Works about BIOISOSTERES
Results: 105
3,3‐Difluorooxetane–A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery.
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- Chemistry - A European Journal, 2024, v. 30, n. 72, p. 1, doi. 10.1002/chem.202403277
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- Article
Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes.
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- Chemistry - A European Journal, 2024, v. 30, n. 12, p. 1, doi. 10.1002/chem.202304070
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- Article
Scaffold Editing of Cubanes into Homocubanes, Homocuneanes via Cuneanes.
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- Chemistry - A European Journal, 2024, v. 30, n. 9, p. 1, doi. 10.1002/chem.202303063
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- Article
Overcoming a Radical Polarity Mismatch in Strain‐Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone‐ and Carbonyl‐Containing SF<sub>5</sub>‐Cyclobutanes.
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- Angewandte Chemie, 2024, v. 136, n. 19, p. 1, doi. 10.1002/ange.202319930
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- Article
2‐Oxabicyclo[2.1.1]hexanes: Synthesis, Properties, and Validation as Bioisosteres of ortho‐ and meta‐Benzenes.
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- Angewandte Chemie, 2024, v. 136, n. 19, p. 1, doi. 10.1002/ange.202319831
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- Article
Light‐Driven Synthesis and Functionalization of Bicycloalkanes, Cubanes and Related Bioisosteres.
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- Angewandte Chemie, 2024, v. 136, n. 14, p. 1, doi. 10.1002/ange.202317333
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- Article
1‐Azaspiro[3.3]heptane as a Bioisostere of Piperidine.
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- Angewandte Chemie, 2023, v. 135, n. 51, p. 1, doi. 10.1002/ange.202311583
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- Article
Rapid and Scalable Halosulfonylation of Strain‐Release Reagents.
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- Angewandte Chemie, 2023, v. 135, n. 3, p. 1, doi. 10.1002/ange.202213508
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- Article
Palladium‐Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes.
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- Angewandte Chemie, 2022, v. 134, n. 41, p. 1, doi. 10.1002/ange.202208204
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- Article
Beyond Bioisosteres: Divergent Synthesis of Azabicyclohexanes and Cyclobutenyl Amines from Bicyclobutanes.
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- Angewandte Chemie, 2022, v. 134, n. 27, p. 1, doi. 10.1002/ange.202204719
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- Article
Cross‐Electrophile C(sp<sup>2</sup>)−Si Coupling of Vinyl Chlorosilanes.
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- Angewandte Chemie, 2020, v. 132, n. 51, p. 23283, doi. 10.1002/ange.202010737
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- Article
Saturated Bioisosteres of ortho‐Substituted Benzenes.
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- Angewandte Chemie, 2020, v. 132, n. 46, p. 20696, doi. 10.1002/ange.202004183
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- Article
Divergent Strain‐Release Amino‐Functionalization of [1.1.1]Propellane with Electrophilic Nitrogen‐Radicals.
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- Angewandte Chemie, 2020, v. 132, n. 21, p. 8302, doi. 10.1002/ange.202000140
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- Article
1,3‐Difunctionalizations of [1.1.1]Propellane via 1,2‐Metallate Rearrangements of Boronate Complexes.
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- Angewandte Chemie, 2020, v. 132, n. 10, p. 3945, doi. 10.1002/ange.201914875
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- Article
Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy‐amino‐λ<sup>6</sup>‐sulfanenitrile Intermediate.
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- Angewandte Chemie, 2019, v. 131, n. 40, p. 14441, doi. 10.1002/ange.201906001
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Enantioselective, Catalytic Vicinal Difluorination of Alkenes.
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- Angewandte Chemie, 2018, v. 130, n. 50, p. 16669, doi. 10.1002/ange.201810328
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- Article
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group.
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- Communications Chemistry, 2020, v. 3, n. 1, p. N.PAG, doi. 10.1038/s42004-020-00368-z
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- Article
Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A<sub>2A</sub>/A<sub>2B</sub> adenosine receptor antagonists.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1514, doi. 10.1080/14756366.2022.2077731
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- Article
1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A 2 α and fatty acid amide hydrolase: bioisosteric replacement of the carboxylic acid moiety.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, p. 131, doi. 10.1080/14756366.2016.1178246
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- Article
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues.
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- Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 1, p. 121, doi. 10.3109/14756366.2015.1005012
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- Article
Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors.
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- Canadian Journal of Chemistry, 2016, v. 94, n. 3, p. 240, doi. 10.1139/cjc-2015-0475
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- Article
Synthesis and fungicidal activities of positional isomers of the N-thienylcarboxamide.
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- Journal of Pesticide Science, 2021, v. 46, n. 2, p. 229, doi. 10.1584/jpestics.D20-062
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- Article
Strain‐Release‐Driven Modular Synthesis of Oxetane‐Based Amide Bioisosteres: Concise, Robust and Scalable Approach.
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- Angewandte Chemie, 2024, v. 136, n. 42, p. 1, doi. 10.1002/ange.202410554
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- Article
Deconstruction – Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold.
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- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, p. 1, doi. 10.33594/00000033
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- Article
Structure-Based Evolution of Subtype-Selective Neurotensin Receptor Ligands.
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- ChemistryOpen, 2014, v. 3, n. 5, p. 206, doi. 10.1002/open.201402031
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- Article
Acceleration of Binding Site Comparisons by Graph Partitioning.
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- Molecular Informatics, 2015, v. 34, n. 8, p. 550, doi. 10.1002/minf.201500028
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- Article
Bioisosteres and Scaffold Hopping in Medicinal Chemistry.
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- Molecular Informatics, 2014, v. 33, n. 6/7, p. 458, doi. 10.1002/minf.201400037
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- Article
Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins.
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- Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0483-5
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- Article
Probing the Orthosteric Binding Site of GABA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres.
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- Neurochemical Research, 2014, v. 39, n. 6, p. 1005, doi. 10.1007/s11064-013-1226-6
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- Article
Antioxidant properties in a non-polar environment of difluoromethyl bioisosteres of methyl hydroxycinnamates.
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- Journal of Pharmacy & Pharmacology, 2016, v. 68, n. 2, p. 233, doi. 10.1111/jphp.12507
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- Article
Agrochemical lead optimization by scaffold hopping.
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- Pest Management Science, 2018, v. 74, n. 2, p. 282, doi. 10.1002/ps.4755
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- Article
Heterocyclic chemistry in crop protection.
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- Pest Management Science, 2013, v. 69, n. 10, p. 1106, doi. 10.1002/ps.3615
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- Article
Reaction Paradigms that Leverage Cycloaddition and Ring Strain to Construction Bicyclic Aryl Bioisosteres from Bicyclo[1.1.0]butanes.
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- Asian Journal of Organic Chemistry, 2024, v. 13, n. 5, p. 1, doi. 10.1002/ajoc.202400045
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- Article
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres.
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- Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00155
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- Article
Photoredox‐Catalyzed Decarboxylative Oxidation of Arylacetic Acids.
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- Chemistry - An Asian Journal, 2018, v. 13, n. 17, p. 2410, doi. 10.1002/asia.201800529
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- Article
Context-dependent similarity analysis of analogue series for structure–activity relationship transfer based on a concept from natural language processing.
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- Journal of Cheminformatics, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13321-025-00951-3
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- Article
High‐performance liquid chromatographic and subcritical fluid chromatographic separation of α‐arylated ß‐carboline, N‐alkylated tetrahydroisoquinolines and their bioisosteres on polysaccharide‐based chiral stationary phases
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- Journal of Separation Science, 2019, v. 42, n. 17, p. 2779, doi. 10.1002/jssc.201900228
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- Article
Melatonin and its bioisosteres as potential therapeutic agents for the treatment of retinopathy of prematurity.
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- Chemical Biology & Drug Design, 2024, v. 103, n. 3, p. 1, doi. 10.1111/cbdd.14504
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- Article
Bioisosteric modification on benzylidene‐carbonyl compounds improved the drug‐likeness and maintained the antifungal activity against Sporothrix brasiliensis.
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- Chemical Biology & Drug Design, 2022, v. 99, n. 3, p. 391, doi. 10.1111/cbdd.13994
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- Article
Functionalization of Cubane Formation of C−C and C−Heteroatom Bonds.
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- Helvetica Chimica Acta, 2024, v. 107, n. 2, p. 1, doi. 10.1002/hlca.202300200
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- Article
Routes to labeled tetrazoles (microreview).
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- Chemistry of Heterocyclic Compounds, 2016, v. 52, n. 8, p. 533, doi. 10.1007/s10593-016-1924-5
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- Article
In a search for selective inhibitors of carbonic anhydrases: coumarin and its bioisosteres - synthesis and derivatization.
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- Chemistry of Heterocyclic Compounds, 2015, v. 51, n. 7, p. 607, doi. 10.1007/s10593-015-1748-8
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Synthetic studies on the tetrasubstituted D-ring of cystobactamids lead to potent terephthalic acid antibiotics.
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- Communications Chemistry, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42004-024-01337-6
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- Article
A Review of Pharmacological Activities of [1,2,4]- Oxadiazoles.
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- International Journal of Pharmaceutical Research (09752366), 2020, p. 1299, doi. 10.31838/ijpr/2020.SP2.121
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- Article
Isocyanide–Based Multicomponent Reactions Coupled One–Pot Process: Efficient Tools to Diversity–Oriented Synthesis of Structural Peptidomimetics.
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- ChemPlusChem, 2024, v. 89, n. 6, p. 1, doi. 10.1002/cplu.202300633
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- Article
Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid.
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- Psychopharmacology, 2014, v. 231, n. 17, p. 3517, doi. 10.1007/s00213-014-3494-5
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- Article
Highly Efficient and Stereoselective Synthesis of 6,7‐Dideoxy‐β‐d‐ido‐octopyranuronates.
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- European Journal of Organic Chemistry, 2022, v. 2022, n. 32, p. 1, doi. 10.1002/ejoc.202200175
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- Article
Difluoromethyl Nitrile Oxide (CF<sub>2</sub>HCNO): A Neglected Chemical Reagent.
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- European Journal of Organic Chemistry, 2017, v. 2017, n. 27, p. 3935, doi. 10.1002/ejoc.201700764
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- Article
Synthesis and Biological Evaluation of Migrastatin Macrotriazoles.
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- European Journal of Organic Chemistry, 2017, v. 2017, n. 1, p. 60, doi. 10.1002/ejoc.201600988
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- Article
Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.
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- Chemical Biology & Drug Design, 2016, v. 88, n. 2, p. 178, doi. 10.1111/cbdd.12744
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- Article