Works matching DE "CHECKPOINT kinase 2"
Results: 143
Mutation in Chek2 triggers von Hippel-Lindau hemangioblastoma growth.
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- Acta Neurochirurgica, 2023, v. 165, n. 12, p. 4241, doi. 10.1007/s00701-023-05825-x
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- Article
Chk2 在 Bmi1 缺失所致的肾脏早衰和纤维化中的作用和机制研究.
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- Progress in Modern Biomedicine, 2023, v. 23, n. 16, p. 3001, doi. 10.13241/j.cnki.pmb.2023.16.001
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- Article
A comprehensive analysis of germline predisposition to early-onset ovarian cancer.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-66324-2
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- Article
Case report: Two sisters with a germline CHEK2 variant and distinct endocrine neoplasias.
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- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.1024108
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- Article
PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal cancer.
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- Annals of Medicine, 2023, v. 55, n. 2, p. 1, doi. 10.1080/07853890.2023.2281659
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- Article
Clinically relevant CHK1 inhibitors abrogate wild-type and Y537S mutant ERα expression and proliferation in luminal primary and metastatic breast cancer cells.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2022, v. 41, n. 1, p. 1, doi. 10.1186/s13046-022-02360-y
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- Article
Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact.
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- PLoS ONE, 2019, v. 14, n. 8, p. 1, doi. 10.1371/journal.pone.0220711
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- Article
EGFR-MEK1/2 cascade negatively regulates bactericidal function of bone marrow macrophages in mice with Staphylococcus aureus osteomyelitis.
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- PLoS Pathogens, 2024, v. 20, n. 8, p. N.PAG, doi. 10.1371/journal.ppat.1012437
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- Article
Thyroid Cancer in Childhood Cancer Survivors: Demographic, Clinical, Germline Genetic Characteristics, Treatment, and Outcome.
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- Journal of Clinical Medicine, 2025, v. 14, n. 2, p. 589, doi. 10.3390/jcm14020589
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- Article
Further Association of Germline CHEK2 Loss-of-Function Variants with Testicular Germ Cell Tumors.
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- Journal of Clinical Medicine, 2023, v. 12, n. 22, p. 7065, doi. 10.3390/jcm12227065
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- Article
Basics, Epidemiology, Diagnosis, and Management of Liver Tumor.
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- 2023
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- Publication type:
- Editorial
Involvement of DNA Damage Response via the Ccndbp1–Atm–Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis.
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- Journal of Clinical Medicine, 2022, v. 11, n. 13, p. 3674, doi. 10.3390/jcm11133674
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- Article
NEDD4L affects stability of the CHEK2/TP53 axis through ubiquitination modification to enhance osteogenic differentiation of periodontal ligament stem cells.
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- Connective Tissue Research, 2024, v. 65, n. 6, p. 433, doi. 10.1080/03008207.2024.2406794
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- Article
Role of Breast Cancer Risk Estimation Models to Identify Women Eligible for Genetic Testing and Risk-Reducing Surgery.
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- Biomedicines, 2024, v. 12, n. 4, p. 714, doi. 10.3390/biomedicines12040714
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- Article
Hereditary breast cancer next‐generation sequencing panel evaluation in the south region of Brazil: A novel BRCA2 candidate pathogenic variant is reported.
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- Molecular Genetics & Genomic Medicine, 2024, v. 12, n. 8, p. 1, doi. 10.1002/mgg3.2504
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- Article
Risk‐reducing mastectomy decisions among women with mutations in high‐ and moderate‐ penetrance breast cancer susceptibility genes.
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- Molecular Genetics & Genomic Medicine, 2022, v. 10, n. 10, p. 1, doi. 10.1002/mgg3.2031
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- Article
Germline variants in cancer genes in high-risk non-BRCA patients from Puerto Rico.
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- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-54170-6
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- Article
Advancing cancer therapy: new frontiers in targeting DNA damage response.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1474337
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- Article
Advancing cancer therapy: new frontiers in targeting DNA damage response.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1474337
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- Publication type:
- Article
The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1.
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- Oncogene, 2009, v. 28, n. 10, p. 1366, doi. 10.1038/onc.2008.477
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- Article
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
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- Oncogene, 2008, v. 27, n. 28, p. 3977, doi. 10.1038/onc.2008.17
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- Article
Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation.
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- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54922-7
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- Publication type:
- Article
Checkpoint activation drives global gene expression changes in Drosophila nuclear lamina mutants.
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- G3: Genes | Genomes | Genetics, 2022, v. 12, n. 2, p. 1, doi. 10.1093/g3journal/jkab408
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- Publication type:
- Article
FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2.
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- Journal of Experimental & Clinical Cancer Research (17569966), 2020, v. 39, n. 1, p. N.PAG, doi. 10.1186/s13046-020-01677-w
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- Article
Prognostic role of CHEK2, FASN and Her2/neu Expression in Stage Ta-T1 Non-Muscle-Invasive Bladder Cancer (NMIBC).
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- Egyptian Journal of Hospital Medicine, 2023, v. 91, p. 5266, doi. 10.21608/ejhm.2023.305065
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- Article
Visualization of clonal expansion after massive depletion of cells carrying the bovine leukemia virus (BLV) integration sites during the course of disease progression in a BLV naturally-infected cow: a case report.
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- Retrovirology, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12977-022-00609-0
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- Publication type:
- Article
Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2.
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- PLoS Genetics, 2024, v. 20, n. 8, p. 1, doi. 10.1371/journal.pgen.1011375
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- Publication type:
- Article
vaRHC: an R package for semi-automation of variant classification in hereditary cancer genes according to ACMG/AMP and gene-specific ClinGen guidelines.
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- Bioinformatics, 2023, v. 39, n. 3, p. 1, doi. 10.1093/bioinformatics/btad128
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- Publication type:
- Article
Should we be testing for germline and "actionable" mutations in all glioma patients?
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- Neuro-Oncology Practice, 2025, v. 12, n. 1, p. 3, doi. 10.1093/nop/npae121
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- Article
Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters.
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- eLife, 2022, p. 1, doi. 10.7554/eLife.84320
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- Article
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival.
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- Cancer Medicine, 2023, v. 12, n. 15, p. 16142, doi. 10.1002/cam4.6272
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- Article
Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes.
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- Cancer Medicine, 2023, v. 12, n. 1, p. 179, doi. 10.1002/cam4.4916
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- Publication type:
- Article
Racial and ethnic variation in multigene panel testing in a cohort of BRCA1/2-negative individuals who had genetic testing in a large urban comprehensive cancer center.
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- Cancer Medicine, 2022, v. 11, n. 6, p. 1465, doi. 10.1002/cam4.4541
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- Article
Advances in ATM, ATR, WEE1, and CHK1/2 inhibitors in the treatment of PARP inhibitor-resistant ovarian cancer.
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- Cancer Biology & Medicine, 2023, v. 20, n. 12, p. 915, doi. 10.20892/j.issn.2095-3941.2023.0260
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- Article
Pathologic Findings at Risk Reducing Surgery in BRCA and Non- BRCA Mutation Carriers: A Single-Center Experience.
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- Diagnostics (2075-4418), 2022, v. 12, n. 12, p. 3054, doi. 10.3390/diagnostics12123054
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- Article
Genomic Breakpoints' Characterization of a Large CHEK2 Duplication in an Italian Family with Hereditary Breast Cancer.
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- Diagnostics (2075-4418), 2022, v. 12, n. 7, p. N.PAG, doi. 10.3390/diagnostics12071520
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- Article
Chrysin-Induced Regression of Angiogenesis via an Induction of DNA Damage Response and Oxidative Stress in In Vitro and In Vivo Models of Melanoma.
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- Cells (2073-4409), 2023, v. 12, n. 12, p. 1561, doi. 10.3390/cells12121561
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- Article
Red Wine Extract Prevents Oxidative Stress and Inflammation in ARPE-19 Retinal Cells.
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- Cells (2073-4409), 2023, v. 12, n. 10, p. 1408, doi. 10.3390/cells12101408
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- Article
Minor Kinases with Major Roles in Cytokinesis Regulation.
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- Cells (2073-4409), 2022, v. 11, n. 22, p. 3639, doi. 10.3390/cells11223639
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- Article
Apoptotic and DNA Damage Effect of 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose in Cisplatin-Resistant Non-Small Lung Cancer Cells via Phosphorylation of H 2 AX, CHK2 and p53.
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- Cells (2073-4409), 2022, v. 11, n. 8, p. 1343, doi. 10.3390/cells11081343
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- Article
A phase II study evaluating safety and efficacy of niraparib in patients with previously treated homologous recombination defective metastatic esophageal/gastroesophageal junction/proximal gastric adenocarcinoma.
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- Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1435056
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- Article
Hereditary Cancer Genes and Related Risks.
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- Rhode Island Medical Journal, 2023, v. 106, n. 5, p. 12
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- Publication type:
- Article
Comparing Cancer Risk Management between Females with Truncating CHEK2 1100delC versus Missense CHEK2 I157T Variants.
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- Genes, 2024, v. 15, n. 7, p. 881, doi. 10.3390/genes15070881
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- Article
Detection Rate and Spectrum of Pathogenic Variations in a Cohort of 83 Patients with Suspected Hereditary Risk of Kidney Cancer.
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- Genes, 2023, v. 14, n. 11, p. 1991, doi. 10.3390/genes14111991
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- Publication type:
- Article
Impact of High-to-Moderate Penetrance Genes on Genetic Testing: Looking over Breast Cancer.
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- Genes, 2023, v. 14, n. 8, p. 1530, doi. 10.3390/genes14081530
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- Article
Comprehensive Clinical and Genetic Analysis of CHEK2 in Croatian Men with Prostate Cancer.
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- Genes, 2022, v. 13, n. 11, p. 1955, doi. 10.3390/genes13111955
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- Article
Comprehensive splicing analysis of the alternatively spliced CHEK2 exons 8 and 10 reveals three enhancer/silencer‐rich regions and 38 spliceogenic variants.
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- Journal of Pathology, 2024, v. 262, n. 4, p. 395, doi. 10.1002/path.6243
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- Article
Insights into the genetic landscape of pheochromocytomas and paragangliomas in a Brazilian cohort.
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- European Journal of Endocrinology, 2025, v. 192, n. 1, p. 1, doi. 10.1093/ejendo/lvae160
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- Publication type:
- Article
Chromophobe Renal Cell Carcinoma With Extensive Retraction Artifact: A Potential Diagnostic Pitfall From Micropapillary Urothelial Carcinoma.
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- International Journal of Surgical Pathology, 2025, v. 33, n. 1, p. 5, doi. 10.1177/10668969241239678
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- Article
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G<sub>2</sub>/M DNA Damage Checkpoint.
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- PLoS Biology, 2010, v. 8, n. 1, p. 1, doi. 10.1371/journal.pbio.1000287
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- Article