Works matching DE "DIHYDROOROTATE dehydrogenase"
Results: 179
Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts.
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- Cardiovascular Drugs & Therapy, 2023, v. 37, n. 5, p. 1021, doi. 10.1007/s10557-022-07341-z
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- Article
Teriflunomide-induced Raynaud's phenomenon: a serious adverse event, previously unreported.
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- Neurological Sciences, 2022, v. 43, n. 11, p. 6593, doi. 10.1007/s10072-022-06239-w
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Potential Anticancer Agents against Melanoma Cells Based on an As-Synthesized Thiosemicarbazide Derivative.
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- Biomolecules (2218-273X), 2022, v. 12, n. 2, p. 151, doi. 10.3390/biom12020151
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A Novel Graph Neural Network Methodology to Investigate Dihydroorotate Dehydrogenase Inhibitors in Small Cell Lung Cancer.
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- Biomolecules (2218-273X), 2021, v. 11, n. 3, p. 477, doi. 10.3390/biom11030477
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Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
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- Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00997
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Phytophthora infestans Dihydroorotate Dehydrogenase Is a Potential Target for Chemical Control – A Comparison With the Enzyme From Solanum tuberosum.
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- Frontiers in Microbiology, 2019, p. N.PAG, doi. 10.3389/fmicb.2019.01479
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- Article
Cloning and Characterization of Yak DHODH Gene and Its Functional Studies in a Bisphenol S-Induced Ferroptosis Model of Fetal Fibroblasts.
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- Animals (2076-2615), 2023, v. 13, n. 24, p. 3832, doi. 10.3390/ani13243832
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Novel, Long-Acting Drug May Help Prevent and Treat Malaria.
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- JAMA: Journal of the American Medical Association, 2015, v. 314, n. 9, p. 866, doi. 10.1001/jama.2015.9802
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Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments.
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- Journal of Infectious Diseases, 2023, v. 228, n. 5, p. 591, doi. 10.1093/infdis/jiad058
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- Article
The DHODH inhibitor teriflunomide impedes cell proliferation and enhances chemosensitivity to daunorubicin (DNR) in T-cell acute lymphoblastic leukemia.
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- Annals of Hematology, 2024, v. 103, n. 12, p. 5449, doi. 10.1007/s00277-024-05998-0
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- Article
Novel fungicide quinofumelin shows selectivity for fungal dihydroorotate dehydrogenase over the corresponding human enzyme.
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- Journal of Pesticide Science, 2023, v. 48, n. 1, p. 17, doi. 10.1584/jpestics.D22-035
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The target site of the novel fungicide quinofumelin, Pyricularia oryzae class II dihydroorotate dehydrogenase.
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- Journal of Pesticide Science, 2022, v. 47, n. 4, p. 190, doi. 10.1584/jpestics.D22-027
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Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells.
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- 2018
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- journal article
Uridine Inhibits Hepatocellular Carcinoma Cell Development by Inducing Ferroptosis.
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- Journal of Clinical Medicine, 2023, v. 12, n. 10, p. 3552, doi. 10.3390/jcm12103552
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Teriflunomide, a potential novel cause of chronic active colitis.
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- Histopathology, 2020, v. 77, n. 6, p. 1000, doi. 10.1111/his.14122
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Cell‐specific genome‐scale metabolic modeling of SARS‐CoV‐2‐infected lung to identify antiviral enzymes.
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- FEBS Open Bio, 2023, v. 13, n. 12, p. 2172, doi. 10.1002/2211-5463.13710
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Issue Information.
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- FEBS Open Bio, 2019, v. 9, n. 8, p. 1345, doi. 10.1002/2211-5463.12469
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A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.
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- FEBS Open Bio, 2019, v. 9, n. 8, p. 1348, doi. 10.1002/2211-5463.12658
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Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from <italic>Trypanosoma brucei</italic>.
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- FEBS Open Bio, 2018, v. 8, n. 4, p. 680, doi. 10.1002/2211-5463.12403
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- Article
Teriflunomide‐induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.
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- Clinical & Experimental Dermatology, 2021, v. 46, n. 1, p. 166, doi. 10.1111/ced.14339
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- Article
SYNTHESIS OF A NOVEL CHALCONE DERIVATIVE FROM MYRISTICIN FOR SKIN CANCER PREVENTIVE ACTIVITY.
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- Rasayan Journal of Chemistry, 2021, v. 14, n. 3, p. 1493, doi. 10.31788/RJC.2021.1436312
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- Article
Precision Medicine With Leflunomide: Consideration of the DHODH Haplotype and Plasma Teriflunomide Concentration and Modification of Outcomes in Patients With Rheumatoid Arthritis.
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- 2021
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- journal article
Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction.
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- Bioscience Reports, 2013, v. 33, n. 2, p. 217, doi. 10.1042/BSR20120097
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- Article
Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients.
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- Bioscience Reports, 2012, v. 32, n. 6, p. 631, doi. 10.1042/BSR20120046
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- Article
IN-SILICO MOLECULAR DOCKING AND ADME EVALUATION OF FICUS RACEMOSA PHYTOCONSTITUENTS TARGETING GLUCOKINASE AND DIHYDROOROTATE DEHYDROGENASE FOR DIABETES MANAGEMENT.
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- Biochemical & Cellular Archives, 2024, p. 3477, doi. 10.51470/bca.2024.24.1-S.3477
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- Article
Screening for DAX1/EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma.
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- Cancer Medicine, 2023, v. 12, n. 8, p. 9802, doi. 10.1002/cam4.5741
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- Article
Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease.
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- Cells (2073-4409), 2022, v. 11, n. 17, p. 2726, doi. 10.3390/cells11172726
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- Article
New Insights into rice pyrimidine catabolic enzymes.
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- Frontiers in Plant Science, 2023, v. 14, p. 1, doi. 10.3389/fpls.2023.1079778
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Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules.
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- Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.718863
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- Article
Dihydroorotate dehydrogenase inhibitor olorofim has potent in vitro activity against Microascus/Scopulariopsis, Rasamsonia, Penicillium and Talaromyces species.
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- Mycoses, 2023, v. 66, n. 3, p. 242, doi. 10.1111/myc.13548
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In vitro activity of olorofim against clinical isolates of the Fusarium oxysporum and Fusarium solani species complexes.
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- Mycoses, 2021, v. 64, n. 7, p. 748, doi. 10.1111/myc.13273
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Case of femoral pseudarthrosis due to Scedosporium apiospermum in an immunocompetent patient with successful conservative treatment and review of literature.
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- Mycoses, 2018, v. 61, n. 6, p. 400, doi. 10.1111/myc.12739
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Teriflunomide Concentrations in Cerebrospinal Fluid and Plasma in Patients with Multiple Sclerosis: A Pharmacokinetic Study.
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- CNS Drugs, 2023, v. 37, n. 2, p. 181, doi. 10.1007/s40263-023-00985-x
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Teriflunomide attenuates immunopathological changes in the Dark Agouti rat model of experimental autoimmune encephalomyelitis.
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- Frontiers in Neurology, 2013, v. 4, p. 1, doi. 10.3389/fneur.2013.00169
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Unveiling Anti‐Malarial, Antimicrobial, Antioxidant Efficiency and Molecular Docking Study of Synthesized Transition Metal Complexes Derived From Heterocyclic Schiff Base Ligands.
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- Chemistry - An Asian Journal, 2024, v. 19, n. 19, p. 1, doi. 10.1002/asia.202400676
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Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.
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- Genes, 2020, v. 11, n. 12, p. 1468, doi. 10.3390/genes11121468
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Teriflunomide-induced Palmoplantar Lichenoid Eruption: A Case Report.
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- Acta Dermato-Venereologica, 2024, v. 104, p. 1, doi. 10.2340/actadv.v104.40967
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The Novel h DHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis.
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- Viruses (1999-4915), 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/v14102281
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A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses.
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- Viruses (1999-4915), 2022, v. 14, n. 5, p. 928, doi. 10.3390/v14050928
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Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells.
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- Asian Journal of Traditional Medicines, 2021, v. 16, n. 1, p. 1
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- Article
Non-Toxic Fractions of Streptomyces hygroscopicus Subsp. Hygroscopicus Metabolite Suppressed the Growth of Plasmodium Falciparum in Vitro Possibly through L-malate: Quinone Oxidoreductase (PfMQO) Mitochondrial Enzyme Inhibition.
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- Systematic Reviews in Pharmacy, 2020, v. 11, n. 10, p. 524
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Absorption, distribution, metabolism and excretion of <sup>14</sup>C-Emvododstat following a single oral dose in rats and dogs.
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- Xenobiotica, 2022, v. 52, n. 12, p. 1031, doi. 10.1080/00498254.2023.2171925
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In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor.
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- Xenobiotica, 2022, v. 52, n. 2, p. 152, doi. 10.1080/00498254.2021.2010287
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A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.
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- 2018
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- Publication type:
- journal article
In silico-guided engineering of Pseudomonas putida towards growth under micro-oxic conditions.
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- Microbial Cell Factories, 2019, v. 18, n. 1, p. N.PAG, doi. 10.1186/s12934-019-1227-5
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The Warburg effect modulates DHODH role in ferroptosis: a review.
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- Cell Communication & Signaling, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12964-022-01025-9
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Identifying Mendelian disease genes with the Variant Effect Scoring Tool.
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- BMC Genomics, 2013, v. 14, n. Suppl 3, p. 1, doi. 10.1186/1471-2164-14-S3-S3
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- Article
Moving beyond multi-triazole to multi-fungicide resistance: Broader selection of drug resistance in the human fungal pathogen Aspergillus fumigatus.
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- PLoS Pathogens, 2025, v. 21, n. 2, p. 1, doi. 10.1371/journal.ppat.1012851
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Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review.
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- Biological Chemistry, 2023, v. 404, n. 6, p. 569, doi. 10.1515/hsz-2022-0323
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Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 11, p. 1117, doi. 10.1007/s10822-020-00333-x
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- Article