Works about CHO cell

Results: 1271

Immunogenicity and protection of recombinant self-assembling ferritin-hemagglutinin nanoparticle influenza vaccine in mice.

Published in:

Clinical & Experimental Vaccine Research, 2025, v. 14, n. 1, p. 23, doi. 10.7774/cevr.2025.14.e7

By:

Xu Wang;
Ziyao Qin;
Min Zhang;
Baoyuan Shang;
Zhilei Li;
Meiyi Zhao;
Qing Tang;
Qi Tang;
Jian Luo

Publication type:

Article

Native proteins from Galdieria sulphuraria to replace fetal bovine serum in mammalian cell culture.

Published in:

Applied Microbiology & Biotechnology, 2025, v. 109, n. 1, p. 1, doi. 10.1007/s00253-025-13507-0

By:

Eisenberg, Hanna;
Hütker, Svenja;
Berger, Felicitas;
Lang, Imke

Publication type:

Article

Utilizing non-clonal CHO cell derived materials for preclinical studies of complex molecules.

Published in:

BMC Biotechnology, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12896-025-00968-4

By:

Pan, Jessica;
McPhee, Jeffrey;
Dow, Alex;
Burke, Daniel;
Gupta, Balrina;
Rose, Patricia;
Wang, Xiaowen;
Pinto, Nuno;
Letarte, Simon;
Huang, Ying;
Li, Guanghua Benson;
Agarwal, Kitty;
Smith, Katelyn;
Liu, Ren

Publication type:

Article

Recent developments in miRNA based recombinant protein expression in CHO.

Published in:

Biotechnology Letters, 2022, v. 44, n. 5/6, p. 671, doi. 10.1007/s10529-022-03250-1

By:

Bazaz, Masoume;
Adeli, Ahmad;
Azizi, Mohammad;
Soleimani, Masoud;
Mahboudi, Fereidoun;
Davoudi, Noushin

Publication type:

Article

Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion protein.

Published in:

Biotechnology Letters, 2021, v. 43, n. 8, p. 1551, doi. 10.1007/s10529-021-03153-7

By:

Bryan, Laura;
Henry, Michael;
Barron, Niall;
Gallagher, Clair;
Kelly, Ronan M.;
Frye, Christopher C.;
Osborne, Matthew D.;
Clynes, Martin;
Meleady, Paula

Publication type:

Article

Systematically gap-filling the genome-scale metabolic model of CHO cells.

Published in:

Biotechnology Letters, 2021, v. 43, n. 1, p. 73, doi. 10.1007/s10529-020-03021-w

By:

Fouladiha, Hamideh;
Marashi, Sayed-Amir;
Li, Shangzhong;
Li, Zerong;
Masson, Helen O.;
Vaziri, Behrouz;
Lewis, Nathan E.

Publication type:

Article

LC-MS/MS-based quantitative proteomic and phosphoproteomic analysis of CHO-K1 cells adapted to growth in glutamine-free media.

Published in:

Biotechnology Letters, 2020, v. 42, n. 12, p. 2523, doi. 10.1007/s10529-020-02953-7

By:

Kaushik, Prashant;
Curell, Ricardo Valdés-Bango;
Henry, Michael;
Barron, Niall;
Meleady, Paula

Publication type:

Article

Evaluation of different IRES-mediated tricistronic plasmid designs for expression of an anti-PCSK9 biosimilar monoclonal antibody in CHO cells.

Published in:

Biotechnology Letters, 2020, v. 42, n. 12, p. 2511, doi. 10.1007/s10529-020-02952-8

By:

Cruz, Thayana A.;
Pinho, Marcos B.;
Castilho, Leda R.

Publication type:

Article

The glycosylation of anti-rhIFN-α2b recombinant antibodies influences the antigen-neutralizing activity.

Published in:

Biotechnology Letters, 2020, v. 42, n. 8, p. 1369, doi. 10.1007/s10529-020-02879-0

By:

Attallah, Carolina;
Aguilar, María Fernanda;
Forno, Guillermina;
Etcheverrigaray, Marina;
Brigido, Marcelo De Macedo;
Maranhão, Andrea Queiroz;
Oggero, Marcos

Publication type:

Article

Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics.

Published in:

Biotechnology Letters, 2020, v. 42, n. 7, p. 1103, doi. 10.1007/s10529-020-02889-y

By:

Tschorn, Natalie;
Berg, Karen;
Stitz, Jörn

Publication type:

Article

Altered gene expression in CHO cells following polyamine starvation.

Published in:

Biotechnology Letters, 2020, v. 42, n. 6, p. 927, doi. 10.1007/s10529-020-02841-0

By:

Capella Roca, Berta;
Doolan, Padraig;
Barron, Niall;
O'Neill, Fiona;
Clynes, Martin

Publication type:

Article

A novel Xist RNA-mediated chromosome inactivation model using a mouse artificial chromosome.

Published in:

Biotechnology Letters, 2020, v. 42, n. 5, p. 697, doi. 10.1007/s10529-020-02826-z

By:

Inaoka, Daigo;
Sunamura, Naohiro;
Ohira, Takahito;
Nakayama, Yuji;
Kugoh, Hiroyuki

Publication type:

Article

Distance effect characteristic of the matrix attachment region increases recombinant protein expression in Chinese hamster ovary cells.

Published in:

Biotechnology Letters, 2020, v. 42, n. 2, p. 187, doi. 10.1007/s10529-019-02775-2

By:

Zhang, Jun-He;
Zhang, Ji-Hong;
Wang, Xiao-Yin;
Xu, Dan-Hua;
Wang, Tian-Yun

Publication type:

Article

Evaluating the impact of suramin additive on CHO cells producing Fc-fusion protein.

Published in:

Biotechnology Letters, 2019, v. 41, n. 11, p. 1255, doi. 10.1007/s10529-019-02728-9

By:

Lim, Jin-Hyuk;
Cha, Hyun-Myoung;
Han, Hye-Jin;
Kim, Dong-Il

Publication type:

Article

Optimized dual assay for the transgenes selection and screening in CHO cell line development for recombinant protein production.

Published in:

Biotechnology Letters, 2019, v. 41, n. 8/9, p. 929, doi. 10.1007/s10529-019-02711-4

By:

Beketova, Elena V.;
Ibneeva, Liliia R.;
Abdulina, Yulia A.;
Dergousova, Elena A.;
Filatov, Vladimir L.;
Kozlovsky, Stanislav V.;
Shilov, Evgeny S.;
Datskevich, Petr N.;
Rozov, Fedor N.

Publication type:

Article

Feasible development of stable HEK293 clones by CRISPR/Cas9-mediated site-specific integration for biopharmaceuticals production.

Published in:

Biotechnology Letters, 2019, v. 41, n. 8/9, p. 941, doi. 10.1007/s10529-019-02702-5

By:

Yang, Hui;
Wang, Jiaxian;
Zhao, Menglin;
Zhu, Jianwei;
Zhang, Mengxiao;
Wang, Ziyan;
Gao, Yang;
Zhu, Wen;
Lu, Huili

Publication type:

Article

Improved recombinant protein production by regulation of transcription and protein transport in Chinese hamster ovary cells.

Published in:

Biotechnology Letters, 2019, v. 41, n. 6/7, p. 719, doi. 10.1007/s10529-019-02681-7

By:

Chen, Kaiming;
Li, Dong;
Li, Hongwen;
Li, Bing;
Wang, Ruiqin;
Jiang, Lingxiao;
Huang, Lei;
Xu, Xiaoqing;
Li, Jie;
Teng, Fei;
Jiang, Cizhong;
Gu, Hua;
Fang, Jianmin

Publication type:

Article

Engineering CHO cells galactose metabolism to reduce lactate synthesis.

Published in:

Biotechnology Letters, 2019, v. 41, n. 6/7, p. 779, doi. 10.1007/s10529-019-02680-8

By:

Jiménez, N.;
Martínez, V. S.;
Gerdtzen, Z. P.

Publication type:

Article

Human genome-derived TOP1 matrix attachment region enhances transgene expression in the transfected CHO cells.

Published in:

Biotechnology Letters, 2019, v. 41, n. 6/7, p. 701, doi. 10.1007/s10529-019-02673-7

By:

Jia, Yan-Long;
Guo, Xiao;
Wang, Xi-Cheng;
Wang, Tian-Yun

Publication type:

Article

Chromatographic purification of recombinant human erythropoietin.

Published in:

Biotechnology Letters, 2019, v. 41, n. 4/5, p. 483, doi. 10.1007/s10529-019-02656-8

By:

Adamíková, Jana;
Antošová, Monika;
Polakovič, Milan

Publication type:

Article

Cell culture medium supplemented with taurine decreases basic charge variant levels of a monoclonal antibody.

Published in:

Biotechnology Letters, 2018, v. 40, n. 11/12, p. 1487, doi. 10.1007/s10529-018-2606-4

By:

Liu, Mengjuan;
Wang, Jiaqi;
Tang, Hongping;
Fan, Li;
Zhao, Liang;
Wang, Hai-Bin;
Zhou, Yan;
Tan, Wen-Song

Publication type:

Article

Stable expression of infliximab in CRISPR/Cas9-mediated BAK1-deficient CHO cells.

Published in:

Biotechnology Letters, 2018, v. 40, n. 8, p. 1209, doi. 10.1007/s10529-018-2578-4

By:

Miao, Zhi;
Li, Qian;
Zhao, Jian;
Wang, Peng;
Wang, Lei;
He, Hong-Peng;
Wang, Nan;
Zhou, Hao;
Zhang, Tong-Cun;
Luo, Xue-Gang

Publication type:

Article

A simple method to determine IgG light chain to heavy chain polypeptide ratios expressed by CHO cells.

Published in:

Biotechnology Letters, 2016, v. 38, n. 12, p. 2043, doi. 10.1007/s10529-016-2197-x

By:

Gerster, Anja;
Wodarczyk, Claas;
Reichenbächer, Britta;
Köhler, Janet;
Schulze, Andreas;
Krause, Felix;
Müller, Dethardt

Publication type:

Article

Efficient expression of functional human coagulation factor IX in stably-transfected Drosophila melanogaster S2 cells; comparison with the mammalian CHO system.

Published in:

Biotechnology Letters, 2016, v. 38, n. 10, p. 1691, doi. 10.1007/s10529-016-2156-6

By:

Vatandoost, Jafar;
Bos, Mettine

Publication type:

Article

A dual near-infrared and dielectric spectroscopies strategy to monitor populations of Chinese hamster ovary cells in bioreactor.

Published in:

Biotechnology Letters, 2016, v. 38, n. 5, p. 745, doi. 10.1007/s10529-016-2036-0

By:

Courtès, Franck;
Ebel, Bruno;
Guédon, Emmanuel;
Marc, Annie

Publication type:

Article

Transcriptional and post-transcriptional targeting for enhanced transient gene expression in CHO cells.

Published in:

Biotechnology Letters, 2015, v. 37, n. 12, p. 2379, doi. 10.1007/s10529-015-1938-6

By:

Rajendra, Yashas;
Hougland, Maria;
Schmitt, Matthew;
Barnard, Gavin

Publication type:

Article

Culture temperature modulates monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures.

Published in:

Biotechnology Letters, 2015, v. 37, n. 11, p. 2151, doi. 10.1007/s10529-015-1904-3

By:

Zhang, Xintao;
Sun, Ya-Ting;
Tang, Hongping;
Fan, Li;
Hu, Dongdong;
Liu, Jintao;
Liu, Xuping;
Tan, Wen-Song

Publication type:

Article

Transcriptomic variation between different Chinese hamster ovary cell lines.

Published in:

Biotechnology Letters, 2015, v. 37, n. 9, p. 1737, doi. 10.1007/s10529-015-1850-0

By:

Blas, Marjanca;
Francky, Andrej;
Jamnikar, Uroš;
Gaser, Dominik;
Baebler, Špela;
Blejec, Andrej;
Gruden, Kristina

Publication type:

Article

Unstable expression of recombinant antibody during long-term culture of CHO cells is accompanied by histone H3 hypoacetylation.

Published in:

Biotechnology Letters, 2013, v. 35, n. 7, p. 987, doi. 10.1007/s10529-013-1168-8

By:

Paredes, Verenice;
Park, Jeong;
Jeong, Yongsu;
Yoon, Jaeseung;
Baek, Kwanghee

Publication type:

Article

Simplified off-gas analyses in animal cell cultures for process monitoring and control purposes.

Published in:

Biotechnology Letters, 2011, v. 33, n. 11, p. 2103, doi. 10.1007/s10529-011-0686-5

By:

Aehle, Mathias;
Kuprijanov, Artur;
Schaepe, Sebastian;
Simutis, Rimvydas;
Lübbert, Andreas

Publication type:

Article

Multiple glycerol shocks increase the calcium phosphate transfection of non-synchronized CHO cells.

Published in:

Biotechnology Letters, 2006, v. 28, n. 22, p. 1827, doi. 10.1007/s10529-006-9167-7

By:

Grosjean, Frederic;
Bertschinger, Martin;
Hacker, David L.;
Wurm, Florian M.

Publication type:

Article

The M4 insulator, the TM2 matrix attachment region, and the double copy of the heavy chain gene contribute to the enhanced accumulation of the PHB-01 antibody in tobacco plants.

Published in:

Transgenic Research, 2020, v. 29, n. 2, p. 171, doi. 10.1007/s11248-019-00187-6

By:

Ruiz, Yoslaine;
Ramos, Pedro Luis;
Soto, Jeny;
Rodríguez, Meilyn;
Carlos, Natacha;
Reyes, Aneisi;
Callard, Danay;
Sánchez, Yadira;
Pujol, Merardo;
Fuentes, Alejandro

Publication type:

Article

A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 10, p. 1352, doi. 10.1111/jphp.13317

By:

Mentzer, Bengt;
Russo, Andrew F.;
Zhang, Zhongming;
Kuburas, Adisa;
Killoran, Patrick M.;
D'Aloisio, Vera;
Nizic, Laura;
Capel, Vicky;
Kendall, David A.;
Coxon, Christopher R.;
Hutcheon, Gillian A.

Publication type:

Article

Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM‐878.

Published in:

Neuropsychopharmacology Reports, 2020, v. 40, n. 2, p. 182, doi. 10.1002/npr2.12105

By:

Maehara, Shunsuke;
Yuge, Natsuko;
Higashi, Chika;
Ota, Takumi;
Furukawa, Junji;
Takeuchi, Takashi

Publication type:

Article

Machine Learning and Deep Learning Strategies for Chinese Hamster Ovary Cell Bioprocess Optimization.

Published in:

Fermentation (Basel), 2024, v. 10, n. 5, p. 234, doi. 10.3390/fermentation10050234

By:

Baako, Tiffany-Marie D.;
Kulkarni, Sahil Kaushik;
McClendon, Jerome L.;
Harcum, Sarah W.;
Gilmore, Jordon

Publication type:

Article

Using novel chimeric gonadotropins with single (FSH) or dual (LH and FSH) activity to induce follicle development in sheep.

Published in:

Journal of Animal Science, 2006, v. 84, p. 434

By:

Lemke, E. P.;
Adams, B. M.;
Boime, I.;
Adams, T. E.

Publication type:

Article

Steroid-loaded reconstituted high-density lipoprotein nanocarrier: A new treatment for systemic lupus erythematosus.

Published in:

Journal of Biomaterials Applications, 2023, v. 37, n. 9, p. 1542, doi. 10.1177/08853282231154342

By:

Yu, Ye;
Liu, Xuesong;
Ma, Xinyi;
Jiang, Gan;
Song, Qingxiang;
Guo, Ruru;
Wang, Suli;
Gao, Xiaoling;
Lu, Liangjing

Publication type:

Article

基于氧化应激的固态发酵白酒抑制肝癌HepG2细胞增殖.

Published in:

Journal of Chinese Institute of Food Science & Technology / Zhongguo Shipin Xuebao, 2023, v. 23, n. 8, p. 60, doi. 10.16429/j.1009-7848.2023.08.007

By:

周琦;
管祺杰;
耿燕

Publication type:

Article

Development of an intensified fed-batch production platform with doubled titers using N-1 perfusion seed for cell culture manufacturing.

Published in:

Bioresources & Bioprocessing, 2020, v. 7, n. 1, p. 1, doi. 10.1186/s40643-020-00304-y

By:

Xu, Jianlin;
Rehmann, Matthew S.;
Xu, Mengmeng;
Zheng, Shun;
Hill, Charles;
He, Qin;
Borys, Michael C.;
Li, Zheng Jian

Publication type:

Article

Uridine modulates monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch cultures.

Published in:

Bioresources & Bioprocessing, 2018, v. 5, n. 1, p. 1, doi. 10.1186/s40643-018-0228-2

By:

Niu, Huijie;
Wang, Jiaqi;
Liu, Mengjuan;
Chai, Miaomiao;
Zhao, Liang;
Liu, Xuping;
Fan, Li;
Tan, Wen-Song

Publication type:

Article

Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.80944

By:

Le, Thao D. V.;
Liu, Dianxin;
Besing, Gai-Linn K.;
Raghavan, Ritika;
Ellis, Blair J.;
Ceddia, Ryan P.;
Collins, Sheila;
Ayala, Julio E.

Publication type:

Article

Comprehensive modeling of cell culture profile using Raman spectroscopy and machine learning.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-49257-0

By:

Tanemura, Hiroki;
Kitamura, Ryunosuke;
Yamada, Yasuko;
Hoshino, Masato;
Kakihara, Hirofumi;
Nonaka, Koichi

Publication type:

Article

Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-42925-1

By:

Nguyen, Ngan T. B.;
Leung, Hau Wan;
Pang, Kuin Tian;
Tay, Shi Jie;
Walsh, Ian;
Choo, Andre B. H.;
Yang, Yuansheng

Publication type:

Article

Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43661-2

By:

Stuible, Matthew;
Schrag, Joseph D.;
Sheff, Joey;
Zoubchenok, Daria;
Lord-Dufour, Simon;
Cass, Brian;
L'Abbé, Denis;
Pelletier, Alex;
Rossotti, Martin A.;
Tanha, Jamshid;
Gervais, Christian;
Maurice, Roger;
El Bakkouri, Majida;
Acchione, Mauro;
Durocher, Yves

Publication type:

Article

Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43661-2

By:

Stuible, Matthew;
Schrag, Joseph D.;
Sheff, Joey;
Zoubchenok, Daria;
Lord-Dufour, Simon;
Cass, Brian;
L'Abbé, Denis;
Pelletier, Alex;
Rossotti, Martin A.;
Tanha, Jamshid;
Gervais, Christian;
Maurice, Roger;
El Bakkouri, Majida;
Acchione, Mauro;
Durocher, Yves

Publication type:

Article

Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-42925-1

By:

Nguyen, Ngan T. B.;
Leung, Hau Wan;
Pang, Kuin Tian;
Tay, Shi Jie;
Walsh, Ian;
Choo, Andre B. H.;
Yang, Yuansheng

Publication type:

Article

Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-37288-6

By:

Srila, Witsanu;
Baumann, Martina;
Riedl, Markus;
Rangnoi, Kuntalee;
Borth, Nicole;
Yamabhai, Montarop

Publication type:

Article

CHI3L1 induces autophagy through the JNK pathway in lung cancer cells.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-36844-4

By:

Hong, Da Eun;
Yu, Ji Eun;
Yoo, Seung Sik;
Yeo, In Jun;
Son, Dong Ju;
Yun, Jaesuk;
Han, Sang-Bae;
Hong, Jin Tae

Publication type:

Article

Intracellular acidity impedes KCa3.1 activation by Riluzole and SKA-31.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1380655

By:

Cozzolino, Marco;
Panyi, Gyorgy

Publication type:

Article

Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1177003

By:

Peiwen Li;
Xiaohui Tian;
Gongxin Wang;
Enshe Jiang;
Yanming Li;
Guoliang Hao

Publication type:

Article