcinoma of the gastrointestinal tract: a retrospective analysis of five cases.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 5, p. 1325, doi. 10.1007/s00280-011-1619-7

By:

Asayama, Masako;
Fuse, Nozomu;
Yoshino, Takayuki;
Yano, Tomonori;
Tahara, Makoto;
Doi, Toshihiko;
Fujii, Satoshi;
Ohtsu, Atsushi

Publication type:

Article

Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 5, p. 881, doi. 10.1007/s00280-009-1234-z

By:

Scatena, Caroline D.;
Kumer, Jeffrey L.;
Arbitrario, Jennifer P.;
Howlett, Anthony R.;
Hawtin, Rachael E.;
Fox, Judith A.;
Silverman, Jeffrey A.

Publication type:

Article

Relationship of mRNA expressions of RanBP2 and topoisomerase II isoforms to cytotoxicity of amrubicin in human lung cancer cell lines.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 2, p. 237, doi. 10.1007/s00280-009-1151-1

By:

Yoshitsugu Horio;
Osada, Hirotaka;
Shimizu, Junichi;
Ogawa, Shizu;
Hida, Toyoaki;
Sekido, Yoshitaka

Publication type:

Article

Pharmacokinetics and distribution of SN 28049, a novel DNA binding anticancer agent, in mice.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 6, p. 1145, doi. 10.1007/s00280-009-1123-5

By:

Lukka, Pradeep B.;
Paxton, James W.;
Kestell, Philip;
Baguley, Bruce C.

Publication type:

Article

In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 64, n. 6, p. 1059, doi. 10.1007/s00280-009-0962-4

By:

Wolf, Steven J.;
Wakelin, Laurence P. G.;
Zhicong He;
Stewart, Bernard W.;
Catchpoole, Daniel R.

Publication type:

Article

Biological properties of 4-methyl-2,7-diamino-5,10-diphenyl-4,9-diazapyrenium hydrogensulfate (ADAP).

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 62, n. 4, p. 595, doi. 10.1007/s00280-007-0643-0

By:

Marczi, Saška;
Glavaš-Obrovac, Ljubica;
Belovari, Tatjana;
Stojković, Ranko;
Ivanković, Siniša;
Šerić, Vatroslav;
Piantanida, Ivo;
Žinić, Mladen

Publication type:

Article

CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines.

Published in:

2006

By:

Pobst, Lori J.;
Ames, Matthew M.

Publication type:

journal article

Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II.

Published in:

Cancer Chemotherapy & Pharmacology, 2006, v. 57, n. 2, p. 221, doi. 10.1007/s00280-005-0040-5

By:

Hasinoff, Brian B.;
Xing Wu;
Begleiter, Asher;
Guziec, Lynn J.;
Guziec Jr., Frank;
Giorgianni, Angela;
Shaohua Yang;
Yu Jiang;
Yalowich, Jack C.

Publication type:

Article

Differences in the longevity of topo IIα and topo IIβ drug-stabilized cleavable complexes and the relationship to drug sensitivity.

Published in:

Cancer Chemotherapy & Pharmacology, 2004, v. 53, n. 2, p. 155

By:

Errington, Fiona;
Willmore, Elaine;
Leontiou, Chrysoula;
Tilby, Michael J.;
Austin, Caroline A.

Publication type:

Article

In vivo antitumor activity of S16020, a topoisomerase II inhibitor, and doxorubicin against human brain tumor xenografts.

Published in:

2003

By:

Vassal, Gilles;
Merlin, Jean-Louis;
Terrier-Lacombe, Marie-José;
Grill, Jacques;
Parker, Fabrice;
Sainte-Rose, Christian;
Aubert, Geneviève;
Morizet, Jackie;
Sévenet, Nicolas;
Poullain, Marie-Gwenaëlle;
Lucas, Catherine;
Kalifa, Chantal;
Terrier-Lacombe, Marie-José;
Aubert, Geneviève;
Sévenet, Nicolas;
Poullain, Marie-Gwenaëlle

Publication type:

journal article

Influence of chemosensitizers on resistance mechanisms in daunorubicin-resistant Ehrlich ascites tumour cells.

Published in:

2002

By:

Nielsen, Dorte;
Eriksen, Jens;
Maare, Christian;
Friche, Ellen;
Skovsgaard, Torben

Publication type:

journal article

Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma.

Published in:

2001

By:

McLaren, Blair R.;
Whitaker, Darrel;
Robinson, Bruce W.;
Lake, Richard A.;
McLaren, B R;
Whitaker, D;
Robinson, B W;
Lake, R A

Publication type:

journal article

DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway.

Published in:

Cancer Chemotherapy & Pharmacology, 2001, v. 47, n. 6, p. 511, doi. 10.1007/s002800100276

By:

Sang Geon Kim;
Mina Sung;
Keon Wook Kang;
Soon Hoe Kim;
Moon Ho Son;
Won Bae Kim

Publication type:

Article

A phase I trial of amsalog (CI-921) administered by intravenous infusion using a 5-day schedule.

Published in:

2001

By:

Fyfe, D.;
Price, C.;
Langley, R.E.;
Pagonis, C.;
Houghton, J.;
Osborne, L.;
Woll, P.J.;
Gardner, C.;
Baguley, B. C.;
Carmichael, J.;
Cancer Research Campaing Phase I/II Trials Committee

Publication type:

journal article

Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone.

Published in:

2001

By:

Krishnan, Preethi;
Bastow, Kenneth F.;
Krishnan, P;
Bastow, K F

Publication type:

journal article

Phase II and pharmacokinetic/pharmacodynamic trial of sequential topoisomerase I and II inhibition with topotecan and etoposide in advanced non-small-cell lung cancer.

Published in:

2001

By:

Dowlati, Afshin;
Levitan, Nathan;
Gordon, Nahida H.;
Hoppel, Charles L.;
Gosky, David M.;
Remick, Scot C.;
Ingalls, Stephen T.;
Berger, Sossamma J.;
Berger, Nathan A.;
Dowlati, A;
Levitan, N;
Gordon, N H;
Hoppel, C L;
Gosky, D M;
Remick, S C;
Ingalls, S T;
Berger, S J;
Berger, N A

Publication type:

journal article

Mechanism of action of the dual topoisomerase-I and -II inhibitor TAS-103 and activity against (multi)drug resistant cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2000, v. 45, n. 1, p. 78, doi. 10.1007/PL00006747

By:

Minderman, Hans;
Wrzosek, Carol;
Cao, Shousong;
Utsugi, Teruhiro;
Kobunai, Takashi;
Yamada, Yuji;
Rustum, Youcef M.

Publication type:

Article

Cross-resistance of topoisomerase I and II inhibitors in neuroblastoma cell lines.

Published in:

2000

By:

Keshelava, Nino;
Groshen, Susan;
Reynolds, C. Patrick;
Keshelava, N;
Groshen, S;
Reynolds, C P

Publication type:

journal article

Synthesis and biological evaluation of novel naphthoquinone fused cyclic aminoalkylphosphonates and aminoalkylphosphonic monoester.

Published in:

Amino Acids, 2008, v. 35, n. 2, p. 463

By:

Z. W. Miao;
J. Wang;
R. Y. Chen;
X. D. Zhang

Publication type:

Article

Tumor Topoisomerase II Alpha Status and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Breast Cancer.

Published in:

Oncology, 2011, v. 80, n. 3/4, p. 269, doi. 10.1159/000329038

By:

Nikolényi, Alíz;
Sükösd, Farkas;
Kaizer, László;
Csörgő, Erika;
Vörös, András;
Uhercsák, Gabriella;
Ormándi, Katalin;
Lázár, György;
Thurzó, László;
Brodowicz, Thomas;
Kahán, Zsuzsanna

Publication type:

Article

Targeting Her-2/neu in Breast Cancer: As Easy as This!

Published in:

Oncology, 2008, v. 74, n. 3/4, p. 150, doi. 10.1159/000151362

By:

Azim, Hamdy;
Azim Jr., Hatem A.

Publication type:

Article

Serial Topoisomerase II Expression in Primary Breast Cancer and Response to Neoadjuvant Anthracycline-Based Chemotherapy.

Published in:

Oncology, 2004, v. 66, n. 5, p. 388, doi. 10.1159/000079487

By:

Martin-Richard, M.;
Muñoz, M.;
Albanell, J.;
Colomo, L.;
Bellet, M.;
Rey, M. J.;
Tabernero, J.;
Alonso, C.;
Cardesa, A.;
Gascon, P.;
Fernandez, P. L.

Publication type:

Article

An atypical topoisomerase II from archaea with implications for meiotic recombination.

Published in:

Nature, 1997, v. 386, n. 6623, p. 414, doi. 10.1038/386414a0

By:

Bergerat, Agnes;
de Massy, Bernard

Publication type:

Article

Structure and mechanism of DNA topoisomerase II.

Published in:

Nature, 1996, v. 379, n. 6562, p. 225, doi. 10.1038/379225a0

By:

Berger, James M.;
Gamblin, Steven J.

Publication type:

Article

A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells.

Published in:

Nature, 1994, v. 372, n. 6505, p. 467, doi. 10.1038/372467a0

By:

Downes, C. Stephen;
Clarke, Duncan J.

Publication type:

Article

Antigenotoxic Activity of Polyphenolic Composition BP-C2 in Mouse Germ Cells In Vivo.

Published in:

Bulletin of Experimental Biology & Medicine, 2024, v. 177, n. 3, p. 323, doi. 10.1007/s10517-024-06182-0

By:

Zhanataev, A. K.;
Anisina, E. A.;
Malikova, A. D.;
Pligina, K. L.;
Pigarev, S. E.;
Fedoros, E. I.;
Durnev, A. D.;
Anisimov, V. N.

Publication type:

Article

Cumulative effects of ciprofloxacin and pilocarpine on cytotoxicity and G0 phase arrest in hepatoma‐derived Hep G2 cell line.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 10, p. 1383, doi. 10.1111/jphp.13318

By:

Sadeghi, Leila;
Maleki, Somaiyeh;
Dehghan, Gholamreza

Publication type:

Article

Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism.

Published in:

Journal of Pharmacy & Pharmacology, 2016, v. 68, n. 6, p. 729, doi. 10.1111/jphp.12539

By:

Meredith, Ann ‐ Marie;
Dass, Crispin R.

Publication type:

Article

In Vitro Antibacterial, DPPH Radical Scavenging Activities, and In Silico Molecular Modeling of Isolated Compounds from the Roots of Clematis hirsuta.

Published in:

Advances in Pharmacological & Pharmaceutical Sciences, 2024, v. 2024, p. 1, doi. 10.1155/2024/3152929

By:

Duguma, Tolessa;
Melaku, Yadessa;
Garg, Ankita;
Ensermu, Urgessa

Publication type:

Article

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01508-9

By:

Deng, Zhao;
Shen, Dexin;
Yu, Mengxue;
Zhou, Fenfang;
Shan, Danni;
Fang, Yayun;
Jin, Wan;
Qian, Kaiyu;
Li, Shenjuan;
Wang, Gang;
Zhang, Yi;
Ju, Lingao;
Xiao, Yu;
Wang, Xinghuan

Publication type:

Article

Chemical and Pharmacological Assessment of Substituted 1,2,4-Triazole Fused Pyrimidines as Anti-microbial Agent.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2024, v. 58, p. S73, doi. 10.5530/ijper.58.1s.7

By:

Sabale, Prafulla;
Potey, Lata;
Waghmare, Suchita;
Sayyad, Nusrat;
Sabale, Vidya

Publication type:

Article