Works about ALLOSTERIC regulation

Results: 1532

Allosteric modulation of Plasmodium falciparum Isoleucyl tRNA synthetase by South African natural compounds.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0321444

By:

Chepsiror, Curtis;
Veldman, Wayde;
Olotu, Fisayo;
Tastan Bishop, Özlem

Publication type:

Article

Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe.

Published in:

Angewandte Chemie, 2025, v. 137, n. 20, p. 1, doi. 10.1002/ange.202421885

By:

Kosar, Miroslav;
Perera, Themiya;
Ganzoni, Rudolf L. Z.;
Sarott, Roman C.;
Borrega‐Roman, Leire;
Vitale, Rosa Maria;
Ligresti, Alessia;
Rufer, Arne C.;
Guba, Wolfgang;
Grether, Uwe;
Carreira, Erick M.;
Veprintsev, Dmitry B.;
Sykes, David A.

Publication type:

Article

Synthesis of Selectively 13C/2H/15N‐ Labeled Arginine to Probe Protein Conformation and Interaction by NMR Spectroscopy.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 24, p. 1, doi. 10.1002/chem.202500408

By:

Rohden, Darja I.;
Toscano, Giorgia;
Schanda, Paul;
Lichtenecker, Roman J.

Publication type:

Article

A basigin antibody modulates MCTs to impact tumor metabolism and immunity.

Published in:

Cell Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41421-025-00777-1

By:

Zhang, Heng;
Yang, Xuemei;
Xue, Yue;
Huang, Yi;
Mo, Yingxi;
Huang, Yurun;
Zhang, Hong;
Zhang, Xiaofei;
Zhao, Weixin;
Jia, Bin;
Li, Ningning;
Gao, Ning;
Yang, Yue;
Xiang, Dongxi;
Wang, Shan;
Qin Gao, Yi;
Liao, Jun

Publication type:

Article

Tandem Domains with Tuned Interactions Are a Powerful Biological Design Principle.

Published in:

PLoS Biology, 2015, v. 13, n. 12, p. 1, doi. 10.1371/journal.pbio.1002306

By:

Nussinov, Ruth;
Tsai, Chung-Jung

Publication type:

Article

Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001651

By:

Rodgers, Thomas L.;
Townsend, Philip D.;
Burnell, David;
Jones, Matthew L.;
Richards, Shane A.;
McLeish, Tom C. B.;
Pohl, Ehmke;
Wilson, Mark R.;
Cann, Martin J.

Publication type:

Article

Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase

Published in:

PLoS Biology, 2012, v. 10, n. 12, p. 1, doi. 10.1371/journal.pbio.1001452

By:

Larion, Mioara;
Salinas, Roberto Kopke;
Bruschweiler-Li, Lei;
Miller, Brian G.;
Brüschweiler, Rafael

Publication type:

Article

Domain Swapping in Allosteric Modulation of DNA Specificity.

Published in:

PLoS Biology, 2010, v. 8, n. 12, p. 1, doi. 10.1371/journal.pbio.1000554

By:

Park, Chad K.;
Joshi, Hemant K.;
Agrawal, Alka;
Ghare, M. Imran;
Little, Elizabeth J.;
Dunten, Pete W.;
Bitinaite, Jurate;
Horton, Nancy C.

Publication type:

Article

Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition.

Published in:

PLoS Biology, 2009, v. 7, n. 1, p. e1000017, doi. 10.1371/journal.pbio.1000017

By:

Calleja, Véronique;
Laguerre, Michel;
Parker, Peter J.;
Larijani, Banafshé

Publication type:

Article

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates.

Published in:

PLoS Biology, 2005, v. 3, n. 9, p. 1639, doi. 10.1371/journal.pbio.0030299

By:

Porrino, Linda J.;
Daunais, James B.;
Rogers, Gary A.;
Hampson, Robert E.;
Deadwyler, Sam A.

Publication type:

Article

APPLICATION OF A GENERALIZED MWC MODEL FOR THE MATHEMATICAL SIMULATION OF METABOLIC PATHWAYS REGULATED BY ALLOSTERIC ENZYMES.

Published in:

Journal of Bioinformatics & Computational Biology, 2006, v. 4, n. 2, p. 335, doi. 10.1142/S0219720006001862

By:

Najdi, Tarek S.;
Yang, Chin-Rang;
Shapiro, Bruce E.;
Hatfield, G. Wesley;
Mjolsness, Eric D.

Publication type:

Article

Magnetogenese in Wasser, ausgelöst durch einen chemischen Analyten.

Published in:

Angewandte Chemie, 2014, v. 126, n. 1, p. 60, doi. 10.1002/ange.201305662

By:

Hasserodt, Jens;
Kolanowski, Jacek Lukasz;
Touti, Faycal

Publication type:

Article

Bidirectional Regulation of Halide Binding in a Heterometallic Supramolecular Cube.

Published in:

Angewandte Chemie, 2013, v. 125, n. 50, p. 13681, doi. 10.1002/ange.201307478

By:

Ramsay, William J.;
Ronson, Tanya K.;
Clegg, Jack K.;
Nitschke, Jonathan R.

Publication type:

Article

A Single Mutation in a Regulatory Protein Produces Evolvable Allosterically Regulated Catalyst of Nonnatural Reaction.

Published in:

Angewandte Chemie, 2013, v. 125, n. 24, p. 6366, doi. 10.1002/ange.201302339

By:

Moroz, Olesia V.;
Moroz, Yurii S.;
Wu, Yibing;
Olsen, Alissa B.;
Cheng, Hong;
Mack, Korrie L.;
McLaughlin, Jaclyn M.;
Raymond, Elizabeth A.;
Zhezherya, Krystyna;
Roder, Heinrich;
Korendovych, Ivan V.

Publication type:

Article

Dynamics of allosteric modulation of lymphocyte function associated antigen-1 closure-open switch: unveiling the structural mechanisms associated with outside-in signaling activation.

Published in:

Biotechnology Letters, 2017, v. 39, n. 12, p. 1843, doi. 10.1007/s10529-017-2432-0

By:

Abdullahi, Maryam;
Olotu, Fisayo;
Soliman, Mahmoud

Publication type:

Article

Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2006, v. 372, n. 5, p. 354, doi. 10.1007/s00210-006-0033-x

By:

Kathmann, Markus;
Flau, Karsten;
Redmer, Agnes;
Tränkle, Christian;
Schlicker, Eberhard

Publication type:

Article

Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications.

Published in:

Amino Acids, 2010, v. 39, n. 5, p. 1463, doi. 10.1007/s00726-010-0611-6

By:

Flydal, Marte I.;
Mohn, Tonje C.;
Pey, Angel L.;
Siltberg-Liberles, Jessica;
Teigen, Knut;
Martinez, Aurora

Publication type:

Article

Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats.

Published in:

Amino Acids, 2007, v. 32, n. 2, p. 169

By:

K. Kłak;
A. Pałucha;
P. Brański;
M. Sowa

Publication type:

Article

Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels.

Published in:

Nature, 1997, v. 386, n. 6625, p. 612, doi. 10.1038/386612a0

By:

Tibbs, Gareth R.;
Goulding, Evan H.

Publication type:

Article

Transplanting a unique allosteric effect from crocodile into human hemoglobin.

Published in:

Nature, 1995, v. 373, n. 6511, p. 244, doi. 10.1038/373244a0

By:

Komiyama, N. Hennakao;
Miyazaki, Gentaro

Publication type:

Article

Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2.

Published in:

Bulletin of Experimental Biology & Medicine, 2015, v. 160, n. 1, p. 84, doi. 10.1007/s10517-015-3104-5

By:

Khochenkov, D.;
Solomko, E.;
Peretolchina, N.;
Ryabaya, O.;
Stepanova, E.

Publication type:

Article

Kinetic characterization of annotated glycolytic enzymes present in cellulose-fermenting Clostridium thermocellum suggests different metabolic roles.

Published in:

Biotechnology for Biofuels & Bioproducts, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13068-023-02362-8

By:

Daley, Steve R.;
Gallanosa, Patricia Mae;
Sparling, Richard

Publication type:

Article

Allosteric inhibition of myosin by phenamacril: a synergistic mechanism revealed by computational and experimental approaches.

Published in:

Pest Management Science, 2023, v. 79, n. 12, p. 4977, doi. 10.1002/ps.7699

By:

Bao, Yiqiong;
Xu, Yan;
Jia, Fangying;
Li, Mengrong;
Xu, Ran;
Zhang, Feng;
Guo, Jingjing

Publication type:

Article

Substrate-dependent allosteric regulation by switchable catalytic molecular tweezers.

Published in:

Communications Chemistry, 2019, v. 2, n. 1, p. 1, doi. 10.1038/s42004-019-0246-9

By:

Benda, Lorien;
Doistau, Benjamin;
Rossi-Gendron, Caroline;
Chamoreau, Lise-Marie;
Hasenknopf, Bernold;
Vives, Guillaume

Publication type:

Article

Allosteric activation mechanism of DriD, a WYL-domain containing transcription regulator.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08111-x

By:

Cannistraci, Emily;
Srinivasu, Bindu Y.;
Chavez Orozco Jr., Jose;
Gozzi, Kevin;
Wales, Thomas E.;
Schumacher, Maria A.

Publication type:

Article

Mechanistic Studies of dUTPases.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2004, v. 23, n. 8/9, p. 1475, doi. 10.1081/NCN-200027694

By:

Kovári, J.;
Imre, T.;
Szabó, P.;
Vértessy, B.G.

Publication type:

Article

Preclinical Investigation of the Functional Effects of Memantine and Memantine Combined with Galantamine or Donepezil.

Published in:

Neuropsychopharmacology, 2007, v. 32, n. 6, p. 1284, doi. 10.1038/sj.npp.1301259

By:

Woodruff-Pak, Diana S.;
Tobia, Michael J.;
Xilu Jiao;
Beck, Kevin D.;
Servatius, Richard J.

Publication type:

Article

Expanding the Concepts in Protein Structure-Function Relationships and Enzyme Kinetics: Teaching Using Morpheeins.

Published in:

Biochemistry & Molecular Biology Education, 2008, v. 36, n. 4, p. 274, doi. 10.1002/bmb.20211

By:

Lawrence, Sarah H.;
Jaffe, Eileen K.

Publication type:

Article

Allosteric Modulation of Monomeric Proteins.

Published in:

Biochemistry & Molecular Biology Education, 2005, v. 33, n. 3, p. 169, doi. 10.1002/bmb.2005.494033032470

By:

Ascenzi, Paolo;
Bocedi, Alessio;
Bolli, Alessandro;
Polticelli, Fabio;
Fasano, Mauro;
Notari, Stefania

Publication type:

Article

Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 4, p. 1, doi. 10.1080/23723556.2021.1927446

By:

Coassolo, Sébastien;
Davidson, Irwin

Publication type:

Article

TRPML1 gating modulation by allosteric mutations and lipids.

Published in:

eLife, 2024, p. 1

By:

Ninghai Gan;
Yan Han;
Weizhong Zeng;
Youxing Jiang

Publication type:

Article

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.93968

By:

García-Cuesta, Eva M.;
Martínez, Pablo;
Selvaraju, Karthik;
Ulltjärn, Gabriel;
Gómez Pozo, Adrián Miguel;
D'Agostino, Gianluca;
Gardeta, Sofia;
Quijada-Freire, Adriana;
Blanco Gabella, Patricia;
Roca, Carlos;
del Hoyo, Daniel;
Jiménez-Saiz, Rodrigo;
García-Rubia, Alfonso;
Soler Palacios, Blanca;
Lucas, Pilar;
Ayala-Bueno, Rosa;
Santander Acerete, Noelia;
Carrasco, Yolanda;
Sorzano, Carlos Oscar;
Martinez, Ana

Publication type:

Article

Allosteric regulation of kinase activity.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.97084

By:

ANDREOTTI, AMY H.;
DÖTSCH, VOLKER

Publication type:

Article

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.93174

By:

Peverini, Laurie;
Shi, Sophie;
Medjebeur, Karima;
Corringer, Pierre-Jean

Publication type:

Article

The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91506

By:

Olivieri, Cristina;
Yingjie Wang;
Walker, Caitlin;
Subrahmanian, Manu Veliparambil;
Ha, Kim N.;
Bernlohr, David;
Jiali Gao;
Camilloni, Carlo;
Vendruscolo, Michele;
Taylor, Susan S.;
Veglia, Gianluigi

Publication type:

Article

A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.92262

By:

Zhuang Liu;
Gillis, Thomas G.;
Raman, Srivatsan;
Qiang Cui

Publication type:

Article

Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.94503

By:

Galicia, Christian;
Guaitoli, Giambattista;
Fislage, Marcus;
Gloeckner, Christian Johannes;
Versées, Wim

Publication type:

Article

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91040

By:

Ober, Veronica Teresa;
Githure, George Boniface;
Volpato Santos, Yuri;
Becker, Sidney;
Moya Munoz, Gabriel;
Basquin, Jérôme;
Schwede, Frank;
Lorentzen, Esben;
Boshart, Michael

Publication type:

Article

Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91777

By:

Dolcemascolo, Roswitha;
Heras-Hernández, María;
Goiriz, Lucas;
Montagud-Martínez, Roser;
Requena-Menéndez, Alejandro;
Ruiz, Raúl;
Pérez-Ràfols, Anna;
Higuera-Rodríguez, R. Anahí;
Pérez-Ropero, Guillermo;
Vranken, Wim F.;
Martelli, Tommaso;
Kaiser, Wolfgang;
Buijs, Jos;
Rodrigo, Guillermo

Publication type:

Article

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.89489

By:

Lin, David Yin-wei;
Kueffer, Lauren E.;
Juneja, Puneet;
Wales, Thomas E.;
Engen, John R.;
Andreotti, Amy H.

Publication type:

Article

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.89331

By:

Touray, Abdoulie O.;
Rajesh, Rishi;
Isebe, Tony;
Sternlieb, Tamara;
Loock, Mira;
Kutova, Oksana;
Cestari, Igor

Publication type:

Article

Allosteric regulation of kinase activity in living cells.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.90574

By:

Godbole, Shivani Sujay;
Dokholyan, Nikolay V.

Publication type:

Article

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.88982

By:

Aguirre, Tim;
Dornan, Gillian L.;
Hostachy, Sarah;
Neuenschwander, Martin;
Seyffarth, Carola;
Haucke, Volker;
Schütz, Anja;
von Kries, Jens Peter;
Fiedler, Dorothea

Publication type:

Article

Molecular Dynamics Simulations on the Free and Complexed N-Terminal SH2 Domain of SHP-2.

Published in:

In Silico Biology, 2002, v. 2, n. 3, p. 305

By:

Wieligmann, Karin;
De Castro, Luis Felipe Pineda;
Zacharias, Martin

Publication type:

Article

Regulating hippocampal hyperexcitability through GABAB Receptors.

Published in:

Physiological Reports, 2014, v. 2, n. 4, p. n/a, doi. 10.1002/phy2.278

By:

Lang, Min;
Moradi ‐ Chameh, Homeira;
Zahid, Tariq;
Gane, Jonathan;
Wu, Chiping;
Valiante, Taufik;
Zhang, Liang

Publication type:

Article

SOX2 mediates cisplatin resistance in small‐cell lung cancer with downregulated expression of hsa‐miR‐340‐5p.

Published in:

Molecular Genetics & Genomic Medicine, 2020, v. 8, n. 5, p. 1, doi. 10.1002/mgg3.1195

By:

Cui, Fei;
Hao, Zhe‐xue;
Li, Jin;
Zhang, Ya‐lei;
Li, Xu‐kai;
He, Jian‐xing

Publication type:

Article

Bio-Crystallography IV: Structure-based drug design.

Published in:: 2019
Publication type:: Abstract

Unveiling the molecular basis of lobeline's allosteric regulation of NMDAR: insights from molecular modeling.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-49835-2

By:

Remya, Chandran;
Variyar, E. J.;
Omkumar, R. V.;
Sadasivan, C.;
Dileep, K. V.

Publication type:

Article

Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-47284-5

By:

Su, Leila;
Wang, Xin;
Wang, Jianghai;
Luh, Frank;
Yen, Yun

Publication type:

Article

Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular chloride ion.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43700-y

By:

Goda, Ryusei;
Watanabe, Soichi;
Misaka, Takumi

Publication type:

Article