Works matching DE "ANDROSTANE receptors"

Results: 168

Bilirubin as a signaling molecule.

Published in:

Medicinal Research Reviews, 2020, v. 40, n. 4, p. 1335, doi. 10.1002/med.21660

By:

Vítek, Libor

Publication type:

Article

Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver.

Published in:

Journal of the Endocrine Society, 2022, v. 6, n. 12, p. 1, doi. 10.1210/jendso/bvac145

By:

Sen, Anushna;
Goforth, Madison;
Cooper, Kerry K;
Anakk, Sayeepriyadarshini

Publication type:

Article

MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks.

Published in:

Drug Metabolism Reviews, 2015, v. 47, n. 2, p. 191, doi. 10.3109/03602532.2015.1007012

By:

Li, Wenbin;
Li, Jing;
Wang, Rong;
Xie, Hua;
Jia, Zhengping

Publication type:

Article

Sulfotransferase genes: Regulation by nuclear receptors in response to xeno/endo-biotics.

Published in:

Drug Metabolism Reviews, 2013, v. 45, n. 4, p. 441, doi. 10.3109/03602532.2013.835630

By:

Kodama, Susumu;
Negishi, Masahiko

Publication type:

Article

Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR).

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.620197

By:

Niu, Congrong;
Smith, Bill;
Lai, Yurong

Publication type:

Article

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.574176

By:

Duan, Ya-bin;
Zhu, Jun-bo;
Yang, Jian-xin;
Liu, Gui-qin;
Bai, Xue;
Qu, Ning;
Wang, Xue-jun;
Li, Xiang-yang

Publication type:

Article

miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells.

Published in:

Oncogene, 2014, v. 33, n. 28, p. 3717, doi. 10.1038/onc.2013.330

By:

Takwi, A A;
Wang, Y-M;
Wu, J;
Michaelis, M;
Cinatl, J;
Chen, T

Publication type:

Article

Timosaponin AⅢ induces drug-metabolizing enzymes by activating constitutive androstane receptor (CAR) via dephosphorylation of the EGFR signaling pathway.

Published in:

Journal of Biomedical Research, 2024, v. 38, n. 4, p. 382, doi. 10.7555/JBR.38.20240055

By:

Hafiz, Muhammad Zubair;
Jie Pan;
Zhiwei Gao;
Ying Huo;
Haobin Wang;
Wei Liu;
Jian Yang

Publication type:

Article

Assessment of cytochrome P450 induction in canine intestinal organoid models.

Published in:

Xenobiotica, 2024, v. 54, n. 5, p. 217, doi. 10.1080/00498254.2024.2326973

By:

Nagao, Itsuma;
Nakazawa, Meg;
Goyama, Takashi;
Court, Michael H.;
Ambrosini, Yoko M.

Publication type:

Article

Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2.

Published in:

Xenobiotica, 2022, v. 52, n. 4, p. 389, doi. 10.1080/00498254.2022.2079441

By:

Li, Yuhua;
Liao, Zhengzheng;
Wei, Xiaohua;
Xiao, Xiong;
Hu, Jinfang

Publication type:

Article

A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.

Published in:

Xenobiotica, 2021, v. 51, n. 7, p. 752, doi. 10.1080/00498254.2021.1918800

By:

Li, Han;
Wang, Yu-Guang;
Ma, Zeng-Chun;
Yun-Hang, Gao;
Ling, Song;
Teng-Fei, Chen;
Guang-Ping, Zhang;
Gao, Yue

Publication type:

Article

Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system.

Published in:

Xenobiotica, 2020, v. 50, n. 6, p. 654, doi. 10.1080/00498254.2019.1683258

By:

Taniguchi, Mariko;
Miyamoto, Hirotaka;
Tokunaga, Ayako;
Fumoto, Shintaro;
Tanaka, Takashi;
Nishida, Koyo

Publication type:

Article

Porcine interleukin-6 enhances the expression of CYP2C33 through a constitutive androstane receptor/retinoid X receptor-mediated pathway.

Published in:

Xenobiotica, 2019, v. 49, n. 3, p. 257, doi. 10.1080/00498254.2018.1438686

By:

Xie, Lixia;
He, Yucheng;
Zhou, Xiaoqiao;
Li, Xiaowen;
Jin, Xiue;
Wang, Xiliang;
Shi, Deshi

Publication type:

Article

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats.

Published in:

Xenobiotica, 2019, v. 49, n. 2, p. 227, doi. 10.1080/00498254.2018.1437300

By:

Haines, Corinne;
Chatham, Lynsey R.;
Vardy, Audrey;
Elcombe, Clifford R.;
Foster, John R.;
Lake, Brian G.

Publication type:

Article

Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.

Published in:

Journal of Toxicological Sciences, 2017, v. 42, n. 6, p. 773, doi. 10.2131/jts.42.773

By:

Yu Okuda;
Masahiko Kushida;
Hiroko Kikumoto;
Yoshimasa Nakamura;
Hashihiro Higuchi;
Satoshi Kawamura;
Cohen, Samuel M.;
Lake, Brian G.;
Tomoya Yamada

Publication type:

Article

A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice.

Published in:

Journal of Toxicological Sciences, 2016, v. 41, n. 6, p. 801, doi. 10.2131/jts.41.801

By:

Kei Tamura;
Kaoru Inoue;
Miwa Takahashi;
Saori Matsuo;
Yukio Kodama;
Midori Yoshida

Publication type:

Article

Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARa activities.

Published in:

Journal of Toxicological Sciences, 2016, v. 41, n. 5, p. 677, doi. 10.2131/jts.41.677

By:

Chieri Fujino;
Yuki Tamura;
Satoko Tange;
Hiroyuki Nakajima;
Seigo Sanoh;
Yoko Watanabe;
Naoto Uramaru;
Hiroyuki Kojima;
Kouichi Yoshinari;
higeru Ohta;
Shigeyuki Kitamura

Publication type:

Article

Dose-dependent difference of nuclear receptors involved in murine liver hypertrophy by piperonyl butoxide.

Published in:

Journal of Toxicological Sciences, 2015, v. 40, n. 6, p. 787, doi. 10.2131/jts.40.787

By:

Yohei Sakamoto;
Midori Yoshida;
Kei Tamura;
Miwa Takahashi;
Yukio Kodama;
Kaoru Inoue

Publication type:

Article

T0901317, a potent LXR agonist, is an inverse agonist of CAR.

Published in:

Journal of Toxicological Sciences, 2013, v. 38, n. 3, p. 309, doi. 10.2131/jts.38.309

By:

Yuichiro Kanno;
Nobuaki Tanuma;
Ami Takahashi;
Yoshio Inouye

Publication type:

Article

Influence of signaling kinases on functional dynamics of nuclear receptor CAR.

Published in:

Molecular & Cellular Biochemistry, 2019, v. 461, n. 1/2, p. 127, doi. 10.1007/s11010-019-03596-7

By:

Yende, Ashutosh S.;
Tyagi, Rakesh K.

Publication type:

Article

Dimethylesculetin ameliorates maternal glucose intolerance and fetal overgrowth in high-fat diet-fed pregnant mice via constitutive androstane receptor.

Published in:

Molecular & Cellular Biochemistry, 2016, v. 419, n. 1/2, p. 185, doi. 10.1007/s11010-016-2772-4

By:

Masuyama, Hisashi;
Mitsui, Takashi;
Maki, Jota;
Tani, Kazumasa;
Nakamura, Keiichiro;
Hiramatsu, Yuji

Publication type:

Article

Meta-analysis of the effect of CYP2B6, CYP2A6, UGT2B7 and CAR polymorphisms on efavirenz plasma concentrations.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2019, v. 74, n. 11, p. 3281, doi. 10.1093/jac/dkz329

By:

Ayuso, Pedro;
Neary, Megan;
Chiong, Justin;
Owen, Andrew

Publication type:

Article

Constitutive Androstane Receptor Agonist Initiates Metabolic Activity Required for Hepatocyte Proliferation.

Published in:

Biochemistry (00062979), 2023, v. 88, n. 8, p. 1061, doi. 10.1134/S0006297923080023

By:

Mazin, Mark E.;
Perevalova, Alina M.;
Yarushkin, Andrei A.;
Pustylnyak, Yuliya A.;
Rogachev, Artem D.;
Prokopyeva, Elena A.;
Gulyaeva, Lyudmila F.;
Pustylnyak, Vladimir O.

Publication type:

Article

Mechanisms of Regulation of the P-Glycoprotein Transporter Protein Functioning under the Action of Nitric Oxide.

Published in:

Biochemistry (00062979), 2022, v. 87, n. 4, p. 366, doi. 10.1134/S000629792204006X

By:

Shchulkin, Aleksey V.;
Abalenikhina, Yulia V.;
Sudakova, Elena A.;
Mylnikov, Pavel Yu.;
Yakusheva, Elena N.

Publication type:

Article

The Effect of Natural Products on the Metabolism of Boar Taint Compounds in Porcine Hepatocytes.

Published in:

Journal of Animal Science, 2023, v. 101, p. 314, doi. 10.1093/jas/skad281.374

By:

Bone, Christine;
Squires, E. James

Publication type:

Article

Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-14032-0

By:

Petros, Zelalem;
Habtewold, Abiy;
Makonnen, Eyasu;
Aklillu, Eleni

Publication type:

Article

The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor.

Published in:

Cells (2073-4409), 2020, v. 9, n. 7, p. 1641, doi. 10.3390/cells9071641

By:

Creusot, Nicolas;
Gassiot, Matthieu;
Alaterre, Elina;
Chiavarina, Barbara;
Grimaldi, Marina;
Boulahtouf, Abdelhay;
Toporova, Lucia;
Gerbal-Chaloin, Sabine;
Daujat-Chavanieu, Martine;
Matheux, Alice;
Rahmani, Roger;
Gongora, Céline;
Evrard, Alexandre;
Pourquier, Philippe;
Balaguer, Patrick

Publication type:

Article

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity.

Published in:

Cells (2073-4409), 2020, v. 9, n. 5, p. 1192, doi. 10.3390/cells9051192

By:

Marx-Stoelting, Philip;
Knebel, Constanze;
Braeuning, Albert

Publication type:

Article

Neonatal rat osteoblasts bioconvert testosterone to non-phenolic metabolites with estrogen-like effects on bone cell proliferation and differentiation.

Published in:

Hormone Molecular Biology & Clinical Investigation, 2013, v. 13, n. 3, p. 41, doi. 10.1515/hmbci-2012-0035

By:

Enríquez, Juana;
Larrea, Fernando;
Santillán, René;
Hernández, Ángeles;
Herrero, Bertha;
Pérez-Palacios, Gregorio;
Lemus, Ana E.

Publication type:

Article

The Roles of Co-Chaperone CCRP/DNAJC7 in Cyp2b10 Gene Activation and Steatosis Development in Mouse Livers.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0115663

By:

Ohno, Marumi;
Kanayama, Tomohiko;
Moore, Rick;
Ray, Manas;
Negishi, Masahiko

Publication type:

Article

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor.

Published in:: PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0104594
Publication type:: Article

Constitutive Androstane Receptor Ligands Modulate the Anti-Tumor Efficacy of Paclitaxel in Non-Small Cell Lung Cancer Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0099484

By:

Fukumasu, Heidge;
Rochetti, Arina L.;
Pires, Pedro R. L.;
Silva, Edson R.;
Mesquita, Ligia G.;
Strefezzi, Ricardo F.;
De Carvalho, Daniel D.;
Dagli, Maria L.

Publication type:

Article

Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0096263

By:

Mathäs, Marianne;
Nuβhag, Christian;
Burk, Oliver;
Gödtel-Armbrust, Ute;
Herlyn, Holger;
Wojnowski, Leszek;
Windshügel, Björn

Publication type:

Article

Coordinated Regulation of Nuclear Receptor CAR by CCRP/DNAJC7, HSP70 and the Ubiquitin-Proteasome System.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0096092

By:

Timsit, Yoav E.;
Negishi, Masahiko

Publication type:

Article

Nuclear Receptor-Mediated Alleviation of Alcoholic Fatty Liver by Polyphenols Contained in Alcoholic Beverages.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0087142

By:

Yao, Ruiqing;
Yasuoka, Akihito;
Kamei, Asuka;
Ushiama, Shota;
Kitagawa, Yoshinori;
Rogi, Tomohiro;
Shibata, Hiroshi;
Abe, Keiko;
Misaka, Takumi

Publication type:

Article

Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061802

By:

Shizu, Ryota;
Benoki, Satoshi;
Numakura, Yuki;
Kodama, Susumu;
Miyata, Masaaki;
Yamazoe, Yasushi;
Yoshinari, Kouichi

Publication type:

Article

MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041291

By:

Shizu, Ryota;
Shindo, Sawako;
Yoshida, Takemi;
Numazawa, Satoshi

Publication type:

Article

The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.

Published in:

Archives of Toxicology, 2025, v. 99, n. 5, p. 2197, doi. 10.1007/s00204-025-03982-9

By:

Henderson, C. J.;
McLaren, A. W.;
MacLeod, A. K.;
Lin, D.;
Cameron, A. R.;
Chatham, L. R.;
Moggs, J.;
Inesta-Vaquera, F.;
Thomson, John P.;
Meehan, Richard R.;
Chakravarty, P.;
Schwarz, M.;
Wolf, C. Roland

Publication type:

Article

Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver.

Published in:

Archives of Toxicology, 2022, v. 96, n. 10, p. 2739, doi. 10.1007/s00204-022-03338-7

By:

Sprenger, Heike;
Rasinger, Josef Daniel;
Hammer, Helen;
Naboulsi, Wael;
Zabinsky, Elke;
Planatscher, Hannes;
Schwarz, Michael;
Poetz, Oliver;
Braeuning, Albert

Publication type:

Article

Cross-species analysis of hepatic cytochrome P450 and transport protein expression.

Published in:

Archives of Toxicology, 2021, v. 95, n. 1, p. 117, doi. 10.1007/s00204-020-02939-4

By:

Hammer, Helen;
Schmidt, Felix;
Marx-Stoelting, Philip;
Pötz, Oliver;
Braeuning, Albert

Publication type:

Article

β-catenin signaling, the constitutive androstane receptor and their mutual interactions.

Published in:

Archives of Toxicology, 2020, v. 94, n. 12, p. 3983, doi. 10.1007/s00204-020-02935-8

By:

Braeuning, Albert;
Pavek, Petr

Publication type:

Article

Constitutive androstane receptor (CAR) mediates dieldrin-induced liver tumorigenesis in mouse.

Published in:

Archives of Toxicology, 2020, v. 94, n. 8, p. 2873, doi. 10.1007/s00204-020-02781-8

By:

Wang, Zemin;
Wu, Qiangen;
Li, Xilin;
Klaunig, James E.

Publication type:

Article

Array-based Western-blotting reveals spatial differences in hepatic signaling and metabolism following CAR activation.

Published in:

Archives of Toxicology, 2020, v. 94, n. 4, p. 1265, doi. 10.1007/s00204-020-02680-y

By:

Treindl, Fridolin;
Zabinsky, Elke;
Kling, Simon;
Schwarz, Michael;
Braeuning, Albert;
Templin, Markus F.

Publication type:

Article

Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3.

Published in:

Archives of Toxicology, 2019, v. 93, n. 8, p. 2247, doi. 10.1007/s00204-019-02495-6

By:

Keminer, Oliver;
Windshügel, Björn;
Essmann, Frank;
Lee, Serene M. L.;
Schiergens, Tobias S.;
Schwab, Matthias;
Burk, Oliver

Publication type:

Article

Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Published in:

Archives of Toxicology, 2017, v. 91, n. 6, p. 2375, doi. 10.1007/s00204-017-1948-3

By:

Jeske, Judith;
Windshügel, Björn;
Thasler, Wolfgang;
Schwab, Matthias;
Burk, Oliver

Publication type:

Article

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.

Published in:

Archives of Toxicology, 2017, v. 91, n. 6, p. 2365, doi. 10.1007/s00204-016-1888-3

By:

Abe, Taiki;
Takahashi, Mirei;
Kano, Makoto;
Amaike, Yuto;
Ishii, Chizuru;
Maeda, Kazuhiro;
Kudoh, Yuki;
Morishita, Toru;
Hosaka, Takuomi;
Sasaki, Takamitsu;
Kodama, Susumu;
Matsuzawa, Atsushi;
Kojima, Hiroyuki;
Yoshinari, Kouichi

Publication type:

Article

Regulation of gene expression by CAR: an update.

Published in:

Archives of Toxicology, 2015, v. 89, n. 7, p. 1045, doi. 10.1007/s00204-015-1522-9

By:

Kobayashi, Kaoru;
Hashimoto, Mari;
Honkakoski, Paavo;
Negishi, Masahiko

Publication type:

Article

Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.

Published in:

Archives of Toxicology, 2015, v. 89, n. 1, p. 57, doi. 10.1007/s00204-014-1230-x

By:

Lim, Yun-Ping;
Cheng, Ching-Hao;
Hung, Dong-Zong;
Chen, Chao-Jung;
Chen, Wei-Cheng;
Ma, Wei-Chih;
Lin, Yu-Hsien;
Chen, Cing-Yu;
Chang, Shih-Yu;
Chen, Jih-Jung;
Wan, Lei;
Yokoi, Tsuyoshi;
Nakajima, Miki

Publication type:

Article

Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor.

Published in:

Journal of Applied Toxicology, 2017, v. 37, n. 8, p. 967, doi. 10.1002/jat.3445

By:

Wang, Zemin;
Li, Xilin;
Wu, Qiangen;
Lamb, James C.;
Klaunig, James E.

Publication type:

Article

CHARACTERIZAÇÃO DA EXPRESSÃO DO RECEPTOR CAR E SUA ASSOCIAÇÃO INVERSA COM A PROLIFERAÇÃO CELULAR EM NEOPLASIAS EPITELAIS.

Published in:

Archives of Veterinary Science, 2013, v. 18, n. 3, p. 283

By:

Barra, Camila Neri;
de Francisco Strefezzi, Ricardo;
Rochetti, Arina Lázaro;
Fukumasu, Heidge

Publication type:

Article