Works matching DE "DNA topoisomerase I"

Results: 1234

Trick and treat.

Published in:

OncoImmunology, 2014, v. 3, n. 2, p. N.PAG, doi. 10.4161/onci.27811

By:

Boisgerault, Nicolas;
Vile, Richard G

Publication type:

Article

Hypercellular Proinflammatory Microenvironment Inhibits the Etoposide-Induced DNA Damage in Acute Monocytic Leukemia Cells.

Published in:

Biochemistry (00062979), 2025, v. 90, n. 5, p. 553, doi. 10.1134/S000629792560019X

By:

Kobyakova, Margarita I.;
Krasnov, Kirill S.;
Krestinina, Olga V.;
Baburina, Yulia L.;
Senotov, Anatoly S.;
Lomovskaya, Yana V.;
Meshcheriakova, Elena I.;
Lomovsky, Alexey I.;
Zvyagina, Alena I.;
Pyatina, Kira V.;
Fadeeva, Irina S.;
Fadeev, Roman S.

Publication type:

Article

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60534-6

By:

González-Almela, Esther;
Castells-Garcia, Alvaro;
Le Dily, François;
Merino, Manuel Fernández;
Carnevali, Davide;
Cusco, Pol;
Di Croce, Luciano;
Cosma, Maria Pia

Publication type:

Article

USP37 prevents premature disassembly of stressed replisomes by TRAIP.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60139-z

By:

Kochenova, Olga V.;
D'Alessandro, Giuseppina;
Pilger, Domenic;
Schmid, Ernst;
Richards, Sean L.;
Garcia, Marcos Rios;
Jhujh, Satpal S.;
Voigt, Andrea;
Gupta, Vipul;
Carnie, Christopher J.;
Alex Wu, R.;
Gueorguieva, Nadia;
Lam, Simon;
Stewart, Grant S.;
Walter, Johannes C.;
Jackson, Stephen P.

Publication type:

Article

A systematic insight into glycycoumarin as potential IL-8/topo I inhibitor from natural products collected in Taibai mountain based on the combination of in silico and bioassay.

Published in:

Journal of Computer-Aided Molecular Design, 2025, v. 39, n. 1, p. 1, doi. 10.1007/s10822-025-00611-6

By:

Tan, Na-Na;
Lu, Jia;
Li, Zhuang-Hong;
Zhang, Shi-Ping;
Wang, Huan;
Hu, Jing-Bo;
Wang, Tian;
Xiao, Jian;
Wang, Xiao-Ling;
Wang, Le

Publication type:

Article

Results of a phase 1/2 study of sacituzumab tirumotecan in patients with unresectable locally advanced or metastatic solid tumors refractory to standard therapies.

Published in:

Journal of Hematology & Oncology, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13045-025-01705-2

By:

Ouyang, Quchang;
Rodon, Jordi;
Liang, Yan;
Wu, Xinhong;
Li, Qun;
Song, Lihua;
Yan, Min;
Tong, Zhongsheng;
Liu, YunPeng;
Wainberg, Zev A.;
Wang, Ying;
Geng, Cuizhi;
Ulahannan, Susanna V.;
Yu, Guohua;
Sharma, Manish R.;
Wang, Xiang;
Wang, Judy S.;
Spira, Alexander;
Zhao, Weihong;
Sanborn, Rachel E.

Publication type:

Article

Fermentation Optimization of Loonamycin Production by Marine Nocardiopsis flavescens.

Published in:

Journal of Basic Microbiology, 2025, v. 65, n. 6, p. 1, doi. 10.1002/jobm.70012

By:

Zhou, Tianyu;
Cao, Yuan;
Zhang, Zhicheng;
Shi, Jing;
Ge, Huiming;
An, Faliang;
Ye, Jiang;
Wang, Ruida;
Wu, Haizhen

Publication type:

Article

Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas.

Published in:

Cancer Chemotherapy & Pharmacology, 2025, v. 95, n. 1, p. 1, doi. 10.1007/s00280-025-04778-5

By:

O'Sullivan Coyne, Geraldine;
Kummar, Shivaani;
Rubinstein, Larry V.;
Wilsker, Deborah;
Moore, Nancy;
Hogu, Murielle;
Piekarz, Richard;
Covey, Joe;
Beumer, Jan H.;
Ferry-Galow, Katherine V.;
Villaruz, Liza C.;
Hollingshead, Melinda G.;
Holleran, Julianne L.;
Deppas, Joshua J.;
Pommier, Yves;
Ko, Brian;
Johnson, Barry C.;
Parchhment, Ralph E.;
Ivy, Percy;
Doroshow, James H.

Publication type:

Article

The DNA Topoisomerase 1 Contributes to Stress Response in Saccharomyces cerevisiae , Regardless Its Catalytic Activity.

Published in:

Biology (2079-7737), 2025, v. 14, n. 5, p. 499, doi. 10.3390/biology14050499

By:

D'Alfonso, Anna;
Egidi, Alessandra;
Proietti, Ludovica;
Camilloni, Giorgio

Publication type:

Article

Highly Brominated Quinolines: Synthesis, Characterization, and Investigation of Anticancer Activities Supported by Molecular Dynamics.

Published in:

Chemical Biology & Drug Design, 2025, v. 105, n. 5, p. 1, doi. 10.1111/cbdd.70120

By:

Çakmak, Osman;
Ökten, Salih;
Köprülü, Tuğba Kul;
Andac, Cenk A.;
Tekin, Şaban;
Arslan, Seyfullah Oktay

Publication type:

Article

Dumpling GNN: Hybrid GNN Enables Better ADC Payload Activity Prediction Based on the Chemical Structure.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4859, doi. 10.3390/ijms26104859

By:

Xu, Shengjie;
Xie, Lingxi;
Dai, Rujie;
Lyu, Zehua

Publication type:

Article

In Silico Approach to Design of New Multi-Targeted Inhibitors Based on Quinoline Ring with Potential Anticancer Properties.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4620, doi. 10.3390/ijms26104620

By:

Czyżnikowska, Żaneta;
Mysłek, Martyna;
Marciniak, Aleksandra;
Płaczek, Remigiusz;
Kotynia, Aleksandra;
Krzyżak, Edward

Publication type:

Article

New Dimethoxyaryl-Sesquiterpene Derivatives with Cytotoxic Activity Against MCF-7 Breast Cancer Cells: From Synthesis to Topoisomerase I/II Inhibition and Cell Death Mechanism Studies.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4539, doi. 10.3390/ijms26104539

By:

Araque, Ileana;
Vergara, Rut;
Mella, Jaime;
Aránguiz, Pablo;
Espinoza-Catalán, Luis;
Salas, Cristian O.;
Barrero, Alejandro F.;
Quílez del Moral, José;
Villena, Joan;
Cuellar, Mauricio A.

Publication type:

Article

Topoisomerase I poisoning results in PARP-mediated replication fork reversal.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 4, p. 417, doi. 10.1038/nsmb.2258

By:

Ray Chaudhuri, Arnab;
Hashimoto, Yoshitami;
Herrador, Raquel;
Neelsen, Kai J;
Fachinetti, Daniele;
Bermejo, Rodrigo;
Cocito, Andrea;
Costanzo, Vincenzo;
Lopes, Massimo

Publication type:

Article

Redox Modulation of the Activity of DNA Topoisomerase I from Carrot (Daucus carota) Mitochondria.

Published in:

Doklady Biochemistry & Biophysics, 2001, v. 377, n. 1-6, p. 82, doi. 10.1023/A:1011523522080

By:

Konstantinov, Yu. M.;
Tarasenko, V. I.;
Rogozin, I. B.

Publication type:

Article

Nanoparticles for Triple Drug Release for Combined Chemo‐ and Photodynamic Therapy.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 59, p. 14610, doi. 10.1002/chem.202101842

By:

Martínez‐Edo, Gabriel;
Xue, Evelyn Y.;
Ha, Summer Y. Y.;
Pontón, Iris;
González‐Delgado, José Antonio;
Borrós, Salvador;
Torres, Tomás;
Ng, Dennis K. P.;
Sánchez‐García, David

Publication type:

Article

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 32, p. 7219, doi. 10.1002/chem.202000117

By:

Elgaher, Walid A. M.;
Hamed, Mostafa M.;
Baumann, Sascha;
Herrmann, Jennifer;
Siebenbürger, Lorenz;
Krull, Jana;
Cirnski, Katarina;
Kirschning, Andreas;
Brönstrup, Mark;
Müller, Rolf;
Hartmann, Rolf W.

Publication type:

Article

A Twisting Electronic Nanoswitch Made of DNA.

Published in:

Angewandte Chemie, 2014, v. 126, n. 51, p. 14279, doi. 10.1002/ange.201407729

By:

Huang, Yu Chuan;
Sen, Dipankar

Publication type:

Article

Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity.

Published in:

Angewandte Chemie, 2014, v. 126, n. 47, p. 13026, doi. 10.1002/ange.201408012

By:

Malina, Jaroslav;
Farrell, Nicholas P.;
Brabec, Viktor

Publication type:

Article

Chitosan Schiff base electrospun fabrication and molecular docking assessment for nonleaching antibacterial nanocomposite production.

Published in:

Cellulose, 2023, v. 30, n. 6, p. 3505, doi. 10.1007/s10570-023-05124-9

By:

Ali, Eman AboBakr;
Abo-Salem, Heba M.;
Arafa, Amany A.;
Nada, Ahmed A.

Publication type:

Article

Metal complexes of 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone: cytotoxic activity and investigation on the mode of action of the gold(III) complex.

Published in:

BioMetals, 2016, v. 29, n. 3, p. 515, doi. 10.1007/s10534-016-9933-5

By:

Sâmia, Luciana;
Parrilha, Gabrieli;
Silva, Jeferson;
Ramos, Jonas;
Souza-Fagundes, Elaine;
Castelli, Silvia;
Vutey, Venn;
Desideri, Alessandro;
Beraldo, Heloisa

Publication type:

Article

Iron and zinc binding activity of Escherichia coli topoisomerase I homolog YrdD.

Published in:

BioMetals, 2014, v. 27, n. 2, p. 229, doi. 10.1007/s10534-013-9698-z

By:

Cheng, Zishuo;
Tan, Guoqiang;
Wang, Wu;
Su, Xiaolu;
Landry, Aaron;
Lu, Jianxin;
Ding, Huangen

Publication type:

Article

Biological and cytoselective anticancer properties of copper(II)-polypyridyl complexes modulated by auxiliary methylated glycine ligand.

Published in:

BioMetals, 2012, v. 25, n. 5, p. 1061, doi. 10.1007/s10534-012-9572-4

By:

Seng, Hoi-Ling;
Wang, Wai-San;
Kong, Siew-Ming;
Alan Ong, Han-Kiat;
Win, Yip-Foo;
Raja Abd. Rahman, Raja;
Chikira, Makoto;
Leong, Weng-Kee;
Ahmad, Munirah;
Khoo, Alan;
Ng, Chew-Hee

Publication type:

Article

Escherichia coli topoisomerase I is an iron and zinc binding protein.

Published in:

BioMetals, 2011, v. 24, n. 4, p. 729, doi. 10.1007/s10534-011-9425-6

By:

Jianxin Lu;
Wu Wang;
Guoqiang Tan;
Landry, Aaron P.;
Peng Yi;
Fan Si;
Yaguang Ren;
Huangen Ding

Publication type:

Article

Progression-free survival and overall survival of patients with clear cell carcinoma of the ovary treated with paclitaxel-carboplatin or irinotecan-cisplatin: retrospective analysis.

Published in:

International Journal of Clinical Oncology, 2007, v. 12, n. 4, p. 256, doi. 10.1007/s10147-007-0670-1

By:

Takano, Masashi;
Sugiyama, Toru;
Yaegashi, Nobuo;
Suzuki, Mitsuaki;
Tsuda, Hiroshi;
Sagae, Satoru;
Udagawa, Yasuhiro;
Kuzuya, Kazuo;
Kigawa, Junzo;
Takeuchi, Satoshi;
Tsuda, Hitoshi;
Moriya, Takuya;
Kikuchi, Yoshihiro

Publication type:

Article

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update.

Published in:

Medicinal Research Reviews, 2022, v. 42, n. 1, p. 513, doi. 10.1002/med.21852

By:

Laxmikeshav, Kritika;
Kumari, Pooja;
Shankaraiah, Nagula

Publication type:

Article

Dual DNA topoisomerase 1 and tyrosyl‐DNA phosphodiesterase 1 inhibition for improved anticancer activity.

Published in:

Medicinal Research Reviews, 2019, v. 39, n. 4, p. 1427, doi. 10.1002/med.21587

By:

Zakharenko, Alexandra;
Dyrkheeva, Nadezhda;
Lavrik, Olga

Publication type:

Article

Bee Trypanosomatids: First Steps in the Analysis of the Genetic Variation and Population Structure of Lotmaria passim, Crithidia bombi and Crithidia mellificae.

Published in:

Microbial Ecology, 2022, v. 84, n. 3, p. 856, doi. 10.1007/s00248-021-01882-w

By:

Bartolomé, Carolina;
Buendía-Abad, María;
Ornosa, Concepción;
De la Rúa, Pilar;
Martín-Hernández, Raquel;
Higes, Mariano;
Maside, Xulio

Publication type:

Article

Development of DNA delivery system using Pseudomonas exotoxin A and a DNA binding region of human DNA topoisomerase I.

Published in:

Applied Microbiology & Biotechnology, 2000, v. 53, n. 5, p. 558, doi. 10.1007/s002530051657

By:

Chen, T.-Y.;
Hsu, C.-T.;
Chang, K.-H.;
Ting, C.-Y.;
Whang-Peng, J.;
Hui, C.-F.;
Hwang, J.

Publication type:

Article

Evidences of a natively unfolded state for the human topoisomerase IB N-terminal domain.

Published in:

Amino Acids, 2011, v. 41, n. 4, p. 945, doi. 10.1007/s00726-010-0794-x

By:

Vassallo, Oscar;
Castelli, Silvia;
D'Annessa, Ilda;
Rocca, Blasco;
Stella, Lorenzo;
Knudsen, Birgitta;
Desideri, Alessandro

Publication type:

Article

Discovery of candidate KEN-box motifs using Cell Cycle keyword enrichment combined with native disorder prediction and motif conservation.

Published in:

Bioinformatics, 2008, v. 24, n. 4, p. 453, doi. 10.1093/bioinformatics/btm624

By:

Sushama Michael;
Gilles TravÃ©;
Chenna Ramu;
Claudia Chica;
Toby J. Gibson

Publication type:

Article

Molecular Docking Studies on Methanolic Propolis Extracts Collected from Different Regions in Saudi Arabia as a Potential Inhibitor of Topoisomerase IIβ.

Published in:

Separations (2297-8739), 2022, v. 9, n. 12, p. 392, doi. 10.3390/separations9120392

By:

Al-Khalaf, Areej A.;
Alabdelkareem, Ibrahim;
Al-Rejaie, Salim S.;
Mohany, Mohamed;
Hozzein, Wael N.

Publication type:

Article

Engineered liposomes bearing camptothecin analogue for tumour targeting: in vitro and ex-vivo studies.

Published in:

Journal of Liposome Research, 2021, v. 31, n. 4, p. 326, doi. 10.1080/08982104.2020.1801725

By:

Saraf, Shivani;
Jain, Ankit;
Tiwari, Ankita;
Verma, Amit;
Jain, Sanjay K.

Publication type:

Article

Bidirectional pharmacodynamic interaction between pegylated liposomal CKD-602 (S-CKD602) and monocytes in patients with refractory solid tumors.

Published in:

Journal of Liposome Research, 2011, v. 21, n. 2, p. 158, doi. 10.3109/08982104.2010.496085

By:

Zamboni, William C.;
Maruca, Lauren J.;
Strychor, Sandra;
Zamboni, Beth A.;
Ramalingam, Suresh;
Edwards, Robert P.;
Kim, JK;
Bang, YJ;
Lee, HY;
Friedland, David M.;
Stoller, Ronald G.;
Belani, Chandra P.;
Ramanathan, Ramesh K.

Publication type:

Article

Diphenyl Ditelluride-Induced Cell Cycle Arrest and Apoptosis: A Relation with Topoisomerase I Inhibition.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2015, v. 116, n. 3, p. 273, doi. 10.1111/bcpt.12315

By:

Jorge, Patrícia M.;
Oliveira, Iuri M.;
Filippi Chiela, Eduardo C.;
Viau, Cassiana M.;
Saffi, Jenifer;
Horn, Fabiana;
Rosa, Renato M.;
Guecheva, Temenouga N.;
Pêgas Henriques, João A.

Publication type:

Article

Chemical Composition of Various Nepeta cataria Plant Organs' Methanol Extracts Associated with In Vivo Hepatoprotective and Antigenotoxic Features as well as Molecular Modeling Investigations.

Published in:

Plants (2223-7747), 2022, v. 11, n. 16, p. 2114, doi. 10.3390/plants11162114

By:

Vukić, Milena D.;
Vuković, Nenad L.;
Mladenović, Milan;
Tomašević, Nevena;
Matić, Sanja;
Stanić, Snežana;
Sapienza, Filippo;
Ragno, Rino;
Božović, Mijat;
Kačániová, Miroslava

Publication type:

Article

The Role of DNA Topoisomerase Binding Protein 1 (TopBP1) in Genome Stability in Arabidopsis.

Published in:

Plants (2223-7747), 2021, v. 10, n. 12, p. 2568, doi. 10.3390/plants10122568

By:

Parra-Nunez, Pablo;
Cooper, Claire;
Sanchez-Moran, Eugenio

Publication type:

Article

Topoisomerase I prevents transcription-replication conflicts at transcription termination sites.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 1, p. 1, doi. 10.1080/23723556.2020.1843951

By:

Liu, Yaqun;
Lin, Yea-Lih;
Pasero, Philippe;
Chen, Chun-Long

Publication type:

Article

Accumulation of AID in immunoglobulin variable genes in the absence of Topoisomerase I.

Published in:

Turkish Journal of Immunology, 2016, v. 4, p. 22

By:

Saribasak, Huseyin;
Maul, Robert W.;
Cao, Zheng;
Gearhart, Patricia J.

Publication type:

Article

Number of Meiotic Double-Strand Breaks Influences Crossover Distribution in Arabidopsis.

Published in:

Plant Cell, 2018, v. 30, n. 10, p. 2628, doi. 10.1105/tpc.18.00531

By:

Xue, Ming;
Wang, Jun;
Jiang, Luguang;
Wang, Minghui;
Wolfe, Sarah;
Pawlowski, Wojciech P.;
Wang, Yingxiang;
He, Yan

Publication type:

Article

Joseph J. Kieber.

Published in:

Plant Cell, 2018, v. 30, n. 2, p. 255, doi. 10.1105/tpc.18.00110

By:

Roy, Sonali

Publication type:

Article

DEK Domain-Containing Protein Modulates Chromatin Structure and Function in Arabidopsis.

Published in:

Plant Cell, 2014, v. 26, n. 11, p. 4328, doi. 10.1105/tpc.114.129254

By:

Waidmann, Sascha;
Kusenda, Branislav;
Mayerhofer, Juliane;
Mechtler, Karl;
Jonak, Claudia

Publication type:

Article

DNA Topoisomerase I Affects Polycomb Group Protein-Mediated Epigenetic Regulation and Plant Development by Altering Nucleosome Distribution in Arabidopsis.

Published in:

Plant Cell, 2014, v. 26, n. 7, p. 2803, doi. 10.1105/tpc.114.124941

By:

Liu, Xigang;
Gao, Lei;
Dinh, Thanh Theresa;
Shi, Ting;
Li, Dongming;
Wang, Ruozhong;
Guo, Lin;
Xiao, Langtao;
Chen, Xuemei

Publication type:

Article

MGOUN1 Encodes an Arabidopsis Type IB DNA Topoisomerase Required in Stem Cell Regulation and to Maintain Developmentally Regulated Gene Silencing.

Published in:

Plant Cell, 2010, v. 22, n. 3, p. 716, doi. 10.1105/tpc.109.068296

By:

Graf, Philipp;
Dolzblasz, Alicja;
Würschum, Tobias;
Lenhard, Michael;
Pfreundt, Ulrike;
Laux, Thomas

Publication type:

Article

Chronic exposure to the gibberellin derivative GA-13315 sensitizes breast cancer MCF-7 cells but not colon cancer HCT116 cells to irinotecan.

Published in:

Oncology Letters, 2020, v. 20, n. 6, p. N.PAG, doi. 10.3892/ol.2020.12144

By:

Cheng, Xianliang;
Wang, Guohui;
Liao, Yuan;
Mo, Jiao;
Qing, Chen

Publication type:

Article

MicroRNA-139 suppresses hepatocellular carcinoma cell proliferation and migration by directly targeting Topoisomerase I.

Published in:

Oncology Letters, 2019, v. 17, n. 2, p. 1903

By:

Zhang, Pengfei;
Yin, Jikai;
Yuan, Lijuan;
Wang, Qing;
Du, Xilin;
Dong, Rui;
Wang, Chengguo;
Bai, Qiangshan;
Ji, Ling;
Zhang, Guizhi;
Lu, Jianguo

Publication type:

Article

Asiatic acid prevents the development of interstitial lung disease in a hypochlorous acid‑induced mouse model of scleroderma.

Published in:

Oncology Letters, 2018, v. 15, n. 6, p. 8711, doi. 10.3892/ol.2018.8412

By:

Xia, Xiaoru;
Dai, Caijun;
Yu, Hua;
Huang, Xiaoying;
ChEN, Ali;
Tan, Yingxia;
Wang, Liangxing

Publication type:

Article

Antitumor effects and mechanisms of Ganoderma extracts and spores oil.

Published in:

Oncology Letters, 2016, v. 12, n. 5, p. 3571, doi. 10.3892/ol.2016.5059

By:

CHUN CHEN;
PENG LI;
YE LI;
GUAN YAO;
JIAN-HUA XU

Publication type:

Article

Anticancer effects of CKD-602 (Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines.

Published in:

Oncology Letters, 2015, v. 9, n. 1, p. 136, doi. 10.3892/ol.2014.2648

By:

YOUNG-KYUN KIM;
NA-YOUN KOO;
PIL-YOUNG YUN

Publication type:

Article

An In-Silico Identification of Potential Flavonoids against Kidney Fibrosis Targeting TGFβR-1.

Published in:

Life (2075-1729), 2022, v. 12, n. 11, p. 1764, doi. 10.3390/life12111764

By:

Rahman, MD. Hasanur;
Biswas, Partha;
Dey, Dipta;
Hannan, Md. Abdul;
Sahabuddin, Md.;
Araf, Yusha;
Kwon, Youngjoo;
Emran, Talha Bin;
Ali, Md. Sarafat;
Uddin, Md Jamal

Publication type:

Article