Works matching DE "CHECKPOINT kinase 2"

Results: 153

A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G<sub>2</sub>/M DNA Damage Checkpoint.

Published in:

PLoS Biology, 2010, v. 8, n. 1, p. 1, doi. 10.1371/journal.pbio.1000287

By:

van Vugt, Marcel A. T. M.;
Gardino, Alexandra K.;
Linding, Rune;
Ostheimer, Gerard J.;
Reinhardt, H. Christian;
Shao-En Ong;
Tan, Chris S.;
Hua Miao;
Keezer, Susan M.;
Jeijin Li;
Pawson, Tony;
Lewis, Timothy A.;
Carr, Steven A.;
Smerdon, Stephen J.;
Brummelkamp, Thijn R.;
Yaffe, Michael B.

Publication type:

Article

Rethinking the use of germline CHEK2 mutation as a marker for PARP inhibitor sensitivity.

Published in:

JNCI Cancer Spectrum, 2024, v. 8, n. 4, p. 1, doi. 10.1093/jncics/pkae045

By:

Hayman, Thomas J

Publication type:

Article

The genomic landscape of breast and non-breast cancers from individuals with germline CHEK2 deficiency.

Published in:

JNCI Cancer Spectrum, 2024, v. 8, n. 4, p. 1, doi. 10.1093/jncics/pkae044

By:

Hinić, Snežana;
Post, Rachel S van der;
Vreede, Lilian;
Schuurs-Hoeijmakers, Janneke;
Koene, Saskia;
Jansen, Erik A M;
Bervoets-Metge, Franziska;
Mensenkamp, Arjen R;
Hoogerbrugge, Nicoline;
Ligtenberg, Marjolijn J L;
Voer, Richarda M de

Publication type:

Article

CHEK2 knockout is a therapeutic target for TP53-mutated hepatocellular carcinoma.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-023-01777-4

By:

Chen, Yuyan;
Zhu, Zhengyi;
Wu, Xingyu;
Li, Hui;
Guan, Wenxian;
Ren, Haozhen

Publication type:

Article

BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01611-x

By:

Li, Lemin;
Wang, Linchen;
Liu, Dian;
Zhao, Yongchao

Publication type:

Article

Prevalence of Constitutional Pathogenic Variant in a Cohort of 348 Patients With Multiple Primary Cancer Addressed in Oncogenetic Consultation.

Published in:

Molecular Genetics & Genomic Medicine, 2025, v. 13, n. 3, p. 1, doi. 10.1002/mgg3.70086

By:

Lepage, Mathis;
Uhrhammer, Nancy;
Molnar, Ioana;
Privat, Maud;
Ponelle‐Chachuat, Flora;
Gay‐Bellile, Mathilde;
Bidet, Yannick;
Cavaillé, Mathias

Publication type:

Article

Hereditary breast cancer next‐generation sequencing panel evaluation in the south region of Brazil: A novel BRCA2 candidate pathogenic variant is reported.

Published in:

Molecular Genetics & Genomic Medicine, 2024, v. 12, n. 8, p. 1, doi. 10.1002/mgg3.2504

By:

Duarte, Cesar Augusto B.;
dos Santos, Carlos Alberto;
de Oliveira, Cristine Domingues D.;
Spautz, Cleverton César;
Sumita, Laura Masami;
Nakatani, Sueli Massumi

Publication type:

Article

Risk‐reducing mastectomy decisions among women with mutations in high‐ and moderate‐ penetrance breast cancer susceptibility genes.

Published in:

Molecular Genetics & Genomic Medicine, 2022, v. 10, n. 10, p. 1, doi. 10.1002/mgg3.2031

By:

Comeaux, Jacob G.;
Culver, Julie O.;
Lee, John E.;
Dondanville, Danielle;
McArthur, Heather L.;
Quinn, Emily;
Gorman, Nicholas;
Ricker, Charité;
Li, Ming;
Lerman, Caryn

Publication type:

Article

Insights into the DNA damage response and tumor drug resistance.

Published in:

Cancer Biology & Medicine, 2025, v. 22, n. 3, p. 197, doi. 10.20892/j.issn.2095-3941.2025.0020

By:

Xiaolu Ma;
Zina Cheng;
Caixia Guo

Publication type:

Article

Advances in ATM, ATR, WEE1, and CHK1/2 inhibitors in the treatment of PARP inhibitor-resistant ovarian cancer.

Published in:

Cancer Biology & Medicine, 2023, v. 20, n. 12, p. 915, doi. 10.20892/j.issn.2095-3941.2023.0260

By:

Qin Tang;
Xin Wang;
Haixia Wang;
Lin Zhong;
Dongling Zou

Publication type:

Article

Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43001-y

By:

Zhen, Zhengyi;
Chen, Yu;
Wang, Haiyan;
Tang, Huanyin;
Zhang, Haiping;
Liu, Haipeng;
Jiang, Ying;
Mao, Zhiyong

Publication type:

Article

Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three enhancer/silencer‐rich regions and 38 spliceogenic variants.

Published in:

Journal of Pathology, 2024, v. 262, n. 4, p. 395, doi. 10.1002/path.6243

By:

Sanoguera‐Miralles, Lara;
Llinares‐Burguet, Inés;
Bueno‐Martínez, Elena;
Ramadane‐Morchadi, Lobna;
Stuani, Cristiana;
Valenzuela‐Palomo, Alberto;
García‐Álvarez, Alicia;
Pérez‐Segura, Pedro;
Buratti, Emanuele;
de la Hoya, Miguel;
Velasco‐Sampedro, Eladio A

Publication type:

Article

Germline DNA Damage Response Gene Mutations in Localized Prostate Cancer.

Published in:

Medicina (1010660X), 2024, v. 60, n. 1, p. 73, doi. 10.3390/medicina60010073

By:

Januskevicius, Tomas;
Vaicekauskaite, Ieva;
Sabaliauskaite, Rasa;
Matulevicius, Augustinas;
Vezelis, Alvydas;
Ulys, Albertas;
Jarmalaite, Sonata;
Jankevicius, Feliksas

Publication type:

Article

A phase IA dose-escalation study of PHI-101, a new checkpoint kinase 2 inhibitor, for platinum-resistant recurrent ovarian cancer.

Published in:

2022

By:

Park, Soo Jin;
Chang, Suk-Joon;
Suh, Dong Hoon;
Kong, Tae Wook;
Song, Heekyoung;
Kim, Tae Hun;
Kim, Jae-Weon;
Kim, Hee Seung;
Lee, Sung-Jong

Publication type:

journal article

Co-abrogation of Chk1 and Chk2 by potent oncolytic adenovirus potentiates the antitumor efficacy of cisplatin or irradiation.

Published in:

Cancer Gene Therapy, 2014, v. 21, n. 5, p. 209, doi. 10.1038/cgt.2014.20

By:

Ye, F;
Yang, Z;
Liu, Y;
Gong, D;
Ji, T;
Wang, J;
Xi, B;
Zhou, J;
Ma, D;
Gao, Q

Publication type:

Article

Baicalein Induces G 2 /M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells.

Published in:

Molecules, 2023, v. 28, n. 3, p. 1039, doi. 10.3390/molecules28031039

By:

Chuang, Tzu-Chao;
Shao, Wei-Syun;
Hsu, Shih-Chung;
Lee, Shou-Lun;
Kao, Ming-Ching;
Wang, Vinchi

Publication type:

Article

Theaflavin-3,3′-Digallate Suppresses Human Ovarian Carcinoma OVCAR-3 Cells by Regulating the Checkpoint Kinase 2 and p27 kip1 Pathways.

Published in:

Molecules, 2019, v. 24, n. 4, p. 673, doi. 10.3390/molecules24040673

By:

Gao, Ying;
Yin, Junfeng;
Tu, Youying;
Chen, Yi Charlie

Publication type:

Article

Mutation in Chek2 triggers von Hippel-Lindau hemangioblastoma growth.

Published in:

Acta Neurochirurgica, 2023, v. 165, n. 12, p. 4241, doi. 10.1007/s00701-023-05825-x

By:

Cabrera-Montes, Jorge;
Aguirre, Daniel T.;
Viñas-López, Jesús;
Lorente-Herraiz, Laura;
Recio-Poveda, Lucía;
Albiñana, Virginia;
Pérez-Pérez, Julián;
Botella, Luisa M.;
Cuesta, Angel M.

Publication type:

Article

Understanding oocyte ageing.

Published in:

Minerva Obstetrics & Gynecology, 2024, v. 76, n. 3, p. 284, doi. 10.23736/S2724-606X.24.05343-0

By:

HOMER, Hayden A.

Publication type:

Article

Role of Breast Cancer Risk Estimation Models to Identify Women Eligible for Genetic Testing and Risk-Reducing Surgery.

Published in:

Biomedicines, 2024, v. 12, n. 4, p. 714, doi. 10.3390/biomedicines12040714

By:

Irelli, Azzurra;
Patruno, Leonardo Valerio;
Chiatamone Ranieri, Sofia;
Di Giacomo, Daniela;
Malatesta, Sara;
Alesse, Edoardo;
Tessitore, Alessandra;
Cannita, Katia

Publication type:

Article

Variation Analysis in Premenopausal and Postmenopausal Breast Cancer Cases.

Published in:

Journal of Personalized Medicine, 2024, v. 14, n. 4, p. 434, doi. 10.3390/jpm14040434

By:

Erdogdu, Ibrahim Halil;
Orenay-Boyacioglu, Seda;
Boyacioglu, Olcay;
Gurel, Duygu;
Akdeniz, Nurten;
Meteoglu, Ibrahim

Publication type:

Article

Overexpression of CHK1 and CHK2 in pediatric patients of B -acute lymphoblastic leukemia.

Published in:

Iranian Journal of Pediatric Hematology & Oncology, 2023, v. 13, n. 4, p. 233, doi. 10.18502/ijpho.v13i4.13769

By:

Heidari, Farshad;
Faranoush, Mohammad;
Amini, Ali;
Rahimian, Elahe;
Kazemi, Kamyar;
Paridar, Mostafa;
Safa, Majid

Publication type:

Article

Citrinin Provoke DNA Damage and Cell-Cycle Arrest Related to Chk2 and FANCD2 Checkpoint Proteins in Hepatocellular and Adenocarcinoma Cell Lines.

Published in:

Toxins, 2024, v. 16, n. 7, p. 321, doi. 10.3390/toxins16070321

By:

Stupin Polančec, Darija;
Homar, Sonja;
Jakšić, Daniela;
Kopjar, Nevenka;
Šegvić Klarić, Maja;
Dabelić, Sanja

Publication type:

Article

Synchronous Papillary Thyroid Cancer and Colorectal Cancer in a Young Patient with a CHEK2 Mutation.

Published in:

2024

By:

Hoskins, Sydney Brooke;
Torgerson, Leslie

Publication type:

Case Study

Chromophobe Renal Cell Carcinoma With Extensive Retraction Artifact: A Potential Diagnostic Pitfall From Micropapillary Urothelial Carcinoma.

Published in:

International Journal of Surgical Pathology, 2025, v. 33, n. 1, p. 5, doi. 10.1177/10668969241239678

By:

Sangoi, Ankur R.;
Pivovarcikova, Kristyna;
Akgul, Mahmut;
Williamson, Sean R.;
Ulamec, Monica;
Rogala, Joanna Dominica;
Martinek, Petr;
Vanecek, Tomas;
Hes, Ondrej;
Alaghehbandan, Reza

Publication type:

Article

DNA damage-related proteins in smokers and non-smokers with oral cancer.

Published in:

Brazilian Oral Research, 2022, v. 36, p. 1, doi. 10.1590/1807-3107bor-2022.vol36.0027

By:

SCHUCH, Lauren Frenzel;
DE ARRUDA, José Alcides Almeida;
VIANA, Karolina Skarlet Silva;
CALDEIRA, Patrícia Carlos;
ABREU, Mauro Henrique Nogueira Guimarães;
BERNARDES, Vanessa Fátima;
de AGUIAR, Maria Cássia Ferreira

Publication type:

Article

Risk of lymphoid malignancy associated with cancer predisposition genes.

Published in:

Blood Cancer Journal, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41408-025-01283-z

By:

Boddicker, Nicholas J.;
Mwangi, Raphael;
Robinson, Dennis P.;
Allmer, Cristine;
Rosenthal, Allison C.;
Habermann, Thomas M.;
Feldman, Andrew L.;
Rimsza, Lisa M.;
King, Rebecca L.;
Larson, Melissa C.;
Negaard, Bri J.;
Norman, Aaron D.;
Rajkumar, Nikhil;
Ansell, Stephen M.;
Dispenzieri, Angela;
Murray, David L.;
Rajkumar, Vincent;
Kumar, Shaji;
Abeykoon, Jithma P.;
Nowakowski, Grzegorz S.

Publication type:

Article

Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54922-7

By:

Black, Elizabeth M.;
Ramírez Parrado, Carlos Andrés;
Trier, Isabelle;
Li, Wenxue;
Joo, Yoon Ki;
Pichurin, Jennifer;
Liu, Yansheng;
Kabeche, Lilian

Publication type:

Article

Sterigmatocystin, 5-Methoxysterigmatocistin, and Their Combinations are Cytotoxic and Genotoxic to A549 and HepG2 Cells and Provoke Phosphorylation of Chk2, but not FANCD2 Checkpoint Proteins.

Published in:

Toxins, 2021, v. 13, n. 7, p. 464, doi. 10.3390/toxins13070464

By:

Dabelić, Sanja;
Kifer, Domagoj;
Jakšić, Daniela;
Kopjar, Nevenka;
Klarić, Maja Šegvić

Publication type:

Article

Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02360-y

By:

Pescatori, Sara;
Leone, Stefano;
Cipolletti, Manuela;
Bartoloni, Stefania;
di Masi, Alessandra;
Acconcia, Filippo

Publication type:

Article

CHEK2 gene in breast cancer.

Published in:

Romanian Medical Journal, 2022, v. 69, n. 3, p. 15, doi. 10.37897/RMJ.2022.S3.4

By:

Maioru, Ovidiu;
Pop, Lucian;
Radoi, Viorica;
Ursu, Radu;
Bacalbasa, Nicolae;
Balescu, Irina;
Suciu, Ioan D.

Publication type:

Article

Genetic factors involved in breast cancer.

Published in:

Romanian Medical Journal, 2022, v. 69, n. 3, p. 10, doi. 10.37897/RMJ.2022.S3.2

By:

Ursu, Radu;
Truica, Radu Alexandru;
Cojocaru, Alexandra;
Prepelita, Diana;
Pop, Lucian;
Radoi, Viorica;
Bacalbasa, Nicolae;
Balescu, Irina

Publication type:

Article

Molecular Docking and 3D QSAR Studies of Chk2 Inhibitors.

Published in:

Chemical Biology & Drug Design, 2009, v. 73, n. 3, p. 292, doi. 10.1111/j.1747-0285.2009.00773.x

By:

Pasha, Fahran Ahmad;
Muddassar, Muhammad;
Seung Joo Cho

Publication type:

Article

Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2024, v. 109, n. 11, p. 2720, doi. 10.1210/clinem/dgae268

By:

Sousa, Sunita M C De;
McCormack, Ann;
Orsmond, Andreas;
Shen, Angeline;
Yates, Christopher J;
Clifton-Bligh, Roderick;
Santoreneos, Stephen;
King, James;
Feng, Jinghua;
Toubia, John;
Torpy, David J;
Scott, Hamish S

Publication type:

Article

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells.

Published in:

BMC Biology, 2021, v. 19, n. 1, p. 1, doi. 10.1186/s12915-021-00965-x

By:

García-Santisteban, Iraia;
Llopis, Alba;
Krenning, Lenno;
Vallejo-Rodríguez, Jon;
van den Broek, Bram;
Zubiaga, Ana M.;
Medema, René H.

Publication type:

Article

Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors.

Published in:

Molecular Cancer, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12943-024-02147-z

By:

Murray, Clare E.;
Kornepati, Anand V. R.;
Ontiveros, Carlos;
Liao, Yiji;
de la Peña Avalos, Bárbara;
Rogers, Cody M.;
Liu, Zexuan;
Deng, Yilun;
Bai, Haiyan;
Kari, Suresh;
Padron, Alvaro S.;
Boyd, Jacob T.;
Reyes, Ryan;
Clark, Curtis A.;
Svatek, Robert S.;
Li, Rong;
Hu, Yanfen;
Wang, Meiling;
Conejo-Garcia, José R.;
Byers, Lauren A.

Publication type:

Article

CHK2 Promotes Anoikis and is Associated with the Progression of Papillary Thyroid Cancer.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2018, v. 45, n. 4, p. 1590, doi. 10.1159/000487724

By:

Wenjing Zhao;
Shaobo Chen;
Xianming Hou;
Ge Chen;
Yupei Zhao

Publication type:

Article

New perspective on DNA response pathway (DDR) in glioblastoma, focus on classic biomarkers and emerging roles of ncRNAs.

Published in:

Expert Reviews in Molecular Medicine, 2023, v. 25, p. 1, doi. 10.1017/erm.2023.10

By:

Pirlog, Bianca Oana;
Ilut, Silvina;
Pirlog, Radu;
Chiroi, Paul;
Nutu, Andreea;
Radutiu, Delia Ioana;
Cuc, George Daniel;
Berindan-Neagoe, Ioana;
Nabavi, Seyed Fazel;
Filosa, Rosanna;
Nabavi, Seyed Mohammad

Publication type:

Article

CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation.

Published in:

Antioxidants, 2022, v. 11, n. 6, p. 1166, doi. 10.3390/antiox11061166

By:

Guo, Ran;
Wang, Shan-Shan;
Jiang, Xiao-You;
Zhang, Ye;
Guo, Yang;
Cui, Hong-Yan;
Guo, Qi-Qiang;
Cao, Liu;
Xie, Xiao-Chen

Publication type:

Article

Evaluation of Germline CHEK2 Variants and Challenges in Genetic Counseling.

Published in:

Gazi Medical Journal, 2024, v. 35, p. 28

By:

Akar, Ömer Salih;
Demirağ, Güzin;
Polat, Ayfer Kamalı;
Yalçın, İbrahim;
Kefeli, Mehmet;
Yılmaz, Bahiddin;
Çalışkan, Sultan;
Abur, Ümmet;
Altundağ, Engin

Publication type:

Article

A case report of biallelic CHEK2 heterozygous variant presenting with breast cancer.

Published in:

2023

By:

Soleimani, Tahereh;
Bourdon, Corrie;
Davis, Jacquelyn;
Fortes, Thais

Publication type:

Case Study

CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid.

Published in:

Oncology Letters, 2017, v. 13, n. 4, p. 2591, doi. 10.3892/ol.2017.5792

By:

DONG WAN CHOO;
SUNG HO GOH;
YOUNG WOO CHO;
HYE JUNG BAEK;
EUN JUNG PARK;
NOBORU MOTOYAMA;
TAE HYUN KIM;
JOO YOUNG KIM;
SANG SOO KIM

Publication type:

Article

Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-91700-x

By:

Naeem, Wafa;
Nawab, Fouzia;
Sarwar, Muhammad Tahir;
Khalil, Ali Talha;
Gaber, Dalia Ali;
Ahmad, Hilal;
Fazeel, Muhammad;
Alorini, Mohammed;
Khan, Ishtiaq Ahmad;
Irfan, Muhammad;
Khan, Muslim;
Khurram, Syed Ali;
Ali, Asif

Publication type:

Article

The 8<sup>th</sup> Biennial Meeting of Asian Society of Gynecologic Oncology.

Published in:: Journal of Gynecologic Oncology, 2024, v. 35, p. S1
Publication type:: Article

Comments on "The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients".

Published in:

International Journal of Cancer, 2023, v. 152, n. 9, p. 2011, doi. 10.1002/ijc.34432

By:

Kratz, Christian P.;
Evans, D. Gareth

Publication type:

Article

Reply to: Comments on "The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients".

Published in:

International Journal of Cancer, 2023, v. 152, n. 9, p. 2013, doi. 10.1002/ijc.34431

By:

Borkhardt, Arndt;
Wagener, Rabea;
Brozou, Triantafyllia

Publication type:

Article

The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients.

Published in:

International Journal of Cancer, 2023, v. 152, n. 7, p. 1388, doi. 10.1002/ijc.34390

By:

Wagener, Rabea;
Walter, Carolin;
Auer, Franziska;
Alzoubi, Deya;
Hauer, Julia;
Fischer, Ute;
Varghese, Julian;
Dugas, Martin;
Borkhardt, Arndt;
Brozou, Triantafyllia

Publication type:

Article

The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of PlatinumResistance with a Chk2 Inhibitor.

Published in:

Chemotherapy Research & Practice, 2011, p. 1, doi. 10.1155/2011/715469

By:

Xiaobing Liang;
Yi Guo;
William Douglas Figg;
Antonio Tito Fojo;
Michael D.Mueller;
Jing Jie Yu

Publication type:

Article

A second hereditary cancer predisposition syndrome in a patient with lynch syndrome and three primary cancers.

Published in:

2024

By:

Taheny, Annmarie;
McSwaney, Haylie;
Meade, Julia

Publication type:

Case Study

CHEK2 mutations and papillary thyroid cancer: correlation or coincidence?

Published in:

Hereditary Cancer in Clinical Practice, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s13053-022-00211-7

By:

Koen, Kortbeek;
Robin, De Putter;
Eline, Naert

Publication type:

Article