Works about ALLOSTERIC regulation

Results: 1557

Tension-induced suppression of allosteric conformational changes coordinates kinesin-1 stepping.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 7, p. 1, doi. 10.1083/jcb.202501253

By:

Tsukasa Makino;
Ryo Kanada;
Teppei Mori;
Ken-ichi Miyazono;
Yuta Komori;
Haruaki Yanagisawa;
Shoji Takada;
Masaru Tanokura;
Masahide Kikkawa;
Michio Tomishige

Publication type:

Article

Phenacetin[3]Arenes: Mannich‐Type Macrocyclization, Unique Structure, Versatile Functionalization, and Strong Allosteric Binding.

Published in:

Angewandte Chemie, 2025, v. 137, n. 28, p. 1, doi. 10.1002/ange.202504211

By:

Shen, Yanling;
Liang, Xiaotong;
Ma, Tianning;
Zhou, Dayang;
Liu, Wenjia;
Ma, Jingyu;
Wu, Wanhua;
Yu, Zhipeng;
Yang, Cheng

Publication type:

Article

DeepAllo: allosteric site prediction using protein language model (pLM) with multitask learning Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 6, p. 1, doi. 10.1093/bioinformatics/btaf294

By:

Khokhar, Moaaz;
Keskin, Ozlem;
Gursoy, Attila

Publication type:

Article

Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration.

Published in:

Psychopharmacology, 2025, v. 242, n. 7, p. 1653, doi. 10.1007/s00213-025-06747-5

By:

Pachenari, Narges;
Channell, Amy L.;
Belilos, Andrew J.;
Dienel, Samuel J.;
Moussawi, Khaled

Publication type:

Article

From General Anesthetic to Designer Antiepileptic: Propofol's Mechanism of Action Reveals Hope for Precision Treatment of HCN1-Related Epilepsy.

Published in:

Epilepsy Currents, 2025, v. 25, n. 3, p. 192, doi. 10.1177/15357597251318573

By:

Glasscock, Edward

Publication type:

Article

Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M1 positive allosteric modulator VU0467319 for Alzheimer's disease: a single ascending-dose study in healthy participants.

Published in:

Alzheimer's Research & Therapy, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13195-025-01798-4

By:

Conley, Alexander C.;
Key, Alexandra P.;
Blackford, Jennifer U.;
Russell, Jason K.;
Albert, Kimberly M.;
Gong, Xuewen;
Bubser, Michael;
Rook, Jerri M.;
Conn, P. Jeffrey;
Lindsley, Craig W.;
Jones, Carrie K.;
Newhouse, Paul A.

Publication type:

Article

Allosteric Coupling in Full-Length Lyn Kinase Revealed by Molecular Dynamics and Network Analysis.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 12, p. 5835, doi. 10.3390/ijms26125835

By:

Rabipour, Mina;
Hassenrück, Floyd;
Pallaske, Elena;
Röhrig, Fernanda;
Hallek, Michael;
Alvarez-Idaboy, Juan Raul;
Kramer, Oliver;
Rebollido-Rios, Rocio

Publication type:

Article

Coordination of microbial metabolism.

Published in:

Nature Reviews Microbiology, 2014, v. 12, n. 5, p. 327, doi. 10.1038/nrmicro3238

By:

Chubukov, Victor;
Gerosa, Luca;
Kochanowski, Karl;
Sauer, Uwe

Publication type:

Article

Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001651

By:

Rodgers, Thomas L.;
Townsend, Philip D.;
Burnell, David;
Jones, Matthew L.;
Richards, Shane A.;
McLeish, Tom C. B.;
Pohl, Ehmke;
Wilson, Mark R.;
Cann, Martin J.

Publication type:

Article

Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase

Published in:

PLoS Biology, 2012, v. 10, n. 12, p. 1, doi. 10.1371/journal.pbio.1001452

By:

Larion, Mioara;
Salinas, Roberto Kopke;
Bruschweiler-Li, Lei;
Miller, Brian G.;
Brüschweiler, Rafael

Publication type:

Article

Domain Swapping in Allosteric Modulation of DNA Specificity.

Published in:

PLoS Biology, 2010, v. 8, n. 12, p. 1, doi. 10.1371/journal.pbio.1000554

By:

Park, Chad K.;
Joshi, Hemant K.;
Agrawal, Alka;
Ghare, M. Imran;
Little, Elizabeth J.;
Dunten, Pete W.;
Bitinaite, Jurate;
Horton, Nancy C.

Publication type:

Article

Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition.

Published in:

PLoS Biology, 2009, v. 7, n. 1, p. e1000017, doi. 10.1371/journal.pbio.1000017

By:

Calleja, Véronique;
Laguerre, Michel;
Parker, Peter J.;
Larijani, Banafshé

Publication type:

Article

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates.

Published in:

PLoS Biology, 2005, v. 3, n. 9, p. 1639, doi. 10.1371/journal.pbio.0030299

By:

Porrino, Linda J.;
Daunais, James B.;
Rogers, Gary A.;
Hampson, Robert E.;
Deadwyler, Sam A.

Publication type:

Article

Dynamics of allosteric modulation of lymphocyte function associated antigen-1 closure-open switch: unveiling the structural mechanisms associated with outside-in signaling activation.

Published in:

Biotechnology Letters, 2017, v. 39, n. 12, p. 1843, doi. 10.1007/s10529-017-2432-0

By:

Abdullahi, Maryam;
Olotu, Fisayo;
Soliman, Mahmoud

Publication type:

Article

Conformational Transitions and Allosteric Modulation in a Heteromeric Glycine Receptor.

Published in:

Microscopy & Microanalysis, 2024, v. 30, p. 1, doi. 10.1093/mam/ozae044.366

By:

Gibbs, Eric;
Klemm, Emily;
Seiferth, David;
Kumar, Arvind;
Ilca, Serban L;
Biggin, Philip C;
Chakrapani, Sudha

Publication type:

Article

Structural Snapshots of a Dynamic Process in the Regulation of P-Rex, a Metastatic Factor.

Published in:

2019

By:

Cash, Jennifer N.;
Ravala, Sandeep;
Tesmer, John J.G.;
Cianfrocco, Michael A.

Publication type:

Abstract

Mutational analysis to identify the residues essential for the inhibition of N-acetyl glutamate kinase of Corynebacterium glutamicum.

Published in:

Applied Microbiology & Biotechnology, 2015, v. 99, n. 18, p. 7527, doi. 10.1007/s00253-015-6469-5

By:

Huang, Yuanyuan;
Zhang, Hao;
Tian, Hongming;
Li, Cheng;
Han, Shuangyan;
Lin, Ying;
Zheng, Suiping

Publication type:

Article

Mn/Mg-dependent pyruvate kinase from a d-lactic acid-producing bacterium Sporolactobacillus inulinus: characterization of a novel Mn-mediated allosterically regulated enzyme.

Published in:

Applied Microbiology & Biotechnology, 2014, v. 98, n. 4, p. 1583, doi. 10.1007/s00253-013-4907-9

By:

Zheng, Lu;
Xu, Tingting;
Bai, Zhongzhong;
He, Bingfang

Publication type:

Article

Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production.

Published in:

Applied Microbiology & Biotechnology, 2013, v. 97, n. 5, p. 1963, doi. 10.1007/s00253-012-4062-8

By:

Geng, Feng;
Chen, Zhen;
Zheng, Ping;
Sun, Jibin;
Zeng, An-Ping

Publication type:

Article

多体卫星变构关节设计与运动学分析.

Published in:

Journal of Ordnance Equipment Engineering, 2024, v. 45, n. 9, p. 48, doi. 10.11809/bqzbgcxb2024.09.007

By:

白冰涛;
夏鲁瑞;
李森;
徐升

Publication type:

Article

Structural Insights into Plasticity and Discovery of Flavonoid Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease.

Published in:

Biophysica, 2023, v. 3, n. 1, p. 71, doi. 10.3390/biophysica3010006

By:

Saivish, Marielena Vogel;
Menezes, Gabriela de Lima;
Costa, Vivaldo Gomes da;
Nebo, Liliane;
Silva, Gislaine Celestino Dutra da;
Pacca, Carolina Colombelli;
Marques, Rafael Elias;
Nogueira, Maurício Lacerda;
Da Silva, Roosevelt Alves

Publication type:

Article

Mechanistic Explanation of Activation and Inhibition of Crucial Enzymes Involved in Melanin Production.

Published in:

Journal of Computational Biophysics & Chemistry, 2025, v. 24, n. 5, p. 639, doi. 10.1142/S2737416524500753

By:

Suyash, Shreyansh;
Mishra, Avinash;
Tembhre, Manoj Kumar

Publication type:

Article

Protein structure analysis of abnormal hemoglobins; Hb D-Los Angeles, Hb S and Hb G-Coushatta.

Published in:

Medicine Science, 2024, v. 13, n. 2, p. 289, doi. 10.5455/medscience.2024.01.06

By:

Ozturk, Onur

Publication type:

Article

Allosteric activation mechanism of DriD, a WYL-domain containing transcription regulator.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08111-x

By:

Cannistraci, Emily;
Srinivasu, Bindu Y.;
Chavez Orozco Jr., Jose;
Gozzi, Kevin;
Wales, Thomas E.;
Schumacher, Maria A.

Publication type:

Article

Preferential allosteric modulation of Otop1 channels by small molecule compounds.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07775-9

By:

Kong, Xiangjin;
Sun, Jie;
Zhang, Hanhan;
Yin, Yuan;
Liang, Xinyao;
Chen, Yan;
Luo, Guoqing;
Xia, Huixin;
Wang, Youjun;
Liu, Zhonghua;
Tang, Cheng

Publication type:

Article

Site-specific incorporation of 19F-nuclei at protein C-terminus to probe allosteric conformational transitions of metalloproteins.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07331-x

By:

Liu, Xichun;
Guo, Pengfei;
Yu, Qiufan;
Gao, Shu-Qin;
Yuan, Hong;
Tan, Xiangshi;
Lin, Ying-Wu

Publication type:

Article

Site-specific incorporation of 19F-nulcei at protein C-terminus to probe allosteric conformational transitions of metalloproteins.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07331-x

By:

Liu, Xichun;
Guo, Pengfei;
Yu, Qiufan;
Gao, Shu-Qin;
Yuan, Hong;
Tan, Xiangshi;
Lin, Ying-Wu

Publication type:

Article

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07263-6

By:

Schneberger, Niels;
Hendricks, Philipp;
Peter, Martin F.;
Gehrke, Erik;
Binder, Sophie C.;
Koenig, Paul-Albert;
Menzel, Stephan;
Thomas, Gavin H.;
Hagelueken, Gregor

Publication type:

Article

Allostery in homodimeric SARS-CoV-2 main protease.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07138-w

By:

Fornasier, Emanuele;
Fabbian, Simone;
Shehi, Haidi;
Enderle, Janine;
Gatto, Barbara;
Volpin, Daniele;
Biondi, Barbara;
Bellanda, Massimo;
Giachin, Gabriele;
Sosic, Alice;
Battistutta, Roberto

Publication type:

Article

Exploring the Efficacy, Safety, and Clinical Implications of Deucravacitinib in East Asians with Psoriasis: A Narrative Review.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 5, p. 1746, doi. 10.3390/jcm14051746

By:

Bang, Chul-Hwan;
Park, Chul-Jong;
Kim, Yoon-Seob

Publication type:

Article

Index Abstracts.

Published in:: Supramolecular Chemistry, 2012, v. 24, n. 1, p. i, doi. 10.1080/10610278.2012.679058
Publication type:: Article

Allosteric regulation of a reactive squaraine rotaxane endoperoxide.

Published in:

Supramolecular Chemistry, 2012, v. 24, n. 1, p. 14, doi. 10.1080/10610278.2011.611887

By:

Baumes, JeffreyM.;
Murgu, Ivan;
Connell, RichardD.;
Culligan, WilliamJ.;
Oliver, AllenG.;
Smith, BradleyD.

Publication type:

Article

Homogeneous Chemiluminescent Determination of Mercury(II) Using a Peroxidase-Mimicking DNAzyme Assay.

Published in:

Analytical Letters, 2018, v. 51, n. 9, p. 1280, doi. 10.1080/00032719.2017.1378229

By:

Gribas, Anastasia V.;
Sakharov, Ivan Yu.

Publication type:

Article

CONCEPTUAL RECONSTRUCTION AND EPISTEMIC IMPORT: ALLOSTERIC MECHANISTIC EXPLANATIONS AS A UNIFIED THEORY-NET.

Published in:

Crítica, 2017, v. 49, n. 146, p. 5, doi. 10.22201/iifs.18704905e.2017.179

By:

ALLEVA, KARINA;
DÍEZ, JOSÉ;
FEDERICO, LUCÍA

Publication type:

Article

Allosteric regulation of kinase activity.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.97084

By:

ANDREOTTI, AMY H.;
DÖTSCH, VOLKER

Publication type:

Article

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.93174

By:

Peverini, Laurie;
Shi, Sophie;
Medjebeur, Karima;
Corringer, Pierre-Jean

Publication type:

Article

The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91506

By:

Olivieri, Cristina;
Yingjie Wang;
Walker, Caitlin;
Subrahmanian, Manu Veliparambil;
Ha, Kim N.;
Bernlohr, David;
Jiali Gao;
Camilloni, Carlo;
Vendruscolo, Michele;
Taylor, Susan S.;
Veglia, Gianluigi

Publication type:

Article

A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.92262

By:

Zhuang Liu;
Gillis, Thomas G.;
Raman, Srivatsan;
Qiang Cui

Publication type:

Article

Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.94503

By:

Galicia, Christian;
Guaitoli, Giambattista;
Fislage, Marcus;
Gloeckner, Christian Johannes;
Versées, Wim

Publication type:

Article

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91040

By:

Ober, Veronica Teresa;
Githure, George Boniface;
Volpato Santos, Yuri;
Becker, Sidney;
Moya Munoz, Gabriel;
Basquin, Jérôme;
Schwede, Frank;
Lorentzen, Esben;
Boshart, Michael

Publication type:

Article

Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91777

By:

Dolcemascolo, Roswitha;
Heras-Hernández, María;
Goiriz, Lucas;
Montagud-Martínez, Roser;
Requena-Menéndez, Alejandro;
Ruiz, Raúl;
Pérez-Ràfols, Anna;
Higuera-Rodríguez, R. Anahí;
Pérez-Ropero, Guillermo;
Vranken, Wim F.;
Martelli, Tommaso;
Kaiser, Wolfgang;
Buijs, Jos;
Rodrigo, Guillermo

Publication type:

Article

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.89489

By:

Lin, David Yin-wei;
Kueffer, Lauren E.;
Juneja, Puneet;
Wales, Thomas E.;
Engen, John R.;
Andreotti, Amy H.

Publication type:

Article

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.89331

By:

Touray, Abdoulie O.;
Rajesh, Rishi;
Isebe, Tony;
Sternlieb, Tamara;
Loock, Mira;
Kutova, Oksana;
Cestari, Igor

Publication type:

Article

Allosteric regulation of kinase activity in living cells.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.90574

By:

Godbole, Shivani Sujay;
Dokholyan, Nikolay V.

Publication type:

Article

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.88982

By:

Aguirre, Tim;
Dornan, Gillian L.;
Hostachy, Sarah;
Neuenschwander, Martin;
Seyffarth, Carola;
Haucke, Volker;
Schütz, Anja;
von Kries, Jens Peter;
Fiedler, Dorothea

Publication type:

Article

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.83477

By:

Vuckovic, Ziva;
Jinan Wang;
Vi Pham;
Mobbs, Jesse I.;
Belousoff, Matthew J.;
Bhattarai, Apurba;
Burger, Wessel A. C.;
Thompson, Geoff;
Yeasmin, Mahmuda;
Nawaratne, Vindhya;
Leach, Katie;
van der Westhuizen, Emma T.;
Khajehali, Elham;
Yi-Lynn Liang;
Glukhova, Alisa;
Wootten, Denise;
Lindsley, Craig W.;
Tobin, Andrew;
Sexton, Patrick;
Danev, Radostin

Publication type:

Article

Bio-Crystallography IV: Structure-based drug design.

Published in:: 2019
Publication type:: Abstract

Discovery of Benzyl Tetraphosphonate Derivative as Inhibitor of Human Factor Xia.

Published in:

ChemistryOpen, 2020, v. 9, n. 11, p. 1161, doi. 10.1002/open.202000277

By:

Kar, Srabani;
Mottamal, Madhusoodanan;
Al‐Horani, Rami A.

Publication type:

Article

Insights into Allosteric Control of Human Blood Group A and B Glycosyltransferases from Dynamic NMR.

Published in:

ChemistryOpen, 2019, v. 8, n. 6, p. 760, doi. 10.1002/open.201900116

By:

Flügge, Friedemann;
Peters, Thomas

Publication type:

Article

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor.

Published in:

ChemistryOpen, 2017, v. 6, n. 4, p. 501, doi. 10.1002/open.201700062

By:

Jones, BEN J.;
Scopelliti, Rosario;
Tomas, Alejandra;
Bloom, StephEN R.;
Hodson, David J.;
BroichhagEN, Johannes

Publication type:

Article