Works matching DE "DARDARIN"

Results: 627

Rab GTPases are evolutionarily conserved signals mediating selective autophagy.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 5, p. 1, doi. 10.1083/jcb.202410150

By:

Pengwei Zhao;
Rui Tian;
Dandan Song;
Qi Zhu;
Xianming Ding;
Jianqin Zhang;
Beibei Cao;
Mengyuan Zhang;
Yilu Xu;
Jie Fang;
Jieqiong Tan;
Cong Yi;
Hongguang Xia;
Wei Liu;
Wei Zou;
Qiming Sun

Publication type:

Article

Correction: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.

Published in:

2025

By:

Kim, Judong;
Pajarillo, Edward;
Rizor, Asha;
Son, Deok-Soo;
Lee, Jayden;
Aschner, Michael;
Lee, Eunsook

Publication type:

Correction Notice

Autophagy Impairment in Parkinson's Disease: Approaches to Therapy.

Published in:

Molecular Biology, 2025, v. 59, n. 1, p. 51, doi. 10.1134/S0026893324700717

By:

Usenko, T. S.

Publication type:

Article

Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02015-x

By:

Filippini, Alice;
Carini, Giulia;
Barbon, Alessandro;
Gennarelli, Massimo;
Russo, Isabella

Publication type:

Article

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-99580-x

By:

Delgado-Goñi, Teresa;
Connor-Robson, Natalie;
Cioroch, Milena;
Paisey, Stephen;
Marshall, Christopher;
Lane, Emma L.;
Hauton, David;
McCullagh, James;
Magill, Peter J.;
Cragg, Stephanie J.;
Mackay, Clare E.;
Wade-Martins, Richard;
Klein, Johannes C.

Publication type:

Article

Emergent glutamate & dopamine dysfunction in VPS35<sub>(D620N)</sub> knock-in mice and rapid reversal by LRRK2 inhibition.

Published in:

NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-00948-7

By:

Kamesh, A.;
Kadgien, C. A.;
Kuhlmann, N.;
Coady, S.;
Pietrantonio, A.;
Cousineau, Y.;
Khayachi, A.;
Jurado Santos, A.;
Hurley, E. P.;
Barron, J. C.;
Parsons, M. P.;
Milnerwood, A. J.

Publication type:

Article

LRRK2-associated parkinsonism with and without in vivo evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization.

Published in:

Brain Communications, 2025, v. 7, n. 2, p. 1, doi. 10.1093/braincomms/fcaf103

By:

Chahine, Lana M;
Lafontant, David-Erick;
Choi, Seung Ho;
Iwaki, Hirotaka;
Blauwendraat, Cornelis;
Singleton, Andrew B;
Brumm, Michael C;
Alcalay, Roy N;
Merchant, Kalpana;
Nudelman, Kelly Nicole Holohan;
Dagher, Alain;
Vo, Andrew;
Tao, Qin;
Venuto, Charles S;
Kieburtz, Karl;
Poston, Kathleen L;
Bressman, Susan;
Gonzalez-Latapi, Paulina;
Avants, Brian;
Coffey, Christopher

Publication type:

Article

Growth Cone <i>MKK7</i> mRNA Targeting Regulates MAP1b-Dependent Microtubule Bundling to Control Neurite Elongation

Published in:

PLoS Biology, 2012, v. 10, n. 12, p. 1, doi. 10.1371/journal.pbio.1001439

By:

Feltrin, Daniel;
Fusco, Ludovico;
Witte, Harald;
Moretti, Francesca;
Martin, Katrin;
Letzelter, Michel;
Fluri, Erika;
Scheiffele, Peter;
Pertz, Olivier

Publication type:

Article

The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson’s Disease Associated with p.N370S Mutation in the GBA1 Gene.

Published in:

Journal of Integrative Neuroscience, 2024, v. 23, n. 1, p. 1, doi. 10.31083/j.jin2301016

By:

Usenko, Tatiana S.;
Timofeeva, Alla;
Beletskaia, Mariia;
Basharova, Katerina;
Baydakova, Galina;
Bezrukova, Anastasia;
Grunina, Maria;
Emelyanov, Anton;
Miliukhina, Irina;
Zakharova, Ekaterina;
Pchelina, Sofya

Publication type:

Article

Correction: Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

Published in:: Biochemical Journal, 2025, v. 482, n. 7, p. 357, doi. 10.1042/BCJ20200937_COR
Publication type:: Article

Brain age in genetic and idiopathic Parkinson's disease.

Published in:

Brain Communications, 2024, v. 6, n. 6, p. 1, doi. 10.1093/braincomms/fcae382

By:

Teipel, Stefan J;
Hoffmann, Hauke;
Storch, Alexander;
Hermann, Andreas;
Dyrba, Martin;
Schumacher, Julia

Publication type:

Article

Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations.

Published in:

Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0617-y

By:

Takanashi, Masashi;
Funayama, Manabu;
Matsuura, Eiji;
Yoshino, Hiroyo;
Li, Yuanzhe;
Tsuyama, Sho;
Takashima, Hiroshi;
Nishioka, Kenya;
Hattori, Nobutaka

Publication type:

Article

LRRK2 contributes to monocyte dysregulation in Parkinson's disease.

Published in:

Acta Neuropathologica Communications, 2016, v. 4, p. 1, doi. 10.1186/s40478-016-0396-2

By:

Bliederhaeuser, Corinna;
Zondler, Lisa;
Grozdanov, Veselin;
Ruf, Wolfgang P.;
Brenner, David;
Melrose, Heather L.;
Bauer, Peter;
Ludolph, Albert C.;
Gillardon, Frank;
Kassubek, Jan;
Weishaupt, Jochen H.;
Danzer, Karin M.

Publication type:

Article

Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.92673

By:

Jongkyun Kang;
Guodong Huang;
Long Ma;
Youren Tong;
Shahapal, Anu;
Phoenix Chen;
Jie Shen

Publication type:

Article

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.87255

By:

Xiang Wang;
Bondar, Vitaliy V.;
Davis, Oliver B.;
Maloney, Michael T.;
Agam, Maayan;
Chin, Marcus Y.;
Cheuk-Nga Ho, Audrey;
Ghosh, Rajarshi;
Leto, Dara E.;
Joy, David;
Calvert, Meredith E. K.;
Lewcock, Joseph W.;
Di Paolo, Gilbert;
Thorne, Robert G.;
Sweeney, Zachary K.;
Henry, Anastasia G.

Publication type:

Article

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.87098

By:

Dhekne, Herschel S.;
Tonelli, Francesca;
Yeshaw, Wondwossen M.;
Chiang, Claire Y.;
Limouse, Charles;
Jaimon, Ebsy;
Purlyte, Elena;
Alessi, Dario R.;
Pfeffer, Suzanne R.

Publication type:

Article

Novel recruitment strategy to enrich for LRRK2 mutation carriers.

Published in:

Molecular Genetics & Genomic Medicine, 2015, v. 3, n. 5, p. 404, doi. 10.1002/mgg3.151

By:

Foroud, Tatiana;
Smith, Danielle;
Jackson, Jacqueline;
Verbrugge, Jennifer;
Halter, Cheryl;
Wetherill, Leah;
Sims, Katherine;
Xin, Winnie;
Arnedo, Vanessa;
Lasch, Shirley;
Marek, Kenneth

Publication type:

Article

Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants – Let's get even more personal.

Published in:

Translational Neurodegeneration, 2020, v. 9, n. 1, p. N.PAG, doi. 10.1186/s40035-020-00218-x

By:

von Linstow, Christian U.;
Gan-Or, Ziv;
Brundin, Patrik

Publication type:

Article

CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson's disease: a study in LRRK2 mutation carriers.

Published in:

Translational Neurodegeneration, 2020, v. 9, n. 1, p. 1, doi. 10.1186/s40035-020-00192-4

By:

Majbour, Nour K.;
Aasly, Jan O.;
Hustad, Eldbjørg;
Thomas, Mercy A.;
Vaikath, Nishant N.;
Elkum, Naser;
van de Berg, Wilma D. J.;
Tokuda, Takahiko;
Mollenhauer, Brit;
Berendse, Henk W.;
El-Agnaf, Omar M. A.

Publication type:

Article

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression.

Published in:

Translational Neurodegeneration, 2018, v. 7, p. 1, doi. 10.1186/s40035-018-0106-z

By:

Cho, Hyun Jin;
Xie, Chengsong;
Cai, Huaibin

Publication type:

Article

Cloning of Rice Blast Resistance Gene Pik2-H4 and Screening of Its Interaction Protein.

Published in:

Plant Diseases & Pests, 2014, v. 5, n. 4, p. 26

By:

Liu Hao;
Sun Dayuan;
Wang Hui;
Chen Zhiqiang

Publication type:

Article

Asporin activates coordinated invasion of scirrhous gastric cancer and cancer-associated fibroblasts.

Published in:

Oncogene, 2015, v. 34, n. 5, p. 650, doi. 10.1038/onc.2013.584

By:

Satoyoshi, R;
Kuriyama, S;
Aiba, N;
Yashiro, M;
Tanaka, M

Publication type:

Article

Structure and regulation of full-length human leucine-rich repeat kinase 1.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40532-2

By:

Metcalfe, Riley D.;
Martinez Fiesco, Juliana A.;
Bonet-Ponce, Luis;
Kluss, Jillian H.;
Cookson, Mark R.;
Zhang, Ping

Publication type:

Article

Increased Oxidative Stress Markers in Cerebrospinal Fluid from Healthy Subjects with Parkinson's Disease-Associated LRRK2 Gene Mutations.

Published in:

Frontiers in Aging Neuroscience, 2017, v. 9, p. 1, doi. 10.3389/fnagi.2017.00089

By:

Loeffler, David A.;
Klaver, Andrea C.;
Coffey, Mary P.;
Aasly, Jan O.;
LeWitt, Peter A.

Publication type:

Article

68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.

Published in:

Frontiers in Aging Neuroscience, 2017, v. 8, p. 1, doi. 10.3389/fnagi.2016.00337

By:

Thomas, Joseph M.;
Tianxia Li;
Wei Yang;
Fengtian Xue;
Fishman, Paul S.;
Smith, Wanli W.;
Reddy, P. Hemachandra;
Thomas, Bobby

Publication type:

Article

Olfactory dysfunction in sporadic Parkinson's Disease and LRRK2 carriers.

Published in:

Acta Neurologica Scandinavica, 2014, v. 129, n. 5, p. 300, doi. 10.1111/ane.12172

By:

Johansen, K. K.;
Warø, B. J.;
Aasly, J. O.

Publication type:

Article

Expression of microRNA in human retinal pigment epithelial cells following infection with Zaire ebolavirus.

Published in:

BMC Research Notes, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13104-019-4671-8

By:

Oliver, Genevieve F.;
Orang, Ayla V.;
Appukuttan, Binoy;
Marri, Shashikanth;
Michael, Michael Z.;
Marsh, Glenn A.;
Smith, Justine R.

Publication type:

Article

Correction: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.

Published in:

2024

By:

Kim, Judong;
Pajarillo, Edward;
Rizor, Asha;
Son, Deok-Soo;
Lee, Jayden;
Aschner, Michael;
Lee, Eunsook

Publication type:

Correction Notice

Expression of Concern: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia.

Published in:: 2023
Publication type:: Correction Notice

Designing peptides predicted to bind to the omicron variant better than ACE2 via computational protein design and molecular dynamics.

Published in:

PLoS ONE, 2023, v. 18, n. 10, p. 1, doi. 10.1371/journal.pone.0292589

By:

Sitthiyotha, Thassanai;
Treewattanawong, Wantanee;
Chunsrivirot, Surasak

Publication type:

Article

Post-translational modification and mitochondrial function in Parkinson’s disease.

Published in:

Frontiers in Molecular Neuroscience, 2024, p. 1, doi. 10.3389/fnmol.2023.1329554

By:

Shishi Luo;
Danling Wang;
Zhuohua Zhang

Publication type:

Article

The function of Golgi apparatus in LRRK2-associated Parkinson's disease.

Published in:

Frontiers in Molecular Neuroscience, 2023, v. 16, p. 1, doi. 10.3389/fnmol.2023.1097633

By:

Yonghang Wei;
Awan, Maher un Nisa;
Liping Bai;
Jie Bai

Publication type:

Article

LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00556

By:

Rivero-Ríos, Pilar;
Romo-Lozano, María;
Fasiczka, Rachel;
Naaldijk, Yahaira;
Hilfiker, Sabine

Publication type:

Article

Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00526

By:

Mabrouk, Omar S.;
Chen, Siwei;
Edwards, Amanda L.;
Yang, Minhua;
Hirst, Warren D.;
Graham, Danielle L.

Publication type:

Article

"LRRK2: Autophagy and Lysosomal Activity".

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00498

By:

Madureira, Marta;
Connor-Robson, Natalie;
Wade-Martins, Richard

Publication type:

Article

Guilt-by-Association – Functional Insights Gained From Studying the LRRK2 Interactome.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00485

By:

Gloeckner, Christian Johannes;
Porras, Pablo

Publication type:

Article

Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00376

By:

Cabezudo, Diego;
Baekelandt, Veerle;
Lobbestael, Evy

Publication type:

Article

Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2.

Published in:

Frontiers in Neuroscience, 2020, p. 1, doi. 10.3389/fnins.2020.00302

By:

Manschwetus, Jascha T.;
Wallbott, Maximilian;
Fachinger, Alexandra;
Obergruber, Claudia;
Pautz, Sabine;
Bertinetti, Daniela;
Schmidt, Sven H.;
Herberg, Friedrich W.

Publication type:

Article

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00227

By:

Kuwahara, Tomoki;
Iwatsubo, Takeshi

Publication type:

Article

Vesicular Dysfunction and the Pathogenesis of Parkinson's Disease: Clues From Genetic Studies.

Published in:

Frontiers in Neuroscience, 2020, v. 13, p. 1, doi. 10.3389/fnins.2019.01381

By:

Ebanks, Kirsten;
Lewis, Patrick A.;
Bandopadhyay, Rina

Publication type:

Article

Bioenergetics and Autophagic Imbalance in Patients-Derived Cell Models of Parkinson Disease Supports Systemic Dysfunction in Neurodegeneration.

Published in:

Frontiers in Neuroscience, 2019, p. 1, doi. 10.3389/fnins.2019.00894

By:

González-Casacuberta, Ingrid;
Juárez-Flores, Diana Luz;
Morén, Constanza;
Garrabou, Gloria

Publication type:

Article

Leucine-Rich Repeat Kinase 2 Is Associated With Activation of the Paraventricular Nucleus of the Hypothalamus and Stress-Related Gastrointestinal Dysmotility.

Published in:

Frontiers in Neuroscience, 2019, p. 1, doi. 10.3389/fnins.2019.00905

By:

Maekawa, Tatsunori;
Tsushima, Hiromichi;
Kawakami, Fumitaka;
Kawashima, Rei;
Kodo, Masaru;
Imai, Motoki;
Ichikawa, Takafumi

Publication type:

Article

LRRK2 Kinase Inhibitor PF-06447475 Protects Drosophila melanogaster against Paraquat-Induced Locomotor Impairment, Life Span Reduction, and Oxidative Stress.

Published in:

Neurochemical Research, 2024, v. 49, n. 9, p. 2440, doi. 10.1007/s11064-024-04141-9

By:

Quintero-Espinosa, Diana A.;
Jimenez-Del-Rio, Marlene;
Velez-Pardo, Carlos

Publication type:

Article

The Role of Human LRRK2 in Acute Methylmercury Toxicity in Caenorhabditis elegans.

Published in:

Neurochemical Research, 2021, v. 46, n. 11, p. 2991, doi. 10.1007/s11064-021-03394-y

By:

Ke, Tao;
Rocha, Joao B. T.;
Tinkov, Alexey A.;
Santamaria, Abel;
Bowman, Aaron B.;
Aschner, Michael

Publication type:

Article

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.

Published in:

Neurochemical Research, 2019, v. 44, n. 6, p. 1446, doi. 10.1007/s11064-018-2650-4

By:

Langston, Rebekah G.;
Rudenko, Iakov N.;
Kumaran, Ravindran;
Hauser, David N.;
Kaganovich, Alice;
Ponce, Luis Bonet;
Mamais, Adamantios;
Ndukwe, Kelechi;
Dillman, Allissa A.;
Al-Saif, Amr M.;
Beilina, Aleksandra;
Cookson, Mark R.

Publication type:

Article

Disease-Toxicant Interactions in Parkinson's Disease Neuropathology.

Published in:

Neurochemical Research, 2017, v. 42, n. 6, p. 1772, doi. 10.1007/s11064-016-2052-4

By:

Kwakye, Gunnar;
McMinimy, Rachael;
Aschner, Michael

Publication type:

Article

Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease.

Published in:

Neurochemical Research, 2016, v. 41, n. 10, p. 2675, doi. 10.1007/s11064-016-1982-1

By:

Mendivil-Perez, Miguel;
Velez-Pardo, Carlos;
Jimenez-Del-Rio, Marlene

Publication type:

Article

The Neurobiology of LRRK2 and its Role in the Pathogenesis of Parkinson's Disease.

Published in:

Neurochemical Research, 2014, v. 39, n. 3, p. 576, doi. 10.1007/s11064-013-1073-5

By:

Rideout, Hardy;
Stefanis, Leonidas

Publication type:

Article

Molecular dynamic investigation for Roco4 kinase inhibitor as treatment options for parkinsonism.

Published in:

Journal of Molecular Modeling, 2024, v. 30, n. 5, p. 1, doi. 10.1007/s00894-024-05925-0

By:

Dutta, Kankana;
Ravi, Lokesh

Publication type:

Article

The structure of SALM5 suggests a dimeric assembly for the presynaptic RPTP ligand recognition.

Published in:

PEDS: Protein Engineering, Design & Selection, 2018, v. 31, n. 5, p. 147, doi. 10.1093/protein/gzy012

By:

Karki, Sudeep;
Paudel, Prodeep;
Sele, Celeste;
Shkumatov, Alexander V;
Kajander, Tommi

Publication type:

Article