Works about CYCLIN-dependent kinases

Results: 3957

Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59930-9

By:

Troester, Selina;
Eder, Thomas;
Wukowits, Nadja;
Piontek, Martin;
Fernández-Pernas, Pablo;
Schmoellerl, Johannes;
Haladik, Ben;
Manhart, Gabriele;
Allram, Melanie;
Maurer-Granofszky, Margarita;
Scheidegger, Nastassja;
Nebral, Karin;
Superti-Furga, Giulio;
Meisel, Roland;
Bornhauser, Beat;
Valent, Peter;
Dworzak, Michael N.;
Zuber, Johannes;
Boztug, Kaan;
Grebien, Florian

Publication type:

Article

The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs.

Published in:

Cell Biochemistry & Biophysics, 2025, v. 83, n. 2, p. 2349, doi. 10.1007/s12013-024-01646-6

By:

Brunie, Manon;
Robichaud, Mika A.;
Touaibia, Mohamed;
Martin, Luc J.

Publication type:

Article

Dalpiciclib plus aromatase inhibitor versus neoadjuvant chemotherapy for ER-positive, HER2-negative breast cancer.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1566146

By:

Wang, Haoqi;
Zhang, Guoyu;
Gao, Wei;
Li, Sainan;
Yang, Shan;
Zhang, Xi;
Wang, Jiaxing;
Li, Chunxiao;
Gao, Shan;
Geng, Cuizhi

Publication type:

Article

SECONDARY METABOLISM OF LICHENS AS THE CYTOTOXIC AGENT TO KILL THE CANCER CELLS.

Published in:

Obstetrics & Gynaecology Forum, 2024, v. 34, n. 3, p. 2196

By:

Khathayer, Firas;
Almola, Zakaria Sami;
Kadhim, Sabah Zyara

Publication type:

Article

CDK4/6 Inhibitors-Induced Macrocytosis Is Not Associated with Hemolysis and Does Not Impact Hemoglobin Homeostasis.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1567, doi. 10.3390/cancers17091567

By:

Barroso, Tiago;
Costa, Leila;
Gonçalves, Lisa;
Patel, Vanessa;
Araújo, João;
Pinho, Inês;
Monteiro, Carolina;
Esperança-Martins, Miguel;
Abreu, Catarina;
de Sousa, Rita Teixeira;
Pais, Helena;
Nogueira-Costa, Gonçalo;
Torres, Sofia;
Ribeiro, Leonor Abreu;
da Costa, Luís Marques

Publication type:

Article

Mechanistic Roles of Transcriptional Cyclin-Dependent Kinases in Oncogenesis: Implications for Cancer Therapy.

Published in:

Cancers, 2025, v. 17, n. 9, p. 1554, doi. 10.3390/cancers17091554

By:

Alrouji, Mohammed;
Alshammari, Mohammed S.;
Anwar, Saleha;
Venkatesan, Kumar;
Shamsi, Anas

Publication type:

Article

Targeting ETHE1 inhibits tumorigenesis in vitro and in vivo by preventing aerobic glycolysis in gastric adenocarcinoma cells.

Published in:

Oncology Letters, 2025, v. 29, n. 6, p. N.PAG, doi. 10.3892/ol.2025.15032

By:

Li, Fangfei;
Du, Xuan;
Han, Mei;
Feng, Xiaoying;
Jiang, Chunmeng

Publication type:

Article

Implication of TRPM8, CD47, and CDK4 expressions in hepatocellular carcinoma progression.

Published in:

Journal of Immunoassay & Immunochemistry, 2025, v. 46, n. 3, p. 245, doi. 10.1080/15321819.2025.2464718

By:

Hemida, Aiat Shaban;
Tantawy, Mona Saeed

Publication type:

Article

The treatment of breast cancer in the era of precision medicine.

Published in:

Cancer Biology & Medicine, 2025, v. 22, n. 4, p. 322, doi. 10.20892/j.issn.2095-3941.2024.0510

By:

Jingwen Bai;
Yiyang Gao;
Guojun Zhang

Publication type:

Article

Immunohistochemical expression of p16INK4a is predictive of HR-HPV infection in cervical low-grade lesions.

Published in:

Modern Pathology, 2006, v. 19, n. 3, p. 384, doi. 10.1038/modpathol.3800551

By:

Benevolo, Maria;
Mottolese, Marcella;
Marandino, Ferdinando;
Vocaturo, Giuseppe;
Sindico, Roberto;
Piperno, Giulia;
Mariani, Luciano;
Sperduti, Isabella;
Canalini, Paola;
Donnorso, Raffaele P.;
Vocaturo, Amina

Publication type:

Article

Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma.

Published in:

Modern Pathology, 2005, v. 18, n. 10, p. 1377, doi. 10.1038/modpathol.3800434

By:

Hans, Christine P.;
Weisenburger, Dennis D.;
Greiner, Timothy C.;
Chan, Wing C.;
Aoun, Patricia;
Cochran, Gregory T.;
Pan, Zenggang;
Smith, Lynette M.;
Lynch, James C.;
Bociek, Robert Gregory;
Bierman, Philip J.;
Vose, Julie M.;
Armitage, James O.

Publication type:

Article

Prevalence and prognostic significance of microsatellite alterations in young patients with bladder cancer.

Published in:

Modern Pathology, 2005, v. 18, n. 9, p. 1176, doi. 10.1038/modpathol.3800399

By:

Migaldi, Mario;
Sartori, Giuliana;
Rossi, Giulio;
Garagnani, Lorella;
Faraglia, Beatrice;
De Gaetani, Carmela;
Cittadini, Achille;
Trentini, Gian P.;
Sgambato, Alessandro

Publication type:

Article

Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents.

Published in:

Modern Pathology, 2005, v. 18, n. 2, p. 267, doi. 10.1038/modpathol.3800290

By:

Hu, Lulin;
Ming Guo;
Zhi He;
Thornton, Justin;
McDaniel, Larry S;
Hughson, Michael D

Publication type:

Article

Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior.

Published in:

Modern Pathology, 2004, v. 17, n. 12, p. 1464, doi. 10.1038/modpathol.3800220

By:

Nilsson, Kristina;
Svensson, Sofie;
Landberg, Göran

Publication type:

Article

Expression of cell cycle inhibitor p27Kip1 and its inactivator Jab1 in melanocytic lesions.

Published in:

Modern Pathology, 2004, v. 17, n. 7, p. 811, doi. 10.1038/modpathol.3800123

By:

Ivan, Doina;
Diwan, A. Hafeez;
Esteva, Francisco J.;
Prieto, Victor G.

Publication type:

Article

Methylation Analysis of Cyclin-Dependent Kinase Inhibitor Genes in Primary Gastrointestinal Lymphomas.

Published in:

Modern Pathology, 2003, v. 16, n. 8, p. 752, doi. 10.1097/01.MP.0000081728.21368.85

By:

Jai Hyang Go

Publication type:

Article

Prognostic Significance of p27 and Ki-67 Expression in Mucoepidermoid Carcinoma of the Intraoral Minor Salivary Gland.

Published in:

Modern Pathology, 2001, v. 14, n. 10, p. 1008, doi. 10.1038/modpathol.3880426

By:

Okabe, Mitsukuni;
Inagaki, Hiroshi;
Murase, Takayuki;
Inoue, Masahisa;
Nagai, Noriyuki;
Eimoto, Tadaaki

Publication type:

Article

Immunohistochemical Expression of Cell Cycle Proteins E2F-1, Cdk-2, Cyclin E, p27kip1, and Ki-67 in Normal Placenta and Gestational Trophoblastic Disease.

Published in:

Modern Pathology, 2001, v. 14, n. 10, p. 1036, doi. 10.1038/modpathol.3880432

By:

Olvera, Maria;
Harris, Selena;
Amezcua, Charles A.;
McCourty, Althea;
Rezk, Sherif;
Koo, Charles;
Felix, Juan C.;
Brynes, Russell K.

Publication type:

Article

Correction: CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.

Published in:

2015

By:

null, null

Publication type:

Correction Notice

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.

Published in:

PLoS Biology, 2015, v. 13, n. 7, p. 1, doi. 10.1371/journal.pbio.1002207

By:

Xie, Xiao-Jun;
Hsu, Fu-Ning;
Gao, Xinsheng;
Xu, Wu;
Ni, Jian-Quan;
Xing, Yue;
Huang, Liying;
Hsiao, Hao-Ching;
Zheng, Haiyan;
Wang, Chenguang;
Zheng, Yani;
Xiaoli, Alus M.;
Yang, Fajun;
Bondos, Sarah E.;
Ji, Jun-Yuan

Publication type:

Article

A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression.

Published in:

PLoS Biology, 2010, v. 8, n. 9, p. 1, doi. 10.1371/journal.pbio.1000484

By:

Pop, Ramona;
Shearstone, Jeffrey R.;
Qichang Shen;
Ying Liu;
Hallstrom, Kelly;
Koulnis, Miroslav;
Gribnau, Joost;
Socolovsky, Merav

Publication type:

Article

Recruitment of Cln3 Cyclin to Promoters Controls Cell Cycle Entry via Histone Deacetylase and Other Targets.

Published in:

PLoS Biology, 2009, v. 7, n. 9, p. 1, doi. 10.1371/journal.pbio.1000189

By:

Hongyin Wang;
Carey, Lucas B.;
Ying Cai;
Wijnen, Herman;
Futcher, Bruce

Publication type:

Article

Dual Regulation by Pairs of Cyclin-Dependent Protein Kinases and Histone Deacetylases Controls G1 Transcription in Budding Yeast.

Published in:

PLoS Biology, 2009, v. 7, n. 9, p. 1, doi. 10.1371/journal.pbio.1000188

By:

Dongqing Huang;
Kaluarachchi, Supipi;
van Dyk, Dewald;
Friesen, Helena;
Sopko, Richelle;
Wei Ye;
Bastajian, Nazareth;
Moffat, Jason;
Sassi, Holly;
Costanzo, Michael;
Andrews, Brenda J.

Publication type:

Article

Cdk5 Regulates Accurate Maturation of Newborn Granule Cells in the Adult Hippocampus.

Published in:

PLoS Biology, 2008, v. 6, n. 11, p. e272, doi. 10.1371/journal.pbio.0060272

By:

Jessberger, Sebastian;
Aigner, Stefan;
Clemenson Jr., Gregory D.;
Toni, Nicolas;
D. Chichung Lie;
Karalay, Özlem;
Overall, Rupert;
Kempermann, Gerd;
Gage, Fred H.

Publication type:

Article

For New Neurons in an Old Brain, cdk5 Shows the Way.

Published in:

PLoS Biology, 2008, v. 6, n. 11, p. e291, doi. 10.1371/journal.pbio.0060291

By:

Robinson, Richard

Publication type:

Article

Cyclin B1Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression.

Published in:

PLoS Biology, 2007, v. 5, n. 5, p. e123, doi. 10.1371/journal.pbio.0050123

By:

Lindqvist, Arne;
van Zon, Wouter;
Karlsson Rosenthal, Christina;
Wolthuis, Rob M. F

Publication type:

Article

Chemically induced premature chromosome condensation in short-term cultured human peripheral lymphocytes: applications to biodosimetry.

Published in:

Biotechnic & Histochemistry, 2007, v. 82, n. 1, p. 29, doi. 10.1080/10520290701257153

By:

Tsuji, S;
Kanda, R

Publication type:

Article

Electron microscopy evidence that cytoplasmic localization of the p16 INK4A "nuclear" cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas.

Published in:

Biotechnic & Histochemistry, 2004, v. 79, n. 1, p. 5, doi. 10.1080/10520290310001659466

By:

Evangelou, K.;
Bramis, J.;
Peros, I.;
Zacharatos, P.;
Dasiou-Plakida, D.;
Kalogeropoulos, N.;
Asimacopoulos, P.J.;
Kittas, C.;
Marinos, E.;
Gorgoulis, V.G.

Publication type:

Article

Cover Feature: Synthesis of Thiazolidinedione‐ and Triazole‐Linked Organoselenocyanates and Evaluation of Anticancer Activities Against Breast Cancer with Mechanistic Investigations (Chem. Eur. J. 11/2025).

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 11, p. 1, doi. 10.1002/chem.202581102

By:

Pal, Nikita;
Banerjee, Kaustav;
Sarkar, Shilpi;
Mandal, Tapas K.;
Bhabak, Krishna P.

Publication type:

Article

HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.

Published in:

Biotechnology Letters, 2018, v. 40, n. 4, p. 623, doi. 10.1007/s10529-018-2512-9

By:

Zhang, Yu;
Yang, Limin;
Ling, Chunhua;
Heng, Wei

Publication type:

Article

Cyclin-dependent kinase inhibitor, roscovitine, in combination with exogenous cytokinin, N6-benzyladenine, causes increase of cis-cytokinins in immobilized tobacco cells.

Published in:

Biotechnology Letters, 2003, v. 25, n. 6, p. 469, doi. 10.1023/A:1022612905134

By:

Blagoeva, Elitsa;
Malbeck, Jiři;
Gaudinová, Alena;
Vaněk, Tomáš;
Vaňková, Radomíra

Publication type:

Article

Up-regulation of cell cycle regulatory genes after renal ischemia/reperfusion: differential expression of p16(INK4a), p21(WAF1/CIP1) and p27(Kip1) cyclin-dependent kinase inhibitor genes depending on reperfusion time.

Published in:

Transplant International, 2006, v. 19, n. 1, p. 72, doi. 10.1111/j.1432-2277.2005.00227.x

By:

Chkhotua, Archil B.;
Abendroth, Dietmar;
Froeba, Gebhard;
Schelzig, Hubert

Publication type:

Article

Increased expression of p21 (WAF1/CIP1) cyclin-dependent kinase (CDK) inhibitor gene in chronic allograft nephropathy correlates with the number of acute rejection episodes.

Published in:

Transplant International, 2003, v. 16, n. 8, p. 502, doi. 10.1007/s00147-003-0587-1

By:

Archil B. Chkhotua;
Annalisa Altimari;
Elena Gabusi;
Antonia D'Errico;
Sergio Stefoni;
Pasquale Chieco;
Michaela Yakubovich;
Joerg Vienken;
Alexander Yussim;
Walter F. Grigioni

Publication type:

Article

The yeast Pho80–Pho85 cyclin–CDK complex has multiple substrates.

Published in:

Current Genetics, 2004, v. 46, n. 1, p. 1, doi. 10.1007/s00294-004-0501-0

By:

Waters, Norman C.;
Knight, Janine P.;
Creasy, Caretha L.;
Bergman, Lawrence W.

Publication type:

Article

Regulation by phosphorylation of Pho81p, a cyclin-dependent kinase inhibitor in Saccharomyces cerevisiae.

Published in:

Current Genetics, 2004, v. 46, n. 1, p. 10, doi. 10.1007/s00294-004-0502-z

By:

Knight, Janine P.;
Daly, Thomas M.;
Bergman, Lawrence W.

Publication type:

Article

Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 3, p. 559, doi. 10.1007/s00280-010-1520-9

By:

Hamada, Masakazu;
Miki, Tetsuei;
Iwai, Soichi;
Shimizu, Hidetaka;
Yura, Yoshiaki

Publication type:

Article

A phase I clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 6, p. 1113, doi. 10.1007/s00280-010-1269-1

By:

Dickson, Mark A.;
Shah, Manish A.;
Rathkopf, Dana;
Tse, Archie;
Carvajal, Richard D.;
Nian Wu;
Lefkowitz, Robert A.;
Gonen, Mithat;
Cane, Lauren M.;
Dials, Heather J.;
Schwartz, Gary K.

Publication type:

Article

SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 64, n. 4, p. 723, doi. 10.1007/s00280-008-0921-5

By:

Conroy, Andrew;
Stockett, David E.;
Walker, Duncan;
Arkin, Michelle R.;
Hoch, Ute;
Fox, Judith A.;
Hawtin, Rachael Elizabeth

Publication type:

Article

A phase I dose escalation study of the pharmacokinetics and tolerability of ZK 304709, an oral multi-targeted growth inhibitor (MTGI™), in patients with advanced solid tumours.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 64, n. 2, p. 425, doi. 10.1007/s00280-009-0968-y

By:

Scott, Edwina N.;
Thomas, Anne L.;
Molife, L. Rhoda;
Ahmed, Samreen;
Blagden, Sarah;
Fong, Peter C.;
Kowal, Kristin;
McCoy, Candice;
Wiesinger, Herbert;
Steward, Will;
De Bono, Johann

Publication type:

Article

Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 63, n. 6, p. 1131, doi. 10.1007/s00280-008-0832-5

By:

Ze Tian;
Ning An;
Bin Zhou;
Peigen Xiao;
Kohane, Isaac;
Wu, Erxi

Publication type:

Article

A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers.

Published in:

Cancer Chemotherapy & Pharmacology, 2007, v. 60, n. 4, p. 479, doi. 10.1007/s00280-006-0387-2

By:

Camidge, D.;
Pemberton, Mike;
Growcott, Jim;
Amakye, Dereck;
Wilson, David;
Swaisland, Helen;
Forder, Cheryl;
Wilkinson, Robert;
Byth, Kate;
Hughes, Andrew

Publication type:

Article

A first-in-man phase I tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor AZD5438 in healthy male volunteers.

Published in:

Cancer Chemotherapy & Pharmacology, 2007, v. 60, n. 3, p. 391, doi. 10.1007/s00280-006-0371-x

By:

Camidge, D. Ross;
Smethurst, Dominic;
Growcott, Jim;
Barrass, Nigel C.;
Foster, John R.;
Febbraro, Salvatore;
Swaisland, Helen;
Hughes, Andrew

Publication type:

Article

Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo.

Published in:

Cancer Chemotherapy & Pharmacology, 2007, v. 59, n. 4, p. 439, doi. 10.1007/s00280-006-0282-x

By:

Lin, Jing;
Yan, Xiao-Jun;
Chen, Hai-Min

Publication type:

Article

Modulation by phenylacetate of early estrogen-mediated events in MCF-7 breast cancer cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2007, v. 59, n. 2, p. 217, doi. 10.1007/s00280-006-0260-3

By:

Liu, Jingbo;
Li, Jing;
Sidell, Neil

Publication type:

Article

P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats.

Published in:

Cancer Chemotherapy & Pharmacology, 2005, v. 55, n. 2, p. 110, doi. 10.1007/s00280-004-0873-3

By:

Kamath, Amrita V.;
Saeho Chong;
Ming Chang;
Marathe, Punit

Publication type:

Article

CK1δ activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation.

Published in:

Amino Acids, 2016, v. 48, n. 2, p. 579, doi. 10.1007/s00726-015-2114-y

By:

Ianes, Chiara;
Xu, Pengfei;
Werz, Natalie;
Meng, Zhigang;
Henne-Bruns, Doris;
Bischof, Joachim;
Knippschild, Uwe

Publication type:

Article

O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2.

Published in:

Amino Acids, 2013, v. 45, n. 2, p. 339, doi. 10.1007/s00726-013-1504-2

By:

Ding, Fang;
Yu, Lu;
Wang, Meihui;
Xu, Shengjie;
Xia, Qiang;
Fu, Guosheng

Publication type:

Article

Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells.

Published in:

Amino Acids, 2012, v. 42, n. 2/3, p. 655, doi. 10.1007/s00726-011-1040-x

By:

Arısan, Elif;
Çoker, Ajda;
Palavan-Ünsal, Narçin

Publication type:

Article

Skp2 inversely correlates with p27 and tuberin in transformed cells.

Published in:

Amino Acids, 2009, v. 37, n. 2, p. 257, doi. 10.1007/s00726-008-0141-7

By:

M. Rosner;
M. Hanneder;
N. Siegel;
A. Valli;
C. Fuchs;
M. HengstschlÃ¤ger

Publication type:

Article

Significance of Immunohistochemical Expression of p27 and Involucrin as the Marker of Cellular Differentiation of Squamous Cell Carcinoma of the Esophagus.

Published in:

Oncology, 2006, v. 71, n. 5/6, p. 402, doi. 10.1159/000108611

By:

Nozoe, Tadahiro;
Oyama, Tsunehiro;
Takenoyama, Mistuhiro;
Hanagiri, Takeshi;
Sugio, Kenji;
Yasumoto, Kosei

Publication type:

Article