Works about CYCLIN-dependent kinases

Results: 3987

Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02565-y

By:

Yang, Xia;
Liu, Lu;
Yu, Zhongjian;
Chen, Yuanlin;
Xu, Shiting;
Liu, Meiyuan;
Wang, Meng;
Guo, Huili;
Zhang, Zhiwu;
Shan, Bingjie;
Cai, Silin;
Pan, Mengting;
Zhang, Jiangyu;
Wang, Fengpin;
Zheng, Yanfang

Publication type:

Article

CDK13‐Related Disorder: Novel Insights From A Series of 27 Cases and Recommendations for Clinical Management.

Published in:

Clinical Genetics, 2025, v. 108, n. 2, p. 146, doi. 10.1111/cge.14726

By:

Contrò, Gianluca;
Baroni, Maria Chiara;
Caraffi, Stefano Giuseppe;
Napoli, Manuela;
Artuso, Rosangela;
Giliberti, Annarita;
Bargiacchi, Sara;
Mancano, Giorgia;
Traficante, Giovanna;
Mucciolo, Mafalda;
Radio, Francesca Clementina;
Cordeddu, Viviana;
Mancini, Cecilia;
Bottillo, Irene;
Pirro, Federica Anna;
Bonati, Maria Teresa;
Becker, Cord‐Christian;
Carli, Diana;
Mussa, Alessandro;
Gonzalez, Maria Isis Atallah

Publication type:

Article

Clinically proven natural products against breast cancer, with mechanistic insights.

Published in:

Oncology Research, 2025, v. 33, n. 7, p. 1611, doi. 10.32604/or.2025.062778

By:

HASAN, MD. MAHMUDUL;
WASIN, SHAH MD.;
RAHMAN, MISHU;
AZME, EVA;
MOSTAQ, MD. SAQLINE;
NAHID, MD. MAHEDI HASAN;
MOHAMMAD, NOR;
TANJUM, FARJANA AFRIN;
HAQUE, MD. ANAMUL;
MAHMUD, MD ASHIQ;
AMIN, MOHAMMAD NURUL

Publication type:

Article

Targeting WEE1 Kinase for Breast Cancer Therapeutics: An Update.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5701, doi. 10.3390/ijms26125701

By:

Zhang, Zhao;
Harish, Ritika;
Elahi, Naveed;
Saini, Sawanjit;
Telia, Aamir;
Kundlas, Manjit;
Koroleva, Allexes;
Umoh, Israel N.;
Lota, Manpreet;
Bilkhu, Meha;
Kawaiah, Aladdin;
Allala, Manogna R.;
Leukeu, Armelle;
Nebuwa, Emmanuel;
Sharifi, Nadiya;
Ashton, Anthony W.;
Jiao, Xuanmao;
Pestell, Richard G.

Publication type:

Article

Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-00931-8

By:

Marei, Hany E.;
Bedair, Khaled;
Hasan, Anwarul;
Al-Mansoori, Layla;
Gaiba, Alice;
Morrione, Andrea;
Cenciarelli, Carlo;
Giordano, Antonio

Publication type:

Article

XMU-MP-1, Inhibitor of STE20-like MST1/2 Kinases of the Hippo Signaling Pathway, Suppresses the Cell Cycle, Activates Apoptosis and Autophagy, and Induces Death of Hematopoietic Tumor Cells.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 874, doi. 10.3390/ph18060874

By:

Stepchenko, Alexander G.;
Georgieva, Sofia G.;
Pankratova, Elizaveta V.

Publication type:

Article

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.

Published in:

PLoS Biology, 2015, v. 13, n. 7, p. 1, doi. 10.1371/journal.pbio.1002207

By:

Xie, Xiao-Jun;
Hsu, Fu-Ning;
Gao, Xinsheng;
Xu, Wu;
Ni, Jian-Quan;
Xing, Yue;
Huang, Liying;
Hsiao, Hao-Ching;
Zheng, Haiyan;
Wang, Chenguang;
Zheng, Yani;
Xiaoli, Alus M.;
Yang, Fajun;
Bondos, Sarah E.;
Ji, Jun-Yuan

Publication type:

Article

A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression.

Published in:

PLoS Biology, 2010, v. 8, n. 9, p. 1, doi. 10.1371/journal.pbio.1000484

By:

Pop, Ramona;
Shearstone, Jeffrey R.;
Qichang Shen;
Ying Liu;
Hallstrom, Kelly;
Koulnis, Miroslav;
Gribnau, Joost;
Socolovsky, Merav

Publication type:

Article

Recruitment of Cln3 Cyclin to Promoters Controls Cell Cycle Entry via Histone Deacetylase and Other Targets.

Published in:

PLoS Biology, 2009, v. 7, n. 9, p. 1, doi. 10.1371/journal.pbio.1000189

By:

Hongyin Wang;
Carey, Lucas B.;
Ying Cai;
Wijnen, Herman;
Futcher, Bruce

Publication type:

Article

Dual Regulation by Pairs of Cyclin-Dependent Protein Kinases and Histone Deacetylases Controls G1 Transcription in Budding Yeast.

Published in:

PLoS Biology, 2009, v. 7, n. 9, p. 1, doi. 10.1371/journal.pbio.1000188

By:

Dongqing Huang;
Kaluarachchi, Supipi;
van Dyk, Dewald;
Friesen, Helena;
Sopko, Richelle;
Wei Ye;
Bastajian, Nazareth;
Moffat, Jason;
Sassi, Holly;
Costanzo, Michael;
Andrews, Brenda J.

Publication type:

Article

Cdk5 Regulates Accurate Maturation of Newborn Granule Cells in the Adult Hippocampus.

Published in:

PLoS Biology, 2008, v. 6, n. 11, p. e272, doi. 10.1371/journal.pbio.0060272

By:

Jessberger, Sebastian;
Aigner, Stefan;
Clemenson Jr., Gregory D.;
Toni, Nicolas;
D. Chichung Lie;
Karalay, Özlem;
Overall, Rupert;
Kempermann, Gerd;
Gage, Fred H.

Publication type:

Article

For New Neurons in an Old Brain, cdk5 Shows the Way.

Published in:

PLoS Biology, 2008, v. 6, n. 11, p. e291, doi. 10.1371/journal.pbio.0060291

By:

Robinson, Richard

Publication type:

Article

Cyclin B1Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression.

Published in:

PLoS Biology, 2007, v. 5, n. 5, p. e123, doi. 10.1371/journal.pbio.0050123

By:

Lindqvist, Arne;
van Zon, Wouter;
Karlsson Rosenthal, Christina;
Wolthuis, Rob M. F

Publication type:

Article

Oncogenic potential of Cyclin Kinase Subunit-2 in cholangiocarcinoma.

Published in:

Liver International, 2013, v. 33, n. 1, p. 137, doi. 10.1111/liv.12014

By:

Shen, Dong‐Yan;
Zhan, Yi‐Hong;
Wang, Qian‐Ming;
Rui, Gang;
Zhang, Zhi‐Ming

Publication type:

Article

Clinical significance and expression of cyclin kinase subunits 1 and 2 in hepatocellular carcinoma.

Published in:

Liver International, 2010, v. 30, n. 1, p. 119, doi. 10.1111/j.1478-3231.2009.02106.x

By:

Dong-Yan Shen;
Zan-Xi Fang;
Pan You;
Ping-Guo Liu;
Fen Wang;
Chun-Ling Huang;
Xiao-Bin Yao;
Zi-Xuan Chen;
Zhong-Ying Zhang

Publication type:

Article

Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-κB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-α.

Published in:

Liver International, 2009, v. 29, n. 2, p. 291, doi. 10.1111/j.1478-3231.2008.01858.x

By:

Itatsu, ,4Keita;
Sasaki, Motoko;
Harada, Kenichi;
Yamaguchi, Junpei;
Ikeda, Hiroko;
Sato, Yasunori;
Ohta, Tetsuo;
Sato, Hiroshi;
Nagino, Masato;
Nimura, Yuji;
Nakanuma, Yasuni

Publication type:

Article

Hepatocyte senescence in end-stage chronic liver disease: a study of cyclin-dependent kinase inhibitor p21 in liver biopsies as a marker for progression to hepatocellular carcinoma.

Published in:

Liver International, 2007, v. 27, n. 5, p. 662, doi. 10.1111/j.1478-3231.2007.01470.x

By:

Brunt, Elizabeth M.;
Walsh, Sarah N.;
Hayashi, Paul H.;
LaBundy, Jennifer;
Di Bisceglie, Adrian M.

Publication type:

Article

CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis.

Published in:

Journal of Neuro-Oncology, 2019, v. 145, n. 1, p. 35, doi. 10.1007/s11060-019-03286-w

By:

Zhao, Shu-Peng;
Wang, Fan;
Yang, Ming;
Wang, Xiang-Yang;
Jin, Cai-Ling;
Ji, Qian-Kun;
Li, Shuai;
Zhao, Xin-Li

Publication type:

Article

Tumor pharmacokinetics and pharmacodynamics of the CDK4/6 inhibitor ribociclib in patients with recurrent glioblastoma.

Published in:

Journal of Neuro-Oncology, 2019, v. 144, n. 3, p. 563, doi. 10.1007/s11060-019-03258-0

By:

Miller, Todd W.;
Traphagen, Nicole A.;
Li, Jing;
Lewis, Lionel D.;
Lopes, Beatriz;
Asthagiri, Ashok;
Loomba, Johanna;
De Jong, Jenny;
Schiff, David;
Patel, Sohil H.;
Purow, Benjamin W.;
Fadul, Camilo E.

Publication type:

Article

P21Waf1/Cip1 and p27Kip1 are correlated with the development and invasion of prolactinoma.

Published in:

Journal of Neuro-Oncology, 2018, v. 136, n. 3, p. 485, doi. 10.1007/s11060-017-2683-6

By:

Dong, Wei;
Li, Jianhua;
Liu, Qian;
Liu, Chunhui;
Li, Chuzhong;
Song, Guidong;
Zhu, Haibo;
Gao, Hua;
Zhang, Yazhuo

Publication type:

Article

Phloretin induces cell cycle arrest and apoptosis of human glioblastoma cells through the generation of reactive oxygen species.

Published in:

Journal of Neuro-Oncology, 2016, v. 128, n. 2, p. 217, doi. 10.1007/s11060-016-2107-z

By:

Liu, Yuanyuan;
Fan, Chenghe;
Pu, Lv;
Wei, Cui;
Jin, Haiqiang;
Teng, Yuming;
Zhao, Mingming;
Yu, Albert;
Jiang, Feng;
Shu, Junlong;
Li, Fan;
Peng, Qing;
Kong, Jian;
Pan, Bing;
Zheng, Lemin;
Huang, Yining

Publication type:

Article

The Cdk inhibitor flavopiridol enhances temozolomide-induced cytotoxicity in human glioma cells.

Published in:

Journal of Neuro-Oncology, 2013, v. 115, n. 2, p. 169, doi. 10.1007/s11060-013-1220-5

By:

Hayashi, Takuro;
Adachi, Kazuhide;
Ohba, Shigeo;
Hirose, Yuichi

Publication type:

Article

miR-124 radiosensitizes human glioma cells by targeting CDK4.

Published in:

Journal of Neuro-Oncology, 2013, v. 114, n. 3, p. 263, doi. 10.1007/s11060-013-1179-2

By:

Deng, Xubin;
Ma, Lei;
Wu, Minhua;
Zhang, Gong;
Jin, Chuan;
Guo, Yuping;
Liu, Ruilei

Publication type:

Article

Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1.

Published in:

Journal of Neuro-Oncology, 2010, v. 98, n. 1, p. 57, doi. 10.1007/s11060-009-0045-8

By:

Shi, Jinlong;
Zhang, Li;
Shen, Aiguo;
Zhang, Jianguo;
Wang, Yuchan;
Zhao, Yueming;
Zou, Lin;
Ke, Qing;
He, Fei;
Wang, Ping;
Cheng, Chun;
Shi, Gongshen

Publication type:

Article

Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma.

Published in:

Journal of Neuro-Oncology, 2008, v. 90, n. 1, p. 1, doi. 10.1007/s11060-008-9624-3

By:

Jessica Pierson;
Bruce Hostager;
Rong Fan;
Rajeev Vibhakar

Publication type:

Article

How to be a mitotic chromosome.

Published in:

Chromosome Research, 2011, v. 19, n. 3, p. 307, doi. 10.1007/s10577-011-9198-3

By:

Moser, Sandra;
Swedlow, Jason

Publication type:

Article

HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.

Published in:

Biotechnology Letters, 2018, v. 40, n. 4, p. 623, doi. 10.1007/s10529-018-2512-9

By:

Zhang, Yu;
Yang, Limin;
Ling, Chunhua;
Heng, Wei

Publication type:

Article

Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00523-3

By:

Chang, Zhuo;
Kuang, Hai-xue;
Zhou, Xueming;
Zhu, Hui;
Zhang, Yang;
Fu, Yin;
Fu, Qiang;
Jiang, Bei;
Wang, Wei;
Jiang, Sha;
Ren, Li;
Ma, Lei;
Pan, Xue;
Feng, Xiao-ling

Publication type:

Article

Discovery of vanoxerine dihydrochloride as a CDK2/4/6 triple-inhibitor for the treatment of human hepatocellular carcinoma.

Published in:

Molecular Medicine, 2021, v. 27, n. 1, p. 1, doi. 10.1186/s10020-021-00269-4

By:

Zhu, Ying;
Ke, Kun-Bin;
Xia, Zhong-Kun;
Li, Hong-Jian;
Su, Rong;
Dong, Chao;
Zhou, Feng-Mei;
Wang, Lin;
Chen, Rong;
Wu, Shi-Guo;
Zhao, Hui;
Gu, Peng;
Leung, Kwong-Sak;
Wong, Man-Hon;
Lu, Gang;
Zhang, Jian-Ying;
Jiang, Bing-Hua;
Qiu, Jian-Ge;
Shi, Xi-Nan;
Lin, Marie Chia-mi

Publication type:

Article

Establishing a Novel In Vivo Platform to Interrogate the Effects of Pharmacologic and Molecularly Targeted Modulation of CDK5 in the Invasive and Metastatic Potential of Medulloblastoma in Live Experimental Animals.

Published in:

2011

By:

Petrosiute, A;
Myers, J;
Nthale, J;
Davis, K;
Huang, A

Publication type:

Abstract

In vitro therapeutic effects of abemaciclib on triple‐negative breast cancer cells.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 9, p. 1, doi. 10.1002/jbt.22858

By:

Ozman, Zeynep;
Guney Eskiler, Gamze;
Sekeroglu, Mehmet R.

Publication type:

Article

Syringic acid regulates suppression of the STAT3/JNK/AKT pathway via inhibition of human ovarian teratoma cancer cell (PA‐1) growth—in vitro study.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 6, p. 1, doi. 10.1002/jbt.22776

By:

Yang, Lina;
Qu, Changhong;
Jin, Jiaxi;
Yang, Hong;
Pei, Lipeng

Publication type:

Article

Phyllanthin inhibits MOLT‐4 leukemic cancer cell growth and induces apoptosis through the inhibition of AKT and JNK signaling pathway.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 6, p. 1, doi. 10.1002/jbt.22758

By:

Wang, Hui;
Chinnathambi, Arunachalam;
Alahmadi, Tahani Awad;
Alharbi, Sulaiman Ali;
Veeraraghavan, Vishnu Priya;
Krishna Mohan, Surapaneni;
Hussain, Sardar;
Ramamoorthy, Kavitha;
Rengarajan, Thamaraiselvan

Publication type:

Article

Apoptosis oxidative damage‐mediated and antiproliferative effect of selenylated imidazo[1,2‐a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo.

Published in:

Journal of Biochemical & Molecular Toxicology, 2021, v. 35, n. 3, p. 1, doi. 10.1002/jbt.22663

By:

Santos, Daniela Coelho;
Rafique, Jamal;
Saba, Sumbal;
Almeida, Gabriela M.;
Siminski, Tâmila;
Pádua, Cynthia;
Filho, Danilo W.;
Zamoner, Ariane;
Braga, Antonio L.;
Pedrosa, Rozangela C.;
Ourique, Fabiana

Publication type:

Article

Fit‐for‐Purpose Synthesis of CDK2 Inhibitor GNE‐140.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 8, p. 1, doi. 10.1002/hlca.202300023

By:

Ambrosi, Andrea;
Piechowicz, Katarzyna A.;
Tuck, Tyler A.;
Xu, Di;
Zhang, Haiming;
Gosselin, Francis

Publication type:

Article

Exploration of Quantitative StructureReactivity Relationships for the Estimation of Mayr Nucleophilicity.

Published in:

Helvetica Chimica Acta, 2015, v. 98, n. 6, p. 863, doi. 10.1002/hlca.201400366

By:

Pereira, Florbela;
Latino, Diogo A. R. S.

Publication type:

Article

Improved Synthesis of Indirubin Derivatives by Sequential Build-Up of the Indoxyl Unit: First Preparation of Fluorescent Indirubins.

Published in:

Helvetica Chimica Acta, 2012, v. 95, n. 8, p. 1461, doi. 10.1002/hlca.201200042

By:

Riepl, Herbert M.;
Urmann, Corinna

Publication type:

Article

New connections between ubiquitylation and methylation in the co-transcriptional histone modification network.

Published in:

Current Genetics, 2021, v. 67, n. 5, p. 695, doi. 10.1007/s00294-021-01196-x

By:

Pinto, Daniel;
Pagé, Vivane;
Fisher, Robert P.;
Tanny, Jason C.

Publication type:

Article

Lipid flippases in polarized growth.

Published in:

Current Genetics, 2021, v. 67, n. 2, p. 255, doi. 10.1007/s00294-020-01145-0

By:

López-Marqués, Rosa Laura

Publication type:

Article

Two protein kinases UvPmk1 and UvCDC2 with significant functions in conidiation, stress response and pathogenicity of rice false smut fungus Ustilaginoidea virens.

Published in:

Current Genetics, 2020, v. 66, n. 2, p. 409, doi. 10.1007/s00294-019-01029-y

By:

Tang, Jintian;
Bai, Jing;
Chen, Xiaoyang;
Zheng, Lu;
Liu, Hao;
Huang, Junbin

Publication type:

Article

Down-regulation of Cdk1 activity in G1 coordinates the G1/S gene expression programme with genome replication.

Published in:

Current Genetics, 2019, v. 65, n. 3, p. 685, doi. 10.1007/s00294-018-00926-y

By:

García-Blanco, Natalia;
Moreno, Sergio

Publication type:

Article

Regulation of the program of DNA replication by CDK: new findings and perspectives.

Published in:

Current Genetics, 2019, v. 65, n. 1, p. 79, doi. 10.1007/s00294-018-0860-6

By:

Singh, Balveer;
Wu, Pei-Yun Jenny

Publication type:

Article

Create, activate, destroy, repeat: Cdk1 controls proliferation by limiting transcription factor activity.

Published in:

Current Genetics, 2016, v. 62, n. 2, p. 271, doi. 10.1007/s00294-015-0535-5

By:

Benanti, Jennifer

Publication type:

Article

A novel role for lncRNAs in cell cycle control during stress adaptation.

Published in:

Current Genetics, 2015, v. 61, n. 3, p. 299, doi. 10.1007/s00294-014-0453-y

By:

Solé, Carme;
Nadal-Ribelles, Mariona;
de Nadal, Eulàlia;
Posas, Francesc

Publication type:

Article

Metabolic changes during cell growth inhibition by p27 overexpression.

Published in:

Applied Microbiology & Biotechnology, 2003, v. 63, n. 2, p. 164, doi. 10.1007/s00253-003-1385-5

By:

Carvalhal, A. V.;
Marcelino, I.;
Carrondo, M. J. T.

Publication type:

Article

Concomitant Use of Proton Pump Inhibitors and CDK4/6 Inhibitors in Metastatic Hormone-Positive Breast Cancer: A Real-World Cohort Study.

Published in:

Oncology, 2025, v. 103, n. 6, p. 498, doi. 10.1159/000542693

By:

Karhan, Ogur;
İleri, Serdar;
Urakçı, Zuhat;
Arvas, Hayati;
Kılıç, Delyadıl Karakaş;
Sezgin, Yasin;
Erçek, Berrak Merit;
Tunç, Sezai

Publication type:

Article

A Cohort Study of the Antitumor Efficacy and Toxicity Profile of Alpelisib for Metastatic or Locally Advanced HR+, HER2− Breast Cancer: A Single-Institution Experience.

Published in:

Oncology, 2024, v. 102, n. 5, p. 414, doi. 10.1159/000534953

By:

Sarfraz, Humaira;
Bari, Shahla;
Whiting, Junmin;
Sur, Melissa;
Mo, Qianxing;
Armitage, Melissa;
Costa, Ricardo L.B.

Publication type:

Article

Cyclin-Dependent Kinase 9 Inhibition as a Potential Treatment for Hepatocellular Carcinoma.

Published in:

Oncology, 2022, v. 100, n. 11, p. 602, doi. 10.1159/000526978

By:

Shao, Yu-Yun;
Hsu, Hung-Wei;
Wo, Rita Robin;
Wang, Han-Yu;
Cheng, Ann-Lii;
Hsu, Chih-Hung

Publication type:

Article

Significance of Immunohistochemical Expression of p27 and Involucrin as the Marker of Cellular Differentiation of Squamous Cell Carcinoma of the Esophagus.

Published in:

Oncology, 2006, v. 71, n. 5/6, p. 402, doi. 10.1159/000108611

By:

Nozoe, Tadahiro;
Oyama, Tsunehiro;
Takenoyama, Mistuhiro;
Hanagiri, Takeshi;
Sugio, Kenji;
Yasumoto, Kosei

Publication type:

Article

Cell senescence in cardiometabolic diseases.

Published in:

NPJ Aging, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41514-024-00170-4

By:

Grootaert, Mandy O. J.

Publication type:

Article