Works matching DE "CUCURBITACINS"

Results: 80

Improvement of Cucurbitacin B Content in Cucumis melo Pedicel Extracts by Biotransformation Using Recombinant β-Glucosidase.

Published in:

Separations (2297-8739), 2021, v. 8, n. 9, p. 1, doi. 10.3390/separations8090138

By:

Jianfeng Mei;
Xia Wu;
Sujing Zheng;
Xiang Chen;
Zhuliang Huang;
Yichun Wu

Publication type:

Article

Effects of Cucurbitacin E, a Tetracyclic Triterpene Compound from Cucurbitaceae, on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2015, v. 116, n. 5, p. 385, doi. 10.1111/bcpt.12329

By:

Ding, Tonggui;
Zhang, Yuanjin;
Chen, Ang;
Tang, Yu;
Liu, Mingyao;
Wang, Xin

Publication type:

Article

Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells.

Published in:

Oncology Letters, 2017, v. 14, n. 1, p. 145, doi. 10.3892/ol.2017.6148

By:

YINGCHUN QU;
PEIFANG CONG;
CHENGJIANG LIN;
MEIXIA ZHANG;
YIHUI DENG;
LI‑LING, JESSE

Publication type:

Article

Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1.

Published in:

Oncology Letters, 2017, v. 13, n. 6, p. 4905, doi. 10.3892/ol.2017.6086

By:

XIAOLONG HE;
QI GAO;
YAYONG QIANG;
WEI GUO;
YADONG MA

Publication type:

Article

SIMPLE ANALYSIS OF POTENTIAL IMMUNE REGULATION EFFECT OF CUCURBITACIN E ON PROFESSIONAL ATHLETES ENGAGED IN HIGH INTENSITY TRAINING.

Published in:

Carpathian Journal of Food Science & Technology, 2016, v. 8, n. 1, p. 123

By:

Fei Qu

Publication type:

Article

How Does Solvation Affect the Binding of Hydrophilic Amino Saccharides to Cucurbit[7]uril with Exceptional Anomeric Selectivity?

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 44, p. 15791, doi. 10.1002/chem.201602810

By:

Wang, Jianping;
Jang, Yoonjung;
Khedkar, Jayshree K.;
Koo, Jin Young;
Kim, Yonghwi;
Lee, Chang Jun;
Rhee, Young Min;
Kim, Kimoon

Publication type:

Article

Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells.

Published in:

Molecular & Cellular Biochemistry, 2015, v. 409, n. 1/2, p. 33, doi. 10.1007/s11010-015-2509-9

By:

Ku, Jin;
Kim, Soon;
Hong, Se;
Choi, Han-Seok;
Seo, Hye;
Shin, Yong;
Ko, Seong-Gyu

Publication type:

Article

Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-92860-2

By:

Ma, Yunfei;
Yoshida, Takeshi;
Matoba, Kazutaka;
Kida, Katsuhiko;
Shintani, Rito;
Piao, Yingshi;
Jin, Jingchun;
Nishino, Taito;
Hanayama, Rikinari

Publication type:

Article

Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells.

Published in:

Carcinogenesis, 2017, v. 38, n. 2, p. 184, doi. 10.1093/carcin/bgw124

By:

Khan, Naghma;
Jajeh, Farah;
Khan, Mohammad Imran;
Mukhtar, Eiman;
Shabana, Sameh M.;
Mukhtar, Hasan

Publication type:

Article

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2–STAT3 signaling pathway.

Published in:: Carcinogenesis, 2012, v. 33, n. 4, p. 946, doi. 10.1093/carcin/bgs111
Publication type:: Article

Cucurbitacin E Inhibits Proliferation and Migration of Intestinal Epithelial Cells via Activating Cofilin.

Published in:

Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01090

By:

Song, Huapei;
Li, Li;
Sui, Hehuan;
Wang, Pei;
Wang, Fengjun;
Wang, Yu

Publication type:

Article

Evaluation of anticancer potential of Bacopa monnieri L. against MCF-7 and MDA-MB 231 cell line.

Published in:

Journal of Pharmacy & Bioallied Sciences, 2015, v. 7, n. 4, p. 325, doi. 10.4103/0975-7406.168038

By:

Tamboli, E. T.;
Ahmad, Sayeed;
Mallick, Md. Nasar;
Akhtar, Md. Salman;
Najm, Mohd. Zeeshan;
Husain, Syed Akhtar

Publication type:

Article

Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0136236

By:

Jeong, Moon Hee;
Kim, Shang-Jin;
Kang, Hara;
Park, Kye Won;
Park, Woo Jin;
Yang, Seung Yul;
Yang, Dong Kwon

Publication type:

Article

Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0124355

By:

Zha, Qing-Bing;
Zhang, Xiao-Yu;
Lin, Qiu-Ru;
Xu, Li-Hui;
Zhao, Gao-Xiang;
Pan, Hao;
Zhou, Dan;
Ouyang, Dong-Yun;
Liu, Ze-Huan;
He, Xian-Hui

Publication type:

Article

In Vitro and In Vivo Antitumor Activity of a Novel Semisynthetic Derivative of Cucurbitacin B.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0117794

By:

Silva, Izabella T.;
Carvalho, Annelise;
Lang, Karen L.;
Dudek, Sabine E.;
Masemann, Dörthe;
Durán, Fernando J.;
Caro, Miguel S. B.;
Rapp, Ulf R.;
Wixler, Viktor;
Schenkel, Eloir P.;
Simões, Cláudia M. O.;
Ludwig, Stephan

Publication type:

Article

Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0103760

By:

Kong, Yanjie;
Chen, Jianchao;
Zhou, Zhongmei;
Xia, Houjun;
Qiu, Ming-Hua;
Chen, Ceshi

Publication type:

Article

VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0093547

By:

Zhang, Yan-Ting;
Xu, Li-Hui;
Lu, Qun;
Liu, Kun-Peng;
Liu, Pei-Yan;
Ji, Fang;
Liu, Xiao-Ming;
Ouyang, Dong-Yun;
He, Xian-Hui

Publication type:

Article

Cucurbitacin IIb Exhibits Anti-Inflammatory Activity through Modulating Multiple Cellular Behaviors of Mouse Lymphocytes.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0089751

By:

Wang, Yao;
Zhao, Gao-Xiang;
Xu, Li-Hui;
Liu, Kun-Peng;
Pan, Hao;
He, Jian;
Cai, Ji-Ye;
Ouyang, Dong-Yun;
He, Xian-Hui

Publication type:

Article

Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0088140

By:

Guo, Jiajie;
Wu, Guosheng;
Bao, Jiaolin;
Hao, Wenhui;
Lu, Jinjian;
Chen, Xiuping

Publication type:

Article

The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055732

By:

Promkan, Moltira;
Dakeng, Sumana;
Chakrabarty, Subhas;
Bögler, Oliver;
Patmasiriwat, Pimpicha

Publication type:

Article

The role of cucurbitacins in combating cancers: A mechanistic review.

Published in:

Pharmacognosy Reviews, 2018, v. 12, n. 24, p. 157, doi. 10.4103/phrev.phrev_17_18

By:

Alsayari, Abdulrhman;
Halaweish, Fathi;
Gurusamy, Narasimman

Publication type:

Article

Cucurbitacins – An insight into medicinal leads from nature.

Published in:

Pharmacognosy Reviews, 2015, v. 9, n. 17, p. 12, doi. 10.4103/0973-7847.156314

By:

Kaushik, Ujjwal;
Aeri, Vidhu;
Mir, Showkat R.

Publication type:

Article

The highly protective natural medical agents against COVID-19.

Published in:

Bratislava Medical Journal / Bratislavské Lekárske Listy, 2021, v. 122, n. 9, p. 631, doi. 10.4149/BLL_2021_101

By:

F., Gokalp;
K., Sayin

Publication type:

Article

Cucurbitacin‐B attenuates CCl<sub>4</sub>‐induced hepatic fibrosis in mice through inhibition of STAT‐3.

Published in:

Chemical Biology & Drug Design, 2018, v. 91, n. 4, p. 933, doi. 10.1111/cbdd.13160

By:

Sallam, Alaliaa M.;
Esmat, Ahmed;
Abdel‐Naim, Ashraf B.

Publication type:

Article

Biological screening of cucurbitacin inspired estrone analogs targeting mitogen-activated protein kinase (MAPK) pathway.

Published in:

Chemical Biology & Drug Design, 2017, v. 90, n. 3, p. 478, doi. 10.1111/cbdd.12963

By:

Ahmed, Mahmoud S.;
El ‐ Senduny, Fardous;
Taylor, Jessica;
Halaweish, Fathi T.

Publication type:

Article

Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells.

Published in:

Child's Nervous System, 2012, v. 28, n. 3, p. 363, doi. 10.1007/s00381-011-1672-x

By:

Chang, Charn-Jung;
Chiang, Chih-Hung;
Song, Wen-Shin;
Tsai, Shen-Kou;
Woung, Lin-Chung;
Chang, Chin-Hong;
Jeng, Shaw-Yeu;
Tsai, Ching-Yao;
Hsu, Chuan-Chih;
Lee, Hung-Fu;
Huang, Chi-Shuan;
Yung, Ming-Chi;
Liu, Jorn-Hon;
Lu, Kai-Hsi

Publication type:

Article

Anticancer activity of 23,24-dihydrocucurbitacin B against the HeLa human cervical cell line is due to apoptosis and G<sub>2</sub>/M cell cycle arrest.

Published in:

Experimental & Therapeutic Medicine, 2018, v. 15, n. 3, p. 2575, doi. 10.3892/etm.2018.5710

By:

Zhang, Jun-Xiao;
Wei-Tan, Hong;
Hu, Chun-Yan;
Wang, Wei-Qiang;
Chu, Guang-Hua;
Wei, Li-Hui;
Chen, Liu

Publication type:

Article

Cucurbitacin B inhibits cell proliferation and induces apoptosis in human osteosarcoma cells via modulation of the JAK2/STAT3 and MAPK pathways.

Published in:

Experimental & Therapeutic Medicine, 2017, v. 14, n. 1, p. 805, doi. 10.3892/etm.2017.4547

By:

ZHI-REN ZHANG;
MING-XIA GAO;
KAI YANG

Publication type:

Article

Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway.

Published in:

Experimental & Therapeutic Medicine, 2016, v. 12, n. 4, p. 2709, doi. 10.3892/etm.2016.3670

By:

YOU-LI XIE;
WEN-HUI TAO;
TI-XIONG YANG;
JIAN-GUO QIAO

Publication type:

Article

Influence of cucurbitacin-containing phytonematicides on selected nutrient elements in leaf tissues of green bean under greenhouse conditions.

Published in:

Acta Agriculturae Scandinavica: Section B, Soil & Plant Science, 2017, v. 67, n. 8, p. 743, doi. 10.1080/09064710.2017.1343379

By:

Mashela, P. W.;
Pofu, K. M.

Publication type:

Article

Suitable organ(s) in wild Cucumis africanus for the production of nemafric-BL phytonematicide.

Published in:

Acta Agriculturae Scandinavica: Section B, Soil & Plant Science, 2016, v. 66, n. 5, p. 381, doi. 10.1080/09064710.2015.1122829

By:

Shadung, K. G.;
Mashela, P. W.

Publication type:

Article

Bottle Gourd (Lagenaria Siceraria) Toxicity: A "Bitter" Diagnostic Dilemma.

Published in:

2014

By:

KHATIB, KHALID ISMAIL;
BORAWAKE, KAPIL SHARAD

Publication type:

Case Study

AN UPDATED REVIEW OF CUCURBITACINS AND THEIR BIOLOGICAL AND PHARMACOLOGICAL ACTIVITIES.

Published in:

EXCLI Journal, 2015, v. 14, p. 562, doi. 10.17179/excli2015-283

By:

Sun Ok Chung;
Yong Joo Kim;
Sang Un Park

Publication type:

Article

Cucurbitacin B inhibits cell proliferation and induces cell apoptosis in colorectal cancer by modulating methylation status of BTG3.

Published in:

Neoplasma, 2019, v. 66, n. 4, p. 593, doi. 10.4149/neo_2018_180929N729

By:

MAO, D.;
LIU, A. H.;
WANG, Z. P.;
ZHANG, X. W.;
LU, H.

Publication type:

Article

Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target.

Published in:

Cell Communication & Signaling, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1478-811X-11-58

By:

Gabrielsen, Mads;
Schuldt, Maike;
Munro, June;
Borucka, Dagmara;
Cameron, Jenifer;
Baugh, Mark;
Mleczak, Andrzej;
Lilla, Sergio;
Morrice, Nicholas;
Olson, Michael F.

Publication type:

Article

Anti-proliferative effect of 23,24-dihydrocucurbitacin F on human prostate cancer cells through induction of actin aggregation and cofilin-actin rod formation.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 70, n. 3, p. 415, doi. 10.1007/s00280-012-1921-z

By:

Ren, Shuai;
Ouyang, Dong-Yun;
Saltis, Mark;
Xu, Li-Hui;
Zha, Qing-Bing;
Cai, Ji-Ye;
He, Xian-Hui

Publication type:

Article

Cucurbitacin B acts a potential insect growth regulator by antagonizing 20‐hydroxyecdysone activity.

Published in:

Pest Management Science, 2018, v. 74, n. 6, p. 1394, doi. 10.1002/ps.4817

By:

Zou, Chuanshan;
Liu, Shumin;
Liu, Guifen;
Liu, Suning;
Li, Sheng;
Feng, Qili;
Song, Qisheng;
Wang, Jian;
Su, Yunlin

Publication type:

Article

Validation of RNA interference in western corn rootworm Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae) adults.

Published in:

Pest Management Science, 2012, v. 68, n. 4, p. 587, doi. 10.1002/ps.2301

By:

Rangasamy, Murugesan;
Siegfried, Blair D

Publication type:

Article

Cucurbitacins: potential candidates targeting mitogen-activated protein kinase pathway for treatment of melanoma.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2014, v. 29, n. 2, p. 162, doi. 10.3109/14756366.2012.762646

By:

Ahmed, Mahmoud S.;
Halaweish, Fathi T.

Publication type:

Article

Localization of a New Gene for Bitterness in Cucumber.

Published in:

Journal of Heredity, 2013, v. 104, n. 1, p. 134, doi. 10.1093/jhered/ess075

By:

Zhang, Shengping;
Miao, Han;
Sun, Rifei;
Wang, Xiaowu;
Huang, Sanwen;
Wehner, Todd C.;
Gu, Xingfang

Publication type:

Article

Effects of cucurbitacin A on mobility of Meloidogyne incognita second-stage juveniles.

Published in:

Research on Crops, 2018, v. 19, n. 3, p. 504, doi. 10.31830/2348-7542.2018.0001.23

By:

DUBE, Z. P.;
MASHELA, P. W.

Publication type:

Article

Responses of entomopathogenic nematode, Steinernema feltiae to cucurbitacin-containing Nemafric-BL phytonematicide.

Published in:

Research on Crops, 2017, v. 18, n. 4, p. 739, doi. 10.5958/2348-7542.2017.00121.8

By:

MADAURE, J. T.;
MASHELA, P. W.;
WAELE, D. DE

Publication type:

Article

Influence of storage period on concentration of cucurbitacin B from dried Cucumis africanus fruit.

Published in:

Research on Crops, 2017, v. 18, n. 2, p. 327, doi. 10.5958/2348-7542.2017.00056.0

By:

SHADUNG, K. G.;
MASHELA, P. W.

Publication type:

Article

Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture.

Published in:

Drug Discoveries & Therapeutics, 2015, v. 9, n. 4, p. 289, doi. 10.5582/ddt.2015.01041

By:

Binh Cao Quan Nguyen;
Pham Thi Be Tu;
Tawata, Shinkichi;
Maruta, Hiroshi

Publication type:

Article

Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway.

Published in:

PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0178910

By:

Murtaza, Munazza;
Khan, Gulnaz;
Aftab, Meha Fatima;
Afridi, Shabbir Khan;
Ghaffar, Safina;
Ahmed, Ayaz;
Hafizur, Rahman M.;
Waraich, Rizwana Sanaullah

Publication type:

Article

Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells.

Published in:

Bangladesh Journal of Pharmacology, 2016, v. 11, n. 1, p. 110, doi. 10.3329/bjp.v10i4.23791

By:

Chuanhong Wu;
Jiaolin Bao;
Chengwei He;
Jinjian Lu;
Xiuping Chen

Publication type:

Article

Exploring the Cucurbitacin E (CuE) as an Anti-Lung Cancer Lead Compound through Molecular Docking, ADMET, Pass Prediction and Drug Likeness Analysis.

Published in:

Tropical Journal of Natural Product Research, 2024, v. 8, n. 2, p. 6250, doi. 10.26538/tjnpr/v8i2.24

By:

Debnath, Pradip;
Roy, Uthpall K.;
Zaman, Fahmida;
Mukherjee, Pulok K.;
Kard, Amit

Publication type:

Article

The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS.

Published in:

Iranian Journal of Basic Medical Sciences, 2018, v. 21, n. 3, p. 253, doi. 10.22038/ijbms.2018.25175.6236

By:

Jafargholizadeh, Naser;
Zargar, Seyed Jalal;
Aftabi, Younes

Publication type:

Article

ATTRACTING MUTUALISTS AND ANTAGONISTS: PLANT TRAIT VARIATION EXPLAINS THE DISTRIBUTION OF SPECIALIST FLORAL HERBIVORES AND POLLINATORS ON CROPS AND WILD GOURDS.

Published in:

American Journal of Botany, 2014, v. 101, n. 8, p. 1314, doi. 10.3732/ajb.1400171

By:

Theis, Nina;
Barber, Nicholas A.;
Gillespie, Sandra D.;
Hazzard, Ruth V.;
Adler, Lynn S.

Publication type:

Article

Inhibition of SENP5 by Cucurbitacin B Suppresses Cell Growth and Promotes Apoptosis in Osteosarcoma Cells.

Published in:

Tropical Journal of Pharmaceutical Research, 2015, v. 14, n. 9, p. 1573, doi. 10.4314/tjpr.v14i9.5

By:

Jiang-Bo Zhong;
Zhao-Rui Liu;
Sen Liu;
Jian-Qiang Zhao

Publication type:

Article