Works matching DE "ALLOSTERIC regulation"

Results: 1547

Successful seizure control with cenobamate in juvenile myoclonic epilepsy.

Published in:

Epileptic Disorders, 2025, v. 27, n. 2, p. 307, doi. 10.1002/epd2.20339

By:

Tényi, Dalma;
Horváth, Réka;
Janszky, József

Publication type:

Article

Watercress-derived glucosinolates as potential allosteric PTP1B inhibitors: a dual in silico and in vitro study on insulin signaling modulation.

Published in:

BMC Chemistry, 2025, v. 19, n. 1, p. 1, doi. 10.1186/s13065-025-01544-9

By:

Ahmed, Noha A.;
Allam, Ahmed A.;
Rudayni, Hassan A.;
Alshabrmi, Fahad M.;
Alkhayl, Faris F. Aba;
Abdelrheem, Doaa A.;
Lamsabhi, Al Mokhtar;
Othman, Sarah I.;
Kamel, Emadeldin M.

Publication type:

Article

Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59299-9

By:

Wang, Yuzhu Z.;
Natsume, Koki;
Tanaka, Tatsuki;
Hososhima, Shoko;
Tashiro, Rintaro;
Sano, Fumiya K.;
Akasaka, Hiroaki;
Tsunoda, Satoshi P.;
Shihoya, Wataru;
Kandori, Hideki;
Nureki, Osamu

Publication type:

Article

'Intelligent' proteins.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05770-1

By:

Tripathi, Timir;
Uversky, Vladimir N.;
Giuliani, Alessandro

Publication type:

Article

Valerenic Acid and Pinoresinol as Positive Allosteric Modulators: Unlocking the Sleep-Promoting Potential of Valerian Extract Ze 911.

Published in:

Molecules, 2025, v. 30, n. 11, p. 2344, doi. 10.3390/molecules30112344

By:

Senn, Roman;
Schertler, Lukas;
Bussmann, Hendrik;
Drewe, Juergen;
Boonen, Georg;
Butterweck, Veronika

Publication type:

Article

Resource acquisition in diel cycles and the cost of growing quickly.

Published in:

PLoS Computational Biology, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.pcbi.1013132

By:

Flynn, Kevin J.;
Morozov, Andrew Yu.

Publication type:

Article

Structural and dynamic impacts of single-atom disruptions to guide RNA interactions within the recognition lobe of Geobacillus stearothermophilus Cas9.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.99275

By:

Belato, Helen B.;
Knight, Alexa L.;
D'Ordine, Alexandra M.;
Pindi, Chinmai;
Zhiqiang Fan;
Jinping Luo;
Palermo, Giulia;
Jogl, Gerwald;
Lisi, George P.

Publication type:

Article

Exploiting allosteric modulation: a new frontier for precision medicine.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10650-9

By:

Alum, Esther Ugo;
Udechukwu, Chidozie Dennis;
Obasi, David Chukwu

Publication type:

Article

Realizing mechanical frustration at the nanoscale using DNA origami.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60492-z

By:

Madhvacharyula, Anirudh S.;
Li, Ruixin;
Swett, Alexander A.;
Du, Yancheng;
Seo, Seongmin;
Simmel, Friedrich C.;
Choi, Jong Hyun

Publication type:

Article

Detection of Oral Beta-Lactam Antibiotics Using a Taste Sensor with Surface-Modified Lipid/Polymer Membranes.

Published in:

Chemosensors, 2025, v. 14, n. 5, p. 186, doi. 10.3390/chemosensors13050186

By:

Uchida, Takahiro;
Jiang, Ziyi;
Zhao, Zeyu;
Kimura, Shunsuke;
Onodera, Takeshi;
Toko, Kiyoshi

Publication type:

Article

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 1, p. 37, doi. 10.1038/nsmb.2924

By:

Thevakumaran, Neroshan;
Lavoie, Hugo;
Critton, David A;
Tebben, Andrew;
Marinier, Anne;
Sicheri, Frank;
Therrien, Marc

Publication type:

Article

Mechanism of allosteric activation of SAMHD1 by dGTP.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 11, p. 1304, doi. 10.1038/nsmb.2692

By:

Ji, Xiaoyun;
Wu, Ying;
Yan, Junpeng;
Mehrens, Jennifer;
Yang, Haitao;
DeLucia, Maria;
Hao, Caili;
Gronenborn, Angela M;
Skowronski, Jacek;
Ahn, Jinwoo;
Xiong, Yong

Publication type:

Article

Defining the structural relationship between kainate-receptor deactivation and desensitization.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 9, p. 1054, doi. 10.1038/nsmb.2654

By:

Dawe, G Brent;
Musgaard, Maria;
Andrews, Elizabeth D;
Daniels, Bryan A;
Aurousseau, Mark R P;
Biggin, Philip C;
Bowie, Derek

Publication type:

Article

Allosteric mechanism of water-channel gating by Ca<sup>2+</sup>-calmodulin.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 9, p. 1085, doi. 10.1038/nsmb.2630

By:

Reichow, Steve L;
Clemens, Daniel M;
Freites, J Alfredo;
Németh-Cahalan, Karin L;
Heyden, Matthias;
Tobias, Douglas J;
Hall, James E;
Gonen, Tamir

Publication type:

Article

The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 7, p. 876, doi. 10.1038/nsmb.2595

By:

Watson, Lisa C;
Kuchenbecker, Kristopher M;
Schiller, Benjamin J;
Gross, John D;
Pufall, Miles A;
Yamamoto, Keith R

Publication type:

Article

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 7, p. 900, doi. 10.1038/nsmb.2583

By:

Qi, Ruifeng;
Sarbeng, Evans Boateng;
Liu, Qun;
Le, Katherine Quynh;
Xu, Xinping;
Xu, Hongya;
Yang, Jiao;
Wong, Jennifer Li;
Vorvis, Christina;
Hendrickson, Wayne A;
Zhou, Lei;
Liu, Qinglian

Publication type:

Article

Allostery through DNA.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 410, doi. 10.1038/nsmb0413-410

By:

Chen, Inês

Publication type:

Article

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 477, doi. 10.1038/nsmb.2522

By:

Zhu, Shujia;
Stroebel, David;
Yao, C Andrea;
Taly, Antoine;
Paoletti, Pierre

Publication type:

Article

Structure and function of long noncoding RNAs in epigenetic regulation.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 3, p. 300, doi. 10.1038/nsmb.2480

By:

Mercer, Tim R;
Mattick, John S

Publication type:

Article

Protective degradation.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 13, doi. 10.1038/nsmb.2493

By:

Larochelle, Stéphane

Publication type:

Article

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 9, p. 938, doi. 10.1038/nsmb.2367

By:

Elegheert, Jonathan;
Bracke, Nathalie;
Pouliot, Philippe;
Gutsche, Irina;
Shkumatov, Alexander V;
Tarbouriech, Nicolas;
Verstraete, Kenneth;
Bekaert, Anaïs;
Burmeister, Wim P;
Svergun, Dmitri I;
Lambrecht, Bart N;
Vergauwen, Bjorn;
Savvides, Savvas N

Publication type:

Article

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 7, p. 716, doi. 10.1038/nsmb.2319

By:

Chen, Lei;
Wang, Jue;
Zhang, Yuan-Yuan;
Yan, S Frank;
Neumann, Dietbert;
Schlattner, Uwe;
Wang, Zhi-Xin;
Wu, Jia-Wei

Publication type:

Article

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 4, p. 437, doi. 10.1038/nsmb.2002

By:

Rizk, Shahir S.;
Paduch, Marcin;
Heithaus, John H.;
Duguid, Erica M.;
Sandstrom, Andrew;
Kossiakoff, Anthony A.

Publication type:

Article

Mechanics of Hsp70 chaperones enables differential interaction with client proteins.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 345, doi. 10.1038/nsmb.2006

By:

Schlecht, Rainer;
Erbse, Annette H.;
Bukau, Bernd;
Mayer, Matthias P.

Publication type:

Article

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 364, doi. 10.1038/nsmb.1990

By:

Shen, Aimee;
Lupardus, Patrick J.;
Gersch, Malte M.;
Puri, Aaron W.;
Albrow, Victoria E.;
Garcia, K Christopher;
Bogyo, Matthew

Publication type:

Article

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 316, doi. 10.1038/nsmb.2007

By:

Fairman, James Wesley;
Wijerathna, Sanath Ranjan;
Ahmad, Md Faiz;
Hai Xu;
Nakano, Ryo;
Jha, Shalini;
Prendergast, Jay;
Welin, R. Martin;
Flodin, Susanne;
Roos, Annette;
Nordlund, Pär;
Li, Zongli;
Walz, Thomas;
Dealwis, Chris Godfrey

Publication type:

Article

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 288, doi. 10.1038/nsmb.1978

By:

Freiburger, Lee A.;
Baettig, Oliver M.;
Sprules, Tara;
Berghuis, Albert M.;
Auclair, Karine;
Mittermaier, Anthony K.

Publication type:

Article

Enhanced interrogation: emerging strategies for cell signaling inhibition.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 6, p. 646, doi. 10.1038/nsmb0610-646

By:

Huang, Rong;
Martinez-Ferrando, Isabel;
Cole, Philip A.

Publication type:

Article

Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 2, p. 219, doi. 10.1038/nsmb.1547

By:

Bech-Otschir, Dawadschargal;
Helfrich, Annett;
Enenkel, Cordula;
Consiglieri, Gesa;
Seeger, Michael;
Holzhütter, Hermann-Georg;
Dahlmann, Burkhardt;
Kloetzel, Peter-Michael

Publication type:

Article

Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 10, p. 1084, doi. 10.1038/nsmb.1492

By:

Miller, Paul S.;
Topf, Maya;
Smart, Trevor G.

Publication type:

Article

Factor B structure provides insights into activation of the central protease of the complement system.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 3, p. 224, doi. 10.1038/nsmb1210

By:

Milder, Fin J.;
Gomes, Lucio;
Schouten, Arie;
Janssen, Bert J. C.;
Huizinga, Eric G.;
Romijn, Roland A.;
Hemrika, Wieger;
Roos, Anja;
Daha, Mohamed R.;
Gros, Piet

Publication type:

Article

Dynamically driven protein allostery.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 9, p. 831, doi. 10.1038/nsmb1132

By:

Popovych, Nataliya;
Sun, Shangjin;
Ebright, Richard H.;
Kalodimos, Charalampos G.

Publication type:

Article

Disorder-order folding transitions underlie catalysis in the helicase motor of SecA.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 7, p. 594, doi. 10.1038/nsmb1108

By:

Keramisanou, Dimitra;
Biris, Nikolaos;
Gelis, Ioannis;
Sianidis, Georgios;
Karamanou, Spyridoula;
Economou, Anastassios;
Kalodimos, Charalampos G.

Publication type:

Article

Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099.

Published in:

Veterinary & Comparative Oncology, 2020, v. 18, n. 2, p. 161, doi. 10.1111/vco.12524

By:

Tani, Hiroyuki;
Kurita, Sena;
Miyamoto, Ryo;
Ochiai, Kazuhiko;
Tamura, Kyoichi;
Bonkobara, Makoto

Publication type:

Article

Rhythm and Blues: The Case for Allosteric Modulators.

Published in:

Bio-IT World, 2010, v. 9, n. 3, p. 46

By:

DAVIES, KEVIN

Publication type:

Article

Design, Synthesis, and Application of Stimulus-Sensing Biohybrid Hydrogels.

Published in:

Macromolecular Rapid Communications, 2013, v. 34, n. 20, p. 1594, doi. 10.1002/marc.201300468

By:

Hotz, Natascha;
Wilcke, Louisa;
Weber, Wilfried

Publication type:

Article

The Apparently Unreactive Substrate Facilitates the Electron Transfer for Dioxygen Activation in Rieske Dioxygenases.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 16, p. 1, doi. 10.1002/chem.202103937

By:

Csizi, Katja‐Sophia;
Eckert, Lina;
Brunken, Christoph;
Hofstetter, Thomas B.;
Reiher, Markus

Publication type:

Article

A Switchable Catalyst Duo for Acyl Transfer Proximity Catalysis and Regulation of Substrate Selectivity.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 9, p. 2997, doi. 10.1002/chem.202004416

By:

Goswami, Abir;
Gaikwad, Sudhakar;
Schmittel, Michael

Publication type:

Article

Competition of Ligands and the 18‐mer Binding Domain of the RHAU Helicase for G‐Quadruplexes: Orthosteric or Allosteric Binding Mechanism?

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 3, p. 1113, doi. 10.1002/chem.202004040

By:

Marchand, Adrien;
Beauvineau, Claire;
Teulade‐Fichou, Marie‐Paule;
Zenobi, Renato

Publication type:

Article

Allosteric Control of Naphthalene Diimide Encapsulation and Electron Transfer in Porphyrin Containers: Photophysical Studies and Molecular Dynamics Simulation.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 72, p. 17514, doi. 10.1002/chem.202003151

By:

Zanetti‐Polzi, Laura;
Djemili, Ryan;
Durot, Stéphanie;
Heitz, Valérie;
Daidone, Isabella;
Ventura, Barbara

Publication type:

Article

An Artificial Hemoprotein with Inducible Peroxidase‐ and Monooxygenase‐Like Activities.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 65, p. 14929, doi. 10.1002/chem.202002434

By:

Kariyawasam, Kalani;
Di Meo, Thibault;
Hammerer, Fabien;
Valerio‐Lepiniec, Marie;
Sciortino, Giuseppe;
Maréchal, Jean‐Didier;
Minard, Philippe;
Mahy, Jean‐Pierre;
Urvoas, Agathe;
Ricoux, Rémy

Publication type:

Article

A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.

Published in:

Angewandte Chemie, 2016, v. 128, n. 38, p. 11749, doi. 10.1002/ange.201606242

By:

Murciano ‐ Calles, Javier;
Romney, David K.;
Brinkmann ‐ Chen, Sabine;
Buller, Andrew R.;
Arnold, Frances H.

Publication type:

Article

Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization.

Published in:

Angewandte Chemie, 2016, v. 128, n. 30, p. 8737, doi. 10.1002/ange.201602751

By:

Machida, Takuya;
Dutt, Som;
Winssinger, Nicolas

Publication type:

Article

The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.

Published in:

Angewandte Chemie, 2016, v. 128, n. 25, p. 7292, doi. 10.1002/ange.201603254

By:

Salvi, Nicola;
Papadopoulos, Evangelos;
Blackledge, Martin;
Wagner, Gerhard

Publication type:

Article

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Published in:

Angewandte Chemie, 2016, v. 128, n. 5, p. 1751, doi. 10.1002/ange.201508755

By:

Zhu, Rong;
Sinwel, Doris;
Hasenhuetl, Peter S.;
Saha, Kusumika;
Kumar, Vivek;
Zhang, Peng;
Rankl, Christian;
Holy, Marion;
Sucic, Sonja;
Kudlacek, Oliver;
Karner, Andreas;
Sandtner, Walter;
Stockner, Thomas;
Gruber, Hermann J.;
Freissmuth, Michael;
Newman, Amy Hauck;
Sitte, Harald H.;
Hinterdorfer, Peter

Publication type:

Article

Discovery of a Potent Allosteric Kinase Modulator by Combining Computational and Synthetic Methods.

Published in:

Angewandte Chemie, 2015, v. 127, n. 47, p. 14139, doi. 10.1002/ange.201506310

By:

Kroon, Edwin;
Schulze, Jörg O.;
Süß, Evelyn;
Camacho, Carlos J.;
Biondi, Ricardo M.;
Dömling, Alexander

Publication type:

Article

An Allosteric Receptor by Simultaneous 'Casting' and 'Molding' in a Dynamic Combinatorial Library.

Published in:

Angewandte Chemie, 2015, v. 127, n. 3, p. 847, doi. 10.1002/ange.201408907

By:

Li, Jianwei;
Nowak, Piotr;
Otto, Sijbren

Publication type:

Article

Using the Population-Shift Mechanism to Rationally Introduce 'Hill-type' Cooperativity into a Normally Non-Cooperative Receptor.

Published in:

Angewandte Chemie, 2014, v. 126, n. 36, p. 9625, doi. 10.1002/ange.201403777

By:

Simon, Anna J.;
Vallée-Bélisle, Alexis;
Ricci, Francesco;
Watkins, Herschel M.;
Plaxco, Kevin W.

Publication type:

Article

Magnetogenese in Wasser, ausgelöst durch einen chemischen Analyten.

Published in:

Angewandte Chemie, 2014, v. 126, n. 1, p. 60, doi. 10.1002/ange.201305662

By:

Hasserodt, Jens;
Kolanowski, Jacek Lukasz;
Touti, Faycal

Publication type:

Article

Bidirectional Regulation of Halide Binding in a Heterometallic Supramolecular Cube.

Published in:

Angewandte Chemie, 2013, v. 125, n. 50, p. 13681, doi. 10.1002/ange.201307478

By:

Ramsay, William J.;
Ronson, Tanya K.;
Clegg, Jack K.;
Nitschke, Jonathan R.

Publication type:

Article