Works matching DE "CYCLIN-dependent kinase inhibitors"

Results: 1295

A novel CDK4/6 inhibitor combined with irradiation demonstrates potent anti-tumor efficacy in diffuse midline glioma.

Published in:

Journal of Neuro-Oncology, 2023, v. 163, n. 1, p. 159, doi. 10.1007/s11060-023-04323-5

By:

Zuo, Pengcheng;
Li, Yaopeng;
Wang, Tantan;
Lin, Xingyu;
Wu, Zhen;
Zhang, Junting;
Liao, Xuebin;
Zhang, Liwei

Publication type:

Article

Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cells.

Published in:

Journal of Neuro-Oncology, 2013, v. 111, n. 2, p. 113, doi. 10.1007/s11060-012-1000-7

By:

Whiteway, Susan;
Harris, Peter;
Venkataraman, Sujatha;
Alimova, Irina;
Birks, Diane;
Donson, Andrew;
Foreman, Nicholas;
Vibhakar, Rajeev

Publication type:

Article

P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells.

Published in:

Journal of Neuro-Oncology, 2012, v. 107, n. 3, p. 503, doi. 10.1007/s11060-011-0791-2

By:

Bajbouj, K.;
Mawrin, C.;
Hartig, R.;
Schulze-Luehrmann, J.;
Wilisch-Neumann, A.;
Roessner, A.;
Schneider-Stock, R.

Publication type:

Article

Identification of peripheral blood test parameters predicting the response to palbociclib and endocrine therapy for metastatic breast cancer: a retrospective study in a single institution.

Published in:

Surgery Today, 2025, v. 55, n. 2, p. 188, doi. 10.1007/s00595-024-02893-z

By:

Yamamoto, Misato;
Shibata, Masahiro;
Tanaka, Aya;
Tsunoda, Nobuyuki;
Masuda, Norikazu

Publication type:

Article

Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60).

Published in:

Radiation & Environmental Biophysics, 2013, v. 52, n. 4, p. 471, doi. 10.1007/s00411-013-0486-5

By:

Vávrová, Jiřina;
Zárybnická, Lenka;
Lukášová, Emilie;
Řezáčová, Martina;
Novotná, Eva;
Šinkorová, Zuzana;
Tichý, Aleš;
Pejchal, Jaroslav;
Ďurišová, Kamila

Publication type:

Article

A new perspective on the proper timing of radiotherapy during CDK4/6 inhibitor therapy in patients with “bone-only” metastatic breast cancer.

Published in:

Pathology & Oncology Research, 2023, p. 1, doi. 10.3389/pore.2023.1611369

By:

Tornyi, Ilona;
Árkosy, Peter;
Horváth, Ildikó;
Furka, Andrea

Publication type:

Article

Vitiligo-like lesions induced by cyclin-dependent kinase 4/ 6 inhibitor Palbociclib: a case report and literature review.

Published in:

2023

By:

Shan Gao;
Guanjing Wei;
Yanrong Hao

Publication type:

Case Study

Human Papilloma Virus Early Proteins E6 (HPV16/18-E6) and the Cell Cycle Marker P16 (INK4a) are Useful Prognostic Markers in Uterine Cervical Carcinomas in Qassim Region- Saudi Arabia.

Published in:

Pathology & Oncology Research, 2015, v. 21, n. 1, p. 157, doi. 10.1007/s12253-014-9801-y

By:

Omran, O.;
AlSheeha, M.

Publication type:

Article

Trametinib in combination with hydroxychloroquine or palbociclib in advanced metastatic pancreatic cancer: data from a retrospective, multicentric cohort (AIO AIO-TF/PAK-0123).

Published in:

Journal of Cancer Research & Clinical Oncology, 2024, v. 150, n. 10, p. 1, doi. 10.1007/s00432-024-05954-5

By:

Witte, David;
Pretzell, Ina;
Reissig, Timm M;
Stein, Alexander;
Velthaus, Janna-Lisa;
Alig, Annabel;
Bohnenberger, Hanibal;
Knödler, Maren;
Kurreck, Annika;
Sulzer, Sabrina;
Beyer, Georg;
Dorman, Klara;
Fröhlich, Tabea;
Hegenberg, Stefanie;
Lugnier, Celine;
Saborowski, Anna;
Vogel, Arndt;
Lange, Sebastian;
Reichert, Maximilian;
Flade, Franziska

Publication type:

Article

Precision neuro-oncology: a pilot analysis of personalized treatment in recurrent glioma.

Published in:

Journal of Cancer Research & Clinical Oncology, 2023, v. 149, n. 7, p. 3513, doi. 10.1007/s00432-022-04050-w

By:

Lazaridis, Lazaros;
Schmidt, Teresa;
Oster, Christoph;
Blau, Tobias;
Pierscianek, Daniela;
Siveke, Jens T.;
Bauer, Sebastian;
Schildhaus, Hans-Ulrich;
Sure, Ulrich;
Keyvani, Kathy;
Kleinschnitz, Christoph;
Stuschke, Martin;
Herrmann, Ken;
Deuschl, Cornelius;
Scheffler, Björn;
Kebir, Sied;
Glas, Martin

Publication type:

Article

"Hedgehog pathway": a potential target of itraconazole in the treatment of cancer.

Published in:

Journal of Cancer Research & Clinical Oncology, 2020, v. 146, n. 2, p. 297, doi. 10.1007/s00432-019-03117-5

By:

Wei, Xin;
Liu, Wu;
Wang, Jia Qi;
Tang, Zeyao

Publication type:

Article

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action.

Published in:

Molecules, 2022, v. 27, n. 3, p. 880, doi. 10.3390/molecules27030880

By:

Choi, Peter Jaein;
Tomek, Petr;
Tercel, Moana;
Reynisson, Jóhannes;
Park, Thomas In Hyeup;
Cooper, Elizabeth Alexandra;
Denny, William Alexander;
Jose, Jiney;
Leung, Euphemia

Publication type:

Article

Induction of G2/M Cell Cycle Arrest via p38/p21 Waf1/Cip1 -Dependent Signaling Pathway Activation by Bavachinin in Non-Small-Cell Lung Cancer Cells.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5161, doi. 10.3390/molecules26175161

By:

Pai, Jih-Tung;
Hsu, Ming-Wei;
Leu, Yann-Lii;
Chang, Kuo-Ting;
Weng, Meng-Shih

Publication type:

Article

Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions.

Published in:

Molecules, 2021, v. 26, n. 8, p. 2228, doi. 10.3390/molecules26082228

By:

Kvízová, Jana;
Pavlíčková, Vladimíra;
Kmoníčková, Eva;
Ruml, Tomáš;
Rimpelová, Silvie

Publication type:

Article

The Cream of the Crop of the Medicinal Chemistry Section of Molecules —2019.

Published in:

2021

By:

Muñoz-Torrero, Diego;
Chemat, Farid

Publication type:

Editorial

Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies.

Published in:

Molecules, 2020, v. 25, n. 21, p. 5134, doi. 10.3390/molecules25215134

By:

García, Santiago;
Mercado-Sánchez, Itzel;
Bahena, Luis;
Alcaraz, Yolanda;
García-Revilla, Marco A.;
Robles, Juvencio;
Santos-Martínez, Nancy;
Ordaz-Rosado, David;
García-Becerra, Rocío;
Vazquez, Miguel A.

Publication type:

Article

Anti-Cancer Potential of Oxialis obtriangulata in Pancreatic Cancer Cell through Regulation of the ERK/Src/STAT3-Mediated Pathway.

Published in:

Molecules, 2020, v. 25, n. 10, p. 2301, doi. 10.3390/molecules25102301

By:

An, Eun-Jin;
Kim, Yumi;
Lee, Seung-Hyeon;
Ko, Hyun Min;
Chung, Won-Seok;
Jang, Hyeung-Jin

Publication type:

Article

Identification of High-Affinity Inhibitors of Cyclin-Dependent Kinase 2 Towards Anticancer Therapy.

Published in:

Molecules, 2019, v. 24, n. 24, p. 4589, doi. 10.3390/molecules24244589

By:

Mohammad, Taj;
Batra, Sagar;
Dahiya, Rashmi;
Baig, Mohammad Hassan;
Rather, Irfan Ahmad;
Dong, Jae-June;
Hassan, Imtaiyaz;
Tylkowski, Bartosz

Publication type:

Article

Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A.

Published in:

Molecules, 2019, v. 24, n. 20, p. 3722, doi. 10.3390/molecules24203722

By:

Waheed, Sana;
Cheng, Robert YS;
Casablanca, Yovanni;
Maxwell, G. Larry;
Wink, David A;
Syed, Viqar

Publication type:

Article

Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation.

Published in:

Molecules, 2019, v. 24, n. 17, p. 3110, doi. 10.3390/molecules24173110

By:

Nishikawa, Sakiko;
Itoh, Yuka;
Tokugawa, Muneshige;
Inoue, Yasumichi;
Nakashima, Ken-ichi;
Hori, Yuka;
Miyajima, Chiharu;
Yoshida, Kou;
Morishita, Daisuke;
Ohoka, Nobumichi;
Inoue, Makoto;
Mizukami, Hajime;
Makino, Toshiaki;
Hayashi, Hidetoshi;
Xuan, Tran Dang

Publication type:

Article

Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling.

Published in:

Molecules, 2018, v. 23, n. 1, p. 149, doi. 10.3390/molecules23010149

By:

Pisár, Martin;
Schütznerová, Eva;
Hančík, Filip;
Popa, Igor;
Trávníček, Zdeněk;
Cankař, Petr

Publication type:

Article

Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of aModel of Musashi-1 RBD1-2 Bound to theMinimum Target RNA.

Published in:

Molecules, 2017, v. 22, n. 7, p. 1207, doi. 10.3390/molecules22071207

By:

Ryo Iwaoka;
Takashi Nagata;
Kengo Tsuda;
Takao Imai;
Hideyuki Okano;
Naohiro Kobayashi;
Masato Katahira

Publication type:

Article

Cyclin-Dependent Kinase Inhibitor p21<sup>WAF1/CIP1</sup> Facilitates the Development of Cardiac Hypertrophy.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2017, v. 42, n. 4, p. 1645, doi. 10.1159/000479407

By:

Tong, Yang-Fei;
Wang, Yan;
Ding, Yuan-Yuan;
Li, Jing-Mei;
Pan, Xi-Chun;
Lu, Xiao-Lan;
Chen, Xiao-Hong;
Liu, Ya;
Zhang, Hai-Gang

Publication type:

Article

Triggering of Suicidal Erythrocyte Death by Fascaplysin.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2016, v. 39, n. 4, p. 1638, doi. 10.1159/000447865

By:

Mischitelli, Morena;
Jemaà, Mohamed;
almasry, Mustafa;
Faggio, Caterina;
Lang, Florian

Publication type:

Article

SGK1-Sensitive Regulation of Cyclin-Dependent Kinase Inhibitor 1B (p27) in Cardiomyocyte Hypertrophy.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2015, v. 37, n. 2, p. 603, doi. 10.1159/000430380

By:

Voelkl, Jakob;
Castor, Tatsiana;
Musculus, Katharina;
Viereck, Robert;
Mia, Sobuj;
Feger, Martina;
Alesutan, Ioana;
Lang, Florian

Publication type:

Article

The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2015, v. 35, n. 5, p. 1943, doi. 10.1159/000374003

By:

Saleh, ayman M.;
aljada, ahmad;
El-abadelah, Mustafa M.;
Taha, Mutasem O.;
Sabri, Salim S.;
Zahra, Jalal a.;
aziz, Mohammad azhar

Publication type:

Article

Decreased mitochondrial transcription factor A and mitochondrial DNA copy number promote cyclin-dependent kinase inhibitor 1A expression and reduce tumorigenic properties of colorectal cancer cells.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01538-4

By:

Buchwaldt, Jessika;
Fritsch, Tania;
Hartmann, Monika;
Witzel, Hagen Roland;
Kloth, Michael;
Roth, Wilfried;
Tagscherer, Katrin E.;
Hartmann, Nils

Publication type:

Article

ARE CDK INHIBITORS MORE EFFECTIVE IN HER-2 NEGATIVE BREAST CANCER THAN IN HER-2 LOW DISEASE?

Published in:

2024

By:

Bülbül, Büşra;
Yıldırım, Serkan

Publication type:

Abstract

EILEEN STUDY: A RETROSPECTIVE REAL-WORLD ANALYSIS OF RESPONSE RATES WITH RIBOCICLIB AND ENDOCRINE THERAPY IN POSTMENOPAUSAL HORMONE RECEPTOR-POSITIVE, HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2-NEGATIVE METASTATIC BREAST CANCER.

Published in:

2024

By:

Karaçin, Cengiz;
Başaran, Gül;
Kaplan, Muhammet Ali;
Göksu, Sema Sezgin;
Gümüş, Mahmut;
Inal, Ali;
Aksoy, Sercan;
Geredeli, Çağlayan;
Küçükzeybek, Yüksel;
Erdem, Dilek;
Gökmen, Erhan;
Harputluoğlu, Hakan;
Çilingiroğlu, Merve;
Gülkaya, Hayriye;
Uysal, Rana;
Nahit Şendur, Mehmet Ali

Publication type:

Abstract

EXPLORING APOPTOTIC EFFECTS OF STENOENDEMIC ACINOS ORONTIUS PLANT EXTRACTS IN GR-M MELANOMA CELLS: INITIAL FINDINGS.

Published in:

Genetics & Applications, 2023, p. 66

By:

Lejla, Lasić;
Jasna, Hanjalić Kurtović;
Lejla, Ušanović;
Merima, Miralem;
Belma, Kalamujić Stroil;
Naris, Pojskić

Publication type:

Article

Double-Faced Immunological Effects of CDK4/6 Inhibitors on Cancer Treatment: Challenges and Perspectives.

Published in:

Bioengineering (Basel), 2024, v. 11, n. 11, p. 1084, doi. 10.3390/bioengineering11111084

By:

Liu, Yongqin;
Deng, Yiying;
Yang, Chang;
Naranmandura, Hua

Publication type:

Article

Effect of CDK4/6 Inhibitors on Tumor Immune Microenvironment.

Published in:

Immunological Investigations, 2024, v. 53, n. 3, p. 437, doi. 10.1080/08820139.2024.2304565

By:

Liu, Jie;
Cheng, Min;
Xu, Jiamei;
Liang, Yue;
Yin, Beibei;
Liang, Jing

Publication type:

Article

Protection Against Cyclophosphamide-Induced Myelosuppression by ZPDC Glycoprotein (24 kDa).

Published in:

Immunological Investigations, 2013, v. 42, n. 1, p. 61, doi. 10.3109/08820139.2012.732166

By:

Lee, Jin;
Lim, Kye-Taek

Publication type:

Article

Personalized ctDNA monitoring in metastatic HR+/HER2− breast cancer patients during endocrine and CDK4/6 inhibitor therapy.

Published in:

NPJ Breast Cancer, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41523-025-00783-2

By:

Fuentes-Antrás, Jesús;
Elliott, Mitchell J.;
Main, Sasha C.;
Echelard, Philippe;
Dou, Aaron;
Bedard, Philippe L.;
Amir, Eitan;
Nadler, Michelle B.;
Meti, Nicholas;
Gregorio, Nancy;
Shah, Elizabeth;
Van de Laar, Emily;
Yu, Celeste;
Deng, Yangqing;
Gates, Lisa;
Murray, Clodagh;
Smith, Christopher G.;
Chevalier, Amber;
Bratman, Scott V.;
Siu, Lillian L.

Publication type:

Article

Baseline cell cycle and immune profiles indicate CDK4/6 inhibitor response in metastatic HR + /HER2- breast cancer.

Published in:

NPJ Breast Cancer, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41523-025-00767-2

By:

Tzetzo, Stephanie L.;
Schultz, Emily;
Wang, Jianxin;
Rosenheck, Hanna R.;
Mahan, Sidney;
Knudsen, Erik S.;
Witkiewicz, Agnieszka K.

Publication type:

Article

MUC1-C dependency in drug resistant HR+/HER2− breast cancer identifies a new target for antibody-drug conjugate treatment.

Published in:

NPJ Breast Cancer, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41523-025-00751-w

By:

Nakashoji, Ayako;
Bhattacharya, Atrayee;
Ozawa, Hiroki;
Haratake, Naoki;
Shigeta, Keisuke;
Fushimi, Atsushi;
Yamashita, Nami;
Matsui, Akira;
Kure, Shoko;
Kameyama, Tomoe;
Takeuchi, Makoto;
Fukuda, Kazumasa;
Yokoe, Takamichi;
Nagayama, Aiko;
Hayahsida, Tetsu;
Kitagawa, Yuko;
Liu, Renyan;
Giordano, Antonio;
Jeselsohn, Rinath;
Shapiro, Geoffrey I.

Publication type:

Article

Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer.

Published in:

NPJ Breast Cancer, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41523-025-00722-1

By:

Raghavendra, Akshara Singareeka;
Kettner, Nicole M.;
Kwiatkowski, Danielle;
Damodaran, Senthil;
Wang, Yan;
Ramirez, David;
Gombos, Dan S.;
Hunt, Kelly K.;
Shen, Yu;
Keyomarsi, Khandan;
Tripathy, Debu

Publication type:

Article

Prevalence, clinicopathologic features and long-term overall survival of early breast cancer patients eligible for adjuvant abemaciclib and/or ribociclib.

Published in:

NPJ Breast Cancer, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41523-025-00726-x

By:

Ladoire, Sylvain;
Kamga, Ariane Mamguem;
Galland, Loick;
Reda, Manon;
Desmoulins, Isabelle;
Mayeur, Didier;
Kaderbhai, Courèche;
Ilie, Silvia;
Hennequin, Audrey;
Talucier, Henri;
Jankowski, Clementine;
Coutant, Charles;
Arnould, Laurent;
Dabakuyo, Sandrine

Publication type:

Article

Adjuvant endocrine therapy with cyclin-dependent kinase 4/6 inhibitor, ribociclib, for localized hormone receptor-positive/HER2– breast cancer (LEADER).

Published in:

NPJ Breast Cancer, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41523-024-00708-5

By:

Spring, Laura M.;
Scarpetti, Lauren;
Medford, Arielle J.;
Niemierko, Andrzej;
Comander, Amy;
Mulvey, Therese;
Schnipper, Lowell;
Isakoff, Steven J.;
Moy, Beverly;
Wander, Seth A.;
Shin, Jennifer;
Ephrem, Zanta;
Laposta, Anneke R.;
Denault, Elyssa;
Abraham, Elizabeth;
Calistro, Gayle;
Kalashnikova, Ekaterina;
Rodriguez, Angel;
Liu, Minetta C.;
Aleshin, Alexey

Publication type:

Article

Palbociclib and letrozole for hormone receptor-positive HER2-negative breast cancer with residual disease after neoadjuvant chemotherapy.

Published in:

NPJ Breast Cancer, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41523-024-00710-x

By:

Pernas, Sonia;
Sanfeliu, Esther;
Villacampa, Guillermo;
Salvador, Javier;
Perelló, Antonia;
González, Xavier;
Jiménez, Begoña;
Merino, María;
Palacios, Patricia;
Pascual, Tomás;
Alba, Emilio;
Villanueva, Lorea;
Chillara, Samyukta;
Ferrero-Cafiero, Juan Manuel;
Galvan, Patricia;
Prat, Aleix;
Ciruelos, Eva

Publication type:

Article

Predictors of response to CDK4/6i retrial after prior CDK4/6i failure in ER+ metastatic breast cancer.

Published in:

NPJ Breast Cancer, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41523-024-00699-3

By:

Mai, Nicholas;
dos Anjos, Carlos H.;
Razavi, Pedram;
Safonov, Anton;
Patil, Sujata;
Chen, Yuan;
Drago, Joshua Z.;
Modi, Shanu;
Bromberg, Jacqueline F.;
Dang, Chau T.;
Liu, Dazhi;
Norton, Larry;
Robson, Mark;
Chandarlapaty, Sarat;
Jhaveri, Komal

Publication type:

Article

The search for CDK4/6 inhibitor biomarkers has been hampered by inappropriate proliferation assays.

Published in:

NPJ Breast Cancer, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41523-024-00624-8

By:

Foy, Reece;
Lew, Kah Xin;
Saurin, Adrian T.

Publication type:

Article

CDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape.

Published in:

NPJ Breast Cancer, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41523-024-00617-7

By:

Chaudhary, Nayan;
Chibly, Alejandro M.;
Collier, Ann;
Martinalbo, Jorge;
Perez-Moreno, Pablo;
Moore, Heather M.;
Luhn, Patricia;
Metcalfe, Ciara;
Hafner, Marc

Publication type:

Article

Emerging systemic therapy options beyond CDK4/6 inhibitors for hormone receptor-positive HER2-negative advanced breast cancer.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00578-3

By:

Ma, Jun;
Chan, Jack Junjie;
Toh, Ching Han;
Yap, Yoon-Sim

Publication type:

Article

Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00571-w

By:

Hopcroft, Lorna;
Wigmore, Eleanor M.;
Williamson, Stuart C.;
Ros, Susana;
Eberlein, Cath;
Moss, Jennifer I.;
Urosevic, Jelena;
Carnevalli, Larissa S.;
Talbot, Sara;
Bradshaw, Lauren;
Blaker, Catherine;
Gunda, Sreeharsha;
Owenson, Venetia;
Hoffmann, Scott;
Sutton, Daniel;
Jones, Stewart;
Goodwin, Richard J. A.;
Willis, Brandon S.;
Rooney, Claire;
DeBruin, Elza

Publication type:

Article

Radiomic predicts early response to CDK4/6 inhibitors in hormone receptor positive metastatic breast cancer.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00574-7

By:

Khorrami, Mohammadhadi;
Viswanathan, Vidya Sakar;
Reddy, Priyanka;
Braman, Nathaniel;
Kunte, Siddharth;
Gupta, Amit;
Abraham, Jame;
Montero, Alberto J.;
Madabhushi, Anant

Publication type:

Article

Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00571-w

By:

Hopcroft, Lorna;
Wigmore, Eleanor M.;
Williamson, Stuart C.;
Ros, Susana;
Eberlein, Cath;
Moss, Jennifer I.;
Urosevic, Jelena;
Carnevalli, Larissa S.;
Talbot, Sara;
Bradshaw, Lauren;
Blaker, Catherine;
Gunda, Sreeharsha;
Owenson, Venetia;
Hoffman, Scott;
Sutton, Daniel;
Jones, Stewart;
Goodwin, Richard J. A.;
Willis, Brandon S.;
Rooney, Claire;
DeBruin, Elza

Publication type:

Article

Pak1 pathway hyper-activation mediates resistance to endocrine therapy and CDK4/6 inhibitors in ER+ breast cancer.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00556-9

By:

Belli, Stefania;
Esposito, Daniela;
Allotta, Alessandra;
Servetto, Alberto;
Ciciola, Paola;
Pesapane, Ada;
Ascione, Claudia M.;
Napolitano, Fabiana;
Di Mauro, Concetta;
Vigliar, Elena;
Iaccarino, Antonino;
De Angelis, Carmine;
Bianco, Roberto;
Formisano, Luigi

Publication type:

Article

Prognostic significance of HER2-low status in HR-positive/HER2-negative advanced breast cancer treated with CDK4/6 inhibitors.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00534-1

By:

Zattarin, Emma;
Presti, Daniele;
Mariani, Luigi;
Sposetti, Caterina;
Leporati, Rita;
Menichetti, Alice;
Corti, Chiara;
Benvenuti, Chiara;
Fucà, Giovanni;
Lobefaro, Riccardo;
Ligorio, Francesca;
Provenzano, Leonardo;
Vingiani, Andrea;
Del Vecchio, Marta;
Griguolo, Gaia;
Sirico, Marianna;
Bernocchi, Ottavia;
Marra, Antonio;
Zagami, Paola;
Agostinetto, Elisa

Publication type:

Article

Resistance to anti-HER2 therapy associated with the TSC2 nonsynonymous variant c.4349 C > G (p.Pro1450Arg) is reversed by CDK4/6 inhibitor in HER2-positive breast cancer.

Published in:

NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00542-1

By:

Yang, Ziyan;
Feng, Jianguo;
Jing, Ji;
Huang, Yuan;
Ye, Wei-Wu;
Lei, Lei;
Wang, Xiao-Jia;
Cao, Wen-Ming

Publication type:

Article