Works matching DE "BROMODOMAIN-containing proteins"

Results: 254

Histone Deacetylation in Alzheimer's Diseases (AD); Hope or Hype.

Published in:

Cell Biochemistry & Biophysics, 2025, v. 83, n. 2, p. 1537, doi. 10.1007/s12013-025-01670-0

By:

Ateya, Nabaa Hisham;
Al-Taie, Sarah F.;
Jasim, Saade Abdalkareem;
Uthirapathy, Subasini;
Chaudhary, Kamlesh;
Rani, Pooja;
Kundlas, Mayank;
Naidu, K. Satyam;
Amer, Nevin Adel;
Ahmed, Jawad Kadhim

Publication type:

Article

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.

Published in:

PLoS Biology, 2015, v. 13, n. 12, p. 1, doi. 10.1371/journal.pbio.1002316

By:

Schulz, Danae;
Mugnier, Monica R.;
Paulsen, Eda-Margaret;
Kim, Hee-Sook;
Chung, Chun-wa W.;
Tough, David F.;
Rioja, Inmaculada;
Prinjha, Rab K.;
Papavasiliou, F. Nina;
Debler, Erik W.

Publication type:

Article

4-Acyl Pyrroles: Mimicking Acetylated Lysines in Histone Code Reading.

Published in:

Angewandte Chemie, 2013, v. 125, n. 52, p. 14305, doi. 10.1002/ange.201307652

By:

Lucas, Xavier;
Wohlwend, Daniel;
Hügle, Martin;
Schmidtkunz, Karin;
Gerhardt, Stefan;
Schüle, Roland;
Jung, Manfred;
Einsle, Oliver;
Günther, Stefan

Publication type:

Article

Nucleophosmin 1 cooperates with BRD4 to facilitate c-Myc transcription to promote prostate cancer progression.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01682-w

By:

Hong, Zhe;
Xu, Chengdang;
Zheng, Shengfeng;
Wang, Xinan;
Tao, Yiran;
Tan, Yao;
Lin, Guowen;
Wu, Denglong;
Ye, Dingwei

Publication type:

Article

BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01611-x

By:

Li, Lemin;
Wang, Linchen;
Liu, Dian;
Zhao, Yongchao

Publication type:

Article

Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4.

Published in:

Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01563-2

By:

Zhou, Dingyan;
Liu, Weizhe;
Zhang, Juanjuan;
Dong, Yucui;
Wu, Jiangli;
Zhang, Yu;
Dai, Cheng;
Zhang, Tingting;
Yang, Gaoshan;
Zhang, Yue;
Li, Aiying

Publication type:

Article

Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells.

Published in:

Immunity, Inflammation & Disease, 2017, v. 5, n. 2, p. 141, doi. 10.1002/iid3.150

By:

Garcia‐Faroldi, Gianni;
Rönnberg, Elin;
Grujic, Mirjana;
Pejler, Gunnar

Publication type:

Article

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00678

By:

Kerscher, Bernhard;
Barlow, Jillian L.;
Rana, Batika M.;
Jolin, Helen E.;
Gogoi, Mayuri;
Bartholomew, Michelle A.;
Jhamb, Deepali;
Pandey, Ashutosh;
Tough, David F.;
van Oosterhout, Antoon J. M.;
McKenzie, Andrew N. J.

Publication type:

Article

Design and evaluation of potent BRD4 Bromodomain inhibitors based on ZA channel hot spot.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2023, v. 32, n. 12, p. 971, doi. 10.5246/jcps.2023.12.078

By:

Huili Li;
Jue Li;
Dandan He;
Ling Tao;
Yubing Jiang;
Xiangchun Shen;
Fei Jiang

Publication type:

Article

Nanovesicles loaded with a TGF-β receptor 1 inhibitor overcome immune resistance to potentiate cancer immunotherapy.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39035-x

By:

Zhou, Mengxue;
Wang, Jiaxin;
Pan, Jiaxing;
Wang, Hui;
Huang, Lujia;
Hou, Bo;
Lai, Yi;
Wang, Fengyang;
Guan, Qingxiang;
Wang, Feng;
Xu, Zhiai;
Yu, Haijun

Publication type:

Article

TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation.

Published in:

Cellular Oncology (2211-3428), 2024, v. 47, n. 5, p. 1973, doi. 10.1007/s13402-024-00981-3

By:

Xue, Changning;
Meng, Hanbing;
Niu, Weihong;
Li, Mengna;
Wei, Jianxia;
Chen, Shipeng;
Zheng, Lemei;
Duan, Yumei;
Deng, Hongyu;
Tang, Faqing;
Fan, Songqing;
Tan, Ming;
Xiong, Wei;
Zhou, Ming

Publication type:

Article

Synergistic Strategies for KMT2A-Rearranged Leukemias: Beyond Menin Inhibitor.

Published in:

Cancers, 2024, v. 16, n. 23, p. 4017, doi. 10.3390/cancers16234017

By:

Cantilena, Sandra;
AlAmeri, Mohamed;
Che, Noelia;
Williams, Owen;
de Boer, Jasper

Publication type:

Article

Triple Combination of Entinostat, a Bromodomain Inhibitor, and Cisplatin Is a Promising Treatment Option for Bladder Cancer.

Published in:

Cancers, 2024, v. 16, n. 19, p. 3374, doi. 10.3390/cancers16193374

By:

Bollmann, Lukas M.;
Lange, Friedrich;
Hamacher, Alexandra;
Biermann, Lukas;
Schäker-Hübner, Linda;
Hansen, Finn K.;
Kassack, Matthias U.

Publication type:

Article

The Prognostic Role of BRD4 Expression in High-Grade Serous Ovarian Cancer.

Published in:

Cancers, 2024, v. 16, n. 11, p. 1962, doi. 10.3390/cancers16111962

By:

Andrikopoulou, Angeliki;
Bletsa, Garyfalia;
Rouvalis, Angeliki;
Tsakogiannis, Dimitris;
Kaparelou, Maria;
Papatheodoridi, Alkistis;
Haidopoulos, Dimitrios;
Liontos, Michalis;
Dimopoulos, Meletios-Athanasios;
Zagouri, Flora

Publication type:

Article

Synergy between BRD9- and IKZF3-Targeting as a Therapeutic Strategy for Multiple Myeloma.

Published in:

Cancers, 2024, v. 16, n. 7, p. 1319, doi. 10.3390/cancers16071319

By:

Chowdhury, Basudev;
Garg, Swati;
Ni, Wei;
Sattler, Martin;
Sanchez, Dana;
Meng, Chengcheng;
Akatsu, Taisei;
Stone, Richard;
Forrester, William;
Harrington, Edmund;
Buhrlage, Sara J.;
Griffin, James D.;
Weisberg, Ellen

Publication type:

Article

Therapeutic Potential of Bromodomain and Extra-Terminal Domain Inhibitors for Synovial Sarcoma Cells.

Published in:

Cancers, 2024, v. 16, n. 6, p. 1125, doi. 10.3390/cancers16061125

By:

Kotani, Yuki;
Imura, Yoshinori;
Nakai, Sho;
Chijimatsu, Ryota;
Takami, Haruna;
Inoue, Akitomo;
Mae, Hirokazu;
Takenaka, Satoshi;
Outani, Hidetatsu;
Okada, Seiji

Publication type:

Article

Anticancer Effects of BRD4 Inhibitor in Epithelial Ovarian Cancer.

Published in:

Cancers, 2024, v. 16, n. 5, p. 959, doi. 10.3390/cancers16050959

By:

Kim, Yeorae;
Park, Wook-Ha;
Suh, Dong-Hoon;
Kim, Kidong;
No, Jae-Hong;
Kim, Yong-Beom

Publication type:

Article

Innovative Breakthroughs for the Treatment of Advanced and Metastatic Synovial Sarcoma.

Published in:

Cancers, 2023, v. 15, n. 15, p. 3887, doi. 10.3390/cancers15153887

By:

Landuzzi, Lorena;
Manara, Maria Cristina;
Pazzaglia, Laura;
Lollini, Pier-Luigi;
Scotlandi, Katia

Publication type:

Article

The Bivalent Bromodomain Inhibitor MT-1 Inhibits Prostate Cancer Growth.

Published in:

Cancers, 2023, v. 15, n. 15, p. 3851, doi. 10.3390/cancers15153851

By:

Shukla, Sanjeev;
Riveros, Carlos;
Al-Toubat, Mohammed;
Chardon-Robles, Jonathan;
Osumi, Teruko;
Serrano, Samuel;
Kase, Adam M.;
Petit, Joachim L.;
Meurice, Nathalie;
Gleba, Justyna;
Copland III, John A.;
Chauhan, Jay;
Fletcher, Steven;
Balaji, K. C.

Publication type:

Article

Molecular Subtypes and Tumor Microenvironment Characteristics of Small-Cell Lung Cancer Associated with Platinum-Resistance.

Published in:

Cancers, 2023, v. 15, n. 14, p. 3568, doi. 10.3390/cancers15143568

By:

Kim, Jihyun;
Kim, Sunshin;
Park, Seog-Yun;
Lee, Geon Kook;
Lim, Kun Young;
Kim, Jin Young;
Hwang, Jung-Ah;
Yu, Namhee;
Kang, Eun Hye;
Hwang, Mihwa;
Song, Bo Ram;
Park, Charny;
Han, Ji-Youn

Publication type:

Article

Sensitization of Resistant Cells with a BET Bromodomain Inhibitor in a Cell Culture Model of Deep Intrinsic Resistance in Breast Cancer.

Published in:

Cancers, 2023, v. 15, n. 7, p. 2036, doi. 10.3390/cancers15072036

By:

Singh, Balraj;
Sarli, Vanessa N.;
Milligan, Ryan D.;
Kinne, Hannah E.;
Shamsnia, Anna;
Washburn, Laura J.;
Addanki, Sridevi;
Lucci, Anthony

Publication type:

Article

BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human Disease.

Published in:

Cancers, 2022, v. 14, n. 17, p. 4068, doi. 10.3390/cancers14174068

By:

Zu, Gaoyu;
Liu, Ying;
Cao, Jingli;
Zhao, Baicheng;
Zhang, Hang;
You, Linya

Publication type:

Article

Functional Roles of Bromodomain Proteins in Cancer.

Published in:

Cancers, 2021, v. 13, n. 14, p. 3606, doi. 10.3390/cancers13143606

By:

Boyson, Samuel P.;
Gao, Cong;
Quinn, Kathleen;
Boyd, Joseph;
Paculova, Hana;
Frietze, Seth;
Glass, Karen C.

Publication type:

Article

Expression of Phosphorylated BRD4 Is Markedly Associated with the Activation Status of the PP2A Pathway and Shows a Strong Prognostic Value in Triple Negative Breast Cancer Patients.

Published in:

Cancers, 2021, v. 13, n. 6, p. 1246, doi. 10.3390/cancers13061246

By:

Sanz-Álvarez, Marta;
Cristóbal, Ion;
Luque, Melani;
Santos, Andrea;
Zazo, Sandra;
Madoz-Gúrpide, Juan;
Caramés, Cristina;
Chiang, Cheng-Ming;
García-Foncillas, Jesús;
Eroles, Pilar;
Albanell, Joan;
Rojo, Federico;
Hurvitz, Sara A.

Publication type:

Article

Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis.

Published in:

Cancers, 2020, v. 12, n. 6, p. 1637, doi. 10.3390/cancers12061637

By:

Wang, Ranran;
Yang, June F.;
Ho, Flora;
Robertson, Erle S.;
You, Jianxin

Publication type:

Article

PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9.

Published in:

Cancers, 2019, v. 11, n. 11, p. 1634, doi. 10.3390/cancers11111634

By:

Bell, Catherine M.;
Raffeiner, Philipp;
Hart, Jonathan R.;
Vogt, Peter K.

Publication type:

Article

Pharmacological Targeting of BET Bromodomain Proteins in Acute Myeloid Leukemia and Malignant Lymphomas: From Molecular Characterization to Clinical Applications.

Published in:

Cancers, 2019, v. 11, n. 10, p. 1483, doi. 10.3390/cancers11101483

By:

Reyes-Garau, Diana;
Ribeiro, Marcelo L.;
Roué, Gaël

Publication type:

Article

When are the BET factors the most sensitive to bromodomain inhibitors?

Published in:

Transcription (2154-1264), 2013, v. 4, n. 2, p. 1, doi. 10.4161/trns.23191

By:

Khochbin, Saadi

Publication type:

Article

Two faces of BRD4.

Published in:

Transcription (2154-1264), 2013, v. 4, n. 1, p. 13, doi. 10.4161/trns.22542

By:

Devaiah, Ballachanda N.;
Singer, Dinah S.

Publication type:

Article

Computational screening of potential bromodomain-containing protein 2 inhibitors for blocking SARS-CoV-2 infection through pharmacophore modeling, molecular docking and molecular dynamics simulation.

Published in:

Arabian Journal of Chemistry, 2024, v. 17, n. 1, p. N.PAG, doi. 10.1016/j.arabjc.2023.105365

By:

Xu, Shaohua;
Yuan, Huicheng;
Li, Ling;
Yang, Kai;
Zhao, Liangcun

Publication type:

Article

LncRNA AL139294.1 can be transported by extracellular vesicles to promote the oncogenic behaviour of recipient cells through activation of the Wnt and NF-κB2 pathways in non-small-cell lung cancer.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2024, v. 43, n. 1, p. 1, doi. 10.1186/s13046-023-02939-z

By:

Ma, Xinyi;
Chen, Zhenhua;
Chen, Wei;
Chen, Ziyuan;
Shang, Yue;
Zhao, Yikai;
Li, Leyi;
Zhou, Chengwei;
He, Jinxian;
Meng, Xiaodan

Publication type:

Article

Fucoxanthin inhibits cardiac fibroblast transdifferentiation by alleviating oxidative stress through downregulation of BRD4.

Published in:

PLoS ONE, 2023, v. 18, n. 9, p. 1, doi. 10.1371/journal.pone.0291469

By:

Han, Jinxia;
Zhang, Yanfang;
Peng, Haisheng

Publication type:

Article

Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.

Published in:

Neurochemical Research, 2024, v. 49, n. 5, p. 1254, doi. 10.1007/s11064-024-04112-0

By:

Li, Xuemei;
Yang, Qinghuan;
Jiang, Peiran;
Wen, Jun;
Chen, Yue;
Huang, Jiagui;
Tian, Mingfen;
Ren, Jiangxia;
Yang, Qin

Publication type:

Article

High Expression Level of BRD4 Is Associated with a Poor Prognosis and Immune Infiltration in Esophageal Squamous Cell Carcinoma.

Published in:

Digestive Diseases & Sciences, 2023, v. 68, n. 7, p. 2997, doi. 10.1007/s10620-023-07907-3

By:

Li, Li;
Gao, Lin;
Zhou, Hong;
Shi, Chao;
Zhang, Xiaojuan;
Zhang, Dongmei;
Liu, Hongbin

Publication type:

Article

Fibronectin type III domain containing protein 5/irisin alleviated sepsis-induced acute kidney injury by abating ferroptosis through the adenosine 5'-monophosphate-activated protein kinase/nuclear factor erythroid-2-related factor 2 signaling pathway.

Published in:

CytoJournal, 2024, v. 21, p. 1, doi. 10.25259/Cytojournal_62_2024

By:

Gui, Shenghao;
Zhu, Chaochao;
Lu, Yunfeng

Publication type:

Article

aBETting therapeutic resistance by Wnt signaling.

Published in:

Cell Research, 2015, v. 25, n. 11, p. 1187, doi. 10.1038/cr.2015.127

By:

Engelke, Carl G;
Chinnaiyan, Arul M

Publication type:

Article

BETs abet Tam-R in ER-positive breast cancer.

Published in:

Cell Research, 2014, v. 24, n. 8, p. 899, doi. 10.1038/cr.2014.90

By:

Alluri, Prasanna G;
Asangani, Irfan A;
Chinnaiyan, Arul M

Publication type:

Article

Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2.

Published in:

Cell Research, 2010, v. 20, n. 5, p. 529, doi. 10.1038/cr.2010.43

By:

Charlop-Powers, Zachary;
Lei Zeng;
Qiang Zhang;
Ming-Ming Zhou

Publication type:

Article

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.

Published in:

Molecular Systems Biology, 2017, v. 13, n. 1, p. n/a, doi. 10.15252/msb.20166796

By:

Fallahi‐Sichani, Mohammad;
Becker, Verena;
Izar, Benjamin;
Baker, Gregory J;
Lin, Jia‐Ren;
Boswell, Sarah A;
Shah, Parin;
Rotem, Asaf;
Garraway, Levi A;
Sorger, Peter K

Publication type:

Article

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 9, p. 1040, doi. 10.1038/nsmb.2642

By:

Delvecchio, Manuela;
Gaucher, Jonathan;
Aguilar-Gurrieri, Carmen;
Ortega, Esther;
Panne, Daniel

Publication type:

Article

Identification of Novel Nuclear Protein Interactions with the N-Terminal Part of Filamin A.

Published in:

Bioscience, Biotechnology & Biochemistry, 2011, v. 75, n. 1, p. 145, doi. 10.1271/bbb.100567

By:

Hao Qiu;
Nomiyama, Ryosuke;
Moriguchi, Keisuke;
Fukada, Takashi;
Sugimoto, Kenji

Publication type:

Article

Pyronaridine as a Bromodomain-Containing Protein 4- N -Terminal Bromodomain (BRD4-BD1) Inhibitor: In Silico Database Mining, Molecular Docking, and Molecular Dynamics Simulation.

Published in:

Molecules, 2023, v. 28, n. 15, p. 5713, doi. 10.3390/molecules28155713

By:

Ibrahim, Mahmoud A. A.;
Abdelhamid, Mahmoud M. H.;
Abdeljawaad, Khlood A. A.;
Abdelrahman, Alaa H. M.;
Mekhemer, Gamal A. H.;
Sidhom, Peter A.;
Sayed, Shaban R. M.;
Paré, Paul W.;
Hegazy, Mohamed-Elamir F.;
Shoeib, Tamer

Publication type:

Article

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications.

Published in:

Molecules, 2023, v. 28, n. 7, p. 3043, doi. 10.3390/molecules28073043

By:

To, Kenneth K. W.;
Xing, Enming;
Larue, Ross C.;
Li, Pui-Kai

Publication type:

Article

A Minireview on BET Inhibitors: Beyond Bromodomain Targeting.

Published in:

Biomedicines, 2025, v. 13, n. 3, p. 594, doi. 10.3390/biomedicines13030594

By:

Iudin, Mikhail S.;
Khodarovich, Yuri M.;
Varizhuk, Anna M.;
Tsvetkov, Vladimir B.;
Severov, Vyacheslav V.

Publication type:

Article

BET Family Protein BRD4: An Emerging Actor in NFκB Signaling in Inflammation and Cancer.

Published in:

Biomedicines, 2018, v. 6, n. 1, p. 16, doi. 10.3390/biomedicines6010016

By:

Hajmirza, Azadeh;
Emadali, Anouk;
Gauthier, Arnaud;
Casasnovas, Olivier;
Gressin, Rémy;
Callanan, Mary B.

Publication type:

Article

Design, Synthesis, and Molecular Docking Study of New Indole Derivatives as BRD4 Inhibitors.

Published in:

Russian Journal of Organic Chemistry, 2025, v. 61, n. 2, p. 280, doi. 10.1134/S1070428024602036

By:

Jin, Gang;
He, Zhangxu;
Yang, Feifei;
Zhang, Jingyu

Publication type:

Article

BRD4: an effective target for organ fibrosis.

Published in:

Biomarker Research, 2024, v. 12, n. 1, p. 1, doi. 10.1186/s40364-024-00641-6

By:

Wei, Qun;
Gan, Cailing;
Sun, Meng;
Xie, Yuting;
Liu, Hongyao;
Xue, Taixiong;
Deng, Conghui;
Mo, Chunheng;
Ye, Tinghong

Publication type:

Article

Long Noncoding RNA MALAT1 Promotes Laryngocarcinoma Development by Targeting miR-708-5p/BRD4 Axis to Regulate YAP1-Mediated Epithelial-Mesenchymal Transition.

Published in:

BioMed Research International, 2022, p. 1, doi. 10.1155/2022/8093949

By:

Wu, Xiaoqin;
Tan, Yenong;
Tang, Xuxia

Publication type:

Article

BRDT gene sequence in human testicular pathologies and the implication of its single nucleotide polymorphism (rs3088232) on fertility.

Published in:

Andrology, 2014, v. 2, n. 4, p. 641, doi. 10.1111/j.2047-2927.2014.00230.x

By:

Barda, S.;
Yogev, L.;
Paz, G.;
Yavetz, H.;
Lehavi, O.;
Hauser, R.;
Doniger, T.;
Breitbart, H.;
Kleiman, S. E.

Publication type:

Article

Protein post-translational modification in SARS-CoV-2 and host interaction.

Published in:

Frontiers in Immunology, 2023, v. 13, p. 1, doi. 10.3389/fimmu.2022.1068449

By:

Nana Cheng;
Mingzhu Liu;
Wanting Li;
BingYue Sun;
Dandan Liu;
Guoqing Wang;
Jingwei Shi;
Lisha Li

Publication type:

Article