Works matching DE "ATAXIN"

Results: 51

Circadian rhythms: Translating time-keeping.

Published in:

Nature Reviews Neuroscience, 2013, v. 14, n. 7, p. 456, doi. 10.1038/nrn3535

By:

Yates, Darran

Publication type:

Article

Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum.

Published in:: Journal of Biomedical Science, 2012, v. 19, n. 1, p. 41, doi. 10.1186/1423-0127-19-41
Publication type:: Article

Expanded and Wild-type Ataxin-3 Modify the Redox Status of SH-SY5Y Cells Overexpressing α-Synuclein.

Published in:

Neurochemical Research, 2017, v. 42, n. 5, p. 1430, doi. 10.1007/s11064-017-2199-7

By:

Noronha, Carolina;
Perfeito, Rita;
Laço, Mário;
Wüllner, Ullrich;
Rego, A.

Publication type:

Article

Changes in Ataxin-10 Expression after Sciatic Nerve Crush in Adult Rats.

Published in:

Neurochemical Research, 2013, v. 38, n. 5, p. 1013, doi. 10.1007/s11064-013-1011-6

By:

Cheng, Xinghai;
Gan, Lin;
Zhao, Jing;
Chen, Minhao;
Liu, Yang;
Wang, Youhua

Publication type:

Article

Author Correction: Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation.

Published in:

2020

By:

Hong, Jun-Ye;
Xue, Wei;
Yue, Hong-Wei;
Yang, Hui;
Jiang, Lei-Lei;
Hu, Hong-Yu;
Wang, Dong-Dong;
Wang, Wen-Ning

Publication type:

Correction Notice

Comparative Genetics of the Poly-Q Tract of Ataxin-1 and Its Binding Protein PQBP-1.

Published in:

Biochemical Genetics, 2012, v. 50, n. 3/4, p. 309, doi. 10.1007/s10528-011-9473-1

By:

Kurosaki, Tatsuaki;
Gojobori, Jun;
Ueda, Shintaroh

Publication type:

Article

RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.

Published in:

Nature, 2013, v. 498, n. 7454, p. 325, doi. 10.1038/nature12204

By:

Park, Jeehye;
Al-Ramahi, Ismael;
Tan, Qiumin;
Mollema, Nissa;
Diaz-Garcia, Javier R.;
Gallego-Flores, Tatiana;
Lu, Hsiang-Chih;
Lagalwar, Sarita;
Duvick, Lisa;
Kang, Hyojin;
Lee, Yoontae;
Jafar-Nejad, Paymaan;
Sayegh, Layal S.;
Richman, Ronald;
Liu, Xiuyun;
Gao, Yan;
Shaw, Chad A.;
Arthur, J. Simon C.;
Orr, Harry T.;
Westbrook, Thomas F.

Publication type:

Article

Epigenetics DNA methylation in the core ataxin-2 gene promoter: novel physiological and pathological implications.

Published in:

Human Genetics, 2012, v. 131, n. 4, p. 625, doi. 10.1007/s00439-011-1101-y

By:

Laffita-Mesa, José;
Bauer, Peter;
Kourí, Vivian;
Peña Serrano, Leodani;
Roskams, Jane;
Almaguer Gotay, Dennis;
Montes Brown, Julio;
Martínez Rodríguez, Pedro;
González-Zaldívar, Yanetza;
Almaguer Mederos, Luís;
Cuello-Almarales, Dany;
Aguiar Santiago, Jorge

Publication type:

Article

Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate-length CAG repeat expansions in Ataxin-2 does not have 1 C2-positive polyglutamine inclusions.

Published in:

Neuropathology & Applied Neurobiology, 2016, v. 42, n. 4, p. 377, doi. 10.1111/nan.12254

By:

Highley, John Robin;
Lorente Pons, Alejandro;
Cooper‐Knock, Johnathan;
Wharton, Stephen B.;
Ince, Paul G.;
Shaw, Pamela J.;
Wood, Jon;
Kirby, Janine

Publication type:

Article

Enzymatic production of mono‐ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin‐3.

Published in:

FEBS Open Bio, 2013, v. 3, n. 1, p. 453, doi. 10.1016/j.fob.2013.10.005

By:

Faggiano, Serena;
Menon, Rajesh P.;
Kelly, Geoff P.;
McCormick, John;
Todi, Sokol V.;
Scaglione, K. Matthew;
Paulson, Henry L.;
Pastore, Annalisa

Publication type:

Article

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0147515

By:

He, Wen-Tian;
Zheng, Xue-Ming;
Zhang, Yu-Hang;
Gao, Yong-Guang;
Song, Ai-Xin;
van der Goot, Françoise Gisou;
Hu, Hong-Yu

Publication type:

Article

Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model.

Published in:

BMC Neuroscience, 2012, v. 13, n. 1, p. 86, doi. 10.1186/1471-2202-13-86

By:

Ajayi, Abiodun;
Xin Yu;
Lindberg, Staffan;
Langel, ï¿½lo;
Strï¿½m, Anna-Lena

Publication type:

Article

Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis.

Published in:

Scientific Reports, 2015, p. 8360, doi. 10.1038/srep08360

By:

Tian, Jie;
Tian, Chuan;
Ding, Yuehe;
Li, Zhe;
Geng, Qizhi;
Xiahou, Zhikai;
Wang, Jue;
Hou, Wenya;
Liao, Ji;
Dong, Meng-Qiu;
Xu, Xingzhi;
Li, Jing

Publication type:

Article

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

Published in:

2017

By:

Weber, Jonasz J.;
Golla, Matthias;
Guaitoli, Giambattista;
Wanichawan, Pimthanya;
Hayer, Stefanie N.;
Hauser, Stefan;
Krah, Ann-Christin;
Nage, Maike;
Samer, Sebastian;
Aronica, Eleonora;
Carlson, Cathrine R.;
Schö, Ludger;
Riess, Olaf;
Gloeckner, Christian J.;
Nguyen, Huu P.;
Hübener-Schmid, Jeannette;
Krahl, Ann-Christin;
Nagel, Maike;
Schöls, Ludger

Publication type:

journal article

Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy.

Published in:

2015

By:

Keiser, Megan S.;
Kordower, Jeffrey H.;
Gonzalez-Alegre, Pedro;
Davidson, Beverly L.

Publication type:

journal article

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.

Published in:

2015

By:

Nóbrega, Clévio;
Carmo-Silva, Sara;
Albuquerque, David;
Vasconcelos-Ferreira, Ana;
Vijayakumar, Udaya-Geetha;
Mendonça, Liliana;
Hirai, Hirokazu;
de Almeida, Luís Pereira;
Pereira de Almeida, Luís

Publication type:

journal article

Interferon beta induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice.

Published in:

Brain: A Journal of Neurology, 2013, v. 136, n. 6, p. 1732, doi. 10.1093/brain/awt061

By:

Chort, Alice;
Alves, Sandro;
Marinello, Martina;
Dufresnois, Béatrice;
Dornbierer, Jean-Gabriel;
Tesson, Christelle;
Latouche, Morwena;
Baker, Darren P.;
Barkats, Martine;
El Hachimi, Khalid H.;
Ruberg, Merle;
Janer, Alexandre;
Stevanin, Giovanni;
Brice, Alexis;
Sittler, Annie

Publication type:

Article

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado–Joseph disease.

Published in:

Brain: A Journal of Neurology, 2012, v. 135, n. 8, p. 2428, doi. 10.1093/brain/aws177

By:

Simões, Ana T.;
Gonçalves, Nélio;
Koeppen, Arnulf;
Déglon, Nicole;
Kügler, Sebastian;
Duarte, Carlos Bandeira;
Pereira de Almeida, Luís

Publication type:

Article

Correction: ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics.

Published in:

2016

By:

Stubenvoll, Michael D.;
Medley, Jeffrey C.;
Irwin, Miranda;
Song, Mi Hye

Publication type:

Correction Notice

Spinocerebellar ataxia type-7: Report of a family in Northwest Nigeria.

Published in:

Annals of African Medicine, 2016, v. 15, n. 2, p. 87, doi. 10.4103/1596-3519.176205

By:

Hamidu Alkali, Nura;
Bwala, Sunday A.;
Alimi, Saeed A.;
Oyakhire, Shyngle I.

Publication type:

Article

FTLD-ALS of TDP-43 type and SCA2 in a family with a full ataxin-2 polyglutamine expansion.

Published in:

2014

By:

Bäumer, Dirk;
East, Simon;
Tseu, Bing;
Zeman, Adam;
Hilton, David;
Talbot, Kevin;
Ansorge, Olaf

Publication type:

Report

Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions.

Published in:

Acta Neuropathologica, 2012, v. 124, n. 2, p. 221, doi. 10.1007/s00401-012-0985-5

By:

Hart, Michael;
Brettschneider, Johannes;
Lee, Virginia;
Trojanowski, John;
Gitler, Aaron

Publication type:

Article

CASO FEMENINO DE ATAXIA ESPINOCEREBELOSA TIPO 10 CON CONDUCTA SUICIDA Y ENDOCRINOPATÍAS ASOCIADAS A LA EXPANSIÓN MASIVA (ATTCT)N DEL GEN ATXN10.

Published in:

2022

By:

Ramirez-Garcia, Sergio A.;
Sánchez-Corona, José;
Volpini-Bertran, Víctor;
Cristina Moran-Moguel, Maria;
Gutiérrez-Rubio, Susan A.;
Castañeda-Cisneros, Gema;
Jiménez-Gil, Javier;
Garcia-Cruz, Diana

Publication type:

Letter to the Editor

Pathogenic polyglutamine expansion length correlates with polarity of the flanking sequences.

Published in:

Molecular Neurodegeneration, 2014, v. 9, n. 1, p. 1, doi. 10.1186/1750-1326-9-45

By:

Meewhi Kim

Publication type:

Article

Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model.

Published in:

Molecular Neurodegeneration, 2013, v. 8, n. 1, p. 1, doi. 10.1186/1750-1326-8-42

By:

Duncan, Carlotta E.;
An, Mahru C.;
Papanikolaou, Theodora;
Rugani, Caitlin;
Vitelli, Cathy;
Ellerby, Lisa M.

Publication type:

Article

The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129727

By:

Bonanomi, Marcella;
Visentin, Cristina;
Invernizzi, Gaetano;
Tortora, Paolo;
Regonesi, Maria Elena

Publication type:

Article

Internal Ribosome Entry Segment Activity of <i>ATXN8</i> Opposite Strand RNA.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0073885

By:

Chen, I-Cheng;
Lin, Hsuan-Yuan;
Hsiao, Ya-Chin;
Chen, Chiung-Mei;
Wu, Yih-Ru;
Shiau, Hsin-Chieh;
Shen, Yu-Fang;
Huang, Kuo-Shiu;
Su, Ming-Tsan;
Hsieh-Li, Hsiu-Mei;
Lee-Chen, Guey-Jen

Publication type:

Article

<i>De Novo</i> Mutations in Ataxin-2 Gene and ALS Risk.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070560

By:

Laffita-Mesa, José Miguel;
Rodríguez Pupo, Jorge Michel;
Moreno Sera, Raciel;
Vázquez Mojena, Yaimee;
Kourí, Vivian;
Laguna-Salvia, Leonides;
Martínez-Godales, Michael;
Valdevila Figueira, José A.;
Bauer, Peter O.;
Rodríguez-Labrada, Roberto;
Zaldívar, Yanetza González;
Paucar, Martin;
Svenningsson, Per;
Pérez, Luís Velázquez

Publication type:

Article

Cerebellar Soluble Mutant Ataxin-3 Level Decreases during Disease Progression in Spinocerebellar Ataxia Type 3 Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062043

By:

Nguyen, Huu Phuc;
Hübener, Jeannette;
Weber, Jonasz Jeremiasz;
Grueninger, Stephan;
Riess, Olaf;
Weiss, Andreas

Publication type:

Article

Requirement for Zebrafish Ataxin-7 in Differentiation of Photoreceptors and Cerebellar Neurons.

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0050705

By:

Yanicostas, Constantin;
Barbieri, Elisa;
Hibi, Masahiko;
Brice, Alexis;
Stevanin, Giovanni;
Soussi-Yanicostas, Nadia

Publication type:

Article

Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0043563

By:

Laço, Mário N.;
Cortes, Luisa;
Travis, Sue M.;
Paulson, Henry L.;
Rego, A. Cristina;
Opal, Puneet

Publication type:

Article

ATXN2 and Its Neighbouring Gene SH2B3 Are Associated with Increased ALS Risk in the Turkish Population.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042956

By:

Lahut, Suna;
Ömür, Özgür;
Uyan, Özgün;
Ağım, Zeynep Sena;
Özoğuz, Aslihan;
Parman, Yeşim;
Deymeer, Feza;
Oflazer, Piraye;
Koç, Filiz;
Özçelik, Hilmi;
Auburger, Georg;
Başak, A. Nazlı;
Veitia, Reiner Albert

Publication type:

Article

Co-Chaperone HSJ1a Dually Regulates the Proteasomal Degradation of Ataxin-3.

Published in:

PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0019763

By:

Xue-Chao Gao;
Chen-Jie Zhou;
Zi-Ren Zhou;
Yu-Hang Zhang;
Xue-Ming Zheng;
Ai-Xin Song;
Hong-Yu Hu

Publication type:

Article

Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics.

Published in:

Biology Direct, 2017, v. 12, p. 1, doi. 10.1186/s13062-016-0173-y

By:

Grasso, Gianvito;
Tuszynski, Jack A.;
Morbiducci, Umberto;
Licandro, Ginevra;
Danani, Andrea;
Deriu, Marco A.

Publication type:

Article

ALS-Associated Ataxin 2 PolyQ Expansions Enhance Stress-Induced Caspase 3 Activation and Increase TDP-43 Pathological Modifications.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 27, p. 9133, doi. 10.1523/JNEUROSCI.0996-12.2012

By:

Hart, Michael P.;
Gitler, Aaron D.

Publication type:

Article

Rad51C-ATXN7 fusion gene expression in colorectal tumors.

Published in:

Molecular Cancer, 2016, v. 15, p. 1, doi. 10.1186/s12943-016-0527-1

By:

Kalvala, Arjun;
Li Gao;
Aguila, Brittany;
Dotts, Kathleen;
Rahman, Mohammad;
Nana-Sinkam, Serge P.;
Xiaoping Zhou;
Qi-En Wang;
Amann, Joseph;
Otterson, Gregory A.;
Villalona-Calero, Miguel A.;
Wenrui Duan

Publication type:

Article

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model.

Published in:

PLoS Genetics, 2015, v. 11, n. 4, p. 1, doi. 10.1371/journal.pgen.1005182

By:

Dansithong, Warunee;
Paul, Sharan;
Figueroa, Karla P.;
Rinehart, Marc D.;
Wiest, Shaina;
Pflieger, Lance T.;
Scoles, Daniel R.;
Pulst, Stefan M.

Publication type:

Article

Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery.

Published in:

PLoS Genetics, 2013, v. 9, n. 3, p. 1, doi. 10.1371/journal.pgen.1003359

By:

Kahle, Juliette J.;
Souroullas, George P.;
Yu, Peng;
Zohren, Fabian;
Lee, Yoontae;
Shaw, Chad A.;
Zoghbi, Huda Y.;
Goodell, Margaret A.

Publication type:

Article

The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.

Published in:

PLoS Biology, 2016, v. 14, n. 11, p. 1, doi. 10.1371/journal.pbio.2000733

By:

Liu, Hongmei;
Li, Xiaoling;
Ning, Guozhu;
Zhu, Shu;
Ma, Xiaolu;
Liu, Xiuli;
Liu, Chunying;
Huang, Min;
Schmitt, Ina;
Wüllner, Ullrich;
Niu, Yamei;
Guo, Caixia;
Wang, Qiang;
Tang, Tie-Shan

Publication type:

Article

Inhibition of Transglutaminase Exacerbates Polyglutamine-Induced Neurotoxicity by Increasing the Aggregation of Mutant Ataxin-3 in an SCA3 Drosophila Model.

Published in:

Neurotoxicity Research, 2015, v. 27, n. 3, p. 259, doi. 10.1007/s12640-014-9506-8

By:

Lin, Yunting;
He, Hua;
Luo, Yingying;
Zhu, Ting;
Duan, Ranhui

Publication type:

Article

Ataxin-2: From RNA Control to Human Health and Disease.

Published in:

Genes, 2017, v. 8, n. 6, p. 157, doi. 10.3390/genes8060157

By:

Ostrowski, Lauren A.;
Hall, Amanda C.;
Mekhail, Karim

Publication type:

Article

Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells.

Published in:

Genes, 2016, v. 7, n. 12, p. 132, doi. 10.3390/genes7120132

By:

Fiszer, Agnieszka;
Wroblewska, Joanna P.;
Nowak, Bartosz M.;
Krzyzosiak, Wlodzimierz J.

Publication type:

Article

Transgenic Models of Spinocerebellar Ataxia Type 10: Modeling a Repeat Expansion Disorder.

Published in:

Genes, 2012, v. 3, n. 3, p. 481, doi. 10.3390/genes3030481

By:

McFarland, Karen N.;
Ashizawa, Tetsuo

Publication type:

Article

ATXN8 −62 G/A promoter polymorphism and risk of Taiwanese Parkinson's disease.

Published in:

European Journal of Neurology, 2012, v. 19, n. 11, p. 1462, doi. 10.1111/j.1468-1331.2012.03749.x

By:

Chen, I.-C.;
Wu, Y.-R.;
Yang, S.-J.;
Kao, S.-H.;
Chen, Y.-C.;
Chang, K.-H.;
Lee, C.-M.;
Lee-Chen, G.-J.;
Chen, C.-M.

Publication type:

Article

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.

Published in:

Molecular Neurodegeneration, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0261-9

By:

Toonen, Lodewijk J. A.;
Overzier, Maurice;
Evers, Melvin M.;
Leon, Leticia G.;
van der Zeeuw, Sander A. J.;
Mei, Hailiang;
Kielbasa, Szymon M.;
Goeman, Jelle J.;
Hettne, Kristina M.;
Magnusson, Olafur Th.;
Poirel, Marion;
Seyer, Alexandre;
't Hoen, Peter A. C.;
van Roon-Mom, Willeke M. C.

Publication type:

Article

Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins.

Published in:

Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0123-2

By:

Alves, Sandro;
Marais, Thibaut;
Biferi, Maria-Grazia;
Furling, Denis;
Marinello, Martina;
Hachimi, Khalid El;
Cartier, Nathalie;
Ruberg, Merle;
Stevanin, Giovanni;
Brice, Alexis;
Barkats, Martine;
Sittler, Annie

Publication type:

Article

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.

Published in:

Nature Genetics, 2014, v. 46, n. 2, p. 152, doi. 10.1038/ng.2853

By:

Kim, Hyung-Jun;
Raphael, Alya R;
LaDow, Eva S;
McGurk, Leeanne;
Weber, Ross A;
Trojanowski, John Q;
Lee, Virginia M-Y;
Finkbeiner, Steven;
Gitler, Aaron D;
Bonini, Nancy M

Publication type:

Article

Nonallele Specific Silencing of Ataxin-7 Improves Disease Phenotypes in a Mouse Model of SCA7.

Published in:

Molecular Therapy, 2014, v. 22, n. 9, p. 1635, doi. 10.1038/mt.2014.108

By:

Ramachandran, Pavitra S;
Boudreau, Ryan L;
Schaefer, Kellie A;
La Spada, Albert R;
Davidson, Beverly L

Publication type:

Article

Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.

Published in:

Cerebellum, 2013, v. 12, n. 3, p. 338, doi. 10.1007/s12311-012-0430-2

By:

Hsieh, Mingli;
Chang, Wei-Hsiu;
Hsu, Chi-Fu;
Nishimori, Isao;
Kuo, Cheng-Liang;
Minakuchi, Tomoko

Publication type:

Article

Sequence Analysis of 5′ Regulatory Regions of the Machado-Joseph Disease Gene ( ATXN3).

Published in:

Cerebellum, 2012, v. 11, n. 4, p. 1045, doi. 10.1007/s12311-012-0373-7

By:

Bettencourt, Conceição;
Raposo, Mafalda;
Kazachkova, Nadiya;
Santos, Cristina;
Kay, Teresa;
Vasconcelos, João;
Maciel, Patrícia;
Donis, Karina;
Saraiva-Pereira, Maria;
Jardim, Laura;
Sequeiros, Jorge;
Bruges-Armas, Jácome;
Lima, Manuela

Publication type:

Article