Works about DIHYDROPYRIMIDINE dehydrogenase

Results: 321

Effective and economical column-based method for RNA isolation from animal cells.

Published in:

Biotechnology Letters, 2019, v. 41, n. 8/9, p. 915, doi. 10.1007/s10529-019-02700-7

By:

Niu, Qiaoge;
Cao, Maosheng;
Chen, Shuxiong;
Zhao, Yun;
Chen, Lu;
Li, Chunjin;
Zhou, Xu

Publication type:

Article

Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in gallbladder carcinoma.

Published in:

Surgery Today, 2012, v. 42, n. 6, p. 565, doi. 10.1007/s00595-012-0118-8

By:

Iwahashi, Shuichi;
Shimada, Mitsuo;
Utsunomiya, Tohru;
Morine, Yuji;
Imura, Satoru;
Ikemoto, Tetsuya;
Mori, Hiroki;
Hanaoka, Jun

Publication type:

Article

Synthesis and Characterization of Two 3,4-Dihydropyrimidinone Derivatives.

Published in:

Diyala Journal for Pure Science, 2018, v. 14, n. 4, p. 170, doi. 10.24237/djps.1404.463B

By:

Ali, Noor Raisan;
Magtoof, Mahmood Shakir

Publication type:

Article

A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations.

Published in:

Modern Rheumatology, 2012, v. 22, n. 1, p. 52, doi. 10.3109/s10165-011-0467-y

By:

Meziani, Roubila;
Yamada, Ryo;
Takahashi, Meiko;
Ohigashi, Kenei;
Morinobu, Akio;
Terao, Chikashi;
Hiratani, Hitomi;
Ohmura, Koichiro;
Yamaguchi, Masao;
Nomura, Takashi;
Vasilescu, Alexandre;
Kokubo, Miki;
Renault, Victor;
Hirosawa, Katsura;
Ratanajaraya, Chanavee;
Heath, Simon;
Mimori, Tsuneyo;
Sakaguchi, Shimon;
Lathrop, Mark;
Melchers, Inga

Publication type:

Article

Capecitabine—A "Permanent Mission" in Head and Neck Cancers "War Council"?

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 19, p. 5582, doi. 10.3390/jcm11195582

By:

Mireștean, Camil Ciprian;
Iancu, Roxana Irina;
Iancu, Dragoș Petru Teodor

Publication type:

Article

In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase.

Published in:

Journal of Clinical Medicine, 2020, v. 9, n. 8, p. 2342, doi. 10.3390/jcm9082342

By:

Hishinuma, Eiji;
Gutiérrez Rico, Evelyn;
Hiratsuka, Masahiro

Publication type:

Article

Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice.

Published in:

Journal of Biological Rhythms, 2023, v. 38, n. 2, p. 171, doi. 10.1177/07487304221148779

By:

Akyel, Yasemin Kubra;
Ozturk Civelek, Dilek;
Ozturk Seyhan, Narin;
Gul, Seref;
Gazioglu, Isil;
Pala Kara, Zeliha;
Lévi, Francis;
Kavakli, Ibrahim Halil;
Okyar, Alper

Publication type:

Article

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD).

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.94075

By:

Ting Zhang;
Ambrodji, Alisa;
Huixing Huang;
Bouchonville, Kelly J.;
Etheridge, Amy S.;
Schmidt, Remington E.;
Bembenek, Brianna M.;
Temesgen, Zoey B.;
Zhiquan Wang;
Innocenti, Federico;
Stroka, Deborah;
Diasio, Robert B.;
Largiadèr, Carlo R.;
Offer, Steven M.

Publication type:

Article

Balance of care activity after EMA recommendation for DPYD gene testing in Galicia.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1523536

By:

Gil-Rodríguez, Almudena;
Recarey-Rama, Sheila;
Rodríguez-Viyuela, Ana;
Barros, Francisco;
Carracedo, Angel;
Maroñas, Olalla

Publication type:

Article

Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2024.1459565

By:

de Haar-Holleman, Amy;
Cortoos, Pieter-Jan;
Vlaeminck, Jelle;
Van Landuyt, Paulien;
Steurbaut, Stephane;
Vaeyens, Freya;
Haufroid, Vincent

Publication type:

Article

Case report: A case of severe capecitabine toxicity due to confirmed in trans compound heterozygosity of a common and rare DPYD variant.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1459565

By:

de Haar-Holleman, Amy;
Cortoos, Pieter-Jan;
Vlaeminck, Jelle;
Van Landuyt, Paulien;
Steurbaut, Stephane;
Vaeyens, Freya;
Haufroid, Vincent

Publication type:

Article

Rare Dihydropyrimidine Dehydrogenase Variants and Toxicity by Floropyrimidines: A Case Report.

Published in:

Frontiers in Oncology, 2019, p. N.PAG, doi. 10.3389/fonc.2019.00139

By:

Palmirotta, Raffaele;
Lovero, Domenica;
Delacour, Hervé;
Le Roy, Audrey;
Cremades, Serge;
Silvestris, Franco

Publication type:

Article

Potential Impact of DPYD Variation on Fluoropyrimidine Drug Response in sub-Saharan African Populations.

Published in:

Frontiers in Genetics, 2021, v. 11, p. N.PAG, doi. 10.3389/fgene.2021.626954

By:

da Rocha, Jorge E. B.;
Lombard, Zané;
Ramsay, Michèle

Publication type:

Article

Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature.

Published in:

Clinics & Practice, 2021, v. 11, n. 3, p. 467, doi. 10.3390/clinpract11030062

By:

Bukhari, Nedal;
Alshangiti, Abdulraheem;
Tashkandi, Emad;
Algarni, Mohammed;
Al-Shamsi, Humaid O.;
Al-Khallaf, Hamoud

Publication type:

Article

A patient with a severe allergic reaction secondary to Efudix 5% cream.

Published in:

Clinical & Experimental Dermatology, 2023, v. 48, n. 6, p. 699, doi. 10.1093/ced/llad072

By:

Lam, Mun Wai;
Cuell, Alexis

Publication type:

Article

The beneficial influence of rhubarb on 5-fluorouracil-induced ileal mucositis and the combined role of aquaporin-4, tumour necrosis factor-α, nuclear factor-kappa B & matrix metalloproteinase-9 in rat model: histological study.

Published in:

Anatomy & Cell Biology, 2020, v. 53, n. 2, p. 228, doi. 10.5115/acb.20.014

By:

Kamar, Samaa Samir;
Baky, Mostafa Hasan;
Omar, Abeer Ibraheem

Publication type:

Article

Clinical characteristics and gene mutation analysis of an adult patient with ETFDH-related multiple acyl-CoA dehydrogenase deficiency.

Published in:

Molecular Medicine Reports, 2020, v. 22, n. 5, p. 4396

By:

Wang, Chenyi;
Lv, Haihong;
Xu, Xia;
Ma, Yuping;
Li, Qian

Publication type:

Article

Viruses with U-DNA: New Avenues for Biotechnology.

Published in:

Viruses (1999-4915), 2021, v. 13, n. 5, p. 875, doi. 10.3390/v13050875

By:

Nagy, Kinga K.;
Skurnik, Mikael;
Vértessy, Beáta G.;
Azeredo, Joana

Publication type:

Article

SSCP Screening of the Dihydropyrimidine Dehydrogenase Gene Polymorphisms of the Japanese Population Using a Semi-automated Electrophoresis Unit.

Published in:

Biochemical Genetics, 2007, v. 45, n. 9, p. 713, doi. 10.1007/s10528-007-9109-7

By:

Okamoto, Yoshihiro;
Ueta, Akihito;
Sumi, Satoshi;
Ito, Tetsuya;
Okubo, Yumiko;
Jose, Yuki;
Ninomiya, Akiko;
Togari, Hajime;
Nishida, Mikio

Publication type:

Article

Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers.

Published in:

British Journal of Cancer, 2013, v. 109, n. 9, p. 2347, doi. 10.1038/bjc.2013.621

By:

Gross, E;
Meul, C;
Raab, S;
Propping, C;
Avril, S;
Aubele, M;
Gkazepis, A;
Schuster, T;
Grebenchtchikov, N;
Schmitt, M;
Kiechle, M;
Meijer, J;
Vijzelaar, R;
Meindl, A;
van Kuilenburg, A B P

Publication type:

Article

Upregulation of ERCC1 and DPD expressions after oxaliplatin-based first-line chemotherapy for metastatic colorectal cancer.

Published in:

British Journal of Cancer, 2012, v. 107, n. 12, p. 1950, doi. 10.1038/bjc.2012.502

By:

Baba, H;
Watanabe, M;
Okabe, H;
Miyamoto, Y;
Sakamoto, Y;
Baba, Y;
Iwatsuki, M;
Chikamoto, A;
Beppu, T

Publication type:

Article

Molecular Insights into How the Dimetal Center in Dihydropyrimidinase Can Bind the Thymine Antagonist 5-Aminouracil: A Different Binding Mode from the Anticancer Drug 5-Fluorouracil.

Published in:

Bioinorganic Chemistry & Applications, 2022, p. 1, doi. 10.1155/2022/1817745

By:

Lin, En-Shyh;
Luo, Ren-Hong;
Yang, Ya-Ching;
Huang, Cheng-Yang

Publication type:

Article

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways.

Published in:

EMBO Journal, 2000, v. 19, n. 20, p. 5542, doi. 10.1093/emboj/19.20.5542

By:

Otterlei, Marit;
Kavli, Bodil;
Standal, Rune;
Skjelbred, Camilla;
Bharati, Sangeeta;
Krokan, Hans Einar

Publication type:

Article

A Guide for Implementing DPYD Genotyping for Systemic Fluoropyrimidines into Clinical Practice.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 117, n. 5, p. 1194, doi. 10.1002/cpt.3567

By:

Ho, Teresa T.;
Smith, D. Max;
Aquilante, Christina L.;
Cicali, Emily J.;
El Rouby, Nihal;
Hertz, Daniel L.;
Imanirad, Iman;
Patel, Jai N.;
Scott, Stuart A.;
Swain, Sandra M.;
Tuteja, Sony;
Hicks, J. Kevin

Publication type:

Article

Personalized Chronomodulated 5‐Fluorouracil Treatment: A Physiologically‐Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 6, p. 1282, doi. 10.1002/cpt.3181

By:

Marok, Fatima Zahra;
Wojtyniak, Jan‐Georg;
Selzer, Dominik;
Dallmann, Robert;
Swen, Jesse J.;
Guchelaar, Henk‐Jan;
Schwab, Matthias;
Lehr, Thorsten

Publication type:

Article

Why is There Still Debate About Recommending DPYD‐Testing Before Fluoropyrimidine Treatment?

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 4, p. 733, doi. 10.1002/cpt.3016

By:

Cascorbi, Ingolf

Publication type:

Article

Reply to "Implementation of DPYD Genotyping in Admixed American Populations: Brazil as a Model Case".

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 1, p. 25, doi. 10.1002/cpt.2922

By:

White, Cassandra;
Scott, Rodney J.;
Paul, Christine;
Ackland, Stephen

Publication type:

Article

Implementation of DPYD Genotyping in Admixed American Populations: Brazil as a Model Case.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 1, p. 23, doi. 10.1002/cpt.2921

By:

Suarez‐Kurtz, Guilherme;
Fernandes, Vanessa Câmara;
Elias, Anna Beatriz Ribeiro

Publication type:

Article

Response to "Plasma Uracil as a DPD Phenotyping Test: Pre‐analytical Handling Matters".

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 3, p. 473, doi. 10.1002/cpt.2775

By:

de With, Mirjam;
Knikman, Jonathan;
Schellens, Jan H. M.;
Gelderblom, Hans;
Cats, Annemieke;
Guchelaar, Henk‐Jan;
Mathijssen, Ron H. J.;
Swen, Jesse J.;
Meulendijks, Didier

Publication type:

Article

From Genes to Endogenous Substrates: Towards a Better Understanding of Drug Metabolizing Enzymes.

Published in:: Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 4, p. 741, doi. 10.1002/cpt.2724
Publication type:: Article

Dihydropyrimidine Dehydrogenase Deficiency and Implementation of Upfront DPYD Genotyping.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 4, p. 791, doi. 10.1002/cpt.2667

By:

White, Cassandra;
Scott, Rodney J.;
Paul, Christine;
Ziolkowski, Andrew;
Mossman, David;
Fox, Stephen B.;
Michael, Michael;
Ackland, Stephen

Publication type:

Article

Highlights.

Published in:: Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 1, p. 16, doi. 10.1002/cpt.2619
Publication type:: Article

Dihydropyrimidine Dehydrogenase Phenotyping Using Pretreatment Uracil: A Note of Caution Based on a Large Prospective Clinical Study.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 1, p. 62, doi. 10.1002/cpt.2608

By:

de With, Mirjam;
Knikman, Jonathan;
de Man, Femke M.;
Lunenburg, Carin A. T. C.;
Henricks, Linda M.;
van Kuilenburg, André B. P.;
Maring, Jan G.;
van Staveren, Maurice C.;
de Vries, Niels;
Rosing, Hilde;
Beijnen, Jos H.;
Pluim, Dick;
Modak, Anil;
Imholz, Alex L. T.;
van Schaik, Ron H. N.;
Schellens, Jan H. M.;
Gelderblom, Hans;
Cats, Annemieke;
Guchelaar, Henk‐Jan;
Mathijssen, Ron H. J.

Publication type:

Article

Individualized Dosing of Fluoropyrimidine‐Based Chemotherapy to Prevent Severe Fluoropyrimidine‐Related Toxicity: What Are the Options?

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 3, p. 591, doi. 10.1002/cpt.2069

By:

Knikman, Jonathan E.;
Gelderblom, Hans;
Beijnen, Jos H.;
Cats, Annemieke;
Guchelaar, Henk‐Jan;
Henricks, Linda M.

Publication type:

Article

In This Issue.

Published in:: Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 681, doi. 10.1002/cpt.1801
Publication type:: Article

An Application of Machine Learning in Pharmacovigilance: Estimating Likely Patient Genotype From Phenotypical Manifestations of Fluoropyrimidine Toxicity.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 944, doi. 10.1002/cpt.1789

By:

Correia Pinheiro, Luis;
Durand, Julie;
Dogné, Jean‐Michel

Publication type:

Article

DPYD and fluoropyrimidines: Using the data as our guide.

Published in:

Pharmacotherapy, 2024, v. 44, n. 12, p. 896, doi. 10.1002/phar.4634

By:

Walko, Christine M.

Publication type:

Article

Adjuvant treatment with Capecitabine in patients who received orthotopic liver transplantation with incidental diagnosis of intrahepatic cholangiocarcinoma. Implications on DPYD polymorphisms assessment: report of two cases and review of the literature.

Published in:

Cancer Chemotherapy & Pharmacology, 2025, v. 95, n. 1, p. 1, doi. 10.1007/s00280-025-04756-x

By:

Liguori, Carolina;
Magi, Simona;
Mandolesi, Alessandra;
Agostini, Andrea;
Svegliati-Baroni, Gianluca;
Benedetti Cacciaguerra, Andrea;
Parisi, Alessandro;
Tiberi, Elisa;
Vivarelli, Marco;
Giovagnoni, Andrea;
Goteri, Gaia;
Castaldo, Pasqualina;
Berardi, Rossana;
Giampieri, Riccardo

Publication type:

Article

Influence of age on pharmacokinetics of capecitabine and its metabolites in older adults with cancer: a pilot study.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 92, n. 2, p. 135, doi. 10.1007/s00280-023-04552-5

By:

Shafiei, Mohsen;
Galettis, Peter;
Beale, Philip;
Reuter, Stephanie E.;
Martin, Jennifer H.;
McLachlan, Andrew J.;
Blinman, Prunella

Publication type:

Article

Assay performance and stability of uracil and dihydrouracil in clinical practice.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 91, n. 3, p. 257, doi. 10.1007/s00280-023-04518-7

By:

Knikman, Jonathan E.;
Rosing, Hilde;
Guchelaar, Henk-Jan;
Cats, Annemieke;
Beijnen, Jos H.

Publication type:

Article

Precision fluoropyrimidines dosing in a compound heterozygous variant carrier of the DPYD gene: a case report.

Published in:

2023

By:

Baiardi, Giammarco;
Clavarezza, Matteo;
Stella, Manuela;
Casazza, Stefania;
De Censi, Andrea;
Mattioli, Francesca

Publication type:

Case Study

Fluoropyrimidine-associated toxicity and DPYD variants c.85T>C, c.496A>G, and c.1236G>A: impact of haplotype.

Published in:

Cancer Chemotherapy & Pharmacology, 2023, v. 91, n. 1, p. 97, doi. 10.1007/s00280-022-04491-7

By:

Medwid, Samantha;
Wigle, Theodore J.;
Kim, Richard B.

Publication type:

Article

Pretherapeutic screening for Dihydropyrimidine deshydrogenase deficiency in measuring uracilemia in dialysis patients leads to a high rate of falsely positive results.

Published in:

2021

By:

Gaible, Clotilde;
Narjoz, Céline;
Loriot, Marie-Anne;
Roueff, Stéphane;
Pallet, Nicolas

Publication type:

journal article

Detecting DPD deficiency: when perfect is the enemy of good.

Published in:

2021

By:

Ciccolini, Joseph;
Milano, Gérard;
Guchelaar, Henk-Jan

Publication type:

Letter

Preemptive screening of DPYD as part of clinical practice: high prevalence of a novel exon 4 deletion in the Finnish population.

Published in:

Cancer Chemotherapy & Pharmacology, 2021, v. 87, n. 5, p. 657, doi. 10.1007/s00280-021-04236-y

By:

Saarenheimo, Jatta;
Wahid, Nesna;
Eigeliene, Natalja;
Ravi, Ravichandra;
Salomons, Gajja S.;
Ojeda, Matilde Fernandez;
Vijzelaar, Raymon;
Jekunen, Antti;
van Kuilenburg, André B. P.

Publication type:

Article

Substrate Diversity of L-Threonic Acid Dehydrogenase Homologs.

Published in:

Biochemistry (00062979), 2020, v. 85, n. 4, p. 463, doi. 10.1134/S0006297920040069

By:

Zhang, C. F.;
Liu, Y. P.;
Wu, X. X.;
Zhang, X. S.;
Huang, H.

Publication type:

Article

干预自噬影响DPD的表达促进5-FU抗结直肠癌疗效的实验研究.

Published in:

China Oncology, 2022, v. 32, n. 12, p. 1199, doi. 10.19401/j.cnki.1007-3639.2022.12.008

By:

崔忠泽;
何双;
温菲菲;
李扬扬;
许晓阳;
路丽祯;
吴淑华

Publication type:

Article

Developing DPYD Genotyping Method for Personalized Fluoropyrimidines Therapy.

Published in:

Journal of Applied Laboratory Medicine, 2024, v. 9, n. 2, p. 295, doi. 10.1093/jalm/jfad092

By:

Wong, Betty Y L;
Li, Zhenyu;
Raphael, Michael Jonathon;
De Angelis, Carlo;
Hwang, David M;
Fu, Lei

Publication type:

Article

Pyrimidine Biosynthesis and Ribonucleoside Metabolism in Species of Pseudomonas.

Published in:

Fermentation (Basel), 2023, v. 9, n. 11, p. 955, doi. 10.3390/fermentation9110955

By:

West, Thomas P.

Publication type:

Article

Eritrodisestesia palmoplantar tras tratamiento perioperatorio con quimioterapia.

Published in:

Sanidad Militar, 2022, v. 78, n. 4, p. 258, doi. 10.4321/S1887-85712022000400009

By:

Granda-Lobato, P.;
Sánchez-López, P.;
Pacheco-Barcia, V.;
Prats-Oliván, P.;
Gonzalo-Salado, M. H.;
Barrena-Castello, G.

Publication type:

Article