Works about DEUBIQUITINATING enzymes

Results: 844

MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.

Published in:

Respiratory Research, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12931-025-03293-8

By:

Zhang, Jiaheng;
Zhan, Yuan;
Deng, Zhesong;
Chen, Shanshan;
Yang, Ruonan;
Zhang, Yating;
Fu, Hao;
Huang, Qian;
Wu, Jixing;
Gu, Yiya;
Xie, Jungang

Publication type:

Article

ELAVL1-mediated USP29 mRNA degradation activates TAK1 driving M1 microglial polarization and neural stem cell differentiation dysregulation in spinal cord injury.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02604-8

By:

Sha, Chunhe;
Pan, Feng;
Liu, Xiaodong;
Wang, Zhiqing;
Liu, Guohui;
Huang, Kai

Publication type:

Article

Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.

Published in:

Frontiers in Physiology, 2025, p. 1, doi. 10.3389/fphys.2025.1607873

By:

Yang, Jingyi;
Wang, Yingdong;
Xu, Yuzhe;
Jia, Xinqi;
Lu, Fangping

Publication type:

Article

ISGylation and E3 ubiquitin ligases: an Atlantic salmon genetic perspective.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1554680

By:

Grimholt, Unni;
Sindre, Hilde;
Sundaram, Arvind Y. M.

Publication type:

Article

OTUB1 promotes colorectal cancer progression by stabilizing GPX4 and inhibiting ferroptosis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03022-z

By:

Lin, Guofeng;
Lin, Xi;
Lin, Qihuang;
Zhao, Jianfeng

Publication type:

Article

USP21-EGFR-Lyn axis drives NSCLC progression and therapeutic potential of USP21 inhibition.

Published in:

2025

By:

Shin, Ji Hye;
Kim, Ji Young;
Kim, Mi-Jeong;
Kang, Yeeun;
Choi, Bongkum;
Kwon, Dohee;
Sung, Yoolim;
Kim, Seo Hyun;
Lee, Ha-Jeong;
Lee, Chaeeun;
Kim, Kyeong Kyu;
Shim, Jae-Hyuck;
Kim, Duk-Hwan;
Chun, Eunyoung;
Lee, Ki-Young

Publication type:

Letter

Study on the mechanism of USP7 promoting endometriosis by regulating DNMT1 deubiquitination level.

Published in:

Biochemistry & Cell Biology, 2025, v. 103, p. 1, doi. 10.1139/bcb-2024-0301

By:

Gao, Xiangming;
Liu, Li;
Liu, Xueqin;
Shen, Yanru;
Fan, Yang

Publication type:

Article

Prevalence and clinical associations of USP8 variants in corticotroph tumours: a systematic review and aggregate data meta-analysis of 2171 cases Open Access.

Published in:

European Journal of Endocrinology, 2025, v. 192, n. 6, p. S41, doi. 10.1093/ejendo/lvaf097

By:

Perez-Rivas, Luis G;
Selzam, Vivian von;
Sharma, Prajina;
Reincke, Martin;
Theodoropoulou, Marily

Publication type:

Article

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03053-6

By:

Jian, Dan;
Hu, Nana;
He, Rong;
He, Le;
Xiao, He;
Peng, Xingqiao;
Peng, Yang;
Yang, Yuxin;
Dai, Xiaoyan;
Wang, Dong;
Feng, Yan;
Dai, Nan;
Chen, Qian

Publication type:

Article

Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61028-1

By:

Han, Jibo;
Lin, Liming;
Fang, Zimin;
Xu, Diyun;
Wang, Lintao;
Ye, Bozhi;
Han, Xue;
Long, Xiaohong;
Min, Julian;
Wu, Gaojun;
Liang, Guang;
Wang, Yi

Publication type:

Article

Decoding polyubiquitin regulation of KV7. 1 (KCNQ1) surface expression with engineered linkage-selective deubiquitinases.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60893-0

By:

Shanmugam, Sri Karthika;
Kanner, Scott A.;
Zou, Xinle;
Amarh, Enoch;
Choudhury, Papiya;
Soni, Rajesh;
Kass, Robert S.;
Colecraft, Henry M.

Publication type:

Article

Ubiquitin-specific proteases in hepatitis: bridging molecular mechanisms and therapeutic potential.

Published in:

Egyptian Liver Journal, 2025, v. 15, n. 1, p. 1, doi. 10.1186/s43066-025-00434-y

By:

Goyal, Kavita;
Afzal, Muhammad;
Bishoyi, Ashok Kumar;
Roopashree, R.;
Saini, Suman;
Sharma, R. S. K.;
Pathak, Piyus Kumar;
Chauhan, Ashish Singh;
Aravindhan, Surendar;
Imran, Mohd;
Abida, Abida Abida

Publication type:

Article

Budget Impact Analysis of the Use of Specific Biomarkers GFAP and UCH-L1 in the Management of Mild Traumatic Brain Injury in Spain.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 12, p. 4095, doi. 10.3390/jcm14124095

By:

Moya Torrecilla, Francisco;
Álvarez-Corral, Gemma;
Gutiérrez Pérez, Eva;
Morell-Garcia, Daniel;
Ortega Pérez, Juan;
Rodríguez, Beatriz Miriam;
Sánchez Martín, Leticia;
Temboury Ruiz, Francisco

Publication type:

Article

USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00596-0

By:

Shin, Jaemin;
Kim, Young Hun;
Lee, Bin;
Chang, Jae Ho;
Choi, Hee Youn;
Lee, Hoojung;
Song, Ki Chan;
Kwak, Man Sup;
Choi, Ji Eun;
Shin, Jeon-Soo

Publication type:

Article

Bone Marrow Mesenchymal Stem Cell‐Derived Exosomal USP10 Alleviates Cerebral Ischemia‐Reperfusion Injury via Stabilizing SLC7A11 by Deubiquitination.

Published in:

Journal of Biochemical & Molecular Toxicology, 2025, v. 39, n. 4, p. 1, doi. 10.1002/jbt.70246

By:

Liu, Nannuan;
Xu, Yue;
Gao, Genshan;
Liu, Yao;
Hu, Wenli

Publication type:

Article

CXCR4 up‐regulation mediated by USP1 deubiquitination promotes the tumorigenesis and immune escape in esophageal squamous‐cell carcinoma.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 11, p. 1, doi. 10.1002/jbt.70004

By:

Xiao, Liang;
Xu, Haixia;
Li, Meixiang;
Lin, Lin;
Zhu, Yan

Publication type:

Article

Identification and validation of a thirteen-gene signature based on ubiquitin related genes in cervical cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02459-6

By:

Ding, Wenxiu;
Liu, Shu;
Zhang, Huiai;
Ding, Hongxia;
Zhou, Shaobing;
Ye, Hongxun

Publication type:

Article

Identification of a deubiquitinating gene-related signature in ovarian cancer using integrated transcriptomic analysis and machine learning framework.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02267-y

By:

Hu, Suwan;
Wang, Mengting

Publication type:

Article

USP37 as a novel regulator of NRF2 protein stability and chemoresistance in HCC.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01913-9

By:

Zhang, Shujiao;
Ding, Feihu;
Jia, Fuxin;
Lu, Xiubo

Publication type:

Article

Cellular parameters shaping pathways of targeted protein degradation.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08104-w

By:

Cardno, Annabel;
Kennedy, Bryony;
Lindon, Catherine

Publication type:

Article

USP22 enhances atherosclerotic plaque stability and macrophage efferocytosis by stabilizing PPARγ.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08116-6

By:

Tang, Senhu;
Lu, Chuanghong;
Meng, Zhongyuan;
Ye, Zihua;
Qin, Yue;
Na, Na;
Xian, Shenglin;
Huang, Feng;
Zeng, Zhiyu

Publication type:

Article

A chromatin-focused CRISPR screen identifies USP22 as a barrier to somatic cell reprogramming.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07899-y

By:

Gürhan, Gülben;
Sevinç, Kenan;
Aztekin, Can;
Gayretli, Mert;
Yılmaz, Alperen;
Yıldız, Abdullah Burak;
Ervatan, Elif Naz;
Morova, Tunç;
Datlı, Elif;
Coleman, Oliver D.;
Kawamura, Akane;
Lack, Nathan A.;
Syed, Hamzah;
Önder, Tamer

Publication type:

Article

Inhibition of SCFKDM2A/USP22-dependent nuclear β-catenin ubiquitylation mediates cerebral ischemic tolerance.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07644-5

By:

Zuo, Yunyan;
Xue, Jiahui;
Wen, Haixia;
Zhan, Lixuan;
Chen, Meiyan;
Sun, Weiwen;
Xu, En

Publication type:

Article

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07051-2

By:

Liu, Yuhan;
Xun, Wenze;
Zhao, Tao;
Huang, Menglin;
Sun, Longhua;
Wen, Guilan;
Kang, Xiuhua;
Wang, Jianbin;
Han, Tianyu

Publication type:

Article

USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06999-5

By:

Cao, Jiahui;
Wu, Shitao;
Zhao, Senfeng;
Wang, Libo;
Wu, Yahui;
Song, Liming;
Sun, Chenguang;
Liu, Yin;
Liu, Zhipu;
Zhu, Rongtao;
Liang, Ruopeng;
Wang, Weijie;
Sun, Yuling

Publication type:

Article

Molecular Regulations of FUNDC1 at ER-Mitochondria Contacts Under Hypoxic Stress.

Published in:

Contact (25152564), 2022, p. 1, doi. 10.1177/25152564221092487

By:

Zhang, Yi;
Zhuang, Haixia;
Liu, Hao;
Feng, Du

Publication type:

Article

龙眼 UBP 家族全基因组鉴定及其在外源胁迫下的表达分析.

Published in:

Journal of Zhejiang University (Science Edition), 2023, v. 50, n. 3, p. 367, doi. 10.3785/j.issn.1008-9497.2023.03.015

By:

童宁;
张春渝;
许小琼;
陈晓慧;
申序;
赖钟雄

Publication type:

Article

USP39 regulates pyruvate handling in non-small cell lung cancer.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02264-0

By:

Becirovic, Tina;
Zhang, Boxi;
Vakifahmetoglu-Norberg, Helin;
Kaminskyy, Vitaliy O.;
Kochetkova, Elena;
Norberg, Erik

Publication type:

Article

USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancer.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02255-1

By:

Shin, Ji Hye;
Kim, Mi-Jeong;
Kim, Ji Young;
Choi, Bongkum;
Kang, Yeeun;
Kim, Seo Hyun;
Lee, Ha-Jeong;
Kwon, Dohee;
Cho, Yong Beom;
Kim, Kyeong Kyu;
Chun, Eunyoung;
Lee, Ki-Young

Publication type:

Article

DUBs in Alzheimer's disease: mechanisms and therapeutic implications.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02237-3

By:

Qin, Biying;
Chen, Xiaodong;
Wang, Feng;
Wang, Yanfeng

Publication type:

Article

DUBs in Alzheimer's disease: mechanisms and therapeutic implications.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02237-3

By:

Qin, Biying;
Chen, Xiaodong;
Wang, Feng;
Wang, Yanfeng

Publication type:

Article

Deubiquitinase JOSD1 tempers hepatic proteotoxicity.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02177-y

By:

Chowdhury, Saheli;
Sen, Abhishek;
Das, Debajyoti;
Chakrabarti, Partha

Publication type:

Article

Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02111-2

By:

Becirovic, Tina;
Zhang, Boxi;
Lindskog, Cecilia;
Norberg, Erik;
Vakifahmetoglu-Norberg, Helin;
Kaminskyy, Vitaliy O.;
Kochetkova, Elena

Publication type:

Article

USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02069-1

By:

Xia, Xiaohong;
Liu, Xiaolin;
Xu, Qiong;
Gu, Jielei;
Ling, Sisi;
Liu, Yajing;
Li, Rongxue;
Zou, Min;
Jiang, Siqin;
Gao, Zhiwei;
Chen, Canshan;
Liu, Shiming;
Liu, Ningning

Publication type:

Article

Ubiquitin specific peptidase 3: an emerging deubiquitinase that regulates physiology and diseases.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02010-6

By:

Wang, Yizhu;
Shi, Yanlong;
Niu, Kaiyi;
Yang, Rui;
Lv, Qingpeng;
Zhang, Wenning;
Feng, Kun;
Zhang, Yewei

Publication type:

Article

Autophagy dysregulation via the USP20-ULK1 axis in the HERC2-related neurodevelopmental disorder.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01931-6

By:

Sala-Gaston, Joan;
Pérez-Villegas, Eva M.;
Armengol, José A.;
Rawlins, Lettie E.;
Baple, Emma L.;
Crosby, Andrew H.;
Ventura, Francesc;
Rosa, Jose Luis

Publication type:

Article

USP22 regulates APL differentiation via PML-RARα stabilization and IFN repression.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01894-8

By:

Kowald, Lisa;
Roedig, Jens;
Karlowitz, Rebekka;
Wagner, Kristina;
Smith, Sonja;
Juretschke, Thomas;
Beli, Petra;
Müller, Stefan;
van Wijk, Sjoerd J. L.

Publication type:

Article

mTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01893-9

By:

Yang, Zhengming;
Yu, Wei;
Xu, Ankai;
Liu, Bing;
Jin, Libin;
Tao, Huimin;
Wang, Dimin

Publication type:

Article

Markers of Aggressiveness in Pituitary Tumors: Update and Perspectives.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 21, p. 6508, doi. 10.3390/jcm11216508

By:

Bioletto, Fabio;
Berton, Alessandro Maria;
Prencipe, Nunzia;
Varaldo, Emanuele;
Bona, Chiara;
Grottoli, Silvia

Publication type:

Article

BRAIN BIOMARKER RESPONSES TO NON-HYPOXIC HYPOBARIA.

Published in:

Aerospace Medicine & Human Performance, 2024, v. 95, n. 8, p. 607

By:

Connolly, Desmond;
Madden, Leigh

Publication type:

Article

PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4.

Published in:

Antioxidants, 2024, v. 13, n. 1, p. 114, doi. 10.3390/antiox13010114

By:

Tao, Hao;
Song, Sheng-Jie;
Fan, Ze-Wen;
Li, Wen-Ting;
Jin, Xin;
Jiang, Wen;
Bai, Jie;
Shi, Zhi-Zhou

Publication type:

Article

Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1.

Published in:

Antioxidants, 2023, v. 12, n. 2, p. 350, doi. 10.3390/antiox12020350

By:

Oikawa, Daisuke;
Shimizu, Kouhei;
Tokunaga, Fuminori

Publication type:

Article

Ubiquitin-Specific Protease 43 Impacts Pancreatic Ductal Adenocarcinoma Prognosis by Altering Its Proliferation and Infiltration of Surrounding Immune Cells.

Published in:

Journal of Immunology Research, 2023, p. 1, doi. 10.1155/2023/4311388

By:

Zhao, Ziqi;
Lin, Zhikun;
Guo, Xin;
Al-danakh, Abdullah;
He, Hui;
Qin, Henan;
Ma, Chi;
Zhang, Ningning;
Tan, Guang

Publication type:

Article

Genome Wide Identification and In-Silico Transcriptional and Expression Analysis Specific Protease Against Biotic Stress in Plant Species.

Published in:

Western Journal of Legal Studies, 2022, n. 1, p. 109

By:

Dutta, Sanjukta;
Sharma, Arti

Publication type:

Article

miR-361-3p overexpression promotes apoptosis and inflammation by regulating the USP49/IκBα/NF-κB pathway to aggravate sepsis-induced myocardial injury.

Published in:

Toxicology Research, 2024, v. 13, n. 6, p. 1, doi. 10.1093/toxres/tfae190

By:

Geng, Huan;
Qi, Luyao;
You, Lijiao;
Feng, Wentao;
Yang, Xiaofang;
Lei, Ming

Publication type:

Article

Mechanism of miR-98-5p in gastric cancer cell proliferation, migration, and invasion through the USP44/CTCFL axis.

Published in:

Toxicology Research, 2024, v. 13, n. 2, p. 1, doi. 10.1093/toxres/tfae040

By:

Zhang, Kangkang;
Zhao, Jinjiang;
Bi, Zhibin;
Feng, Yafei;
Zhang, Huipeng;
Zhang, Jinjie;
Qin, Xiaowei;
Zhao, Yanbo;
Niu, Ruilong;
Mei, Xianghuang;
He, Zhipeng;
Yang, Jingcheng;
Lv, Jiake;
Guo, Wei

Publication type:

Article

Spermidine reduces ISGylation and enhances ISG15–USP18 interaction.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-01425-0

By:

Etori, Haruka;
Asoshina, Riko;
Obita, Takayuki;
Okumura, Fumihiko

Publication type:

Article

Exploring bioactive phytoconstituents as USP21 inhibitors for therapeutic development against cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-94825-1

By:

Anwar, Saleha;
Khan, Mohd Shahnawaz;
Yadav, Dharmendra Kumar;
Shahwan, Moyad;
Shamsi, Anas

Publication type:

Article

USP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-93029-x

By:

Zhou, Bo;
Li, Jie;
Wu, Shuai;
Zhang, Haomiao;
Luo, Yuanbo;
Chen, Jingxiang;
Chen, Geng

Publication type:

Article

Blood-based biomarkers suggest prolonged axonal Injury following pediatric mild traumatic brain injury.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-024-84053-4

By:

Mayer, Andrew R.;
Wick, Tracey V.;
McQuaid, Jessica R.;
Boucher, Masen L.;
Dodd, Andrew B.;
Robertson-Benta, Cidney R.;
van der Horn, Harm J.;
Erhardt, Erik B.;
Sapien, Robert E.;
Tarawneh, Rawan;
Mannix, Rebekah

Publication type:

Article