Works matching DE "ALLOSTERIC enzymes"

Results: 219

Resveratrol and Its Metabolite as Potential Allosteric Regulators of Monoamine Oxidase A Activity in the Brain and Liver Under Chronic Predator Stress.

Published in:

Biomedicines, 2025, v. 13, n. 5, p. 1196, doi. 10.3390/biomedicines13051196

By:

Novak, Jurica;
Tseilikman, Olga B.;
Shatilov, Vladislav A.;
Zhukov, Maxim S.;
Shevyrin, Vadim A.;
Khismatullina, Zuhra R.;
Fedorova, Albina M.;
Patrikyan, Georgiy N.;
Khaibullin, Timur L.;
Tseilikman, Vadim E.

Publication type:

Article

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 477, doi. 10.1038/nsmb.2522

By:

Zhu, Shujia;
Stroebel, David;
Yao, C Andrea;
Taly, Antoine;
Paoletti, Pierre

Publication type:

Article

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 1, p. 29, doi. 10.1038/nsmb.2446

By:

Zhang, Wei;
Tyl, Marek;
Ward, Richard;
Sobott, Frank;
Maman, Joseph;
Murthy, Andal S;
Watson, Aleksandra A;
Fedorov, Oleg;
Bowman, Andrew;
Owen-Hughes, Tom;
El Mkami, Hassane;
Murzina, Natalia V;
Norman, David G;
Laue, Ernest D

Publication type:

Article

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 9, p. 876, doi. 10.1038/nsmb.2379

By:

Dou, Hao;
Buetow, Lori;
Sibbet, Gary J;
Cameron, Kenneth;
Huang, Danny T

Publication type:

Article

Allosteric regulation of Argonaute proteins by miRNAs.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 2, p. 144, doi. 10.1038/nsmb.1736

By:

Djuranovic, Sergej;
Zinchenko, Michelle Kim;
Hur, Junho K.;
Nahvi, Ali;
Brunelle, Julie L.;
Rogers, Elizabeth J.;
Green, Rachel

Publication type:

Article

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 2, p. 151, doi. 10.1038/nsmb.1743

By:

Yuan Tian;
Bassit, Bhramdeo;
Deming Chau;
Yue-Ming Li

Publication type:

Article

Light‐Triggered Control of Glucocerebrosidase Inhibitors: Towards Photoswitchable Pharmacological Chaperones.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 19, p. 1, doi. 10.1002/chem.202203841

By:

Clemente, Francesca;
Davighi, Maria Giulia;
Matassini, Camilla;
Cardona, Francesca;
Goti, Andrea;
Morrone, Amelia;
Paoli, Paolo;
Tejero, Tomás;
Merino, Pedro;
Cacciarini, Martina

Publication type:

Article

A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).

Published in:

Angewandte Chemie, 2015, v. 127, n. 17, p. 5255, doi. 10.1002/ange.201412154

By:

Kaniskan, H. Ümit;
Szewczyk, Magdalena M.;
Yu, Zhengtian;
Eram, Mohammad S.;
Yang, Xiaobao;
Schmidt, Keith;
Luo, Xiao;
Dai, Miao;
He, Feng;
Zang, Irene;
Lin, Ying;
Kennedy, Steven;
Li, Fengling;
Dobrovetsky, Elena;
Dong, Aiping;
Smil, David;
Min, Sun ‐ Joon;
Landon, Melissa;
Lin ‐ Jones, Jennifer;
Huang, Xi ‐ Ping

Publication type:

Article

Selektive C-C-Bindungsspaltung zur stereoselektiven Synthese acyclischer Systeme.

Published in:

Angewandte Chemie, 2015, v. 127, n. 2, p. 424, doi. 10.1002/ange.201405067

By:

Marek, Ilan;
Masarwa, Ahmad;
Delaye, Pierre ‐ Olivier;
Leibeling, Markus

Publication type:

Article

Pseudiline: halogenierte, allosterische Inhibitoren des Enzyms IspD aus dem Mevalonat-unabhängigen Biosyntheseweg.

Published in:

Angewandte Chemie, 2014, v. 126, n. 8, p. 2267, doi. 10.1002/ange.201309557

By:

Kunfermann, Andrea;
Witschel, Matthias;
Illarionov, Boris;
Martin, René;
Rottmann, Matthias;
Höffken, H. Wolfgang;
Seet, Michael;
Eisenreich, Wolfgang;
Knölker, Hans ‐ Joachim;
Fischer, Markus;
Bacher, Adelbert;
Groll, Michael;
Diederich, François

Publication type:

Article

Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition.

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 2, p. 902, doi. 10.1002/med.21746

By:

Rubio‐Ruiz, Belén;
Serrán‐Aguilera, Lucía;
Hurtado‐Guerrero, Ramón;
Conejo‐García, Ana

Publication type:

Article

Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.

Published in:

Biochemical Journal, 2023, v. 480, n. 17, p. 1411, doi. 10.1042/BCJ20230207

By:

Voronkova, Maria A.;
Hansen, Heather L.;
Cooper, Madison P.;
Miller, Jacob;
Sukumar, Narayanasami;
Geldenhuys, Werner J.;
Robart, Aaron R.;
Webb, Bradley A.

Publication type:

Article

Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity.

Published in:

Drug Metabolism Reviews, 2018, v. 50, n. 1, p. 3, doi. 10.1080/03602532.2018.1428342

By:

Dopart, Rachel;
Lu, Dai;
Lichtman, Aron H.;
Kendall, Debra A.

Publication type:

Article

133. DIRECT MEASUREMENT OF THE FREE FRACTION RATIO FOR TWO SPECIES COMPARISON OF PLASMA PROTEIN BINDING.

Published in:: 2002
Publication type:: Abstract

Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network.

Published in:

Plant Cell, 2017, v. 29, n. 6, p. 1480, doi. 10.1105/tpc.17.00186

By:

Xing, Anqi;
Last, Robert L.

Publication type:

Article

Pyruvate Kinase Deficiency: Current Challenges and Future Prospects.

Published in:

Journal of Blood Medicine, 2022, v. 13, p. 461, doi. 10.2147/JBM.S353907

By:

Fattizzo, Bruno;
Cavallaro, Francesca;
Marcello, Anna Paola Maria Luisa;
Vercellati, Cristina;
Barcellini, Wilma

Publication type:

Article

Regulation of Canine Skeletal Muscle Phosphofructokinase-1 by Adenine Nucleotides.

Published in:

International Journal of Applied Research in Veterinary Medicine, 2019, v. 17, n. 2, p. 10

By:

Shuichiro Kanai;
Takuro Shimada;
Takanori Narita;
Ken Okabayashi

Publication type:

Article

Regulation of Canine Skeletal Muscle Phosphofructokinase-1 by Adenine Nucleotides.

Published in:

International Journal of Applied Research in Veterinary Medicine, 2019, v. 17, n. 1, p. 10

By:

Shuichiro Kanai;
Takuro Shimada;
Takanori Narita;
Ken Okabayashi

Publication type:

Article

Evaluation of Inhibitory Effect of Self-Etch Adhesives Incorporated with Proanthocyanidin on Cysteine Cathepsins Present in Dentin Hybrid Layer Using Gelatin Zymography: An In vitro Study.

Published in:

Journal of Pharmacy & Bioallied Sciences, 2021, v. 13, p. S516, doi. 10.4103/jpbs.JPBS_535_20

By:

Senthamilselvan, Arun;
Ravikumar, Kaarunya;
Mallikarjunan, D. Y.;
Annadurai, Thendral;
Samynathan, Mothiraj;
Varshini, R. Jeya

Publication type:

Article

Evaluation of inhibitory effect of self-etch adhesives incorporated with proanthocyanidin on cysteine cathepsins present in dentin hybrid layer using gelatin zymography: An In vitro study.

Published in:

Journal of Pharmacy & Bioallied Sciences, 2021, v. 13, p. 516, doi. 10.4103/jpbs.JPBS_535_20

By:

Senthamilselvan, Arun;
Ravikumar, Kaarunya;
Mallikarjunan, D;
Annadurai, Thendral;
Samynathan, Mothiraj;
Varshini, R

Publication type:

Article

Exploring targeted therapy of osteosarcoma using proteomics data.

Published in:

OncoTargets & Therapy, 2017, v. 10, p. 565, doi. 10.2147/OTT.S119993

By:

Parunya Chaiyawat;
Jongkolnee Settakorn;
Apiruk Sangsin;
Pimpisa Teeyakasem;
Jeerawan Klangjorhor;
Aungsumalee Soongkhaw;
Dumnoensun Pruksakorn

Publication type:

Article

Allosteric and Chelate Cooperativity in Divalent Crown Ether/Ammonium Complexes with Strong Binding Enhancement.

Published in:

Chemistry - A European Journal, 2016, v. 22, n. 43, p. 15475, doi. 10.1002/chem.201603098

By:

von Krbek, Larissa K. S.;
Achazi, Andreas J.;
Solleder, Marthe;
Weber, Marcus;
Paulus, Beate;
Schalley, Christoph A.

Publication type:

Article

The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase.

Published in:

Molecular & Cellular Biochemistry, 2010, v. 344, n. 1/2, p. 253, doi. 10.1007/s11010-010-0549-8

By:

Treberg, Jason;
Brosnan, Margaret;
Brosnan, John

Publication type:

Article

Site-Directed Mutagenesis Implicates a Threonine Residue in TM6 in the Subtype Selectivities of UH-AH 37 and Pirenzepine at Muscarinic Receptors.

Published in:

Pharmacology, 2000, v. 61, n. 2, p. 62, doi. 10.1159/000028382

By:

Ellis, John;
Seidenberg, Margaret

Publication type:

Article

Enzymatic synthesis of 2′-ara and 2′-deoxy analogues of c-di-GMP.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2015, v. 34, n. 6, p. 416, doi. 10.1080/15257770.2015.1006775

By:

Shchokolova, Anastasia S.;
Rymko, Alexander N.;
Kvach, Sergey V.;
Shabunya, Polina S.;
Fatykhava, Svetlana A.;
Zinchenko, Anatoly I.

Publication type:

Article

Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 11, p. 833, doi. 10.3390/antibiotics9110833

By:

Gianquinto, Eleonora;
Tondi, Donatella;
D'Arrigo, Giulia;
Lazzarato, Loretta;
Spyrakis, Francesca

Publication type:

Article

Glycogen phosphorylase revisited: extending the resolution of the R‐ and T‐state structures of the free enzyme and in complex with allosteric activators.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2021, v. 77, n. 9, p. 303, doi. 10.1107/S2053230X21008542

By:

Leonidas, Demetres D.;
Zographos, Spyros E.;
Tsitsanou, Katerina E.;
Skamnaki, Vassiliki T.;
Stravodimos, George;
Kyriakis, Efthimios

Publication type:

Article

Comprehensive virtual screening of 4.8 k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 MPRO.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94951-6

By:

Jiménez-Avalos, Gabriel;
Vargas-Ruiz, A. Paula;
Delgado-Pease, Nicolás E.;
Olivos-Ramirez, Gustavo E.;
Sheen, Patricia;
Fernández-Díaz, Manolo;
Quiliano, Miguel;
Zimic, Mirko;
COVID-19 Working Group in Perú;
Agurto-Arteaga, Andres;
Antiparra, Ricardo;
Ardiles-Reyes, Manuel;
Calderon, Katherine;
Cauna-Orocollo, Yudith;
de Grecia Cauti-Mendoza, Maria;
Chipana-Flores, Naer;
Choque-Guevara, Ricardo;
Chunga-Girón, Xiomara;
Criollo-Orozco, Manuel;
De La Cruz, Lewis

Publication type:

Article

Structure and evolution of the luciferin-regenerating enzyme (LRE) gene from the firefly Photinus pyralis.

Published in:

Insect Molecular Biology, 2003, v. 12, n. 4, p. 365, doi. 10.1046/j.1365-2583.2003.00418.x

By:

Day, J. C.;
Bailey, M. J.

Publication type:

Article

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes.

Published in:

Cellular Microbiology, 2011, v. 13, n. 6, p. 836, doi. 10.1111/j.1462-5822.2011.01582.x

By:

Sicard, Audrey;
Semblat, Jean-Philippe;
Doerig, Caroline;
Hamelin, Romain;
Moniatte, Marc;
Dorin-Semblat, Dominique;
Spicer, Julie A.;
Srivastava, Anubhav;
Retzlaff, Silke;
Heussler, Volker;
Waters, Andrew P.;
Doerig, Christian

Publication type:

Article

An additional substrate binding site in a bacterial phenylalanine hydroxylase.

Published in:

European Biophysics Journal, 2013, v. 42, n. 9, p. 691, doi. 10.1007/s00249-013-0919-8

By:

Ronau, Judith;
Paul, Lake;
Fuchs, Julian;
Corn, Isaac;
Wagner, Kyle;
Liedl, Klaus;
Abu-Omar, Mahdi;
Das, Chittaranjan

Publication type:

Article

Chromatin fiber functional organization: Some plausible models.

Published in:

European Physical Journal E -- Soft Matter, 2006, v. 19, n. 3, p. 279, doi. 10.1140/epje/i2005-10050-6

By:

Lesne, A.;
Victor, J.-M.

Publication type:

Article

Probing the Interactions of 31 Mycotoxins with Xanthine Oxidase: Alternariol, Alternariol-3-Sulfate, and α-Zearalenol Are Allosteric Inhibitors of the Enzyme.

Published in:

Toxins, 2023, v. 15, n. 4, p. 250, doi. 10.3390/toxins15040250

By:

Balázs, Orsolya;
Dombi, Ágnes;
Zsidó, Balázs Zoltán;
Hetényi, Csaba;
Vida, Róbert György;
Poór, Miklós

Publication type:

Article

Palonosetron Hydrochloride in the Treatment of chemotherapy-Induced nausea and Vomiting.

Published in:

Clinical Medicine: Therapeutics, 2009, n. 1, p. 1145, doi. 10.4137/CMT.S2179

By:

Quan Li;
Roddy, Julianna V. F.;
Berger, Michael

Publication type:

Article

Engineering allosteric regulation in protein kinases.

Published in:

Science Signaling, 2018, v. 11, n. 555, p. 1, doi. 10.1126/scisignal.aar3250

By:

Pincus, David;
Pandey, Jai P.;
Feder, Zoë A.;
Creixell, Pau;
Resnekov, Orna;
Reynolds, Kimberly A.

Publication type:

Article

Targeting flexibility: a structure-based computational study revealing allosteric HIV-1 protease inhibitors.

Published in:

2014

By:

Kunze, Jens;
Todoroff, Nickolay;
Rodrigues, Tiago;
Schneider, Petra;
Schneider, Gisbert

Publication type:

Abstract

Sequence Analysis and Molecular Characterization of Clonorchis sinensis Hexokinase, an Unusual Trimeric 50-kDa Glucose-6-Phosphate-Sensitive Allosteric Enzyme.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0107940

By:

Chen, Tingjin;
Ning, Dan;
Sun, Hengchang;
Li, Ran;
Shang, Mei;
Li, Xuerong;
Wang, Xiaoyun;
Chen, Wenjun;
Liang, Chi;
Li, Wenfang;
Mao, Qiang;
Li, Ye;
Deng, Chuanhuan;
Wang, Lexun;
Wu, Zhongdao;
Huang, Yan;
Xu, Jin;
Yu, Xinbing

Publication type:

Article

Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase).

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0106243

By:

Haymond, Amanda;
Johny, Chinchu;
Dowdy, Tyrone;
Schweibenz, Brandon;
Villarroel, Karen;
Young, Richard;
Mantooth, Clark J.;
Patel, Trishal;
Bases, Jessica;
Jose, Geraldine San;
Jackson, Emily R.;
Dowd, Cynthia S.;
Couch, Robin D.

Publication type:

Article

The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0103552

By:

van Bel, Nikki;
van der Velden, Yme;
Bonnard, Damien;
Le Rouzic, Erwann;
Das, Atze T.;
Benarous, Richard;
Berkhout, Ben

Publication type:

Article

The Tertiary Origin of the Allosteric Activation of E. coli Glucosamine-6-Phosphate Deaminase Studied by Sol-Gel Nanoencapsulation of Its T Conformer.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0096536

By:

Zonszein, Sergio;
Álvarez-Añorve, Laura I.;
Vázquez-Núñez, Roberto J.;
Calcagno, Mario L.

Publication type:

Article

Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0084808

By:

Boyce, Sarah E.;
Tirunagari, Neeraj;
Niedziela-Majka, Anita;
Perry, Jason;
Wong, Melanie;
Kan, Elaine;
Lagpacan, Leanna;
Barauskas, Ona;
Hung, Magdeleine;
Fenaux, Martijn;
Appleby, Todd;
Watkins, William J.;
Schmitz, Uli;
Sakowicz, Roman

Publication type:

Article

An Allosteric Regulator of R7-RGS Proteins Influences Light-Evoked Activity and Glutamatergic Waves in the Inner Retina.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082276

By:

Cain, Matthew D.;
Vo, Bradly Q.;
Kolesnikov, Alexander V.;
Kefalov, Vladimir J.;
Culican, Susan M.;
Kerschensteiner, Daniel;
Blumer, Kendall J.

Publication type:

Article

Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0071242

By:

Shi, Rong;
Chen, Ze-Yong;
Zhu, Dao-Wei;
Li, Chunmin;
Shan, Yufei;
Xu, Genjun;
Lin, Sheng-Xiang

Publication type:

Article

Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072092

By:

Zhang, Li-Na;
Xu, Lei;
Zhou, Hua-Yong;
Wu, Ling-Yan;
Li, Yuan-Yuan;
Pang, Tao;
Xia, Chun-Mei;
Qiu, Bei-Ying;
Gu, Min;
Dong, Tian-Cheng;
Li, Jing-Ya;
Shen, Jing-Kang;
Li, Jia

Publication type:

Article

Allosteric Inhibitors of the NS3 Protease from the Hepatitis C Virus.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069773

By:

Abian, Olga;
Vega, Sonia;
Sancho, Javier;
Velazquez-Campoy, Adrian

Publication type:

Article

Evolution of Acetylcholinesterase and Butyrylcholinesterase in the Vertebrates: An Atypical Butyrylcholinesterase from the Medaka Oryzias latipes.

Published in:

2011

By:

Pezzementi, Leo;
Nachon, Florian;
Chatonnet, Arnaud

Publication type:

Art Reproduction

Evolution of Allosteric Citrate Binding Sites on 6-phosphofructo-1-kinase.

Published in:

PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0015447

By:

Usenik, Aleksandra;
Legiša, Matic

Publication type:

Article

Ligand Depletion in vivo Modulates the Dynamic Range and Cooperativity of Signal Transduction.

Published in:

PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008449

By:

Edelstein, Stuart J.;
Stefan, Melanie I.;
Novère, Nicolas Le

Publication type:

Article

Effects of drought stress on the quality of licorice.

Published in:

Pharmacognosy Magazine, 2022, v. 18, n. 80, p. 976, doi. 10.4103/pm.pm_84_22

By:

Fan, Jian;
Shen, Ying;
He, Lu-Wen;
Deng, Dai-Qian;
Meng, Xiang-Cai

Publication type:

Article

Mitigation of Radiation-Induced Dermatitis by Activation of Aldehyde Dehydrogenase 2 Using Topical Alda-1 in Mice.

Published in:

Radiation Research, 2012, v. 178, n. 1, p. 69, doi. 10.1667/RR2861.1

By:

Shoucheng Ning;
Budas, Grant R.;
Churchill, Eric N.;
Che-Hong Chen;
Knox, Susan J.;
Mochly-Rosen, Daria

Publication type:

Article