Works matching DE "ALPHA-synuclein"

Results: 1516

Parkinson's paradox: alpha-synuclein's selective strike on SNc dopamine neurons over VTA.

Published in:

NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-01055-3

By:

Phan, L.;
Miller, D.;
Gopinath, A.;
Lin, M.;
Miller, E. J.;
Guenther, D.;
Quintin, S.;
Borg, D.;
Hasanpour-Segherlou, Z.;
Newman, A.;
Sorrentino, Z.;
Seibold, J.;
Hoh, B.;
Giasson, B.;
Khoshbouei, H.

Publication type:

Article

Parkinson Disease Signaling Pathways, Molecular Mechanisms, and Potential Therapeutic Strategies: A Comprehensive Review.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6416, doi. 10.3390/ijms26136416

By:

Khan, Muhammad S.;
Nasiripour, Somayyeh;
Bopassa, Jean C.

Publication type:

Article

The Emerging Role of the Molecular Chaperone Clusterin in Parkinson's Disease.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6351, doi. 10.3390/ijms26136351

By:

Carini, Giulia;
Mohammed, Salihu;
Filippini, Alice;
Ramazzina, Ileana;
Russo, Isabella

Publication type:

Article

Soluble and Insoluble Lysates from the Human A53T Mutant α-Synuclein Transgenic Mouse Model Induces α-Synucleinopathy Independent of Injection Site.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6254, doi. 10.3390/ijms26136254

By:

Barnes, Justin;
Vermilyea, Scott C.;
Meints, Joyce;
Martell-Martinez, Héctor;
Lee, Michael K.

Publication type:

Article

Common SNCA Genetic Variants and Parkinson's Disease Risk: A Systematic Review and Meta-Analysis.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6001, doi. 10.3390/ijms26136001

By:

Mohammadi, Raziyeh;
Shirazi, Mahdi;
Sadat-Madani, Sayedeh Fatemeh;
Yeo Cheng Long, Matthew Zachary;
Singh, Corrine Lee;
Tan, Jayne Y.;
Deng, Xiao;
Hashemi Fard, Seyed Majid;
Ng, Samuel Y. E.;
Ng, Adeline S. L.;
Tan, Louis C. S.;
Saffari, Seyed Ehsan

Publication type:

Article

Subclinical detection of misfolded alpha-synuclein in the blood of M83 mice.

Published in:

2025

By:

Bruyère-Ostells, Lilian;
Verchère, Jérémy;
Bétemps, Dominique;
Almela, Florian;
Baron, Thierry;
Bougard, Daisy

Publication type:

Letter

STING Signaling Pathway as a Target for Neuroprotective Therapy in Parkinson's Disease.

Published in:

Journal of Evolutionary Biochemistry & Physiology, 2025, v. 61, n. 3, p. 657, doi. 10.1134/S0022093025030019

By:

Usenko, T. S.

Publication type:

Article

Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease.

Published in:

Annals of Neurology, 2025, v. 98, n. 1, p. 147, doi. 10.1002/ana.27250

By:

Müller, Laura;
Özdüzenciler, Pelin;
Schedlich‐Teufer, Charlotte;
Seger, Aline;
Jergas, Hannah;
Fink, Gereon R.;
Willbold, Dieter;
Sommerauer, Michael;
Barbe, Michael T.;
Tamgüney, Gültekin

Publication type:

Article

Mutant α-synuclein takes down autophagy.

Published in:

Science Signaling, 2025, v. 18, n. 894, p. N.PAG, doi. 10.1126/scisignal.aea2255

By:

Ferrarelli, Leslie K.

Publication type:

Article

Correction: Preclinical assessment of a ganglioside-targeted therapy for Parkinson's disease with the first-in-class adaptive peptide AmyP53.

Published in:

2025

By:

Fantini, Jacques;
Azzaz, Fodil;
Aulas, Anaïs;
Chahinian, Henri;
Yahi, Nouara

Publication type:

Correction Notice

Alpha-synuclein seed amplification assay longitudinal outcomes in Lewy body disease spectrum.

Published in:

Brain: A Journal of Neurology, 2025, v. 148, n. 6, p. 2038, doi. 10.1093/brain/awae405

By:

Mastrangelo, Andrea;
Mammana, Angela;
Hall, Sara;
Stomrud, Erik;
Zenesini, Corrado;
Rossi, Marcello;
Janelidze, Shorena;
Ticca, Alice;
Palmqvist, Sebastian;
Magliocchetti, Franco;
Baiardi, Simone;
Mattsson-Carlgren, Niklas;
Hansson, Oskar;
Parchi, Piero

Publication type:

Article

Conformational Equilibria in Monomeric -Synuclein at the Single-Molecule Level.

Published in:

PLoS Biology, 2008, v. 6, n. 1, p. e6, doi. 10.1371/journal.pbio.0060006

By:

Sandal, Massimo;
Valle, Francesco;
Tessari, Isabella;
Mammi, Stefano;
Bergantino, Elisabetta;
Musiani, Francesco;
Brucale, Marco;
Bubacco, Luigi;
Samorí, Bruno

Publication type:

Article

DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation.

Published in:

PLoS Biology, 2004, v. 2, n. 10, p. 1, doi. 10.1371/journal.pbio.0020362

By:

Shendelman, Shoshana;
Jonason, Alan;
Martinat, Cecile;
Leete, Thomas;
Abeliovich, Asa

Publication type:

Article

Adsorption of alpha-synuclein and inhibition of fibril formation by nanocellulose and gold-coated-nanocellulose.

Published in:

Cellulose, 2024, v. 31, n. 6, p. 3797, doi. 10.1007/s10570-024-05827-7

By:

Lamtar Mohammadi, Elika;
Keikha, Reza;
Outeiro, Tiago Fleming;
Jebali, Ali

Publication type:

Article

Beneficial effect of 5‐HT1b/1d agonist on Parkinson's disease by modulating glutamate and reducing deposition of α‐synuclein.

Published in:

Journal of Biochemical & Molecular Toxicology, 2024, v. 38, n. 1, p. 1, doi. 10.1002/jbt.23627

By:

Tripathi, Alok Shiomurti;
Fatima, Needa;
Tripathi, Pankaj;
Tripathi, Rina;
Alka;
Zaki, Magdi E. A.;
Mohapatra, Lucy;
Yasir, Mohammad;
Maurya, Rahul K

Publication type:

Article

α-Synuclein and β-synuclein enhance secretion protein production in baculovirus expression vector system.

Published in:

Applied Microbiology & Biotechnology, 2013, v. 97, n. 9, p. 3875, doi. 10.1007/s00253-012-4679-7

By:

Teng, Chao-Yi;
Chang, Shou-Lin;
Tsai, Meng-Feng;
Wu, Tzong-Yuan

Publication type:

Article

FDA Accepts Protocol for Annovis Bio's Buntanetap Phase 3 Alzheimer Disease Trial.

Published in:: Patient Care (Online), 2025, p. 11
Publication type:: Article

Complex modulation of cytokine-induced α-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells.

Published in:

Glycobiology, 2022, v. 32, n. 4, p. 333, doi. 10.1093/glycob/cwab126

By:

Cheng, Fang;
Fransson, Lars-Åke;
Mani, Katrin

Publication type:

Article

Neuroprotective Effects of Hesperidin and Naringin in SK-N-AS Cell as an In Vitro Model for Alzheimer's Disease.

Published in:

Journal of the American Nutrition Association, 2023, v. 42, n. 4, p. 418, doi. 10.1080/07315724.2022.2062488

By:

Kuşi, Müjgan;
Becer, Eda;
Vatansever, Hafize Seda;
Yücecan, Sevinç

Publication type:

Article

Computational Modeling of the Effect of Trifluoroethanol on the Conformation of α-Synuclein Peptide.

Published in:

Journal of Computational Biophysics & Chemistry, 2022, v. 21, n. 6, p. 695, doi. 10.1142/S2737416522500296

By:

Pakzadiyan, Atena;
Jalili, Seifollah

Publication type:

Article

Investigation of Inhibition Effect of Nicotine and Dopamine on Alpha-synuclein.

Published in:

Journal of Computational Biophysics & Chemistry, 2021, v. 20, n. 5, p. 477, doi. 10.1142/S2737416521500265

By:

Alıcı, Hakan

Publication type:

Article

Higher alpha-synuclein aggregate density does not lead to more severe dopaminergic cell loss in the AAV-mediated overexpression model of Parkinson's Disease: A timecourse study.

Published in:

Journal of Research in Pharmacy, 2021, v. 25, n. 3, p. 352, doi. 10.29228/jrp.25

By:

TEL, Banu Cahide;
KAZKAYASI, İnci;
TELLİ, Gökçen;
ÇINAR, Elif;
MUTLUAY, Sevgi Uğur;
YALÇIN-ÇAKMAKLI, Gül;
SAKA, Esen;
ELİBOL, Bülent

Publication type:

Article

α-Synuclein Interactions in Mitochondria-ER Contacts: A Possible Role in Parkinson's Disease.

Published in:

Contact (25152564), 2022, p. 1, doi. 10.1177/25152564221119347

By:

Erustes, Adolfo Garcia;
Guarache, Gabriel Cicolin;
Guedes, Erika da Cruz;
Leão, Anderson Henrique França Figueredo;
Pereira, Gustavo José da Silva;
Smaili, Soraya Soubhi

Publication type:

Article

α-Synuclein Interactions in Mitochondria-ER Contacts: A Possible Role in Parkinson's Disease.

Published in:

Contact (25152564), 2022, v. 5, p. 1, doi. 10.1177/25152564221119347

By:

Garcia Erustes, Adolfo;
Cicolin Guarache, Gabriel;
da Cruz Guedes, Erika;
França Figueredo Leão, Anderson Henrique;
da Silva Pereira, Gustavo José;
Soubhi Smaili, Soraya

Publication type:

Article

Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02062-8

By:

Yoshida, Shun;
Hasegawa, Takafumi;
Nakamura, Takaaki;
Sato, Kazuki;
Sugeno, Naoto;
Ishiyama, Shun;
Sekiguchi, Kiyotoshi;
Tobita, Muneshige;
Takeda, Atsushi;
Aoki, Masashi

Publication type:

Article

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson's disease.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01939-y

By:

Niu, Xiao-yun;
Xie, Xi-xiu;
Tuo, Hou-zhen;
Lv, Cui-ping;
Huang, Ya-ru;
Zhu, Jie;
Liang, Shi-yu;
Du, Xiao-yu;
Yang, Cheng-gang;
Hou, Sheng-jie;
Sun, Xiao-ying;
Li, Ling-jie;
Cui, Fang;
Huang, Qi-xin;
Jia, Ying-bo;
Wang, Yu-jiong;
Liu, Rui-tian

Publication type:

Article

Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01848-0

By:

Gu, Rou;
Bai, Liping;
Yan, Fang;
Zhang, Se;
Zhang, Xianwen;
Deng, Ruhua;
Zeng, Xiansi;
Sun, Bo;
Hu, Xiaomei;
Li, Ye;
Bai, Jie

Publication type:

Article

Thioredoxin-1 decreases alpha-synuclein induced by MPTP through promoting autophagy-lysosome pathway.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01848-0

By:

Gu, Rou;
Bai, Liping;
Yan, Fang;
Zhang, Se;
Zhang, Xianwen;
Deng, Ruhua;
Zeng, Xiansi;
Sun, Bo;
Hu, Xiaomei;
Li, Ye;
Bai, Jie

Publication type:

Article

Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson's disease autonomic dysfunction.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01824-8

By:

Li, Yangxia;
Tong, Qing;
Wang, Ye;
Cheng, Yue;
Geng, Yao;
Tian, Tian;
Yuan, Yongsheng;
Fan, Yi;
Lu, Ming;
Zhang, Kezhong

Publication type:

Article

Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01816-8

By:

Hong, Bin;
Ohtake, Yosuke;
Itokazu, Takahide;
Yamashita, Toshihide

Publication type:

Article

Alpha-Synuclein and Microglia in Parkinson's Disease: From Pathogenesis to Therapeutic Prospects.

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 23, p. 7243, doi. 10.3390/jcm13237243

By:

Eo, Hyemi;
Kim, Sehwan;
Jung, Un Ju;
Kim, Sang Ryong

Publication type:

Article

Non-Surgical Periodontal Therapy's Influence on Alpha-Synuclein and Inflammatory Marker Levels: A Pilot Study.

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 12, p. 3586, doi. 10.3390/jcm13123586

By:

Lyra, Patrícia;
Botelho, João;
Rota, Silvia;
Poplawska-Domaszewicz, Karolina;
Machado, Vanessa;
Guerreiro, Daniela;
Proença, Luís;
Barroso, Helena;
Mendes, José João;
Chaudhuri, Kallol Ray

Publication type:

Article

Evaluation of Alpha-Synuclein Cerebrospinal Fluid Levels in Several Neurological Disorders.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 11, p. 3139, doi. 10.3390/jcm11113139

By:

Agnello, Luisa;
Lo Sasso, Bruna;
Vidali, Matteo;
Scazzone, Concetta;
Gambino, Caterina Maria;
Piccoli, Tommaso;
Bivona, Giulia;
Ciaccio, Anna Maria;
Giglio, Rosaria Vincenza;
La Bella, Vincenzo;
Ciaccio, Marcello

Publication type:

Article

A Microplate-Based Approach to Map Interactions between TDP-43 and α-Synuclein.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 3, p. 573, doi. 10.3390/jcm11030573

By:

Jamerlan, Angelo M.;
An, Seong Soo A.

Publication type:

Article

New Horizon of Multiple System Atrophy Research.

Published in:

Cerebellum, 2024, v. 23, n. 1, p. 1, doi. 10.1007/s12311-024-01667-0

By:

Tsuji, Shoji;
Wenning, Gregor

Publication type:

Article

Disease Mechanisms of Multiple System Atrophy: What a Parallel Between the Form of Pasta and the Alpha-Synuclein Assemblies Involved in MSA and PD Tells Us.

Published in:

Cerebellum, 2024, v. 23, n. 1, p. 13, doi. 10.1007/s12311-022-01417-0

By:

Melki, Ronald

Publication type:

Article

Neuropathology of Multiple System Atrophy, a Glioneuronal Degenerative Disease.

Published in:

Cerebellum, 2024, v. 23, n. 1, p. 2, doi. 10.1007/s12311-022-01407-2

By:

Wakabayashi, Koichi;
Miki, Yasuo;
Tanji, Kunikazu;
Mori, Fumiaki

Publication type:

Article

Exploring Influence of Production Area and Harvest Time on Specialized Metabolite Content of Glycyrrhiza glabra Leaves and Evaluation of Antioxidant and Anti-Aging Properties.

Published in:

Antioxidants, 2024, v. 13, n. 1, p. 93, doi. 10.3390/antiox13010093

By:

Docimo, Teresa;
Celano, Rita;
Lambiase, Alessia;
Di Sanzo, Rosa;
Serio, Simona;
Santoro, Valentina;
Coccetti, Paola;
Russo, Mariateresa;
Rastrelli, Luca;
Piccinelli, Anna Lisa

Publication type:

Article

Tyrosine Nitroxidation Does Not Affect the Ability of α-Synuclein to Bind Anionic Micelles, but It Diminishes Its Ability to Bind and Assemble Synaptic-like Vesicles.

Published in:

Antioxidants, 2023, v. 12, n. 6, p. 1310, doi. 10.3390/antiox12061310

By:

Uceda, Ana Belén;
Frau, Juan;
Vilanova, Bartolomé;
Adrover, Miquel

Publication type:

Article

Early-Life Exposure to Commercial Formulation Containing Deltamethrin and Cypermethrin Insecticides Impacts Redox System and Induces Unexpected Regional Effects in Rat Offspring Brain.

Published in:

Antioxidants, 2023, v. 12, n. 5, p. 1047, doi. 10.3390/antiox12051047

By:

Mekircha, Fatiha;
Fedeli, Donatella;
Nasuti, Cinzia;
Kecies, Hadjer;
Gabbianelli, Rosita;
Bordoni, Laura

Publication type:

Article

Multifunctional Metallothioneins as a Target for Neuroprotection in Parkinson's Disease.

Published in:

Antioxidants, 2023, v. 12, n. 4, p. 894, doi. 10.3390/antiox12040894

By:

Miyazaki, Ikuko;
Asanuma, Masato

Publication type:

Article

Interaction and Redox Chemistry between Iron, Dopamine, and Alpha-Synuclein C-Terminal Peptides.

Published in:

Antioxidants, 2023, v. 12, n. 4, p. 791, doi. 10.3390/antiox12040791

By:

Schifano, Fabio;
Dell'Acqua, Simone;
Nicolis, Stefania;
Casella, Luigi;
Monzani, Enrico

Publication type:

Article

α-Synuclein Toxicity in Drosophila melanogaster Is Enhanced by the Presence of Iron: Implications for Parkinson's Disease.

Published in:

Antioxidants, 2023, v. 12, n. 2, p. 261, doi. 10.3390/antiox12020261

By:

Agostini, Francesco;
Bubacco, Luigi;
Chakrabarti, Sasanka;
Bisaglia, Marco

Publication type:

Article

Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo.

Published in:

Antioxidants, 2022, v. 11, n. 12, p. 2466, doi. 10.3390/antiox11122466

By:

Won, Seok Joon;
Fong, Rebecca;
Butler, Nicholas;
Sanchez, Jennifer;
Zhang, Yiguan;
Wong, Candance;
Tambou Nzoutchoum, Olive;
Huynh, Annie;
Pan, June;
Swanson, Raymond A.

Publication type:

Article

Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson's disease in the Chinese population.

Published in:

European Journal of Medical Research, 2024, v. 29, n. 1, p. 1, doi. 10.1186/s40001-024-01705-x

By:

Li, Jiaqi;
Duan, Suying;
Yang, Jing;
Zheng, Honglin;
Yuan, Yanpeng;
Tang, Mibo;
Wang, Yanlin;
Liu, Yutao;
Xia, Zongping;
Luo, Haiyang;
Xu, Yuming

Publication type:

Article

Role of GSK3β/α-synuclein axis in methamphetamine-induced neurotoxicity in PC12 cells.

Published in:

Toxicology Research, 2018, v. 7, n. 2, p. 221, doi. 10.1039/c7tx00189d

By:

Li, Lizeng;
Chen, Si;
Wang, Yue;
Yue, Xia;
Xu, Jingtao;
Xie, Weibing;
Qiu, Pingming;
Liu, Chao;
Wang, AiFeng;
Wang, Huijun

Publication type:

Article

Effect of hydrogen sulfide on alpha-synuclein aggregation and cell viability.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-99794-z

By:

Ostrakhovitch, Elena A.;
Song, Eun-Suk;
Stegemann, Johannah E.;
McLeod, Michael;
Yamasaki, Tritia R.

Publication type:

Article

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05797

By:

Kellie, John F.;
Higgs, Richard E.;
Ryder, John W.;
Major, Anthony;
Beach, Thomas G.;
Adler, Charles H.;
Merchant, Kalpana;
Knierman, Michael D.

Publication type:

Article

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49402-x

By:

Mastenbroek, Sophie E.;
Vogel, Jacob W.;
Collij, Lyduine E.;
Serrano, Geidy E.;
Tremblay, Cécilia;
Young, Alexandra L.;
Arce, Richard A.;
Shill, Holly A.;
Driver-Dunckley, Erika D.;
Mehta, Shyamal H.;
Belden, Christine M.;
Atri, Alireza;
Choudhury, Parichita;
Barkhof, Frederik;
Adler, Charles H.;
Ossenkoppele, Rik;
Beach, Thomas G.;
Hansson, Oskar

Publication type:

Article

Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49016-3

By:

Mao, Xiaobo;
Gu, Hao;
Kim, Donghoon;
Kimura, Yasuyoshi;
Wang, Ning;
Xu, Enquan;
Kumbhar, Ramhari;
Ming, Xiaotian;
Wang, Haibo;
Chen, Chan;
Zhang, Shengnan;
Jia, Chunyu;
Liu, Yuqing;
Bian, Hetao;
Karuppagounder, Senthilkumar S.;
Akkentli, Fatih;
Chen, Qi;
Jia, Longgang;
Hwang, Heehong;
Lee, Su Hyun

Publication type:

Article