Works matching DE "DARDARIN"

Results: 664

LRRK2 kinase modulates glucose-stimulated insulin secretion via RAB8 phosphorylation and ciliogenesis.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05810-w

By:

Dule, Nevia;
Marku, Algerta;
Galli, Alessandra;
Pischedda, Francesca;
Lama, Adriano;
Castagna, Michela;
Marciani, Paola;
Bertuzzi, Federico;
Piccoli, Giovanni;
Perego, Carla

Publication type:

Article

Role of LRRK2 in axonal transport and Parkinson’s disease.

Published in:

Biochemical Journal, 2025, v. 482, n. 13, p. 905, doi. 10.1042/BCJ20253133

By:

Twellsieck, Björn;
Boecker, C. Alexander

Publication type:

Article

Mild Chronic Colitis Exacerbates Intracerebral Inflammation in Mice with Parkinson's Disease Through LRRK2-Mediated Regulation of NF-κB Activation and Inhibition of Nrf2.

Published in:

Journal of Inflammation Research, 2025, v. 18, p. 8493, doi. 10.2147/JIR.S526777

By:

Yang, Manqi;
Ke, Linping;
Geng, Yiman;
Hu, Piao;
Qiu, Yao;
Liu, Ziwen;
Zhang, Xueqin;
Wan, Fuxin;
Jacob, Joe Antony;
Liao, Jingling

Publication type:

Article

Recent advances in targeting LRRK2 for Parkinson's disease treatment.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06354-0

By:

Karami, Mahsa;
Sanaye, Pantea Majma;
Ghorbani, Atousa;
Amirian, Roshanak;
Goleij, Pouya;
Babamohamadi, Mehregan;
Izadi, Zhila

Publication type:

Article

Elucidating Pathological Mechanisms and Developing Biomarkers of Parkinson's Disease.

Published in:

Neurology & Clinical Neuroscience, 2025, v. 13, n. 4, p. 236, doi. 10.1111/ncn3.70013

By:

Hatano, Taku

Publication type:

Article

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson's disease.

Published in:

Brain: A Journal of Neurology, 2025, v. 148, n. 6, p. 2075, doi. 10.1093/brain/awae404

By:

Cortés, Adriana;
Phung, Toan K;
Mena, Lorena de;
Garrido, Alicia;
Infante, Jon;
Ruíz-Martínez, Javier;
Galmés-Ordinas, Miquel À;
Glendinning, Sophie;
Pérez, Jesica;
Roig, Ana;
Soto, Marta;
Cosgaya, Marina;
Ravasi, Valeria;
Fernández, Manel;
Rubiano-Castro, Alejandro;
Díaz, Ramón;
Hernández-Eguiazu, Haizea;
Sánchez-Quintana, Coro;
Vinagre-Aragón, Ana;
Mondragón, Elisabet

Publication type:

Article

Correction: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.

Published in:: Biochemical Journal, 2025, v. 482, n. 12, p. 901, doi. 10.1042/BJ20100483_COR
Publication type:: Article

Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson's disease–linked LRRK2-mutant mice.

Published in:

Science Signaling, 2025, v. 18, n. 893, p. 1, doi. 10.1126/scisignal.ads5761

By:

Jaimon, Ebsy;
Lin, Yu-En;
Tonelli, Francesca;
Antico, Odetta;
Alessi, Dario R.;
Pfeffer, Suzanne R.

Publication type:

Article

Growth Cone <i>MKK7</i> mRNA Targeting Regulates MAP1b-Dependent Microtubule Bundling to Control Neurite Elongation

Published in:

PLoS Biology, 2012, v. 10, n. 12, p. 1, doi. 10.1371/journal.pbio.1001439

By:

Feltrin, Daniel;
Fusco, Ludovico;
Witte, Harald;
Moretti, Francesca;
Martin, Katrin;
Letzelter, Michel;
Fluri, Erika;
Scheiffele, Peter;
Pertz, Olivier

Publication type:

Article

Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease.

Published in:

Glycobiology, 2021, v. 31, n. 11, p. 1416, doi. 10.1093/glycob/cwab046

By:

Reza, Safoura;
Ugorski, Maciej;
Suchański, Jarosław

Publication type:

Article

Antioxidant, Osteogenic, and Neuroprotective Effects of Homotaurine in Aging and Parkinson's Disease Models.

Published in:

Antioxidants, 2025, v. 14, n. 3, p. 249, doi. 10.3390/antiox14030249

By:

Minoia, Arianna;
Piritore, Francesca Cristiana;
Bolognin, Silvia;
Pessoa, João;
Bernardes de Jesus, Bruno;
Tiso, Natascia;
Romanelli, Maria Grazia;
Schwamborn, Jens Christian;
Dalle Carbonare, Luca;
Valenti, Maria Teresa

Publication type:

Article

Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.92673

By:

Jongkyun Kang;
Guodong Huang;
Long Ma;
Youren Tong;
Shahapal, Anu;
Phoenix Chen;
Jie Shen

Publication type:

Article

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.87255

By:

Xiang Wang;
Bondar, Vitaliy V.;
Davis, Oliver B.;
Maloney, Michael T.;
Agam, Maayan;
Chin, Marcus Y.;
Cheuk-Nga Ho, Audrey;
Ghosh, Rajarshi;
Leto, Dara E.;
Joy, David;
Calvert, Meredith E. K.;
Lewcock, Joseph W.;
Di Paolo, Gilbert;
Thorne, Robert G.;
Sweeney, Zachary K.;
Henry, Anastasia G.

Publication type:

Article

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.87098

By:

Dhekne, Herschel S.;
Tonelli, Francesca;
Yeshaw, Wondwossen M.;
Chiang, Claire Y.;
Limouse, Charles;
Jaimon, Ebsy;
Purlyte, Elena;
Alessi, Dario R.;
Pfeffer, Suzanne R.

Publication type:

Article

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-99580-x

By:

Delgado-Goñi, Teresa;
Connor-Robson, Natalie;
Cioroch, Milena;
Paisey, Stephen;
Marshall, Christopher;
Lane, Emma L.;
Hauton, David;
McCullagh, James;
Magill, Peter J.;
Cragg, Stephanie J.;
Mackay, Clare E.;
Wade-Martins, Richard;
Klein, Johannes C.

Publication type:

Article

Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-94165-0

By:

Albanese, Federica;
Domenicale, Chiara;
Mercatelli, Daniela;
Brugnoli, Alberto;
Dovero, Sandra;
Bezard, Erwan;
Morari, Michele

Publication type:

Article

Using computer modeling to find new LRRK2 inhibitors for parkinson's disease.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-86926-8

By:

García, María C.;
Cuesta, Sebastián A.;
Mora, José R.;
Paz, Jose L.;
Marrero-Ponce, Yovani;
Alexis, Frank;
Márquez, Edgar A.

Publication type:

Article

ACCP Abstract Booklet.

Published in:: Clinical Pharmacology in Drug Development, 2022, v. 11, p. 1, doi. 10.1002/cpdd.1151
Publication type:: Article

Role of leucine-rich repeat kinase 2 in severe acute pancreatitis.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1364839

By:

Yasuo Otsuka;
Kosuke Minaga;
Masatoshi Kudo;
Tomohiro Watanabe

Publication type:

Article

Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-57453-x

By:

Zhu, Hongxian;
Sydor, Andrew M.;
Yan, Bing-Ru;
Li, Ren;
Boniecki, Michal T.;
Lyons, Carina;
Cygler, Miroslaw;
Muise, Aleixo M.;
Maxson, Michelle E.;
Grinstein, Sergio;
Raught, Brian;
Brumell, John H.

Publication type:

Article

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52723-6

By:

Li, Xingjian;
Zhu, Hanwen;
Huang, Bik Tzu;
Li, Xianting;
Kim, Heesoo;
Tan, Haiyan;
Zhang, Yuanxi;
Choi, Insup;
Peng, Junmin;
Xu, Pingyi;
Sun, Ji;
Yue, Zhenyu

Publication type:

Article

Take a deep breath: peptide signalling in stomatal patterning and differentiation.

Published in:

Journal of Experimental Botany, 2013, v. 64, n. 17, p. 5243, doi. 10.1093/jxb/ert246

By:

Richardson, Lynn G. L.;
Torii, Keiko U.

Publication type:

Article

Editorial: Genotype-Phenotype Correlation in Parkinsonian Conditions.

Published in:

2021

By:

Marsili, Luca;
Mata, Ignacio F.;
Kauffman, Marcelo A.

Publication type:

Editorial

LIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort.

Published in:

Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.710572

By:

Usnich, Tatiana;
Vollstedt, Eva-Juliane;
Schell, Nathalie;
Skrahina, Volha;
Bogdanovic, Xenia;
Gaber, Hanaa;
Förster, Toni M.;
Heuer, Andreas;
Koleva-Alazeh, Natalia;
Csoti, Ilona;
Basak, Ayse Nazli;
Ertan, Sibel;
Genc, Gencer;
Bauer, Peter;
Lohmann, Katja;
Grünewald, Anne;
Schymanski, Emma L.;
Trinh, Joanne;
Schaake, Susen;
Berg, Daniela

Publication type:

Article

Neuroprotective Role of Ranolazine in Parkinson Disease: Drosophila Melanogaster Model.

Published in:

Scripta Medica, 2025, v. 56, n. 1, p. 15, doi. 10.5937/scriptamed56-53259

By:

Parvesh;
Kumar, Sandeep;
Singh, Govind;
Khatri, Ramchander;
Shkula, Sunil;
Kaushik, Kamal;
Lather, Amit;
Hooda, Tanuj

Publication type:

Article

Topological Fingerprints as an Aid in Finding Structural Patterns for LRRK2 Inhibition.

Published in:

Molecular Informatics, 2014, v. 33, n. 4, p. 269, doi. 10.1002/minf.201300057

By:

Kahn, Iiris;
Lomaka, Andre;
Karelson, Mati

Publication type:

Article

In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation.

Published in:

Stem Cell Research & Therapy, 2021, v. 12, n. 1, p. 1, doi. 10.1186/s13287-021-02585-2

By:

Chang, Kuo-Hsuan;
Huang, Cheng-Yen;
Ou-Yang, Chih-Hsin;
Ho, Chang-Han;
Lin, Han-Yi;
Hsu, Chia-Lang;
Chen, You-Tzung;
Chou, Yu-Chi;
Chen, Yi-Jing;
Chen, Ying;
Lin, Jia-Li;
Wang, Ji-Kuan;
Lin, Pei-Wen;
Lin, Ying-Ru;
Lin, Miao-Hsia;
Tseng, Chi-Kang;
Lin, Chin-Hsien

Publication type:

Article

Effects of sevoflurane on leucine-rich repeat kinase 2-associated Drosophila model of Parkinson's disease.

Published in:

Molecular Medicine Reports, 2015, v. 11, n. 3, p. 2062, doi. 10.3892/mmr.2014.2966

By:

ZHIMING SHAN;
SONG CAI;
TAO ZHANG;
LITING KUANG;
QI WANG;
HUANHUAN XIU;
JING WEN;
HUAIYU GU;
KANGQING XU

Publication type:

Article

Modeling Parkinson's Disease Using Induced Pluripotent Stem Cells.

Published in:

Stem Cells International, 2020, p. 1, doi. 10.1155/2020/1061470

By:

Hu, Xinchao;
Mao, Chengyuan;
Fan, Liyuan;
Luo, Haiyang;
Hu, Zhengwei;
Zhang, Shuo;
Yang, Zhihua;
Zheng, Huimin;
Sun, Huifang;
Fan, Yu;
Yang, Jing;
Shi, Changhe;
Xu, Yuming

Publication type:

Article

Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic Target.

Published in:

European Neurology, 2018, v. 79, n. 5/6, p. 256, doi. 10.1159/000488938

By:

Chen, Jinhua;
Chen, Ying;
Pu, Jiali

Publication type:

Article

Isolation and characterization of Toll-like receptor 21 and 22 genes from Nile tilapia, Oreochromis niloticus (Linnaeus).

Published in:

Aquaculture Research, 2017, v. 48, n. 7, p. 3528, doi. 10.1111/are.13179

By:

Pang, Ji ‐ cai;
Gao, Feng ‐ ying;
Wang, Miao;
Zhao, Jin ‐ liang;
Lu, Mai ‐ xin

Publication type:

Article

Regulation of Parkinson's disease-associated genes by Pumilio proteins and microRNAs in SH-SY5Y neuronal cells.

Published in:

PLoS ONE, 2022, v. 17, n. 9, p. 1, doi. 10.1371/journal.pone.0275235

By:

Snoderly-Foster, Lisa J.;
Olivas, Wendy M.

Publication type:

Article

Spatio-temporal dynamics of pathogenic variants associated with monogenic disorders reconstructed with ancient DNA.

Published in:

PLoS ONE, 2022, v. 17, n. 6, p. 1, doi. 10.1371/journal.pone.0269628

By:

Toncheva, Draga;
Marinova, Maria;
Borovska, Plamenka;
Serbezov, Dimitar

Publication type:

Article

Evolutionary Divergence of TNL Disease-Resistant Proteins in Soybean (Glycine max) and Common Bean (Phaseolus vulgaris).

Published in:

Biochemical Genetics, 2018, v. 56, n. 4, p. 397, doi. 10.1007/s10528-018-9851-z

By:

Neupane, Surendra;
Ma, Qin;
Mathew, Febina M.;
Varenhorst, Adam J.;
Andersen, Ethan J.;
Nepal, Madhav P.

Publication type:

Article

Bioinformatics Analysis of NBS-LRR Encoding Resistance Genes in Setaria italica.

Published in:

Biochemical Genetics, 2016, v. 54, n. 3, p. 232, doi. 10.1007/s10528-016-9715-3

By:

Zhao, Yan;
Weng, Qiaoyun;
Song, Jinhui;
Ma, Hailian;
Yuan, Jincheng;
Liu, Yinghui;
Dong, Zhiping

Publication type:

Article

NLRC5 Mediates Cytokine Secretion in RAW264.7 Macrophages and Modulated by the JAK2/STAT3 Pathway.

Published in:

Inflammation, 2014, v. 37, n. 3, p. 835, doi. 10.1007/s10753-013-9804-y

By:

Li, Lin;
Xu, Tao;
Huang, Cheng;
Peng, Yunyun;
Li, Jun

Publication type:

Article

Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation.

Published in:

Frontiers in Cellular Neuroscience, 2024, p. 1, doi. 10.3389/fncel.2024.1366098

By:

Valderhaug, Vibeke Devold;
Ramstad, Ola Huse;
van de Wijdeven, Rosanne;
Heiney, Kristine;
Nichele, Stefano;
Sandvig, Axel;
Sandvig, Ioanna

Publication type:

Article

Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr<sup>175</sup> tau.

Published in:

Frontiers in Cellular Neuroscience, 2023, p. 01, doi. 10.3389/fncel.2023.1272899

By:

Donison, Neil;
Hintermayer, Matthew;
Subramaniam, Maegha;
Santandrea, Erin;
Volkening, Kathryn;
Strong, Michael J.

Publication type:

Article

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations.

Published in:

Frontiers in Cellular Neuroscience, 2023, p. 1, doi. 10.3389/fncel.2023.1229213

By:

Labrador-Garrido, Adahir;
Siying Zhong;
Hughes, Laura;
Keshiya, Shikara;
Kim, Woojin S.;
Halliday, Glenda M.;
Dzamko, Nicolas

Publication type:

Article

Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration.

Published in:

2020

By:

Volta, Mattia;
Lewis, Patrick A.;
Lobbestael, Evy

Publication type:

Editorial

Progress in LRRK2 -Associated Parkinson's Disease Animal Models.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00674

By:

Seegobin, Steven P.;
Heaton, George R.;
Liang, Dongxiao;
Choi, Insup;
Blanca Ramirez, Marian;
Tang, Beisha;
Yue, Zhenyu

Publication type:

Article

LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00719

By:

Dues, Dylan J.;
Moore, Darren J.

Publication type:

Article

LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00556

By:

Rivero-Ríos, Pilar;
Romo-Lozano, María;
Fasiczka, Rachel;
Naaldijk, Yahaira;
Hilfiker, Sabine

Publication type:

Article

Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00526

By:

Mabrouk, Omar S.;
Chen, Siwei;
Edwards, Amanda L.;
Yang, Minhua;
Hirst, Warren D.;
Graham, Danielle L.

Publication type:

Article

"LRRK2: Autophagy and Lysosomal Activity".

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00498

By:

Madureira, Marta;
Connor-Robson, Natalie;
Wade-Martins, Richard

Publication type:

Article

Guilt-by-Association – Functional Insights Gained From Studying the LRRK2 Interactome.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00485

By:

Gloeckner, Christian Johannes;
Porras, Pablo

Publication type:

Article

A cognitive fMRI study in non-manifesting LRRK2 and GBA carriers.

Published in:

Brain Structure & Function, 2017, v. 222, n. 3, p. 1207, doi. 10.1007/s00429-016-1271-4

By:

Bregman, Noa;
Thaler, Avner;
Mirelman, Anat;
Helmich, Rick;
Gurevich, Tanya;
Orr-Urtreger, Avi;
Marder, Karen;
Bressman, Susan;
Bloem, Bastiaan;
Giladi, Nir

Publication type:

Article

NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease.

Published in:

Mediators of Inflammation, 2017, p. 1, doi. 10.1155/2017/8316560

By:

Guo, Honglei;
Bi, Xiao;
Zhou, Ping;
Zhu, Shijian;
Ding, Wei

Publication type:

Article

Genetinių tyrimų svarba Parkinsono ligos diagnostikoje.

Published in:

Neurologijos Seminarai, 2023, v. 27, n. 4, p. 235, doi. 10.15388/NS.2023.27.98.4

By:

Dakinevičiūtė, D.;
Čičelienė, J.

Publication type:

Article

Dietary Amino Acids Impact LRRK2-Induced Neurodegeneration in Parkinson's Disease Models.

Published in:

Journal of Neuroscience, 2020, v. 40, n. 32, p. 6234, doi. 10.1523/jneurosci.2809-19.2020

By:

Chittoor-Vinod, Vinita G.;
Villalobos-Cantor, Steffany;
Roshak, Hanna;
Shea, Kelsey;
Abalde-Atristain, Leire;
Martin, Ian

Publication type:

Article