Works matching DE "ADENO-associated virus"

Results: 1179

A clinician's guide to AAV production – How manufacturing platforms shape vector properties.

Published in:

Medizinische Genetik, 2025, v. 37, n. 3, p. 169, doi. 10.1515/medgen-2025-2024

By:

Magnus, Jørgen;
Käsbach, Jonas

Publication type:

Article

In vivo applications and toxicities of AAV-based gene therapies in rare diseases.

Published in:

Orphanet Journal of Rare Diseases, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13023-025-03893-z

By:

Zhao, Qian;
Peng, Huifang;
Ma, Yujin;
Yuan, Huijun;
Jiang, Hongwei

Publication type:

Article

Aiming for spatial and temporal control of gene expression.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.107945

By:

IGOR TRAVISANO, STANISLAO;
CHING-LING LIEN

Publication type:

Article

Modulation of neuronal α1-adrenergic receptor reduces tauopathy and neuroinflammation by inhibiting the STING/NF-κB/NLRP3 signaling pathway in Alzheimer's disease mice.

Published in:

Journal of Neuroinflammation, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12974-025-03506-3

By:

Li, Bo;
Wang, Li;
Xiao, Yan;
Tang, Zhi;
Wang, Yang;
Sun, Ting;
Qi, Xiaolan

Publication type:

Article

Rett syndrome: advances in Understanding MeCP2 function, potential gene therapies, and public health implications.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10802-x

By:

Ali, Nadia E.;
Tariq, Nabeela;
Naz, Gul;
Abalkhail, Adil;
Kausar, Tasleem;
Mazhar, Ismail;
Zia, Sana;
Aqib, Amjad I.;
Khan, Najeeb Ullah

Publication type:

Article

12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis.

Published in:

Molecular Medicine, 2025, v. 31, n. 1, p. 1, doi. 10.1186/s10020-025-01297-0

By:

Chen, Jia Wei;
Chen, Shi Li;
Wu, Xin Rui;
Shu, Xin Yi;
Tang, Si Yi;
Yuan, He;
Li, You Ran;
Quan, Jin Wei;
Feng, Shuo;
Zhang, Rui Yan;
Yang, Chen Die;
Lu, Lin;
Wang, Xiao Qun

Publication type:

Article

Channeling Seizure Control: Optogenetics in Human Brain Slices.

Published in:

Epilepsy Currents, 2025, v. 25, n. 4, p. 275, doi. 10.1177/15357597251333157

By:

Rolston, John D.

Publication type:

Article

N4BP3 Activates TLR4-NF-κB Pathway in Inflammatory Bowel Disease by Promoting K48-Linked IκBα Ubiquitination.

Published in:

Journal of Inflammation Research, 2025, v. 18, p. 7167, doi. 10.2147/JIR.S518155

By:

Jiang, Wang;
Yin, Jie;
Han, Min;
He, Wenhua;
Zhao, Yan;
Hu, Jinyue;
Wang, Meiwei;
Wang, Sikai;
Xu, Jiafan;
Deng, Chongtian;
Li, Jiajia;
Gong, Xiaonuo;
Shen, Yueming

Publication type:

Article

Preclinical Evaluation of the Systemic Safety, Efficacy, and Biodistribution of a Recombinant AAV8 Vector Expressing FIX-TripleL in Hemophilia B Mice: Implications for Human Gene Therapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6073, doi. 10.3390/ijms26136073

By:

Chou, Sheng-Chieh;
Huang, Cheng-Po;
Su, Ying-Hui;
Yu, Chih-Hsiang;
Yang, Yung-Li;
Wang, Ssu-Chia;
Lin, Yi-Hsiu;
Chen, Yen-Ting;
Li, Jia-Yi;
Chang, Yen-Ting;
Chen, Su-Yu;
Lin, Shu-Wha

Publication type:

Article

P.116 Improving the NeuroD1-AAV-based gene therapy intracerebral injection protocol for optimal neuronal recovery.

Published in:

2025

By:

Taheri, G;
Masotti, BA;
Garcia, GR;
Wan, R;
Wilson, M;
Cook, DJ

Publication type:

Abstract

Rett syndrome: advances in Understanding MeCP2 function, potential gene therapies, and public health implications.

Published in:

Molecular Biology Reports, 2025, v. 52, n. 1, p. 1, doi. 10.1007/s11033-025-10802-x

By:

Ali, Nadia E.;
Tariq, Nabeela;
Naz, Gul;
Abalkhail, Adil;
Kausar, Tasleem;
Mazhar, Ismail;
Zia, Sana;
Aqib, Amjad I.;
Khan, Najeeb Ullah

Publication type:

Article

Preclinical evaluation of the efficacy and safety of adeno-associated virus 8-tissue-nonspecific alkaline phosphatase-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia

Published in:

Journal of Bone & Mineral Research, 2025, v. 40, n. 4, p. 463, doi. 10.1093/jbmr/zjaf005

By:

de Oliveira, Flavia Amadeu;
Tokuhara, Cintia Kazuko;
Mohamed, Fatma F;
Narisawa, Sonoko;
Lira dos Santos, Elis J;
Andras, Natalie L;
Shadid, Mohammad;
Miyake, Koichi;
Foster, Brian L;
Millán, José Luis

Publication type:

Article

Novel Immune Response Evasion Strategy to Redose Adeno-associated Viral Vectors and Prolong Survival in Surfactant Protein-B–Deficient Mice.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2025, v. 73, n. 1, p. 120, doi. 10.1165/rcmb.2024-0247OC

By:

Kang, Martin H.;
Thomas, Sylvia P.;
Westley, Caralyn;
Blouin, Thomas;
Xu, Liqun;
Chan, Ying Kai;
Lisk, Erin;
Allen, Sarah E.;
Vadivel, Arul;
Nangle, Kennedy;
Ramamurthy, Janani;
Pei, Yanlong;
Lewis, Lunndon A.;
Chiang, Jessica J.;
Romeo, Martin J.;
Vaena, Silvia;
O'Quinn, Elizabeth C.;
Schrecker, Henry D.;
Langdon, Casey G.;
Nietert, Paul J.

Publication type:

Article

A Versatile Reporter Platform for Evaluating HDR- and NHEJ-Based Genome Editing in Airway Epithelial Cell Cultures Using an rAAV Vector.

Published in:

Viruses (1999-4915), 2025, v. 17, n. 6, p. 821, doi. 10.3390/v17060821

By:

Park, Soo Yeun;
Feng, Zehua;
Zhang, Xiujuan;
Tang, Yinghua;
Richart, Donovan;
Vorhies, Kai E.;
Qiu, Jianming;
Engelhardt, John F.;
Yan, Ziying

Publication type:

Article

Myelin Membrane Assembly Is Driven by a Phase Transition of Myelin Basic Proteins Into a Cohesive Protein Meshwork.

Published in:

PLoS Biology, 2013, v. 11, n. 6, p. 1, doi. 10.1371/journal.pbio.1001577

By:

Aggarwal, Shweta;
Snaidero, Nicolas;
Pähler, Gesa;
Frey, Steffen;
Sánchez, Paula;
Zweckstetter, Markus;
Janshoff, Andreas;
Schneider, Anja;
Weil, Marie-Theres;
Schaap, Iwan A. T.;
Görlich, Dirk;
Simons, Mikael

Publication type:

Article

Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery.

Published in:

Journal of Neuro-Oncology, 2018, v. 139, n. 2, p. 293, doi. 10.1007/s11060-018-2889-2

By:

Volak, Adrienn;
Leroy, Stanley G.;
Natasan, Jeya Shree;
Park, David J.;
Cheah, Pike See;
Maus, Andreas;
Fitzpatrick, Zachary;
Hudry, Eloise;
Pinkham, Kelsey;
Gandhi, Sheetal;
Hyman, Bradley T.;
Mu, Dakai;
Guhasarkar, Dwijit;
Stemmer-Rachamimov, Anat O.;
Sena-Esteves, Miguel;
Badr, Christian E.;
Maguire, Casey A.

Publication type:

Article

Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Published in:

Biotechnology Letters, 2024, v. 46, n. 6, p. 945, doi. 10.1007/s10529-024-03520-0

By:

Pistek, Martina;
Andorfer, Peter;
Grabherr, Reingard;
Kraus, Barbara;
Hernandez Bort, Juan A.

Publication type:

Article

Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Published in:

Biotechnology Letters, 2022, v. 44, n. 1, p. 77, doi. 10.1007/s10529-021-03205-y

By:

Bayer, Benjamin;
Maccani, Andreas;
Jahn, Johanna;
Duerkop, Mark;
Kapeller, Ewald;
Pletzenauer, Robert;
Kraus, Barbara;
Striedner, Gerald;
Hernandez Bort, Juan A.

Publication type:

Article

Efficient removal of antibodies to adeno‐associated viruses by immunoadsorption.

Published in:

Journal of Clinical Apheresis, 2023, v. 38, n. 5, p. 590, doi. 10.1002/jca.22069

By:

Boedecker‐Lips, Simone;
Judel, Andreas;
Holtz, Stefan;
Mayer, Magnus;
Klimpke, Pascal;
Kraus, Daniel;
Schreiner, Thomas;
Gerstmayer, Bernhard;
Eulitz, Klaus;
Mayer, Magnus Christopher;
Weinmann‐Menke, Julia

Publication type:

Article

Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms.

Published in:

Molecular Medicine, 2022, v. 28, n. 1, p. 1, doi. 10.1186/s10020-022-00493-6

By:

Ni, Jiali;
Zhu, Haiyan;
Lu, Li;
Zhao, Zihe;
Jiang, Jiaxuan;
You, Xiaokang;
Wang, Yuzhu;
Ma, Yuliang;
Yang, Zirui;
Hou, Yayi;
Dou, Huan

Publication type:

Article

Role and fate of SP100 protein in response to Rep-dependent nonviral integration system.

Published in:

Applied Microbiology & Biotechnology, 2013, v. 97, n. 3, p. 1141, doi. 10.1007/s00253-012-3992-5

By:

Xue, Yuan-Yuan;
Wang, Ran;
Yue, Yang-Bo;
Xue, Jing-Lun;
Chen, Jin-Zhong

Publication type:

Article

Protocol: Adeno-Associated Virus-Mediated Gene Transfer in Ex Vivo Cultured Embryonic Mammary Gland.

Published in:

Journal of Mammary Gland Biology & Neoplasia, 2020, v. 25, n. 4, p. 409, doi. 10.1007/s10911-020-09461-4

By:

Lan, Qiang;
Mikkola, Marja L.

Publication type:

Article

Adeno‐associated viral vector gene therapy: Challenges for the paediatric hepatologist.

Published in:

Journal of Pediatric Gastroenterology & Nutrition, 2024, v. 79, n. 3, p. 485, doi. 10.1002/jpn3.12326

By:

Jagadisan, Barath;
Dhawan, Anil

Publication type:

Article

FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes.

Published in:

NPJ Regenerative Medicine, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41536-022-00227-6

By:

Liang, Chi-Qian;
Zhou, Deng-Cheng;
Peng, Wen-Tao;
Chen, Wu-Yun;
Wu, Hai-Yan;
Zhou, Yi-Min;
Gu, Wei-Li;
Park, Kyu-Sang;
Zhao, Hui;
Pi, Long-Quan;
Zheng, Li;
Feng, Shan-Shan;
Cai, Dong-Qing;
Qi, Xu-Feng

Publication type:

Article

Exercise improves depressive-like behavior in adolescent mice by regulating sphingosine and ceramide metabolism through microglial CerS1.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08347-7

By:

Li, Naigang;
Yao, Yuan;
Du, Jingyi;
Wu, Dong;
Qiao, Xinghui;
Peng, Fan;
Meng, Fei;
Zhang, Yanan;
Wang, Liyan;
Hao, Aijun;
Zhou, Wenjuan

Publication type:

Article

SunTag-PE: a modular prime editing system enables versatile and efficient genome editing.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07893-4

By:

Liu, Jiashuo;
Zhang, Jingjing;
Zhao, Tingting;
Zhao, Mengya;
Su, Min;
Chen, Ye;
Huang, Zheying;
Wang, Yuyan;
Zhong, Chaoyue;
Hu, Zheng;
Zhou, Ping;
Tian, Rui;
He, Dan

Publication type:

Article

SunTag-PE: a modular prime editing system enables versatile and efficient genome editing.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07893-4

By:

Liu, Jiashuo;
Zhang, Jingjing;
Zhao, Tingting;
Zhao, Mengya;
Su, Min;
Chen, Ye;
Huang, Zheying;
Wang, Yuyan;
Zhong, Chaoyue;
Hu, Zheng;
Zhou, Ping;
Tian, Rui;
He, Dan

Publication type:

Article

RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07407-8

By:

Jiang, Huanyu;
Zhang, Yubiao;
Hu, Geliang;
Ji, Piyao;
Ming, Jianghua;
Li, Yaming;
Zhou, Yan

Publication type:

Article

Nr1d1 inhibition mitigates intermittent hypoxia-induced pulmonary hypertension via Dusp1-mediated Erk1/2 deactivation and mitochondrial fission attenuation.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02219-5

By:

Pan, Zhou;
Yao, Yan;
Liu, Xu;
Wang, Yixuan;
Zhang, Xinyue;
Zha, Shiqian;
Hu, Ke

Publication type:

Article

Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02087-z

By:

Wang, Dongyun;
Li, Yue;
Li, Guiying;
Liu, Mengyu;
Zhou, Zihui;
Wu, Ming;
Song, Shan;
Bian, Yawei;
Dong, Jiajia;
Li, Xinran;
Du, Yunxia;
Zhang, Tao;
Shi, Yonghong

Publication type:

Article

TNF-α/TNFR1 activated astrocytes exacerbate depression-like behavior in CUMS mice.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01987-4

By:

Gao, Mengjiao;
Song, Yu;
Liu, Yaqi;
Miao, Yuqing;
Guo, Yanwu;
Chai, Huihui

Publication type:

Article

Emerging Immunogenicity and Genotoxicity Considerations of Adeno-Associated Virus Vector Gene Therapy for Hemophilia.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 11, p. 2471, doi. 10.3390/jcm10112471

By:

Monahan, Paul E.;
Négrier, Claude;
Tarantino, Michael;
Valentino, Leonard A.;
Mingozzi, Federico

Publication type:

Article

Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 9, p. 1321, doi. 10.3390/jcm8091321

By:

Ma, Hongxia;
Lu, Yuanqing;
Lowe, Keith;
van der Meijden-Erkelens, Lonneke;
Wasserfall, Clive;
Atkinson, Mark A.;
Song, Sihong

Publication type:

Article

Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.87730

By:

Jain, Nina K.;
Ogden, Pierce J.;
Church, George M.

Publication type:

Article

Medullary tachykinin precursor 1 neurons promote rhythmic breathing.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.85575

By:

Rousseau, Jean-Philippe;
Furdui, Andreea;
Scarpellini, Carolina da Silveira;
Horner, Richard L.;
Montandon, Gaspard

Publication type:

Article

Tiered sympathetic control of cardiac function revealed by viral tracing and single cell transcriptome profiling.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.86295

By:

Sharma, Sachin;
Littman, Russell;
Tompkins, John D.;
Arneson, Douglas;
Contreras, Jaime;
Dajani, Al-Hassan;
Ang, Kaitlyn;
Tsanhani, Amit;
Xin Sun;
Jay, Patrick Y.;
Herzog, Herbert;
Xia Yang;
Ajijola, Olujimi A.

Publication type:

Article

Cell tropism of adeno-associated viruses within the mouse inner ear in vivo: from embryonic to adult stages.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-98007-x

By:

Iranfar, Sepideh;
Cornille, Maxence;
Roldan, Mauricio Saenz;
Plion, Baptiste;
Lecomte, Marie-José;
Safieddine, Saaid;
Lahlou, Ghizlene

Publication type:

Article

PET imaging of AAV9 and AAVBR1 trafficking in normal mice.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-86815-0

By:

Bansal, Aditya;
Sharma, Shalini;
Kethamreddy, Manasa;
Pandey, Mukesh K.

Publication type:

Article

The role of CLDN11 in promotion of granulosa cell proliferation in polycystic ovary syndrome via activation of the PI3K-AKT signalling pathway.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-88189-9

By:

Wang, Min;
Chen, Tong;
Zheng, Jiani;
Shen, Caomeihui;
He, Guitian;
Zhang, Jingshun;
Zhang, Boqi;
Zheng, Lianwen

Publication type:

Article

Vector modifications to eliminate transposase expression following piggyBac-mediated transgenesis.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep07403

By:

Chakraborty, Syandan;
Ha Yeun Ji;
Jack Chen;
Gersbach, Charles A.;
Kam W. Leong1

Publication type:

Article

Novel Adeno-associated Viruses Derived From Pig Tissues Transduce Most Major Organs in Mice.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep06644

By:

Bello, Alexander;
Chand, Allan;
Aviles, Jenna;
Soule, Geoff;
Auricchio, Alberto;
Kobinger, Gary P.

Publication type:

Article

Adeno-Associated Viral Vectors Show Serotype Specific Transduction of Equine Joint Tissue Explants and Cultured Monolayers.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05861

By:

Hemphill, Daniel D.;
McIlwraith, C. Wayne;
Samulski, R. Jude;
Goodrich, Laurie R.

Publication type:

Article

Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05506

By:

Yoshiyuki Yamazaki;
Yukihiko Hirai;
Koichi Miyake;
Takashi Shimada

Publication type:

Article

Resveratrol inhibits ferroptosis in the lung tissues of heat stroke-induced rats via the Nrf2 pathway.

Published in:

BMC Pharmacology & Toxicology, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s40360-024-00810-1

By:

Du, Liwen;
Zhu, Xueqi;
Jiang, Zhenluo;
Wang, Weidong;
Liu, Peng;
Zhu, Leilei;
Zhang, Fangqi

Publication type:

Article

GAS-STING signaling plays an essential pathogenetic role in Doxorubicin-Induced Cardiotoxicity.

Published in:

BMC Pharmacology & Toxicology, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s40360-022-00631-0

By:

Xiao, Zilong;
Yu, Ziqing;
Chen, Chaofeng;
Chen, Ruizhen;
Su, Yangang

Publication type:

Article

Administration of chiglitazar reverses chronic stress-induced depressive-like symptoms in mice via activation of hippocampal PPARα and BDNF.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1587399

By:

Zhou, Jiu-Jian;
Zhao, Jie;
Gao, Shang-Yan;
Gao, Yuan-yuan;
Chen, Cheng;
Ding, Yi;
Wu, Zhong-hua;
Chen, Pu-Jian

Publication type:

Article

Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00441

By:

Selot, Ruchita;
Arumugam, Sathyathithan;
Mary, Bertin;
Cheemadan, Sabna;
Jayandharan, Giridhara R.

Publication type:

Article

Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors.

Published in:

Frontiers in Oncology, 2019, p. N.PAG, doi. 10.3389/fonc.2019.00052

By:

Reul, Johanna;
Frisch, Janina;
Engeland, Christine E.;
Thalheimer, Frederic B.;
Hartmann, Jessica;
Ungerechts, Guy;
Buchholz, Christian J.

Publication type:

Article

Erratum: The HLA class-II immunopeptidomes of AAV capsids proteins.

Published in:: Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1261322
Publication type:: Article

Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1191188

By:

Quan Li;
Zongde Yang;
Kun Wang;
Zhi Chen;
Hongxing Shen

Publication type:

Article