Works about BIOISOSTERES

Results: 115

High‐performance liquid chromatographic and subcritical fluid chromatographic separation of α‐arylated ß‐carboline, N‐alkylated tetrahydroisoquinolines and their bioisosteres on polysaccharide‐based chiral stationary phases

Published in:

Journal of Separation Science, 2019, v. 42, n. 17, p. 2779, doi. 10.1002/jssc.201900228

By:

Bajtai, Attila;
Lajkó, Gyula;
Németi, Gábor;
Szatmári, István;
Fülöp, Ferenc;
Péter, Antal;
Ilisz, István

Publication type:

Article

Functionalization of Cubane Formation of C−C and C−Heteroatom Bonds.

Published in:

Helvetica Chimica Acta, 2024, v. 107, n. 2, p. 1, doi. 10.1002/hlca.202300200

By:

Yasukawa, Tomohiro;
Håheim, Katja S.;
Cossy, Janine

Publication type:

Article

BIOISOSTERS' IMPACT ON WINE CONDITIONING.

Published in:

Lucrari Stiintifice, Universitatea de Stiinte Agricole Si Medicina Veterinara Ion Ionescu de la Brad Iasi, Seria Horticultura, 2024, v. 67, n. 1, p. 97

By:

Roxana, TUCALIUC;
Ioana, BUȚERCHI;
Marius, NICULAUA;
V., COTEA Valeriu

Publication type:

Article

Structure-Based Evolution of Subtype-Selective Neurotensin Receptor Ligands.

Published in:

ChemistryOpen, 2014, v. 3, n. 5, p. 206, doi. 10.1002/open.201402031

By:

Schaab, Carolin;
Kling, Ralf Christian;
Einsiedel, Jürgen;
Hübner, Harald;
Clark, Tim;
Seebach, Dieter;
Gmeiner, Peter

Publication type:

Article

Acceleration of Binding Site Comparisons by Graph Partitioning.

Published in:

Molecular Informatics, 2015, v. 34, n. 8, p. 550, doi. 10.1002/minf.201500028

By:

Krotzky, Timo;
Klebe, Gerhard

Publication type:

Article

Bioisosteres and Scaffold Hopping in Medicinal Chemistry.

Published in:

Molecular Informatics, 2014, v. 33, n. 6/7, p. 458, doi. 10.1002/minf.201400037

By:

Brown, Nathan

Publication type:

Article

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors.

Published in:

Canadian Journal of Chemistry, 2016, v. 94, n. 3, p. 240, doi. 10.1139/cjc-2015-0475

By:

Petrella, Stéphanie;
Aubry, Alexandra;
Janvier, Geneviève;
Coutant, Eloi P.;
Cartier, Alex;
Dao, Thuy-Ha;
Bonhomme, Frédéric J.;
Motreff, Laurence;
Pissis, Cédric;
Bizet, Chantal;
Clermont, Dominique;
Begaud, Evelyne;
Retailleau, Pascal;
Munier-Lehmann, Hélène;
Capton, Estelle;
Mayer, Claudine;
Janin, Yves L.

Publication type:

Article

A BIOISOSTERES’ APPLICATION AS INTERNAL STANDARD FOR SIMULTANEOUS DETERMINATION OF THREE TRIAZINE ANTICOCCIDIAL CHEMICALS BY UPLC.

Published in:

Journal of Liquid Chromatography & Related Technologies, 2014, v. 37, n. 6, p. 786, doi. 10.1080/10826076.2012.758143

By:

Ma, Danpeng;
Xue, Feiqun;
Zhang, Lifang;
Fei, Chenzhong;
Zhang, Yue

Publication type:

Article

Physicochemical and Biological Evaluation of gem‐Difluorinated Saturated Oxygen Heterocycles as Bioisosteres for Drug Discovery.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 10, p. 1, doi. 10.1002/chem.202404390

By:

Melnykov, Kostiantyn P.;
Liashuk, Oleksandr S.;
Holovach, Serhii;
Shatnia, Valeriia;
Horbenko, Artur;
Lesyk, Dmytro;
Melnyk, Varvara;
Skrypnik, Daniil;
Beshtynarska, Anna;
Borysko, Petro;
Viniichuk, Oleksandr;
Grygorenko, Oleksandr O.

Publication type:

Article

Double Strain‐Release (3+3)‐Cycloaddition: Lewis Acid Catalyzed Reaction of Bicyclobutane Carboxylates and Aziridines.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 9, p. 1, doi. 10.1002/chem.202404099

By:

George, Malini;
Mindner, Jasper;
Wittmer, Silas;
Knyazev, Daniil A.;
Werz, Daniel B.

Publication type:

Article

3,3‐Difluorooxetane–A Versatile Functional Group for Bioisosteric Replacements in Drug Discovery.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 72, p. 1, doi. 10.1002/chem.202403277

By:

Liashuk, Oleksandr S.;
Fedinchyk, Anastasiya;
Melnykov, Kostiantyn P.;
Herasymchuk, Maksym;
Alieksieieva, Diana;
Lesyk, Dmytro;
Bas, Yuliia P.;
Keda, Tetiana Ye.;
Yatsymyrskiy, Andriy V.;
Holota, Yuliia;
Borysko, Petro;
Yarmolchuk, Volodymyr S.;
Grygorenko, Oleksandr O.

Publication type:

Article

Organometallic Bridge Diversification of Bicyclo[1.1.1]pentanes.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 12, p. 1, doi. 10.1002/chem.202304070

By:

Anderson, Joseph M.;
Poole, Darren L.;
Cook, Gemma C.;
Murphy, John A.;
Measom, Nicholas D.

Publication type:

Article

Scaffold Editing of Cubanes into Homocubanes, Homocuneanes via Cuneanes.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 9, p. 1, doi. 10.1002/chem.202303063

By:

Takebe, Hiyori;
Matsubara, Seijiro

Publication type:

Article

Cover Feature: Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration (Chem. Eur. J. 60/2021).

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 60, p. 14786, doi. 10.1002/chem.202103635

By:

Lutter, Ferdinand H.;
Jouffroy, Matthieu

Publication type:

Article

Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 60, p. 14816, doi. 10.1002/chem.202102130

By:

Lutter, Ferdinand H.;
Jouffroy, Matthieu

Publication type:

Article

Light‐Driven Synthesis and Functionalization of Bicycloalkanes, Cubanes and Related Bioisosteres.

Published in:

Angewandte Chemie, 2024, v. 136, n. 14, p. 1, doi. 10.1002/ange.202317333

By:

Cuadros, Sara;
Paut, Julien;
Anselmi, Elsa;
Dagousset, Guillaume;
Magnier, Emmanuel;
Dell'Amico, Luca

Publication type:

Article

1‐Azaspiro[3.3]heptane as a Bioisostere of Piperidine.

Published in:

Angewandte Chemie, 2023, v. 135, n. 51, p. 1, doi. 10.1002/ange.202311583

By:

Kirichok, Alexander A.;
Tkachuk, Hennadii;
Kozyriev, Yevhenii;
Shablykin, Oleh;
Datsenko, Oleksandr;
Granat, Dmitry;
Yegorova, Tetyana;
Bas, Yuliya P.;
Semirenko, Vitalii;
Pishel, Iryna;
Kubyshkin, Vladimir;
Lesyk, Dmytro;
Klymenko‐Ulianov, Oleksii;
Mykhailiuk, Pavel K.

Publication type:

Article

Rapid and Scalable Halosulfonylation of Strain‐Release Reagents.

Published in:

Angewandte Chemie, 2023, v. 135, n. 3, p. 1, doi. 10.1002/ange.202213508

By:

Pickford, Helena D.;
Ripenko, Vasyl;
McNamee, Ryan E.;
Holovchuk, Serhii;
Thompson, Amber L.;
Smith, Russell C.;
Mykhailiuk, Pavel K.;
Anderson, Edward A.

Publication type:

Article

Palladium‐Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes.

Published in:

Angewandte Chemie, 2022, v. 134, n. 41, p. 1, doi. 10.1002/ange.202208204

By:

Choi, Kyoungmin;
Mormino, Michael G.;
Kalkman, Eric D.;
Park, John;
Hartwig, John F.

Publication type:

Article

Beyond Bioisosteres: Divergent Synthesis of Azabicyclohexanes and Cyclobutenyl Amines from Bicyclobutanes.

Published in:

Angewandte Chemie, 2022, v. 134, n. 27, p. 1, doi. 10.1002/ange.202204719

By:

Dhake, Kushal;
Woelk, Kyla J.;
Becica, Joseph;
Un, Andy;
Jenny, Sarah E.;
Leitch, David C.

Publication type:

Article

Cross‐Electrophile C(sp2)−Si Coupling of Vinyl Chlorosilanes.

Published in:

Angewandte Chemie, 2020, v. 132, n. 51, p. 23283, doi. 10.1002/ange.202010737

By:

Duan, Jicheng;
Wang, Ke;
Xu, Guang‐Li;
Kang, Shaolin;
Qi, Liangliang;
Liu, Xue‐Yuan;
Shu, Xing‐Zhong

Publication type:

Article

Saturated Bioisosteres of ortho‐Substituted Benzenes.

Published in:

Angewandte Chemie, 2020, v. 132, n. 46, p. 20696, doi. 10.1002/ange.202004183

By:

Denisenko, Aleksandr;
Garbuz, Pavel;
Shishkina, Svetlana V.;
Voloshchuk, Nataliya M.;
Mykhailiuk, Pavel K.

Publication type:

Article

Divergent Strain‐Release Amino‐Functionalization of [1.1.1]Propellane with Electrophilic Nitrogen‐Radicals.

Published in:

Angewandte Chemie, 2020, v. 132, n. 21, p. 8302, doi. 10.1002/ange.202000140

By:

Kim, Ji Hye;
Ruffoni, Alessandro;
Al‐Faiyz, Yasair S. S.;
Sheikh, Nadeem S.;
Leonori, Daniele

Publication type:

Article

1,3‐Difunctionalizations of [1.1.1]Propellane via 1,2‐Metallate Rearrangements of Boronate Complexes.

Published in:

Angewandte Chemie, 2020, v. 132, n. 10, p. 3945, doi. 10.1002/ange.201914875

By:

Yu, Songjie;
Jing, Changcheng;
Noble, Adam;
Aggarwal, Varinder K.

Publication type:

Article

Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy‐amino‐λ6‐sulfanenitrile Intermediate.

Published in:

Angewandte Chemie, 2019, v. 131, n. 40, p. 14441, doi. 10.1002/ange.201906001

By:

Briggs, Edward L.;
Tota, Arianna;
Colella, Marco;
Degennaro, Leonardo;
Luisi, Renzo;
Bull, James A.

Publication type:

Article

Enantioselective, Catalytic Vicinal Difluorination of Alkenes.

Published in:

Angewandte Chemie, 2018, v. 130, n. 50, p. 16669, doi. 10.1002/ange.201810328

By:

Scheidt, Felix;
Schäfer, Michael;
Sarie, Jérôme C.;
Daniliuc, Constantin G.;
Molloy, John J.;
Gilmour, Ryan

Publication type:

Article

Diastereocontrolled Monoprotodeboronation of β‐Sulfinimido gem‐Bis(boronates): A General and Stereoselective Route to α,β‐Disubstituted β‐Aminoalkylboronates.

Published in:

Angewandte Chemie, 2018, v. 130, n. 32, p. 10461, doi. 10.1002/ange.201804277

By:

Li, Xiangyu;
Hall, Dennis G.

Publication type:

Article

Berichtigung: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.

Published in:

Angewandte Chemie, 2018, v. 130, n. 28, p. 8491, doi. 10.1002/ange.201711161

By:

Chalmers, Benjamin A.;
Xing, Hui;
Houston, Sevan;
Clark, Charlotte;
Ghassabian, Sussan;
Kuo, Andy;
Cao, Benjamin;
Reitsma, Andrea;
Murray, Cody‐Ellen P.;
Stok, Jeanette E.;
Boyle, Glen M.;
Pierce, Carly J.;
Littler, Stuart W.;
Winkler, David A.;
Bernhardt, Paul V.;
Pasay, Cielo;
De Voss, James J.;
McCarthy, James;
Parsons, Peter G.;
Walter, Gimme H.

Publication type:

Article

Deconstruction – Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2021, v. 55, p. 1, doi. 10.33594/00000033

By:

Ritter, Nadine;
Korff, Marvin;
Markus, Alexander;
Schepmann, Dirk;
Seebohm, Guiscard;
Schreiber, Julian A.;
Wünsch, Bernhard

Publication type:

Article

In silico design of sitagliptin bioisosteres as new inhibitors of Mpro SARS-CoV-2.

Published in:

Journal of Applied Pharmaceutical Science, 2024, v. 14, n. 12, p. 145, doi. 10.7324/JAPS.2024.192856

By:

Abad-Giron, Abelardo;
Asmad-Cruz, Lucero;
Cordova-Muñoz, Angella M.;
Gamarra-Sanchez, Cesar D.;
Silva-Correa, Carmen R.;
Villarreal-La Torre, Víctor E.

Publication type:

Article

In silico design of new ketorolac bioisosteres as anti-inflammatory agents.

Published in:

Journal of Applied Pharmaceutical Science, 2024, v. 14, n. 4, p. 155, doi. 10.7324/JAPS.2024.162337

By:

Gamarra-Sánchez, César D.;
Rodriguez-Silva, Cristhian N.;
Cordova-Muñoz, Angella;
Asmad-Cruz, Lucero;
Silva-Correa, Carmen R.;
Villarreal-La Torre, Víctor E.

Publication type:

Article

Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors.

Published in:

Pharmaceutics, 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/pharmaceutics14040715

By:

Luque-Navarro, Pilar María;
Mariotto, Elena;
Ballarotto, Marco;
Rubbini, Gianluca;
Aguilar-Troyano, Francisco José;
Fasiolo, Alberto;
Torretta, Archimede;
Parisini, Emilio;
Macchiarulo, Antonio;
Laso, Alejandro;
Marco, Carmen;
Viola, Giampietro;
Carrasco-Jimenez, María Paz;
López-Cara, Luisa Carlota

Publication type:

Article

First International Electronic Conference on Medicinal Chemistry (ECMC-1).

Published in:

Pharmaceuticals (14248247), 2016, v. 9, n. 1, p. 14, doi. 10.3390/ph9010014

By:

Mayence, Annie;
Vanden Eynde, Jean Jacques

Publication type:

Article

1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015).

Published in:

Pharmaceuticals (14248247), 2016, v. 9, n. 1, p. 1, doi. 10.3390/ph9010001

By:

Le Borgne, Marc;
Haidar, Samer;
Duval, Olivier;
Wünsch, Bernhard;
Jose, Joachim

Publication type:

Article

Fragrances of Cage Bicyclic Benzene Bioisosteres.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 22, p. 1, doi. 10.1002/chem.202404716

By:

O'Donohue, Grace R. M.;
Chow, Sharon;
Houston, Sevan D.;
Nguyen, Thoa T. L.;
Paul Savage, G.;
Smyth, Heather E.;
Williams, Craig M.

Publication type:

Article

Enzymatic Synthesis of Saturated Bioisosteres of Ortho‐Substituted Benzenes by Artificial Photoenzyme.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 20, p. 1, doi. 10.1002/chem.202404519

By:

Bai, Yuting;
Sheng, Yuhui;
Fu, Yi;
Zhou, Zhi;
Wu, Jing

Publication type:

Article

Routes to labeled tetrazoles (microreview).

Published in:

Chemistry of Heterocyclic Compounds, 2016, v. 52, n. 8, p. 533, doi. 10.1007/s10593-016-1924-5

By:

Leduskrasts, Kaspars

Publication type:

Article

In a search for selective inhibitors of carbonic anhydrases: coumarin and its bioisosteres - synthesis and derivatization.

Published in:

Chemistry of Heterocyclic Compounds, 2015, v. 51, n. 7, p. 607, doi. 10.1007/s10593-015-1748-8

By:

Žalubovskis, Raivis

Publication type:

Article

Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2022, v. 37, n. 1, p. 1514, doi. 10.1080/14756366.2022.2077731

By:

Zhi Li;
Lijuan Kou;
Xinzhen Fu;
Zeping Xie;
Maolei Xu;
Lin Guo;
Tiantian Lin;
Shizhou Gong;
Shumin Zhang;
Ming Liu

Publication type:

Article

1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A 2 α and fatty acid amide hydrolase: bioisosteric replacement of the carboxylic acid moiety.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, p. 131, doi. 10.1080/14756366.2016.1178246

By:

Althaus, Jan;
Hake, Theresa;
Hanekamp, Walburga;
Lehr, Matthias

Publication type:

Article

Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 1, p. 121, doi. 10.3109/14756366.2015.1005012

By:

Puskullu, M. Orhan;
Shirinzadeh, Hanif;
Nenni, Merve;
Gurer-Orhan, Hande;
Suzen, Sibel

Publication type:

Article

Synthesis and antitumor activities of 3-substituted-analine derivatives: structure modifications of Tuv part of tubulysins.

Published in:

Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0483-5

By:

Shao, Mingsha;
Bai, Xinfa;
Ma, Xuan;
Yan, Ning;
Yao, Lei

Publication type:

Article

Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 3, p. 1375, doi. 10.3390/ijms25031375

By:

Müller, Patrick;
Zimmer, Collin;
Frey, Ariane;
Holzmann, Gideon;
Weldert, Annabelle Carolin;
Schirmeister, Tanja

Publication type:

Article

Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8259, doi. 10.3390/ijms23158259

By:

Xu, Kuiying;
Hsieh, Chia-Ju;
Lee, Ji Youn;
Riad, Aladdin;
Izzo, Nicholas J.;
Look, Gary;
Catalano, Susan;
Mach, Robert H.

Publication type:

Article

Non-Classical Inhibition of Carbonic Anhydrase.

Published in:

International Journal of Molecular Sciences, 2016, v. 17, n. 7, p. 1150, doi. 10.3390/ijms17071150

By:

Lomelino, Carrie L.;
Supuran, Claudiu T.;
McKenna, Robert

Publication type:

Article

A Review of Pharmacological Activities of [1,2,4]- Oxadiazoles.

Published in:

International Journal of Pharmaceutical Research (09752366), 2020, p. 1299, doi. 10.31838/ijpr/2020.SP2.121

By:

AGGARWAL, SUNAINA;
GOYAL, ANJU;
KAUR, RAJWINDER;
SINGH, GURDYAL

Publication type:

Article

Visualizing GABA transporters in vivo: an overview of reported radioligands and future directions.

Published in:

EJNMMI Research, 2023, v. 13, n. 1, p. 1, doi. 10.1186/s13550-023-00992-5

By:

Knippenberg, Niels;
Bauwens, Matthias;
Schijns, Olaf;
Hoogland, Govert;
Florea, Alexandru;
Rijkers, Kim;
Cleij, Thomas J.;
Eersels, Kasper;
van Grinsven, Bart;
Diliën, Hanne

Publication type:

Article

Difluoromethyl Nitrile Oxide (CF2HCNO): A Neglected Chemical Reagent.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 27, p. 3935, doi. 10.1002/ejoc.201700764

By:

Khutorianskyi, Andrii;
Chalyk, Bohdan;
Borysko, Petro;
Kondratiuk, Anna;
Mykhailiuk, Pavel K.

Publication type:

Article

Synthesis and Biological Evaluation of Migrastatin Macrotriazoles.

Published in:

European Journal of Organic Chemistry, 2017, v. 2017, n. 1, p. 60, doi. 10.1002/ejoc.201600988

By:

Gabba, Adele;
Robakiewicz, Stefania;
Taciak, Bartłomiej;
Ulewicz, Katarzyna;
Broggini, Gianluigi;
Rastelli, Giulio;
Krol, Magadalena;
Murphy, Paul V.;
Passarella, Daniele

Publication type:

Article

4′-Selenonucleosides as Next-Generation Nucleosides.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 28, p. 6115, doi. 10.1002/ejoc.201500429

By:

Sahu, Pramod K.;
Naik, Siddhi D.;
Yu, Jinha;
Jeong, Lak Shin

Publication type:

Article