Works matching DE "CYCLIC nucleotide phosphodiesterases"

Results: 169

Cardiac Cyclic Nucleotide Phosphodiesterases: Roles and Therapeutic Potential in Heart Failure.

Published in:

Cardiovascular Drugs & Therapy, 2020, v. 34, n. 3, p. 401, doi. 10.1007/s10557-020-06959-1

By:

Preedy, Michael E. J.

Publication type:

Article

The British Society for Cardiovascular Research Autumn 2019 Meeting Incorporating the Bernard and Joan Marshall Research Awards.

Published in:

2020

By:

Sinha, Sanjay;
Grieve, David J.

Publication type:

Editorial

Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine-Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography.

Published in:

Molecules, 2019, v. 24, n. 22, p. 4149, doi. 10.3390/molecules24224149

By:

Ritawidya, Rien;
Wenzel, Barbara;
Teodoro, Rodrigo;
Toussaint, Magali;
Kranz, Mathias;
Deuther-Conrad, Winnie;
Dukic-Stefanovic, Sladjana;
Ludwig, Friedrich-Alexander;
Scheunemann, Matthias;
Brust, Peter

Publication type:

Article

Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193.

Published in:

2016

By:

Hostetler, Eric;
Fan, Hong;
Joshi, Aniket;
Zeng, Zhizhen;
Eng, Waisi;
Gantert, Liza;
Holahan, Marie;
Meng, Xianjun;
Miller, Patricia;
O'Malley, Stacey;
Purcell, Mona;
Riffel, Kerry;
Salinas, Cristian;
Williams, Mangay;
Ma, Bennett;
Buist, Nicole;
Smith, Sean;
Coleman, Paul;
Cox, Christopher;
Flores, Brock

Publication type:

journal article

An auto-inhibited state of protein kinase G and implications for selective activation.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.79530

By:

Sharma, Rajesh;
Jeong Joo Kim;
Liying Qin;
Henning, Philipp;
Madoka Akimoto;
VanSchouwen, Bryan;
Kaur, Gundeep;
Sankaran, Banumathi;
MacKenzie, Kevin R.;
Melacini, Giuseppe;
Casteel, Darren E.;
Herberg, Friedrich W.;
Kim, Choel

Publication type:

Article

Protein microarray analysis identifies cyclic nucleotide phosphodiesterase as an interactor of Nogo-A.

Published in:

Neuropathology, 2010, v. 30, n. 1, p. 7, doi. 10.1111/j.1440-1789.2009.01035.x

By:

Sumiyoshi, Kenta;
Obayashi, Shinya;
Tabunoki, Hiroko;
Arima, Kunimasa;
Satoh, Jun-ichi

Publication type:

Article

An improved DNA-based test for detection of the codon 616 mutation in the alpha cyclic GMP phosphodiesterase gene that causes progressive retinal atrophy in the Cardigan Welsh Corgi.

Published in:

Veterinary Ophthalmology, 2002, v. 5, n. 2, p. 103, doi. 10.1046/j.1463-5224.2002.00223.x

By:

Petersen-Jones, Simon M.;
Entz, David D.

Publication type:

Article

Differential function of the α2A-adrenoceptor and phosphodiesterase-3B in human adipocytes of different origin.

Published in:

International Journal of Obesity, 2005, v. 29, n. 12, p. 1413, doi. 10.1038/sj.ijo.0803042

By:

Dicker, A.;
Kaaman, M.;
van Harmelen, V.;
Åström, G.;
Blanc, K. L.;
Rydén, M.

Publication type:

Article

Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery.

Published in:

British Journal of Pharmacology, 2003, v. 139, n. 3, p. 513, doi. 10.1038/sj.bjp.0705277

By:

Pauvert, O.;
Lugnier, C.;
Keravis, T.;
Marthan, R.;
Rousseau, E.;
Savineau, J.P.

Publication type:

Article

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).

Published in:

British Journal of Pharmacology, 2002, v. 136, n. 3, p. 421, doi. 10.1038/sj.bjp.0704743

By:

MacKenzie, Simon J.;
Baillie, George S.;
McPhee, Ian;
MacKenzie, Carolynn;
Seamons, Rachael;
McSorley, Theresa;
Millen, Jenni;
Beard, Matthew B.;
Houslay, Miles D.;
van Heeke, Gino

Publication type:

Article

Short-term regulation of PDE4 activity.

Published in:

British Journal of Pharmacology, 2002, v. 136, n. 3, p. 339, doi. 10.1038/sj.bjp.0704741

By:

Manganiello, V.

Publication type:

Article

Regression of fibrosis by cilostazol in a rat model of thioacetamide-induced liver fibrosis: Up regulation of hepatic cAMP, and modulation of inflammatory, oxidative stress and apoptotic biomarkers.

Published in:

PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0216301

By:

El Awdan, Sally A.;
Abdel Rahman, Rehab F.;
Ibrahim, Heba M.;
Hegazy, Rehab R.;
El Marasy, Salma A.;
Badawi, Manal;
Arbid, Mahmoud S.

Publication type:

Article

Effect of pranlukast on neonatal rats with periventricular leukomalacia.

Published in:

Chinese Journal of Contemporary Pediatrics, 2020, v. 22, n. 6, p. 656, doi. 10.7499/j.issn.1008-8830.1912139

By:

YE Xiao-Yan;
WANG Da-Yu;
XU Yan;
WANG Jun

Publication type:

Article

The Function of Vascular Smooth Muscle Phosphodiesterase III is Preserved in Healthy Human Aging.

Published in:

CTS: Clinical & Translational Science, 2010, v. 3, n. 5, p. 239, doi. 10.1111/j.1752-8062.2010.00232.x

By:

Elvebak, Rachel L.;
Eisenach, John H.;
Joyner, Michael J.;
Nicholson, Wayne T.

Publication type:

Article

Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25-35 in rats.

Published in:

Metabolic Brain Disease, 2016, v. 31, n. 4, p. 779, doi. 10.1007/s11011-016-9814-1

By:

Zhuo, Yeye;
Guo, Haibiao;
Cheng, Yufang;
Wang, Chuang;
Wang, Canmao;
Wu, Jingang;
Zou, Zhengqiang;
Gan, Danna;
Li, Yiwen;
Xu, Jiangping

Publication type:

Article

Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.

Published in:

Metabolic Brain Disease, 2009, v. 24, n. 3, p. 481

By:

Elizabeth Borysiewicz;
Daniel Fil;
Gregory Konat

Publication type:

Article

Effects of Trypsin on the Cyclic AMP System of the Pig Skin.

Published in:

Journal of Investigative Dermatology, 1981, v. 76, n. 6, p. 511, doi. 10.1111/1523-1747.ep12521237

By:

Iizuka, H.;
Aoyagi, T.;
Kamigaki, K.;
Kato, N.;
Nemoto, O.;
Miura, Y.

Publication type:

Article

Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 1, p. 1, doi. 10.1111/jnc.16274

By:

Markusson, Sigurbjörn;
Raasakka, Arne;
Schröder, Marcel;
Sograte‐Idrissi, Shama;
Rahimi, Amir Mohammad;
Asadpour, Ommolbanin;
Körner, Henrike;
Lodygin, Dmitri;
Eichel‐Vogel, Maria A.;
Chowdhury, Risha;
Sutinen, Aleksi;
Muruganandam, Gopinath;
Iyer, Manasi;
Cooper, Madeline H.;
Weigel, Maya K.;
Ambiel, Nicholas;
Werner, Hauke B.;
Zuchero, J. Bradley;
Opazo, Felipe;
Kursula, Petri

Publication type:

Article

Radiosynthesis and biological evaluation of the new PDE10A radioligand [<sup>18</sup>F]AQ28A.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2017, v. 60, n. 1, p. 36, doi. 10.1002/jlcr.3471

By:

Wagner, Sally;
Teodoro, Rodrigo;
Deuther ‐ Conrad, Winnie;
Kranz, Mathias;
Scheunemann, Matthias;
Fischer, Steffen;
Wenzel, Barbara;
Egerland, Ute;
Hoefgen, Norbert;
Steinbach, Jörg;
Brust, Peter

Publication type:

Article

In vitro effects of PDE5 inhibitors sildenafil, vardenafil and tadalafil on isolated human ureteral smooth muscle: a basic research approach.

Published in:

Urological Research, 2007, v. 35, n. 1, p. 49, doi. 10.1007/s00240-006-0073-1

By:

Gratzke, Christian;
Ückert, Stefan;
Kedia, Giorgi;
Reich, Oliver;
Schlenker, Boris;
Seitz, Michael;
Becker, Armin J.;
Stief, Christian G.

Publication type:

Article

Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence.

Published in:

Molecules, 2022, v. 27, n. 23, p. 8448, doi. 10.3390/molecules27238448

By:

Angelopoulou, Efthalia;
Pyrgelis, Efstratios-Stylianos;
Piperi, Christina

Publication type:

Article

Effect of polycaprolactone/carbon nanotube scaffold implantation along with liposomal ellagic acid in hippocampal synaptogenesis after spinal cord injury.

Published in:

Nanomedicine Journal, 2023, v. 10, n. 3, p. 197, doi. 10.22038/NMJ.2023.72151.1776

By:

Gholami, Arman Abroumand;
Gheybi, Fatemeh;
Molavi, Amir Mahdi;
Tahmasebi, Fatemeh;
Papi, Arash;
Babaloo, Hamideh

Publication type:

Article

The utility of sildenafil citrate for infertile men with sexual dysfunction: a pilot study.

Published in:

BJU International, 2007, v. 100, n. 3, p. 603, doi. 10.1111/j.1464-410X.2007.07038.x

By:

Boorjian, Stephen;
Hopps, Carin V.;
Ghaly, Sameh W.;
Parker, Marilyn;
Mulhall, John P.

Publication type:

Article

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Published in:

Oncogene, 2015, v. 34, n. 12, p. 1499, doi. 10.1038/onc.2014.94

By:

Li, N;
Lee, K;
Xi, Y;
Zhu, B;
Gary, B D;
Ramírez-Alcántara, V;
Gurpinar, E;
Canzoneri, J C;
Fajardo, A;
Sigler, S;
Piazza, J T;
Chen, X;
Andrews, J;
Thomas, M;
Lu, W;
Li, Y;
Laan, D J;
Moyer, M P;
Russo, S;
Eberhardt, B T

Publication type:

Article

3′,5′-Cyclic nucleotide phosphodiesterase 11A: localization in human tissues.

Published in:

International Journal of Impotence Research, 2005, v. 17, n. 4, p. 320, doi. 10.1038/sj.ijir.3901317

By:

Loughney, K.;
Taylor, J.;
Florio, V. A.

Publication type:

Article

Molecular aspects of spermatogenesis. Detection of mRNA transcripts of cyclic nucleotide phosphodiesterase subtypes in ejaculated human spermatozoa.

Published in:

Molecular Human Reproduction, 1999, v. 5, n. 8, doi. 10.1093/molehr/5.8.732

By:

Richter, W.;
Dettmer, D.;
Glander, H.-J.

Publication type:

Article

Sildenafil: A Review of its Use in Pulmonary Arterial Hypertension.

Published in:

Drugs, 2008, v. 68, n. 3, p. 383, doi. 10.2165/00003495-200868030-00009

By:

Croom, Katherine F;
Curran, Monique P

Publication type:

Article

Therapeutic Applications of Sildenafil Citrate in the Management of Paediatric Pulmonary Hypertension.

Published in:

Drugs, 2007, v. 67, n. 1, p. 57, doi. 10.2165/00003495-200767010-00005

By:

Leibovitch, Leah;
Matok, Ilan;
Paret, Gideon

Publication type:

Article

The G protein preference of orexin receptors is currently an unresolved issue.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38764-3

By:

Kukkonen, Jyrki P.

Publication type:

Article

Light up the COVID-19.

Published in:

Journal of Medical Signals & Sensors, 2022, v. 12, n. 4, p. 347, doi. 10.4103/jmss.jmss_135_21

By:

Neghab, Hoda;
Soheilifar, Mohammad;
Djavid, Gholamreza

Publication type:

Article

Functional Proteomic Profiling of Phosphodiesterases Using SeraFILE Separations Platform.

Published in:

International Journal of Proteomics, 2012, p. 1, doi. 10.1155/2012/515372

By:

Oka, Amita R.;
Kuruc, Matthew P.;
Gujarathi, Ketan M.;
Roy, Swapan

Publication type:

Article

CYCLIC NUCLEOTID PHOSPHODIESTERASES: ROLES IN HEALTH AND DISEASES.

Published in:

2012

By:

ERDOGAN, Suat

Publication type:

Abstract

PDE10A Inhibitors—Clinical Failure or Window Into Antipsychotic Drug Action?

Published in:

Frontiers in Neuroscience, 2021, v. 14, p. N.PAG, doi. 10.3389/fnins.2020.600178

By:

Menniti, Frank S.;
Chappie, Thomas A.;
Schmidt, Christopher J.

Publication type:

Article

The Antiplatelet and Antithrombotic Effects of PF-253, a Potent and Selective PDE5 Inhibitor, in the Rabbit Folts Model of Arterial Thrombosis.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1166

By:

McClanahan, Thomas Blanc;
Zhiwu Lin;
Liguo Chi;
Rapp, Steve;
MacInesss, Alan

Publication type:

Article

Distinct PDE4D splice variants regulate beta-adrenergic signaling in neonatal mouse cardiac myocytes.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A997, doi. 10.1096/fasebj.21.6.a997-b

By:

Richter, Wito;
Day, Peter;
Wang, Yvonne;
Bruss, Matthew;
Wang, Ping;
Kobilka, Brian;
Conti, Marco

Publication type:

Article

Protein kinase A phosphorylation of human phosphodiesterase 3B stimulates enzyme activity, promotes 14-3-3 protein binding and inhibits phosphatase- catalyzed inactivation.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A796

By:

Jimmo, Sandra Lynn;
Palmer, Dan;
Raymond, Dan;
Wilson, Lindsay;
Carter, Rhonda;
Maurice, Donald

Publication type:

Article

Vascular smooth muscle cell podosomes: dynamic actin-based structures coordinating pro and anti migratory effects of cAMP elevating agents.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A796

By:

Carter, Rhonda L.;
Furmaniak-Kazmierczak, Emilia;
Farber, Alison;
Cote, Graham P.;
Maurice, Donald H.

Publication type:

Article

Phosphodiesterase Inhibition Decreases Vascular Endothelial Permeability Without Global Changes in cAMP: Potential Role of Phosphodiesterase/VE-Cadherin Signaling Complexes.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A796

By:

Ovens, Jeffrey D.;
Maurice, Donald H.

Publication type:

Article

Integrating cAMP and phospholipid signaling: role of phosphodiesterase 3B.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A796, doi. 10.1096/fasebj.21.6.a796

By:

Wilson, Lindsay S.;
Maurice, Donald H.

Publication type:

Article

Caffeine Enhances ATP Release from Erythrocytes: Consequences for Peripheral Vascular Perfusion.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A479, doi. 10.1096/fasebj.21.5.a479-d

By:

Ellsworth, Mary L.;
Chrzaszcz, MaryAnn;
O'Keefe, Emily;
Achilleus, David;
Bowles, Elizabeth;
Sprague, Randy S.

Publication type:

Article

Artificial intelligence utility for drug development: ChatGPT and beyond.

Published in:

2024

By:

Gurwitz, David;
Shomron, Noam

Publication type:

Product Review

Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction.

Published in:

Cardiology, 2015, v. 132, n. 1, p. 45, doi. 10.1159/000430783

By:

Heijman, Jordi;
Heusch, Gerd;
Dobrev, Dobromir

Publication type:

Article

The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).

Published in:

Biochemical Journal, 2014, v. 459, n. 3, p. 539, doi. 10.1042/BJ20131681

By:

XIE, Moses;
BLACKMAN, Brigitte;
SCHEITRUM, Colleen;
MIKA, Delphine;
BLANCHARD, Elise;
LEI, Tao;
CONTI, Marco;
RICHTER, Wito

Publication type:

Article

Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.

Published in:

Biochemical Journal, 2013, v. 456, n. 3, p. 463, doi. 10.1042/BJ20130064

By:

VANG, Amanda G.;
HOUSLEY, William;
DONG, Hongli;
BASOLE, Chaitali;
BEN-SASSON, Shlomo Z.;
KREAM, Barbara E.;
EPSTEIN, Paul M.;
CLARK, Robert B.;
BROCKE, Stefan

Publication type:

Article

Effects of Nitrosyl Iron Complexes with Thiocarbamide and Its Aliphatic Derivatives on Activities of Ca-ATPase of Sarcoplasmic Reticulum and cGMP Phosphodiesterase.

Published in:

Bulletin of Experimental Biology & Medicine, 2017, v. 163, n. 1, p. 54, doi. 10.1007/s10517-017-3736-8

By:

Tatyanenko, L.;
Shmatko, N.;
Sanina, N.;
Dobrokhotova, O.;
Pikhteleva, I.;
Kotel'nikov, A.;
Aldoshin, S.

Publication type:

Article

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.

Published in:

PLoS Neglected Tropical Diseases, 2017, v. 11, n. 7, p. 1, doi. 10.1371/journal.pntd.0005680

By:

Long, Thavy;
Rojo-Arreola, Liliana;
Shi, Da;
El-Sakkary, Nelly;
Jarnagin, Kurt;
Rock, Fernando;
Meewan, Maliwan;
Jr.Rascón, Alberto A.;
Lin, Lin;
Cunningham, Katherine A.;
Lemieux, George A.;
Podust, Larissa;
Abagyan, Ruben;
Ashrafi, Kaveh;
McKerrow, James H.;
Caffrey, Conor R.

Publication type:

Article

Signaling and adaptive mechanisms in trypanosomatids: a possible Achilles heel in the fight against trypanosomiasis.

Published in:

Actualidades Biológicas, 2022, v. 44, p. 24

By:

Vilchez Larrea, Salomé Catalina;
Cecilia Schoijet, Alejandra;
Facundo Prego, Alejo;
Daniel Alonso, Guillermo

Publication type:

Article

Phosphodiesterase 4D7 selectively regulates cAMP-mediated control of human arterial endothelial cell transcriptomic responses to fluid shear stress.

Published in:

Canadian Journal of Physiology & Pharmacology, 2021, v. 99, n. 2, p. 179, doi. 10.1139/cjpp-2020-0318

By:

Burke-Kleinman, Jonah;
Maurice, Donald H.

Publication type:

Article

CYCLIC AMP ACCUMULATION IN PSORIATIC SKIN: DIFFERENTIAL RESPONSES TO HISTAMINE, AMP, AND EPINEPHRINE BY THE UNINVOLVED AND INVOLVED EPIDERMIS.

Published in:

Journal of Investigative Dermatology, 1978, v. 70, n. 5, p. 250, doi. 10.1111/1523-1747.ep12541392

By:

Iizuka, Hajime;
Adachi, Kenji;
Halprin, Kenneth M.;
Levine, Victor

Publication type:

Article

CYCLIC NUCLEOTIDE-PHOSPHODIESTERASE IN THE UNINVOLVED AND INVOLVED SKIN OF PSORIASIS.

Published in:

Journal of Investigative Dermatology, 1978, v. 70, n. 5, p. 246, doi. 10.1111/1523-1747.ep12541389

By:

Iizuka, Hajime;
Adachi, Kenji;
Halprin, Kenneth M.;
Levine, Victor

Publication type:

Article