Works matching DE "DIHYDROOROTATE dehydrogenase"

Results: 190

Inhibitory effect of emododstat on respiratory syncytial virus.

Published in:

Tropical Journal of Pharmaceutical Research, 2025, v. 24, n. 4, p. 493, doi. 10.4314/tjpr.v24i4.6

By:

San Li;
Hui-Ming Dang;
Shan Xu;
Lei Liu;
Yi-gang Tong

Publication type:

Article

Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02510-z

By:

Bohacova, Klara;
Nahacka, Zuzana;
Dudova, Jana;
Kovarova, Jaromira;
Rohlena, Jakub;
Rennerova, Michaela;
Kasperova, Barbora Judita;
Stursa, Jan;
Werner, Lukas;
Haluzik, Martin;
Neuzil, Jiri;
Hubackova, Sona Stemberkova

Publication type:

Article

Strategic Targeting of Plasmodium Dihydroorotate Dehydrogenase through Antimicrobial Artemisinin Chiral Centers and their Derivatives: An Integrative Study Using Network Pharmacology and Isothermal Titration Calorimetry.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2024, v. 58, n. 4, p. 1356, doi. 10.5530/ijper.58.4.146

By:

ur Rehman, Zia

Publication type:

Article

Synthesis of Substituted Aryl Incorporated Oxazolo[4,5-b]Pyridine-Triazole Derivatives: Anticancer Evaluation and Molecular Docking Studies.

Published in:

Polycyclic Aromatic Compounds, 2023, v. 43, n. 1, p. 915, doi. 10.1080/10406638.2021.2021256

By:

Sireesha, Reddymasu;
Tej, Mandava Bhuvan;
Poojith, Nuthalapati;
Sreenivasulu, Reddymasu;
Musuluri, Murali;
Subbarao, Mannam

Publication type:

Article

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.87292

By:

Mullen, Nicholas J.;
Shukla, Surendra K.;
Thakur, Ravi;
Kollala, Sai Sundeep;
Dezhen Wang;
Chaika, Nina;
Santana, Juan F.;
Miklavcic, William R.;
LaBreck, Drew A.;
Mallareddy, Jayapal Reddy;
Price, David H.;
Natarajan, Amarnath;
Mehla, Kamiya;
Sykes, David B.;
Hollingsworth, Michael A.;
Singh, Pankaj K.

Publication type:

Article

Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.85023

By:

Mandt, Rebecca E. K.;
Luth, Madeline R.;
Tye, Mark A.;
Mazitschek, Ralph;
Ottilie, Sabine;
Winzeler, Elizabeth A.;
Lafuente-Monasterio, Maria Jose;
Javier Gamo, Francisco;
Wirth, Dyann F.;
Lukens, Amanda K.

Publication type:

Article

Teriflunomide, a potential novel cause of chronic active colitis.

Published in:

Histopathology, 2020, v. 77, n. 6, p. 1000, doi. 10.1111/his.14122

By:

Kővári, Bence;
Zachs, Jeffrey;
Murchie, Brent;
Lauwers, Gregory Y

Publication type:

Article

Tridentate xanthene-based hydrazone ligands and their mononuclear transition metal complexes: synthesis, anti-malarial, antimicrobial and molecular docking studies.

Published in:

Research on Chemical Intermediates, 2024, v. 50, n. 3, p. 1409, doi. 10.1007/s11164-023-05222-0

By:

Rani, Manju;
Devi, Jai;
Kumar, Binesh;
Arora, Tanisha;
Taxak, Bharti

Publication type:

Article

An efficient synthesis of rearranged new biologically active benzimidazoles derived from 2-formyl carvacrol.

Published in:

Research on Chemical Intermediates, 2022, v. 48, n. 1, p. 401, doi. 10.1007/s11164-021-04601-9

By:

Bhoi, Rahul T.;
Rajput, Jamatsing D.;
Bendre, Ratnamala S.

Publication type:

Article

Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38753-6

By:

Zhan, Meixiao;
Ding, Yufeng;
Huang, Shanzhou;
Liu, Yuhang;
Xiao, Jing;
Yu, Hua;
Lu, Ligong;
Wang, Xiongjun

Publication type:

Article

Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species.

Published in:

PLoS ONE, 2023, v. 18, n. 8, p. 1, doi. 10.1371/journal.pone.0289441

By:

Pinder, Corinne;
Lebedinec, Ressa;
Levine, Tim P.;
Birch, Mike;
Oliver, Jason D.

Publication type:

Article

GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation.

Published in:

PLoS ONE, 2023, v. 18, n. 4, p. 1, doi. 10.1371/journal.pone.0284332

By:

Yang, He-Yu;
Sun, Xu;
Zhen, Shu-Qing;
Yu, Liang-Zhu;
Ding, Jie-Qiong;
Liu, Ling;
Xie, Min;
Zhu, Hai-Li

Publication type:

Article

A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.

Published in:

2018

By:

Murphy, Sean C.;
Duke, Elizabeth R.;
Shipman, Kelly J.;
Jensen, Ryan L.;
Youyi Fong;
Ferguson, Sue;
Janes, Holly E.;
Gillespie, Kevin;
Seilie, Annette M.;
Hanron, Amelia E.;
Rinn, Laurie;
Fishbaugher, Matthew;
VonGoedert, Tracie;
Fritzen, Emma;
Kappe, Stefan H.;
Ming Chang;
Sousa, Jason C.;
Marcsisin, Sean R.;
Chalon, Stephan;
Duparc, Stephan

Publication type:

journal article

Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice.

Published in:

Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03013-x

By:

Zhang, Shutian;
Zhao, Dajun;
Yang, Zhaohua;
Wang, Fanshun;
Yang, Shouguo;
Wang, Chunsheng

Publication type:

Article

Review of the novel antifungal drug olorofim (F901318).

Published in:

BMC Infectious Diseases, 2024, v. 24, n. 1, p. 1, doi. 10.1186/s12879-024-10143-3

By:

Vanbiervliet, Yuri;
Van Nieuwenhuyse, Tine;
Aerts, Robina;
Lagrou, Katrien;
Spriet, Isabel;
Maertens, Johan

Publication type:

Article

Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review.

Published in:

Biological Chemistry, 2023, v. 404, n. 6, p. 569, doi. 10.1515/hsz-2022-0323

By:

Alipoor, Reza;
Ranjbar, Reza

Publication type:

Article

Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts.

Published in:

Cardiovascular Drugs & Therapy, 2023, v. 37, n. 5, p. 1021, doi. 10.1007/s10557-022-07341-z

By:

Alexander, Emily Davis;
Aldridge, Jessa L.;
Burleson, T. Samuel;
Frasier, Chad R.

Publication type:

Article

Regioselective Synthesis of 5- and 3-Hydroxy- N -Aryl-1 H -Pyrazole-4-Carboxylates and Their Evaluation as Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase.

Published in:

Molecules, 2022, v. 27, n. 15, p. 4764, doi. 10.3390/molecules27154764

By:

Vah, Luka;
Medved, Tadej;
Grošelj, Uroš;
Klemenčič, Marina;
Podlipnik, Črtomir;
Štefane, Bogdan;
Wagger, Jernej;
Novinec, Marko;
Svete, Jurij

Publication type:

Article

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study.

Published in:

Molecules, 2022, v. 27, n. 12, p. 3660, doi. 10.3390/molecules27123660

By:

Galati, Salvatore;
Sainas, Stefano;
Giorgis, Marta;
Boschi, Donatella;
Lolli, Marco L.;
Ortore, Gabriella;
Poli, Giulio;
Tuccinardi, Tiziano

Publication type:

Article

Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in Plasmodium falciparum : Recent Survey upon Synthesis and Biological Evaluation of Potential Drugs against Malaria.

Published in:

Molecules, 2021, v. 26, n. 18, p. 5711, doi. 10.3390/molecules26185711

By:

Koumpoura, Christina L.;
Robert, Anne;
Athanassopoulos, Constantinos M.;
Baltas, Michel

Publication type:

Article

The Mitochondria-Independent Cytotoxic Effect of Leflunomide on RPMI-8226 Multiple Myeloma Cell Line.

Published in:

Molecules, 2021, v. 26, n. 18, p. 5653, doi. 10.3390/molecules26185653

By:

Adamczuk, Grzegorz;
Humeniuk, Ewelina;
Iwan, Magdalena;
Natorska-Chomicka, Dorota;
Adamczuk, Kamila;
Korga-Plewko, Agnieszka

Publication type:

Article

The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines.

Published in:

Molecules, 2019, v. 24, n. 22, p. 4095, doi. 10.3390/molecules24224095

By:

C. S. Pinheiro, Luiz;
M. Feitosa, Lívia;
O. Gandi, Marilia;
F. Silveira, Flávia;
Boechat, Nubia;
Sülsen, Valeria Patricia;
Moglioni, Albertina

Publication type:

Article

Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates.

Published in:

Molecules, 2019, v. 24, n. 21, p. 3917, doi. 10.3390/molecules24213917

By:

Oramas-Royo, Sandra;
López-Rojas, Priscila;
Amesty, Ángel;
Gutiérrez, David;
Flores, Ninoska;
Martín-Rodríguez, Patricia;
Fernández-Pérez, Leandro;
Estévez-Braun, Ana

Publication type:

Article

Structural Optimization and Structure–Activity Relationship of 4-Thiazolidinone Derivatives as Novel Inhibitors of Human Dihydroorotate Dehydrogenase.

Published in:

Molecules, 2019, v. 24, n. 15, p. 2780, doi. 10.3390/molecules24152780

By:

Zeng, Fanxun;
Quan, Lina;
Yang, Guantian;
Qi, Tiantian;
Zhang, Letian;
Li, Shiliang;
Li, Honglin;
Zhu, Lili;
Xu, Xiaoyong

Publication type:

Article

Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase.

Published in:

Molecules, 2018, v. 23, n. 6, p. 1254, doi. 10.3390/molecules23061254

By:

Xu, Le;
Li, Wenjie;
Diao, Yanyan;
Sun, Hongxia;
Li, Honglin;
Zhu, Lili;
Zhou, Hongchang;
Zhao, Zhenjiang

Publication type:

Article

Combination of consensus and ensemble docking strategies for the discovery of human dihydroorotate dehydrogenase inhibitors.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-91069-7

By:

Chilingaryan, Garri;
Abelyan, Narek;
Sargsyan, Arsen;
Nazaryan, Karen;
Serobian, Andre;
Zakaryan, Hovakim

Publication type:

Article

Chemical Constituents of the Bark of Zanthoxylum gilletii (Rutaceae) and Their In Vitro Antiplasmodial and Molecular Docking Studies.

Published in:

Journal of Chemistry, 2022, p. 1, doi. 10.1155/2022/1111817

By:

Dzouemo, Liliane Clotilde;
Mouthé Happi, Gervais;
Ahmed, Sikiru Akinyeye;
Dongmo Tekapi Tsopgni, Willifred;
Nde Akuma, Michael;
Salau, Shina;
Ngeufa Happi, Emmanuel;
Wansi, Jean Duplex

Publication type:

Article

An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase.

Published in:

Journal of Chemistry, 2022, p. 1, doi. 10.1155/2022/5314179

By:

Kyei, Lois Kwane;
Gasu, Edward Ntim;
Ampomah, Gilbert Boadu;
Mensah, Jehoshaphat Oppong;
Borquaye, Lawrence Sheringham

Publication type:

Article

Hailey–Hailey disease (benign familial pemphigus) responsive to treatment with ocrelizumab for multiple sclerosis.

Published in:

British Journal of Dermatology, 2023, v. 189, n. 2, p. 232, doi. 10.1093/bjd/ljad101

By:

Adamson, Sarah R;
Higgins, Claire L;
Veysey, Emma

Publication type:

Article

BI25: Eruptive keratoacanthomas in association with leflunomide and adalimumab treatment for psoriatic arthritis: an insight into cancer prevention?

Published in:: British Journal of Dermatology, 2022, v. 187, p. 115, doi. 10.1111/bjd.21367
Publication type:: Article

In vitro activity of olorofim against clinical isolates of the Fusarium oxysporum and Fusarium solani species complexes.

Published in:

Mycoses, 2021, v. 64, n. 7, p. 748, doi. 10.1111/myc.13273

By:

Badali, Hamid;
Cañete‐Gibas, Connie;
Patterson, Hoja;
Sanders, Carmita;
Mermella, Barbara;
Garcia, Victor;
Mele, James;
Fan, Hongxin;
Wiederhold, Nathan P.

Publication type:

Article

Case of femoral pseudarthrosis due to Scedosporium apiospermum in an immunocompetent patient with successful conservative treatment and review of literature.

Published in:

Mycoses, 2018, v. 61, n. 6, p. 400, doi. 10.1111/myc.12739

By:

Dinh, Aurélien;
Demay, Olivier;
Rottman, Martin;
Gaudot, Fabrice;
Bougnoux, Marie‐Elisabeth;
Bouchand, Frédérique;
Coignard, Hélène;
Rouzaud, Claire;
Davido, Benjamin;
Duran, Clara;
Nich, Christophe

Publication type:

Article

Cell‐specific genome‐scale metabolic modeling of SARS‐CoV‐2‐infected lung to identify antiviral enzymes.

Published in:

FEBS Open Bio, 2023, v. 13, n. 12, p. 2172, doi. 10.1002/2211-5463.13710

By:

Chen, Ke‐Lin;
Wang, Feng‐Sheng

Publication type:

Article

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03441-3

By:

Ladds, Marcus J. G. W.;
van Leeuwen, Ingeborg M. M.;
Drummond, Catherine J.;
Su Chu;
Healy, Alan R.;
Popova, Gergana;
Fernández, Andrés Pastor;
Mollick, Tanzina;
Darekar, Suhas;
Sedimbi, Saikiran K.;
Nekulova, Marta;
Sachweh, Marijke C. C.;
Campbell, Johanna;
Higgins, Maureen;
Tuck, Chloe;
Popa, Mihaela;
Safont, Mireia Mayoral;
Gelebart, Pascal;
Fandalyuk, Zinayida;
Thompson, Alastair M.

Publication type:

Article

Inhibition of pyrimidine biosynthesis by strobilurin derivatives induces differentiation of acute myeloid leukemia cells.

Published in:

Leukemia & Lymphoma, 2022, v. 63, n. 5, p. 1202, doi. 10.1080/10428194.2021.2008382

By:

Shen, Xing;
Zhang, Lu;
Xing, Shuang;
Zhang, Xue-Wen;
Xiong, Guo-Lin;
Cong, Yu-Wen;
Xiao, He;
Wang, Xin-Ru;
Yu, Zu-Yin

Publication type:

Article

Targeting mitochondrial metabolism in acute myeloid leukemia.

Published in:

Leukemia & Lymphoma, 2022, v. 63, n. 3, p. 530, doi. 10.1080/10428194.2021.1992759

By:

Rex, Madison Rush;
Williams, Robert;
Birsoy, Kivanç;
Ta llman, Martin S.;
Stahl, Maximillian

Publication type:

Article

SYNTHESIS OF A NOVEL CHALCONE DERIVATIVE FROM MYRISTICIN FOR SKIN CANCER PREVENTIVE ACTIVITY.

Published in:

Rasayan Journal of Chemistry, 2021, v. 14, n. 3, p. 1493, doi. 10.31788/RJC.2021.1436312

By:

Ansory, H. M.;
Fitriani, I. N.;
Handayani, S.;
Aznam, N.

Publication type:

Article

Exploring the Venom Gland Transcriptome of Bothrops asper and Bothrops jararaca : De Novo Assembly and Analysis of Novel Toxic Proteins.

Published in:

Toxins, 2024, v. 16, n. 12, p. 511, doi. 10.3390/toxins16120511

By:

Espín-Angulo, Joseph;
Vela, Doris

Publication type:

Article

Non-Toxic Fractions of Streptomyces hygroscopicus Subsp. Hygroscopicus Metabolite Suppressed the Growth of Plasmodium Falciparum in Vitro Possibly through L-malate: Quinone Oxidoreductase (PfMQO) Mitochondrial Enzyme Inhibition.

Published in:

Systematic Reviews in Pharmacy, 2020, v. 11, n. 10, p. 524

By:

Cahyono, Alfian Wika;
Fitri, Loeki Enggar;
Nafisatuzzamrudah;
Nugraha, Rivo Yudhinata Brian;
Aulia, Rara;
Febriliani, Fitria;
Ariel, Dio Giovanni;
Mardhiyyah, Kana;
Winarsih, Sri;
Suciati;
Japany, Dian;
Endang, Erwahyuni;
Waluyo, Danang

Publication type:

Article

Molecular docking, molecular dynamics simulation, and in vitro evaluation of hydroxythioxanthone derivatives as antimalarial agents.

Published in:

Thai Journal of Pharmaceutical Sciences, 2024, v. 48, n. 4, p. 1

By:

Hermawan, Faris;
Jumina, Jumina;
Ernawati, Teni;
Asih, Puji Budi Setia;
Rozi, Ismail Ekoprayitno;
Coutrier, Elisabeth Farah Novita;
Syafruddin, Din

Publication type:

Article

Identifying Mendelian disease genes with the Variant Effect Scoring Tool.

Published in:

BMC Genomics, 2013, v. 14, n. Suppl 3, p. 1, doi. 10.1186/1471-2164-14-S3-S3

By:

Carter, Hannah;
Douville, Christopher;
Stenson, Peter D.;
Cooper, David N.;
Karchin, Rachel

Publication type:

Article

Treatment of Invasive Aspergillosis: How It's Going, Where It's Heading.

Published in:

Mycopathologia, 2023, v. 188, n. 5, p. 667, doi. 10.1007/s11046-023-00727-z

By:

Boyer, Johannes;
Feys, Simon;
Zsifkovits, Isabella;
Hoenigl, Martin;
Egger, Matthias

Publication type:

Article

Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones.

Published in:

Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 11, p. 1117, doi. 10.1007/s10822-020-00333-x

By:

Clark, Robert D.;
Morris, Denise N.;
Chinigo, Gary;
Lawless, Michael S.;
Prudhomme, Jacques;
Le Roch, Karine G.;
Lafuente, Maria José;
Ferrer, Santiago;
Gamo, Francisco Javier;
Gadwood, Robert;
Woltosz, Walter S.

Publication type:

Article

S1P РЕЦЕПТОРНИ МОДУЛАТОРИ ЗА ЛЕЧЕНИЕ НА ПРИСТЪПНО-РЕМИТЕНТНА ФОРМА НА МУЛТИПЛЕНА СКЛЕРОЗА – ИКОНОМИЧЕСКИ МРЕЖОВ МЕТААНАЛИЗ.

Published in:

Neurology & Psychiatry, 2022, v. 53, n. 1, p. 3

By:

Веков, Т.;
Велева, Н.;
Драганова, М.;
Колев, Ж.

Publication type:

Article

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00997

By:

Yukiko Miyazaki;
Inaoka, Daniel K.;
Tomoo Shiba;
Hiroyuki Saimoto;
Takaya Sakura;
Eri Amalia;
Yasutoshi Kido;
Chika Sakai;
Mari Nakamura;
Moore, Anthony L.;
Shigeharu Harada;
Kiyoshi Kita

Publication type:

Article

Onychodystrophy following the use of leflunomide for seronegative rheumatoid arthritis.

Published in:

Dermatologic Therapy, 2020, v. 33, n. 6, p. 1, doi. 10.1111/dth.14491

By:

Azhar, Aaminah F.;
Evanson, Bradley;
Parekh, Palak K.

Publication type:

Article

Case report of recalcitrant allergic contact eczema successfully treated with teriflunomide.

Published in:

Dermatologic Therapy, 2019, v. 32, n. 4, p. N.PAG, doi. 10.1111/dth.12947

By:

Reis, Joel;
Duarte, Sara;
Sardoeira, Ana;
Santos, Ernestina;
Sanches, Madalena;
Lobo, Inês;
Selores, Manuela

Publication type:

Article

Issue Information.

Published in:: FEBS Open Bio, 2019, v. 9, n. 8, p. 1345, doi. 10.1002/2211-5463.12469
Publication type:: Article

A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode.

Published in:

FEBS Open Bio, 2019, v. 9, n. 8, p. 1348, doi. 10.1002/2211-5463.12658

By:

Zeng, Ting;
Zuo, Zeping;
Luo, Youfu;
Zhao, Yinglan;
Yu, Yamei;
Chen, Qiang

Publication type:

Article

Crystal structures of FMN‐bound and FMN‐free forms of dihydroorotate dehydrogenase from <italic>Trypanosoma brucei</italic>.

Published in:

FEBS Open Bio, 2018, v. 8, n. 4, p. 680, doi. 10.1002/2211-5463.12403

By:

Kubota, Tomomi;
Tani, Osamu;
Yamaguchi, Tomohiko;
Namatame, Ichiji;
Sakashita, Hitoshi;
Furukawa, Koji;
Yamasaki, Kazuhiko

Publication type:

Article