Works matching DE "DIHYDROOROTATE dehydrogenase"

Results: 199

Identification of genetic variations linked to buparvaquone resistance in Theileria annulata infecting dairy cattle in India.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0326243

By:

Musale, Pankaj;
Khilari, Ajinkya;
Gade, Rohini;
Dhanikachalam, Velu;
Jadhav, Santoshkumar;
Bajpai, Manali;
Turakani, Bhagya;
Joshi, Akshay;
Prajapati, Amar;
Srivastava, Anand;
Swaminathan, Marimuthu;
Joshi, Sachin;
Shanmugam, Dhanasekaran

Publication type:

Article

Direct long-read visualization reveals hidden variation in GCH1 gene copy number and precise expansion steps.

Published in:

BMC Genomics, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12864-025-11859-5

By:

Liu, Shiwei;
Zulawinska, Julia;
Ebel, Emily R.;
Luniewski, Aleksander;
Danis, Charles;
Simpson, Mary Lewis;
Kim, Jane;
Ene, Nnenna;
Braukmann, Thomas Werner Anthony;
Congdon, Molly;
Santos, Webster;
Yeh, Ellen;
Guler, Jennifer L.

Publication type:

Article

Making sense of human colorectal cancer molecular subtypes: mice are stepping in.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02594-7

By:

Green, Caleb;
Roccia, Pamela;
Rufini, Alessandro

Publication type:

Article

Discovery of Novel Inhibitors of Aspergillus fumigatus DHODH via Virtual Screening, MD Simulation, and In Vitro Activity Assay.

Published in:

Molecules, 2025, v. 30, n. 12, p. 2607, doi. 10.3390/molecules30122607

By:

Li, Kaige;
Xia, Wei;
Zhang, John Z. H.

Publication type:

Article

Computational Modeling of Low-Abundance Proteins in Venom Gland Transcriptomes: Bothrops asper and Bothrops jararaca.

Published in:

Toxins, 2025, v. 17, n. 6, p. 262, doi. 10.3390/toxins17060262

By:

Espín-Angulo, Joseph;
Vela, Doris

Publication type:

Article

Treatment of Invasive Aspergillosis: How It's Going, Where It's Heading.

Published in:

Mycopathologia, 2023, v. 188, n. 5, p. 667, doi. 10.1007/s11046-023-00727-z

By:

Boyer, Johannes;
Feys, Simon;
Zsifkovits, Isabella;
Hoenigl, Martin;
Egger, Matthias

Publication type:

Article

Uridine Inhibits Hepatocellular Carcinoma Cell Development by Inducing Ferroptosis.

Published in:

Journal of Clinical Medicine, 2023, v. 12, n. 10, p. 3552, doi. 10.3390/jcm12103552

By:

Zi, Liuliu;
Ma, Wangbin;
Zhang, Lilong;
Qiao, Boyang;
Qiu, Zhendong;
Xu, Junhui;
Zhang, Jiacheng;
Ye, Yahong;
Yang, Yueyuan;
Dong, Keshuai;
Chen, Chen;
Wang, Weixing;
Zhao, Qingyan

Publication type:

Article

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.87292

By:

Mullen, Nicholas J.;
Shukla, Surendra K.;
Thakur, Ravi;
Kollala, Sai Sundeep;
Dezhen Wang;
Chaika, Nina;
Santana, Juan F.;
Miklavcic, William R.;
LaBreck, Drew A.;
Mallareddy, Jayapal Reddy;
Price, David H.;
Natarajan, Amarnath;
Mehla, Kamiya;
Sykes, David B.;
Hollingsworth, Michael A.;
Singh, Pankaj K.

Publication type:

Article

Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.85023

By:

Mandt, Rebecca E. K.;
Luth, Madeline R.;
Tye, Mark A.;
Mazitschek, Ralph;
Ottilie, Sabine;
Winzeler, Elizabeth A.;
Lafuente-Monasterio, Maria Jose;
Javier Gamo, Francisco;
Wirth, Dyann F.;
Lukens, Amanda K.

Publication type:

Article

Microencapsulation, Physicochemical Characterization, and Antioxidant, Antibacterial, and Antiplasmodial Activities of Holothuria atra Microcapsule.

Published in:

Scientifica, 2024, v. 2024, p. 1, doi. 10.1155/2024/5559133

By:

Utami, Prawesty Diah;
Setianingsih, Herin;
Tirto Sari, Dewi Ratih;
Purohit, Shiv Dutt

Publication type:

Article

Isolation and validation of antimalarial compounds from Phyllanthus emblica leaves for new antimalarial drug development.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-99998-3

By:

Naveenkumar, Selvam;
Kamaraj, Chinnaperumal;
Kumarasamy, Vinoth;
Jayaseelan, Chidambaram;
Prem, Pradisha;
Boomija, Rajagopalan Vijayalakshmi;
Suseem, S. R.;
Subramaniyan, Vetriselvan;
Barasarathi, Jayanthi;
Wong, Ling Shing

Publication type:

Article

Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1557133

By:

She, Wei;
Su, Junxiao;
Ma, Wenji;
Ma, Guohai;
Li, Jianfu;
Zhang, Hui;
Qiu, Cheng;
Li, Xingyong

Publication type:

Article

Natural products protect against spinal cord injury by inhibiting ferroptosis: a literature review.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1557133

By:

She, Wei;
Su, Junxiao;
Ma, Wenji;
Ma, Guohai;
Li, Jianfu;
Zhang, Hui;
Qiu, Cheng;
Li, Xingyong

Publication type:

Article

Caffeic Acid Phenethyl Ester as a DHODH Inhibitor and Its Synergistic Anticancer Properties in Combination with 5-Fluorouracil in a Breast Cancer Cell Line.

Published in:

Journal of Experimental Pharmacology, 2022, v. 14, p. 243, doi. 10.2147/JEP.S365159

By:

Amalia, Eri;
Diantini, Ajeng;
Prabandari, Erwahyuni Endang;
Waluyo, Danang;
Subarnas, Anas

Publication type:

Article

Teriflunomide‐induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.

Published in:

Clinical & Experimental Dermatology, 2021, v. 46, n. 1, p. 166, doi. 10.1111/ced.14339

By:

Choudhary, R.;
Ashraf, R.;
Thakur, V.;
Kumaran, M. S.

Publication type:

Article

Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-57906-3

By:

Deng, Haibin;
Zhao, Liang;
Ge, Huixiang;
Gao, Yanyun;
Fu, Yan;
Lin, Yantang;
Masoodi, Mojgan;
Losmanova, Tereza;
Medová, Michaela;
Ott, Julien;
Su, Min;
Wang, Wenxiang;
Peng, Ren-Wang;
Dorn, Patrick;
Marti, Thomas Michael

Publication type:

Article

The Novel h DHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/v14102281

By:

Sibille, Giulia;
Luganini, Anna;
Sainas, Stefano;
Boschi, Donatella;
Lolli, Marco Lucio;
Gribaudo, Giorgio

Publication type:

Article

A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 5, p. 928, doi. 10.3390/v14050928

By:

Zheng, Yucheng;
Li, Shiliang;
Song, Kun;
Ye, Jiajie;
Li, Wenkang;
Zhong, Yifan;
Feng, Ziyan;
Liang, Simeng;
Cai, Zeng;
Xu, Ke

Publication type:

Article

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.

Published in:

Viruses (1999-4915), 2020, v. 12, n. 12, p. 1394, doi. 10.3390/v12121394

By:

Hahn, Friedrich;
Wangen, Christina;
Häge, Sigrun;
Peter, Antonia Sophia;
Dobler, Gerhard;
Hurst, Brett;
Julander, Justin;
Fuchs, Jonas;
Ruzsics, Zsolt;
Überla, Klaus;
Jäck, Hans-Martin;
Ptak, Roger;
Muehler, Andreas;
Gröppel, Manfred;
Vitt, Daniel;
Peelen, Evelyn;
Kohlhof, Hella;
Marschall, Manfred;
Richter, Sara N.;
Flamand, Louis

Publication type:

Article

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro.

Published in:

Viruses (1999-4915), 2020, v. 12, n. 8, p. 821, doi. 10.3390/v12080821

By:

Kim, Yu-Jin;
Cubitt, Beatrice;
Cai, Yingyun;
Kuhn, Jens H.;
Vitt, Daniel;
Kohlhof, Hella;
de la Torre, Juan C.

Publication type:

Article

Virtual screening and molecular dynamic simulations of the antimalarial derivatives of 2-anilino 4-amino substituted quinazolines docked against a Pf-DHODH protein target.

Published in:

Egyptian Journal of Medical Human Genetics, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s43042-022-00329-2

By:

Ibrahim, Zakari Ya'u;
Uzairu, Adamu;
Shallangwa, Gideon Adamu;
Abechi, Stephen Eyije;
Isyaku, Sulaiman

Publication type:

Article

Molecular docking, molecular dynamics simulation, and in vitro evaluation of hydroxythioxanthone derivatives as antimalarial agents.

Published in:

Thai Journal of Pharmaceutical Sciences, 2024, v. 48, n. 4, p. 1

By:

Hermawan, Faris;
Jumina, Jumina;
Ernawati, Teni;
Asih, Puji Budi Setia;
Rozi, Ismail Ekoprayitno;
Coutrier, Elisabeth Farah Novita;
Syafruddin, Din

Publication type:

Article

Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 525, doi. 10.1002/cpt.3136

By:

Yang, Kyunghee;
Kong, Ronald;
Spiegel, Robert;
Baird, John D.;
O'Keefe, Kylie;
Howell, Brett A.;
Watkins, Paul B.

Publication type:

Article

Teriflunomide-induced Raynaud's phenomenon: a serious adverse event, previously unreported.

Published in:

Neurological Sciences, 2022, v. 43, n. 11, p. 6593, doi. 10.1007/s10072-022-06239-w

By:

Riancho, Javier;
Delgado-Alvarado, Manuel;
Riancho-Zarrabeitia, Leyre

Publication type:

Article

Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease.

Published in:

Cells (2073-4409), 2022, v. 11, n. 17, p. 2726, doi. 10.3390/cells11172726

By:

Xie, Lai-Hua;
Fefelova, Nadezhda;
Pamarthi, Sri Harika;
Gwathmey, Judith K.

Publication type:

Article

Editorial: Metabolic Rewiring in Leukemias.

Published in:

2021

By:

Noguera, Nelida I.;
Hasan, Syed K.;
Ammatuna, Emanuele;
Venditti, Adriano

Publication type:

Editorial

Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine.

Published in:

Frontiers in Oncology, 2021, v. 11, p. 1, doi. 10.3389/fonc.2021.684961

By:

Wang, Wanyan;
Cui, Jiayan;
Ma, Hui;
Lu, Weiqiang;
Huang, Jin

Publication type:

Article

Translational Pharmacokinetic-Pharmacodynamic Modeling of a Novel Oral Dihydroorotate Dehydrogenase (DHODH) Inhibitor, HOSU-53 (JBZ-001).

Published in:

Pharmaceutics, 2025, v. 17, n. 4, p. 412, doi. 10.3390/pharmaceutics17040412

By:

Na, Joo Young;
Hai, Min;
Kim, Kyeongmin;
Vibhute, Sandip M.;
Bennett, Chad E.;
Coss, Christopher C.;
Phelps, Mitch A.

Publication type:

Article

Safety and Tolerability of KIO-101 Eye Drops in Healthy Volunteers and Patients with Ocular Surface Disease—A Phase I Study.

Published in:

Pharmaceutics, 2024, v. 16, n. 3, p. 367, doi. 10.3390/pharmaceutics16030367

By:

Schmidl, Doreen;
Hommer, Nikolaus;
Kallab, Martin;
Schlatter, Andreas;
Nadvornik, Clemens;
Obermayr, Franz;
Sperl, Stefan;
Daniels, Eric J.;
Garhöfer, Gerhard

Publication type:

Article

Siccanin Is a Dual-Target Inhibitor of Plasmodium falciparum Mitochondrial Complex II and Complex III.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 7, p. N.PAG, doi. 10.3390/ph15070903

By:

Komatsuya, Keisuke;
Sakura, Takaya;
Shiomi, Kazuro;
Ōmura, Satoshi;
Hikosaka, Kenji;
Nozaki, Tomoyoshi;
Kita, Kiyoshi;
Inaoka, Daniel Ken

Publication type:

Article

Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction.

Published in:

Bioscience Reports, 2013, v. 33, n. 2, p. 217, doi. 10.1042/BSR20120097

By:

JingXian FANG;
Takeshi UCHIUMI;
Mikako YAGI;
Shinya MATSUMOTO;
Rie AMAMOTO;
Shinya TAKAZAKI;
Haruyoshi YAMAZA;
Kazuaki NONAKA;
Dongchon KANG

Publication type:

Article

Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients.

Published in:

Bioscience Reports, 2012, v. 32, n. 6, p. 631, doi. 10.1042/BSR20120046

By:

FANG, JingXian;
UCHIUMI, Takeshi;
YAGI, Mikako;
MATSUMOTO, Shinya;
AMAMOTO, Rie;
SAITO, Toshiro;
TAKAZAKI, Shinya;
KANKI, Tomotake;
YAMAZA, Haruyoshi;
NONAKA, Kazuaki;
KANG, Dongchon

Publication type:

Article

Parasitic Protozoans: Exploring the Potential of N,N'-Bis[2-(5-bromo-7-azabenzimidazol-1-yl)-2-oxoethyl]ethylene-1,3-Diamine and Its Cyclohexyl-1,2-diamine Analogue as TryR and Pf-DHODH Inhibitors.

Published in:

Acta Parasitologica, 2023, v. 68, n. 4, p. 807, doi. 10.1007/s11686-023-00719-5

By:

Oluwafemi, Kola A.;
Oyeneyin, Oluwatoba E.;
Babatunde, Damilare D.;
Agbaffa, Eric B.;
Aigbogun, Jane A.;
Odeja, Oluwakayode O.;
Emmanuel, Abiodun V.

Publication type:

Article

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors.

Published in:

Journal of Molecular Modeling, 2013, v. 19, n. 3, p. 1099, doi. 10.1007/s00894-012-1643-5

By:

Bonomo, Silvia;
Tosco, Paolo;
Giorgis, Marta;
Lolli, Marco;
Fruttero, Roberta

Publication type:

Article

Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs.

Published in:

Xenobiotica, 2022, v. 52, n. 12, p. 1031, doi. 10.1080/00498254.2023.2171925

By:

Ma, Jiyuan;
Ye, Qing;
Northcutt, Valerie;
Babiak, John;
Kong, Ronald

Publication type:

Article

In vitro metabolism, pharmacokinetics and drug interaction potentials of emvododstat, a DHODH inhibitor.

Published in:

Xenobiotica, 2022, v. 52, n. 2, p. 152, doi. 10.1080/00498254.2021.2010287

By:

Ma, Jiyuan;
Kaushik, Diksha;
Yeh, Shirley;
Northcutt, Valerie;
Babiak, John;
Risher, Nicole;
Weetall, Marla;
Moon, Young-Choon;
Welch, Ellen M.;
Molony, Lachlan;
O'Keefe, Kylie;
Kong, Ronald

Publication type:

Article

Selective eradication of pluripotent stem cells by inhibiting DHODH activity.

Published in:

Stem Cells, 2021, v. 39, n. 1, p. 33, doi. 10.1002/stem.3290

By:

Kondo, Toru

Publication type:

Article

Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments.

Published in:

Journal of Infectious Diseases, 2023, v. 228, n. 5, p. 591, doi. 10.1093/infdis/jiad058

By:

Akazawa, Daisuke;
Ohashi, Hirofumi;
Hishiki, Takayuki;
Morita, Takeshi;
Iwanami, Shoya;
Kim, Kwang Su;
Jeong, Yong Dam;
Park, Eun-Sil;
Kataoka, Michiyo;
Shionoya, Kaho;
Mifune, Junki;
Tsuchimoto, Kana;
Ojima, Shinjiro;
Azam, Aa Haeruman;
Nakajima, Shogo;
Park, Hyeongki;
Yoshikawa, Tomoki;
Shimojima, Masayuki;
Kiga, Kotaro;
Iwami, Shingo

Publication type:

Article

Crystal structure of 4-ethyl-2-{[(4-nitrophenyl)methyl]sulfanyl}-6-oxo-1,6-dihydropyrimidine-5-carbonitrile, C14H12N4O3S.

Published in:

Zeitschrift für Kristallographie / New Crystal Structures, 2022, v. 237, n. 5, p. 811, doi. 10.1515/ncrs-2022-0272

By:

El-Emam, Ali A.;
Al-Wahaibi, Lamya H.;
Blacque, Olivier;
Tiekink, Edward R. T.

Publication type:

Article

Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice.

Published in:

Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03013-x

By:

Zhang, Shutian;
Zhao, Dajun;
Yang, Zhaohua;
Wang, Fanshun;
Yang, Shouguo;
Wang, Chunsheng

Publication type:

Article

Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review.

Published in:

Biological Chemistry, 2023, v. 404, n. 6, p. 569, doi. 10.1515/hsz-2022-0323

By:

Alipoor, Reza;
Ranjbar, Reza

Publication type:

Article

Identification of fungal dihydrouracil-oxidase genes by expression in Saccharomyces cerevisiae.

Published in:

Antonie van Leeuwenhoek, 2022, v. 115, n. 11, p. 1363, doi. 10.1007/s10482-022-01779-9

By:

Bouwknegt, Jonna;
Vos, Aurin M.;
Ortiz Merino, Raúl A.;
van Cuylenburg, Daphne C.;
Luttik, Marijke A. H.;
Pronk, Jack T.

Publication type:

Article

Protein-lipid interactions of human dihydroorotate dehydrogenase and three mutants associated with Miller syndrome.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2022, v. 41, n. 12, p. 1337, doi. 10.1080/15257770.2022.2039393

By:

Orozco Rodriguez, Juan Manuel;
Wacklin-Knecht, Hanna;
Knecht, Wolfgang

Publication type:

Article

Protein production, kinetic and biophysical characterization of three human dihydroorotate dehydrogenase mutants associated with Miller syndrome.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2022, v. 41, n. 12, p. 1318, doi. 10.1080/15257770.2021.2023749

By:

Orozco Rodriguez, Juan Manuel;
Krupinska, Ewa;
Wacklin-Knecht, Hanna;
Knecht, Wolfgang

Publication type:

Article

The pathway to pyrimidines: The essential focus on dihydroorotate dehydrogenase, the mitochondrial enzyme coupled to the respiratory chain.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2020, v. 39, n. 10-12, p. 1281, doi. 10.1080/15257770.2020.1723625

By:

Löffler, Monika;
Carrey, Elizabeth A.;
Knecht, Wolfgang

Publication type:

Article

Preparation of human dihydroorotate dehydrogenase for interaction studies with lipid bilayers.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2020, v. 39, n. 10-12, p. 1306, doi. 10.1080/15257770.2019.1708100

By:

Rodriguez, Juan Manuel Orozco;
Krupinska, Ewa;
Wacklin-Knecht, Hanna;
Knecht, Wolfgang

Publication type:

Article

Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2018, v. 37, n. 12, p. 666, doi. 10.1080/15257770.2018.1508692

By:

Peters, Godefridus J.

Publication type:

Article

Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2018, v. 37, n. 6, p. 329, doi. 10.1080/15257770.2018.1460479

By:

Peters, Godefridus J

Publication type:

Article

Orotate (orotic acid): An essential and versatile molecule.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2016, v. 35, n. 10-12, p. 566, doi. 10.1080/15257770.2016.1147580

By:

Löffler, M.;
Carrey, E.A.;
Zameitat, E.

Publication type:

Article

Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02510-z

By:

Bohacova, Klara;
Nahacka, Zuzana;
Dudova, Jana;
Kovarova, Jaromira;
Rohlena, Jakub;
Rennerova, Michaela;
Kasperova, Barbora Judita;
Stursa, Jan;
Werner, Lukas;
Haluzik, Martin;
Neuzil, Jiri;
Hubackova, Sona Stemberkova

Publication type:

Article