Works matching DE "ACTIVIN receptor-like kinase 1"

Results: 43

Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling.

Published in:

Heart & Vessels, 2017, v. 32, n. 5, p. 628, doi. 10.1007/s00380-017-0955-x

By:

Morine, Kevin;
Qiao, Xiaoying;
Paruchuri, Vikram;
Aronovitz, Mark;
Mackey, Emily;
Buiten, Lyanne;
Levine, Jonathan;
Ughreja, Keshan;
Nepali, Prerna;
Blanton, Robert;
Karas, Richard;
Oh, S.;
Kapur, Navin

Publication type:

Article

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway.

Published in:

Frontiers in Pharmacology, 2017, v. 8, p. 1, doi. 10.3389/fphar.2017.00111

By:

Busceti, Carla L.;
Marchitti, Simona;
Bianchi, Franca;
Di Pietro, Paola;
Riozzi, Barbara;
Stanzione, Rosita;
Cannella, Milena;
Battaglia, Giuseppe;
Bruno, Valeria;
Volpe, Massimo;
Fornai, Francesco;
Nicoletti, Ferdinando;
Rubattu, Speranza

Publication type:

Article

Metabolism of Hydrophobic Carbon Sources and Regulation of It in n-Alkane-Assimilating Yeast Yarrowia lipolytica.

Published in:

Bioscience, Biotechnology & Biochemistry, 2013, v. 77, n. 6, p. 1149, doi. 10.1271/bbb.130164

By:

FUKUDA, Ryouichi

Publication type:

Article

Evolution of the leucine-rich repeat receptor-like protein kinase gene family: Ancestral copy number and functional divergence of BAM1 and BAM2 in Brassicaceae.

Published in:

Journal of Systematics & Evolution, 2016, v. 54, n. 3, p. 204, doi. 10.1111/jse.12206

By:

Li, Hao;
Shi, Qian;
Zhang, Zai‐Bao;
Zeng, Li‐Ping;
Qi, Ji;
Ma, Hong

Publication type:

Article

Research on potential biomarkers in hereditary hemorrhagic telangiectasia.

Published in:

Frontiers in Genetics, 2015, v. 6, p. 1, doi. 10.3389/fgene.2015.00115

By:

Botella, Luisa-María;
Albiñana, Virginia;
Ojeda-Fernandez, Luisa;
Recio-Poveda, Lucia;
Bernabéu, Carmelo

Publication type:

Article

Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia.

Published in:

Frontiers in Genetics, 2015, v. 6, p. 1, doi. 10.3389/fgene.2015.00035

By:

Ardelean, Daniela S.;
Letarte, Michelle

Publication type:

Article

Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges.

Published in:

Frontiers in Genetics, 2015, v. 6, p. 1, doi. 10.3389/fgene.2015.00025

By:

Tual-Chalot, Simon;
Oh, S. Paul;
Arthur, Helen M.

Publication type:

Article

Reduced expression of activin receptor-like kinase 7 in breast cancer is associated with tumor progression.

Published in:

Medical Oncology, 2012, v. 29, n. 4, p. 2519, doi. 10.1007/s12032-011-0114-7

By:

Zeng, Fancai;
Xu, Guoxiong;
Zhou, Tiejun;
Yang, Chengwan;
Wang, Xinyan;
Peng, Chun;
Zhou, Hong

Publication type:

Article

Harnessing the BMP signaling pathway to control the formation of cancer stem cells by effects on epithelial-to-mesenchymal transition.

Published in:

Biochemical Society Transactions, 2017, v. 45, n. 1, p. 223, doi. 10.1042/BST20160177

By:

Bosukonda, Ashish;
Carlson, William D.

Publication type:

Article

A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

Published in:

2016

By:

Jimeno, Antonio;
Posner, Marshall R.;
Wirth, Lori J.;
Saba, Nabil F.;
Cohen, Roger B.;
Popa, Elizabeta C.;
Argiris, Athanassios;
Grossmann, Kenneth F.;
Sukari, Ammar;
Wilson, Dawn;
Zhang, Xiaosha;
Sun, Jade;
Glasser, Chad;
Attie, Kenneth M.;
Sherman, Matthew L.;
Pandya, Susan S.;
Weiss, Jared

Publication type:

journal article

DNA Sequence Variation in Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes.

Published in:

2019

By:

Emdin, Connor A.;
Khera, Amit V.;
Aragam, Krishna;
Haas, Mary;
Chaffin, Mark;
Klarin, Derek;
Natarajan, Pradeep;
Bick, Alexander;
Zekavat, Seyedeh M.;
Akihiro Nomura;
Ardissino, Diego;
Wilson, James G.;
Schunkert, Heribert;
McPherson, Ruth;
Watkins, Hugh;
Elosua, Roberto;
Bown, Matthew J.;
Samani, Nilesh J.;
Baber, Usman;
Erdmann, Jeanette

Publication type:

journal article

Inhibition of activin receptor-like kinase 5 induces matrix metallopeptidase 9 expression and aggravates lipopolysaccharide-induced pulmonary injury in mice.

Published in:

European Review for Medical & Pharmacological Sciences, 2013, v. 17, n. 8, p. 1051

By:

MA, B.;
ZHOU, P.-Y.;
NI, W.;
WEI, W.;
BEN, D.-F;
LU, W.;
XIA, Z.-F.

Publication type:

Article

A phase I study of the human anti-activin receptor-like kinase 1 antibody PF-03446962 in Asian patients with advanced solid tumors.

Published in:

Cancer Medicine, 2016, v. 5, n. 7, p. 1454, doi. 10.1002/cam4.724

By:

Doi, Toshihiko;
Lee, Kyung‐Hun;
Kim, Tae‐Min;
Ohtsu, Atsushi;
Kim, Tae Yong;
Ikeda, Masafumi;
Yoh, Kiyotaka;
Gallo Stampino, Corrado;
Hirohashi, Tomoko;
Suzuki, Akiyuki;
Fujii, Yosuke;
Andrew Williams, James;
Bang, Yung‐Jue

Publication type:

Article

Vactosertib, a Novel, Orally Bioavailable Activin Receptor-Like Kinase 5 Inhibitor, Promotes Regression of Fibrotic Plaques in a Rat Model of Peyronie's Disease.

Published in:

World Journal of Men's Health, 2020, v. 38, n. 4, p. 552, doi. 10.5534/wjmh.190071

By:

Kang-Moon Song;
Doo Yong Chung;
Min Ji Choi;
Ghatak, Kalyan;
Minh, Nguyen Nhat;
Limanjaya, Anita;
Mi-Hye Kwon;
Jiyeon Ock;
Guo Nan Yin;
Dae-Kee Kim;
Ji-Kan Ryu;
Jun-Kyu Suh

Publication type:

Article

Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations.

Published in:

Cardiovascular Research, 2015, v. 107, n. 1, p. 143, doi. 10.1093/cvr/cvv148

By:

Rochon, Elizabeth R.;
Wright, Daniel S.;
Schubert, Max M.;
Roman, Beth L.

Publication type:

Article

Essential role for TMEM100 in vascular integrity but limited contributions to the pathogenesis of hereditary haemorrhagic telangiectasia.

Published in:

Cardiovascular Research, 2015, v. 105, n. 3, p. 353, doi. 10.1093/cvr/cvu260

By:

Moon, Eun-Hye;
Kim, Yoo Sung;
Seo, Jiyoung;
Lee, Sabin;
Lee, Young Jae;
Oh, Suk Paul

Publication type:

Article

TGF-β1/ALK5-induced monocyte migration involves PI3K and p38 pathways and is not negatively affected by diabetes mellitus.

Published in:

Cardiovascular Research, 2011, v. 91, n. 3, p. 510, doi. 10.1093/cvr/cvr100

By:

Olieslagers, Servé;
Pardali, Evangelia;
Tchaikovski, Vadim;
ten Dijke, Peter;
Waltenberger, Johannes

Publication type:

Article

Case report: a unique pediatric case of a primary CD8 expressing ALK-1 positive anaplastic large cell lymphoma of skeletal muscle.

Published in:: 2012
Publication type:: Case Study

ALK1 signaling in development and disease: new paradigms.

Published in:

Cellular & Molecular Life Sciences, 2017, v. 74, n. 24, p. 4539, doi. 10.1007/s00018-017-2636-4

By:

Roman, Beth;
Hinck, Andrew

Publication type:

Article

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain.

Published in:

Cellular & Molecular Life Sciences, 2012, v. 69, n. 2, p. 313, doi. 10.1007/s00018-011-0751-1

By:

Bidart, Marie;
Ricard, Nicolas;
Levet, Sandrine;
Samson, Michel;
Mallet, Christine;
David, Laurent;
Subileau, Mariela;
Tillet, Emmanuelle;
Feige, Jean-Jacques;
Bailly, Sabine

Publication type:

Article

What's Next in Discovering the Genetic Basis of PAH?

Published in:

Current Medical Literature: Pulmonary Hypertension, 2012, p. 11

By:

Trembath, Richard

Publication type:

Article

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 12, p. 2776, doi. 10.3390/ijms18122776

By:

Ungefroren, Hendrik;
Witte, David;
Fiedler, Christian;
Gädeken, Thomas;
Kaufmann, Roland;
Lehnert, Hendrik;
Gieseler, Frank;
Rauch, Bernhard H.

Publication type:

Article

Potential Roles of BMP9 in Liver Fibrosis.

Published in:

International Journal of Molecular Sciences, 2014, v. 15, n. 11, p. 20656, doi. 10.3390/ijms151120656

By:

Jianjun Bi;
Shengfang Ge

Publication type:

Article

Retention in the endoplasmic reticulum is the underlying mechanism of some hereditary haemorrhagic telangiectasia type 2 ALK1 missense mutations.

Published in:

Molecular & Cellular Biochemistry, 2013, v. 373, n. 1/2, p. 247, doi. 10.1007/s11010-012-1496-3

By:

Hume, Alistair;
John, Anne;
Akawi, Nadia;
Al-Awadhi, Aydah;
Al-Suwaidi, Sarah;
Al-Gazali, Lihadh;
Ali, Bassam

Publication type:

Article

Heterozygous disruption of activin receptor-like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy.

Published in:

Kidney International, 2014, v. 85, n. 2, p. 319, doi. 10.1038/ki.2013.292

By:

Muñoz-Félix, José M;
López-Novoa, José M;
Martínez-Salgado, Carlos

Publication type:

Article

An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva.

Published in:

Journal of Bone & Mineral Research, 2012, v. 27, n. 8, p. 1746, doi. 10.1002/jbmr.1637

By:

Chakkalakal, Salin A;
Zhang, Deyu;
Culbert, Andria L;
Convente, Michael R;
Caron, Robert J;
Wright, Alexander C;
Maidment, Andrew DA;
Kaplan, Frederick S;
Shore, Eileen M

Publication type:

Article

Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction.

Published in:

Journal of Molecular Medicine, 2015, v. 93, n. 3, p. 289, doi. 10.1007/s00109-014-1211-9

By:

Ehanire, Tosan;
Ren, Licheng;
Bond, Jennifer;
Medina, Manuel;
Li, George;
Bashirov, Latif;
Chen, Lei;
Kokosis, George;
Ibrahim, Mohamed;
Selim, Angelica;
Blobe, Gerard;
Levinson, Howard

Publication type:

Article

Thermoreversible gel for delivery of activin receptor-like kinase 5 inhibitor SB-505124 for glaucoma filtration surgery.

Published in:

Pharmaceutical Development & Technology, 2013, v. 18, n. 4, p. 957, doi. 10.3109/10837450.2011.647035

By:

Sutariya, Vijaykumar;
Miladore, Nicholas;
Geldenhuys, Werner;
Bhatia, Deepak;
Wehrung, Daniel;
Nakamura, Hiroshi

Publication type:

Article

Paediatric pulmonary hypertension caused by an ACVRL1 mutation presenting as Ortner syndrome.

Published in:

2018

By:

Alsheikh, Batool;
Aljohani, Othman;
Coufal, Nicole G.

Publication type:

journal article

Induction of Transforming Growth Factor Beta Receptors following Focal Ischemia in the Rat Brain.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0106544

By:

Pál, Gabriella;
Lovas, Gábor;
Dobolyi, Arpád

Publication type:

Article

Key Role of the Endothelial TGF-β/ALK1/Endoglin Signaling Pathway in Humans and Rodents Pulmonary Hypertension.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100310

By:

Gore, Benoît;
Izikki, Mohamed;
Mercier, Olaf;
Dewachter, Laurence;
Fadel, Elie;
Humbert, Marc;
Dartevelle, Philippe;
Simonneau, Gerald;
Naeije, Robert;
Lebrin, Franck;
Eddahibi, Saadia

Publication type:

Article

Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0098646

By:

Tual-Chalot, Simon;
Mahmoud, Marwa;
Allinson, Kathleen R.;
Redgrave, Rachael E.;
Zhai, Zhenhua;
Oh, S. Paul;
Fruttiger, Marcus;
Arthur, Helen M.

Publication type:

Article

Antisense-Oligonucleotide Mediated Exon Skipping in Activin-Receptor-Like Kinase 2: Inhibiting the Receptor That Is Overactive in Fibrodysplasia Ossificans Progressiva.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069096

By:

Shi, SongTing;
Cai, Jie;
de Gorter, David J. J.;
Sanchez-Duffhues, Gonzalo;
Kemaladewi, Dwi U.;
Hoogaars, Willem M. H.;
Aartsma-Rus, Annemieke;
’t Hoen, Peter A. C.;
ten Dijke, Peter

Publication type:

Article

Enhanced Responses to Angiogenic Cues Underlie the Pathogenesis of Hereditary Hemorrhagic Telangiectasia 2

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063138

By:

Choi, Eun-Jung;
Kim, Yong Hwan;
Choe, Se-woon;
Tak, Yu Gyoung;
Garrido-Martin, Eva M.;
Chang, Myron;
Lee, Young Jae;
Oh, S. Paul

Publication type:

Article

A New Class of Small Molecule Inhibitor of BMP Signaling.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062721

By:

Sanvitale, Caroline E.;
Kerr, Georgina;
Chaikuad, Apirat;
Ramel, Marie-Christine;
Mohedas, Agustin H.;
Reichert, Sabine;
Wang, You;
Triffitt, James T.;
Cuny, Gregory D.;
Yu, Paul B.;
Hill, Caroline S.;
Bullock, Alex N.

Publication type:

Article

Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056442

By:

van Beuge, Marike Marjolijn;
Prakash, Jai;
Lacombe, Marie;
Post, Eduard;
Reker-Smit, Catharina;
Beljaars, Leonie;
Poelstra, Klaas

Publication type:

Article

ADMP controls the size of Spemann's organizer through a network of self-regulating expansion-restriction signals.

Published in:

BMC Biology, 2018, v. 16, p. 1, doi. 10.1186/s12915-018-0483-x

By:

Leibovich, Avi;
Kot-Leibovich, Hadas;
Ben-Zvi, Danny;
Fainsod, Abraham

Publication type:

Article

Transforming growth factor-β1 up-regulates connexin43 expression in human granulosa cells.

Published in:

Human Reproduction, 2015, v. 30, n. 9, p. 2190, doi. 10.1093/humrep/dev175

By:

Yu-Ching Chen;
Hsun-Ming Chang;
Jung-Chien Cheng;
Horng-Der Tsai;
Cheng-HsuanWu;
Leung, Peter C. K.

Publication type:

Article

Translational research.

Published in:: Human Reproduction, 2013, v. 28, n. suppl_1, p. i368, doi. 10.1093/humrep/det225
Publication type:: Article

Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes.

Published in:

Molecular Medicine Reports, 2017, v. 15, n. 6, p. 4139, doi. 10.3892/mmr.2017.6513

By:

JAEWOONG JANG;
YOONJU JUNG;
SANG‑IN CHUNG;
YOOSIK YOON;
SEONG JUN SEO;
SEOK‑MIN KIM;
YAE JIE SHIM;
SOO HYUN CHO

Publication type:

Article

Evolution of Intrahepatic Shunts in a Patient With Hereditary Hemorrhagic Telangiectasia.

Published in:

2018

By:

Haghighat, Leila;
Brandt, Eric J.;
Proctor, Deborah D.;
Garcia-Tsao, Guadalupe;
Pollak, Jeffrey;
Young, Lawrence H.

Publication type:

Case Study

The Expression of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) in Hippocampal Arterioles Declines During Progression of Alzheimer's Disease.

Published in:

Cerebral Cortex Communications, 2020, v. 1, n. 1, p. 1, doi. 10.1093/texcom/tgaa031

By:

Anderson, Kelley E.;
Bellio, Thomas A.;
Aniskovich, Emily;
Adams, Stephanie L.;
Blusztajn, Jan Krzysztof;
Delalle, Ivana

Publication type:

Article

Activin Receptor-Like Kinase 7 Suppresses Lipolysis to Accumulate Fat in Obesity Through Downregulation of Peroxisome Proliferator--Activated Receptor γ and C/EBPα.

Published in:

Diabetes, 2013, v. 62, n. 1, p. 115, doi. 10.2337/db12-0295

By:

Yogosawa, Satomi;
Mizutani, Shin;
Ogawa, Yoshihiro;
Izumi, Tetsuro

Publication type:

Article