Works matching DE "DNA topoisomerase I"
Results: 1200
Design, Synthesis and Bioactive Evaluation of Topo I/ c-MYC Dual Inhibitors to Inhibit Oral Cancer via Regulating the PI3K/AKT/NF-κB Signaling Pathway.
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- Molecules, 2025, v. 30, n. 4, p. 894, doi. 10.3390/molecules30040894
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Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs.
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- Bioscience, Biotechnology & Biochemistry, 2003, v. 67, n. 9, p. 1944, doi. 10.1271/bbb.67.1944
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Two‐Phase Electrosynthesis of Dihydroxycoumestans: Discovery of a New Scaffold for Topoisomerase I Poison.
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- Chemistry - A European Journal, 2024, v. 30, n. 39, p. 1, doi. 10.1002/chem.202401400
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Direct Growth Control of Antibiotic‐Resistant Bacteria Using Visible‐Light‐Responsive Novel Photoswitchable Antibiotics.
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- Chemistry - A European Journal, 2024, v. 30, n. 15, p. 1, doi. 10.1002/chem.202303685
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Tapcin, an In Vivo Active Dual Topoisomerase I/II Inhibitor Discovered by Synthetic Bioinformatic Natural Product (Syn‐BNP)‐Coupled Metagenomics.
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- Angewandte Chemie, 2024, v. 136, n. 17, p. 1, doi. 10.1002/ange.202317187
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Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II.
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- Angewandte Chemie, 2020, v. 132, n. 38, p. 16774, doi. 10.1002/ange.202006089
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Chiral Carbon Dots Mimicking Topoisomerase I To Mediate the Topological Rearrangement of Supercoiled DNA Enantioselectively.
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- Angewandte Chemie, 2020, v. 132, n. 27, p. 11180, doi. 10.1002/ange.202002904
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Transition of average drug‐to‐antibody ratio of trastuzumab deruxtecan in systemic circulation in monkeys using a hybrid affinity capture liquid chromatography‐tandem mass spectrometry.
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- Biopharmaceutics & Drug Disposition, 2023, v. 44, n. 5, p. 380, doi. 10.1002/bdd.2371
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Intracellular dynamics of topoisomerase I inhibitor, CPT-11, by slit-scanning confocal Raman microscopy.
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- Histochemistry & Cell Biology, 2009, v. 132, n. 1, p. 39, doi. 10.1007/s00418-009-0594-0
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Exploitation of Pare Topoisomerase IV as Drug Target for the Treatment of Multidrug-Resistant Bacteria: A Review.
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- Pharmaceutical Chemistry Journal, 2020, v. 54, n. 5, p. 462, doi. 10.1007/s11094-020-02223-w
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DNA topoisomerase-directed anticancerous alkaloids: ADMET-based screening, molecular docking, and dynamics simulation.
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- Biotechnology & Applied Biochemistry, 2016, v. 63, n. 1, p. 125, doi. 10.1002/bab.1346
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Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia.
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- Human Genetics, 2023, v. 142, n. 9, p. 1417, doi. 10.1007/s00439-023-02589-3
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Synthesis, characterization, and investigation of singlet oxygen, DNA interaction, and topoisomerase I inhibition properties of novel zinc(II) phthalocyanine.
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- Turkish Journal of Chemistry, 2019, v. 43, n. 6, p. 1646, doi. 10.3906/kim-1909-32
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Synthesis, in vitro DNA interactions, cytotoxicities, antioxidative activities, and topoisomerase inhibition potentials of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with azo-oxime ligands.
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- Turkish Journal of Chemistry, 2017, v. 41, n. 5, p. 728, doi. 10.3906/kim-1612-53
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The role of DNA topoisomerase 1α (AtTOP1α) in regulating arabidopsis meiotic recombination and chromosome segregation.
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- PeerJ, 2024, p. 1, doi. 10.7717/peerj.17864
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Molecular typing and profiling of topoisomerase mutations causing resistance to ciprofloxacin and levofloxacin in Elizabethkingia species.
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- PeerJ, 2018, p. 1, doi. 10.7717/peerj.5608
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Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes.
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- 2004
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- journal article
4 + n-dimensional water and waves on four and eleven-dimensional manifolds.
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- Open Physics, 2018, v. 16, n. 1, p. 463, doi. 10.1515/phys-2018-0063
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Synthesis, Cytotoxicity, Antioxidant Activity, DFT Calculations, and Docking Studies of New Pyridine-Malonate Derivatives as Potential Anticancer Agents.
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- Polycyclic Aromatic Compounds, 2024, v. 44, n. 10, p. 6615, doi. 10.1080/10406638.2023.2281468
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Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2024, v. 39, n. 1, p. 1, doi. 10.1080/14756366.2024.2302920
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Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2205043
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Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2198163
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Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2023.2171029
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Design, synthesis, molecular modelling and antitumor evaluation of S-glucosylated rhodanines through topo II inhibition and DNA intercalation.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2022.2163996
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Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 1, doi. 10.1080/14756366.2022.2157825
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Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 192, doi. 10.1080/14756366.2022.2140420
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Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2023, v. 38, n. 1, p. 118, doi. 10.1080/14756366.2022.2136172
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Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 502, doi. 10.1080/14756366.2021.2021898
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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1346, doi. 10.1080/14756366.2022.2072308
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From Antarctica to cancer research: a novel human DNA topoisomerase IB inhibitor from Antarctic sponge Dendrilla antarctica.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1404, doi. 10.1080/14756366.2022.2078320
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2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 355, doi. 10.1080/14756366.2021.2015344
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DNA topoisomerases as molecular targets for anticancer drugs.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1781, doi. 10.1080/14756366.2020.1821676
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Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1657, doi. 10.1080/14756366.2020.1806831
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Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2020, v. 35, n. 1, p. 1363, doi. 10.1080/14756366.2020.1780226
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In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 877, doi. 10.1080/14756366.2019.1593159
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The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 818, doi. 10.1080/14756366.2018.1516651
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Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 134, doi. 10.1080/14756366.2018.1507029
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Bulge oligonucleotide as an inhibitory agent of bacterial topoisomerase I.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2018, v. 33, n. 1, p. 319, doi. 10.1080/14756366.2017.1419218
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Design, synthesis and anticancer activity of oxoaporphine alkaloid derivatives.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2014, v. 29, n. 5, p. 722, doi. 10.3109/14756366.2013.845818
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Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2014, v. 29, n. 2, p. 243, doi. 10.3109/14756366.2013.768987
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Antileishmanial activity evaluation of bis-lawsone analogs and DNA topoisomerase-I inhibition studies.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2014, v. 29, n. 2, p. 185, doi. 10.3109/14756366.2013.765413
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Molecular modelling design, synthesis and cytotoxic evaluation of certain substituted 2-(3,4,5-triacetoxybenzoylamino)benzo[ d]thiazole and 2-(galloylamino)benzo[ d]thiazole derivatives having potential topoisomerase-I inhibitory activity.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2013, v. 28, n. 6, p. 1331, doi. 10.3109/14756366.2012.716835
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Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2012, v. 27, n. 3, p. 437, doi. 10.3109/14756366.2011.595712
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Cytotoxic activity of 4′-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2009, v. 24, n. 3, p. 804, doi. 10.1080/14756360802399126
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Iridoids as DNA topoisomerase I poisons.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2005, v. 20, n. 4, p. 389, doi. 10.1080/14756360500141879
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- Article
Indolizino[1,2- b ]quinolines Derived from A-D Rings of Camptothecin: Synthesis and DNA Interaction.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2003, v. 18, n. 2, p. 101, doi. 10.1080/1475636031000093534
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Cytotoxic Bis-3,4-dihydro-β-carbolines and Bis-β-carbolines.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2002, v. 17, n. 6, p. 369, doi. 10.1080/147563021000005631
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Flavonoids As DNA Topoisomerase I Poisons.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2002, v. 17, n. 1, p. 25, doi. 10.1080/14756360290011744
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- Article
Recent Advances with Topotecan in the Treatment of Lung Cancer.
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- Oncologist, 2007, v. 12, n. 10, p. 1194, doi. 10.1634/theoncologist.12-10-1194
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Accumulation of AID in immunoglobulin variable genes in the absence of Topoisomerase I.
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- Turkish Journal of Immunology, 2016, v. 4, p. 22
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