Works matching Chemical genetics

Results: 3840

Matrix Linear Models for High-Throughput Chemical Genetic Screens.

Published in:

Genetics, 2019, v. 212, n. 4, p. 1063, doi. 10.1534/genetics.119.302299

By:

Liang, Jane W.;
Nichols, Robert J.;
Sen, Śaunak

Publication type:

Article

Phosphoproteomics Meets Chemical Genetics: Approaches for Global Mapping and Deciphering the Phosphoproteome.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 20, p. 7637, doi. 10.3390/ijms21207637

By:

Jurcik, Jan;
Sivakova, Barbara;
Cipakova, Ingrid;
Selicky, Tomas;
Stupenova, Erika;
Jurcik, Matus;
Osadska, Michaela;
Barath, Peter;
Cipak, Lubos

Publication type:

Article

The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 4, p. 1451, doi. 10.3390/ijms21041451

By:

Takano, Kei;
Hachiya, Akira;
Murase, Daiki;
Kawasaki, Akiko;
Uda, Hirokazu;
Kasamatsu, Shinya;
Sugai, Yoshiya;
Takahashi, Yoshito;
Hase, Tadashi;
Ohuchi, Atsushi;
Suzuki, Tamio

Publication type:

Article

Screening of herbal extracts influencing hematopoiesis and their chemical genetic effects in embryonic zebrafish

Published in:

Asian Pacific Journal of Tropical Biomedicine, 2012, v. 2, n. s2, p. S1002, doi. 10.1016/S2221-1691(12)60351-7

By:

Kannan, Rajaretinam Rajesh;
Vincent, Samuel Gnana Prakash

Publication type:

Article

Chemical genetics-based development of small molecules targeting hepatitis C virus.

Published in:

Archives of Pharmacal Research, 2017, v. 40, n. 9, p. 1021, doi. 10.1007/s12272-017-0949-3

By:

Jin, Guanghai;
Lee, Jisu;
Lee, Kyeong

Publication type:

Article

Chemical genetic effects of Sargassum wightii during embryonic development in zebrafish.

Published in:

Indian Journal of Pharmacology, 2015, v. 47, n. 2, p. 195, doi. 10.4103/0253-7613.153429

By:

Kannan, Rajaretinam Rajesh;
Iniyan, Appadurai Muthamil;
Samuel Gnana Prakash Vincent

Publication type:

Article

Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer's disease.

Published in:

Alzheimer's Research & Therapy, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13195-022-00994-w

By:

Liu, Weilin;
Li, Jianhong;
Yang, Minguang;
Ke, Xiaohua;
Dai, Yaling;
Lin, Huawei;
Wang, Sinuo;
Chen, Lidian;
Tao, Jing

Publication type:

Article

Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.

Published in:

Journal of Cellular & Molecular Medicine, 2010, v. 14, n. 3, p. 504, doi. 10.1111/j.1582-4934.2010.01018.x

By:

Haan, Claude;
Behrmann, Iris;
Haan, Serge

Publication type:

Article

A chemical genetic strategy identify the PHOSTIN, a synthetic molecule that triggers phosphate starvation responses in Arabidopsis thaliana.

Published in:

New Phytologist, 2016, v. 209, n. 1, p. 161, doi. 10.1111/nph.13591

By:

Bonnot, Clémence;
Pinson, Benoît;
Clément, Mathilde;
Bernillon, Stéphane;
Chiarenza, Serge;
Kanno, Satomi;
Kobayashi, Natsuko;
Delannoy, Etienne;
Nakanishi, Tomoko M.;
Nussaume, Laurent;
Desnos, Thierry

Publication type:

Article

Chemical genetics and its application to moonlighting in glycolytic enzymes.

Published in:

Biochemical Society Transactions, 2014, v. 42, n. 6, p. 1756, doi. 10.1042/BST20140201

By:

Da-Woon Jung;
Woong-Hee Kim;
Williams, Darren R.

Publication type:

Article

Orthogonal Chemical Genetic Approaches for Unraveling Signaling Pathways.

Published in:

IUBMB Life, 2005, v. 57, n. 6, p. 397, doi. 10.1080/15216540500138238

By:

Shah, Kavita

Publication type:

Article

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase.

Published in:

Malaria Journal, 2016, v. 15, p. 1, doi. 10.1186/s12936-016-1580-3

By:

Mitcheson, Deborah F.;
Bottrill, Andrew R.;
Carr, Katherine;
Coxon, Christopher R.;
Cano, Celine;
Golding, Bernard T.;
Griffin, Roger J.;
Fry, Andrew M.;
Doerig, Christian;
Bayliss, Richard;
Tobin, Andrew B.

Publication type:

Article

Chemical-Genetic Interactions of Bacopa monnieri Constituents in Cells Deficient for the DNA Repair Endonuclease RAD1 Appear Linked to Vacuolar Disruption.

Published in:

Molecules, 2021, v. 26, n. 5, p. 1207, doi. 10.3390/molecules26051207

By:

Huangteerakul, Chananya;
Aung, Hsu Mon;
Thosapornvichai, Thitipa;
Duangkaew, Marisa;
Jensen, Amornrat Naranuntarat;
Sukrong, Suchada;
Ingkaninan, Kornkanok;
Jensen, Laran T.;
Di Cesare Mannelli, Lorenzo

Publication type:

Article

Diversity-Oriented Synthesis as a Tool for Chemical Genetics.

Published in:

Molecules, 2014, v. 19, n. 10, p. 16506, doi. 10.3390/molecules191016506

By:

Lenci, Elena;
Guarna, Antonio;
Trabocchi, Andrea

Publication type:

Article

Chemical Genetics of Acetyl-CoA Carboxylases.

Published in:

Molecules, 2013, v. 18, n. 2, p. 1704, doi. 10.3390/molecules18021704

By:

Xuyu Zu;
Jing Zhong;
Dixian Luo;
Jingjing Tan;
Qinghai Zhang;
Ying Wu;
Jianghua Liu;
Renxian Cao;
Gebo Wen;
Deliang Cao

Publication type:

Article

Forward Chemical Genetics in Yeast for Discovery of Chemical Probes Targeting Metabolism.

Published in:

Molecules, 2012, v. 17, n. 11, p. 13098, doi. 10.3390/molecules171113098

By:

Onge, Robert St.;
Schlecht, Ulrich;
Scharfe, Curt;
Evangelista, Marie

Publication type:

Article

Chemical Genetics: Budding Yeast as a Platform for Drug Discovery and Mapping of Genetic Pathways.

Published in:

Molecules, 2012, v. 17, n. 8, p. 9258, doi. 10.3390/molecules17089258

By:

Enserink, Jorrit M.

Publication type:

Article

Deep learning-driven prediction of drug mechanism of action from large-scale chemical-genetic interaction profiles.

Published in:

Journal of Cheminformatics, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13321-022-00596-6

By:

Liu, Chengyou;
Hogan, Andrew M.;
Sturm, Hunter;
Khan, Mohd Wasif;
Islam, Md. Mohaiminul;
Rahman, A. S. M. Zisanur;
Davis, Rebecca;
Cardona, Silvia T.;
Hu, Pingzhao

Publication type:

Article

GENETIC AND CHEMICAL VARIATION OF SERIPHIDIUM QUETTENSE AN ENDEMIC TAXA OF TWO MOUNTAINOUS REGIONS OF QUETTA, PAKISTAN.

Published in:

Applied Ecology & Environmental Research, 2020, v. 18, n. 2, p. 2413, doi. 10.15666/aeer/1802_24132423

By:

SAEED, S.;
AHMED, A.;
LAGHARI, S. K.;
ALI, G. M.;
BEGUM, S.

Publication type:

Article

A Chemical Genetic Screen for Cell Cycle Inhibitors in Zebrafish Embryos.

Published in:

2006

By:

Murphey, Ryan D.;
Stern, Howard M.;
Straub, Christian T.;
Zon, Leonard I.

Publication type:

Letter

New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development.

Published in:

Life (2075-1729), 2022, v. 12, n. 8, p. 1285, doi. 10.3390/life12081285

By:

Aizezi, Yalikunjiang;
Xie, Yinpeng;
Guo, Hongwei;
Jiang, Kai

Publication type:

Article

Dissecting yeast Hog1 MAP kinase pathway using a chemical genetic approach

Published in:

FEBS Letters, 2007, v. 581, n. 6, p. 1209, doi. 10.1016/j.febslet.2007.02.032

By:

Kim, Sungjoon;
Shah, Kavita

Publication type:

Article

Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry

Published in:

FEBS Letters, 2006, v. 580, n. 1, p. 179, doi. 10.1016/j.febslet.2005.11.071

By:

Juris, Stephen J.;
Shah, Kavita;
Shokat, Kevan;
Dixon, Jack E.;
Vacratsis, Panayiotis O.

Publication type:

Article

Chemical Genetic Screening Identifies Sulfonamides That Raise Organellar pH and Interfere with Membrane Traffic.

Published in:

Traffic, 2004, v. 5, n. 7, p. 478, doi. 10.1111/j.1398-9219.2004.00193.x

By:

Nieland, Thomas J. F.;
Yan Feng;
Jing Xu Brown;
Chuang, Tuan Daniel;
Buckett, Peter D.;
Jin Wang;
Xia-Song Xie;
McGraw, Timothy E.;
Kirchhausen, Tomas;
Wessling-Resnick, Marianne

Publication type:

Article

Chemical Genetics -- A Versatile Method to Combine Science and Higher Level Teaching in Molecular Genetics.

Published in:

Molecules, 2012, v. 17, n. 10, p. 11920, doi. 10.3390/molecules171011920

By:

Sandrock, Björn

Publication type:

Article

Chemical Genetics Applied to Elucidate the Physiological Role of Stress-Signaling Molecules on the Wound-Induced Accumulation of Glucosinolates in Broccoli.

Published in:

Plants (2223-7747), 2021, v. 10, n. 12, p. 2660, doi. 10.3390/plants10122660

By:

Torres-Contreras, Ana M.;
Nair, Vimal;
Senés-Guerrero, Carolina;
Pacheco, Adriana;
González-Agüero, Mauricio;
Ramos-Parra, Perla A.;
Cisneros-Zevallos, Luis;
Jacobo-Velázquez, Daniel A.

Publication type:

Article

Facile high-throughput forward chemical genetic screening by in situ monitoring of glucuronidase-based reporter gene expression in Arabidopsis thaliana.

Published in:

Frontiers in Plant Science, 2015, v. 5, p. 1, doi. 10.3389/fpls.2015.00013

By:

Halder, Vivek;
Kombrink, Erich

Publication type:

Article

How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases.

Published in:

Genetics, 2018, v. 208, n. 3, p. 833, doi. 10.1534/genetics.117.300124

By:

Strynatka, Katherine A.;
Gurrola-Gal, Michelle C.;
Berman, Jason N.;
McMaster, Christopher R.

Publication type:

Article

Chemical Genetics Screen Identifies Epigenetic Mechanisms Involved in Dopaminergic and Noradrenergic Neurogenesis in Zebrafish.

Published in:

Frontiers in Genetics, 2020, v. 11, p. 1, doi. 10.3389/fgene.2020.00080

By:

Westphal, Markus;
Sant, Pooja;
Hauser, Alexander-Thomas;
Jung, Manfred;
Driever, Wolfgang

Publication type:

Article

Systems Chemical Genetics-Based Drug Discovery: Prioritizing Agents Targeting Multiple/Reliable Disease-Associated Genes as Drug Candidates.

Published in:

Frontiers in Genetics, 2019, p. N.PAG, doi. 10.3389/fgene.2019.00474

By:

Quan, Yuan;
Luo, Zhi-Hui;
Yang, Qing-Yong;
Li, Jiang;
Zhu, Qiang;
Liu, Ye-Mao;
Lv, Bo-Min;
Cui, Ze-Jia;
Qin, Xuan;
Xu, Yan-Hua;
Zhu, Li-Da;
Zhang, Hong-Yu

Publication type:

Article

Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle.

Published in:

BMC Biochemistry, 2014, v. 15, n. 1, p. 20, doi. 10.1186/1471-2091-15-20

By:

Rodriguez, Susana;
Ellis, Jessica M.;
Wolfgang, Michael J.

Publication type:

Article

Chemical genetics of regeneration: Contrasting temporal effects of CoCl<sub>2</sub> on axolotl tail regeneration.

Published in:

Developmental Dynamics, 2021, v. 250, n. 6, p. 852, doi. 10.1002/dvdy.294

By:

Baddar, Nour W. Al Haj;
Dwaraka, Varun B.;
Ponomareva, Larissa V.;
Thorson, Jon S.;
Voss, S. Randal

Publication type:

Article

Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana.

Published in:

Plant Journal, 2012, v. 71, n. 2, p. 338, doi. 10.1111/j.1365-313X.2012.04991.x

By:

Tóth, Réka;
Gerding-Reimers, Claas;
Deeks, Michael J.;
Menninger, Sascha;
Gallegos, Rafael M.;
Tonaco, Isabella A. N.;
Hübel, Katja;
Hussey, Patrick J.;
Waldmann, Herbert;
Coupland, George

Publication type:

Article

Chemical genetic evidence supporting the taxonomic separation of Loligo gahi from the genus Loligo

Published in:

Antarctic Science, 1994, v. 6, n. 2, p. 143, doi. 10.1017/S0954102094000222

By:

Brierley, A. S.;
Thorpe, J. P.

Publication type:

Article

The emerging field of chemical genetics: potential applications for pesticide discovery.

Published in:

Pest Management Science, 2007, v. 63, n. 12, p. 1165, doi. 10.1002/ps.1452

By:

Walsh, Terence A.

Publication type:

Article

Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis.

Published in:

Angewandte Chemie, 2021, v. 133, n. 40, p. 21995, doi. 10.1002/ange.202100523

By:

Takemoto, Yasushi;
Kadota, Shin;
Minami, Itsunari;
Otsuka, Shinya;
Okuda, Satoshi;
Abo, Masahiro;
Punzalan, Louvy Lynn;
Shen, Yan;
Shiba, Yuji;
Uesugi, Motonari

Publication type:

Article

Chemical genetics to examine cellulose biosynthesis.

Published in:

Frontiers in Plant Science, 2012, v. 3, p. 1, doi. 10.3389/fpls.2012.00309

By:

Debolt, Seth;
Brabham, Chad

Publication type:

Article

Two marine natural products, penicillide and verrucarin J, are identified from a chemical genetic screen for neutral lipid accumulation effectors in Phaeodactylum tricornutum.

Published in:

Applied Microbiology & Biotechnology, 2020, v. 104, n. 6, p. 2731, doi. 10.1007/s00253-020-10411-7

By:

Yu, Mange;
Chen, Xi;
Jiang, Mingcai;
Li, Xiaohui

Publication type:

Article

Chemical Genetics Approach Identifies Abnormal Inflorescence Meristem 1 as a Putative Target of a Novel Sulfonamide That Protects Catalase2-Deficient Arabidopsis against Photorespiratory Stress.

Published in:

Cells (2073-4409), 2020, v. 9, n. 9, p. 2026, doi. 10.3390/cells9092026

By:

van der Meer, Tom;
Verlee, Arno;
Willems, Patrick;
Impens, Francis;
Gevaert, Kris;
Testerink, Christa;
Stevens, Christian V.;
Van Breusegem, Frank;
Kerchev, Pavel

Publication type:

Article

A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58185-8

By:

Allan, Lindsey A.;
Corno, Andrea;
Valverde, Juan Manuel;
Toth, Rachel;
Ly, Tony;
Saurin, Adrian T.

Publication type:

Article

Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus.

Published in:

Developmental Dynamics, 2009, v. 238, n. 6, p. 1287, doi. 10.1002/dvdy.21967

By:

Wheeler, Grant N.;
Brändli, André W.

Publication type:

Article

Modeling the Genetic Components of the Water and Chemical Runoff of Heavy Metals in the Basin of the Nizhnekamskoe Reservoir.

Published in:

Water Resources, 2023, v. 50, n. 4, p. 583, doi. 10.1134/S0097807823040073

By:

Fashchevskaya, T. B.;
Motovilov, Yu. G.;
Kortunova, K. V.

Publication type:

Article

Genetic and Chemical Engineering of Phages for Controlling Multidrug-Resistant Bacteria.

Published in:

Antibiotics (2079-6382), 2021, v. 10, n. 2, p. 202, doi. 10.3390/antibiotics10020202

By:

Guo, Dingming;
Chen, Jingchao;
Zhao, Xueyang;
Luo, Yanan;
Jin, Menglu;
Fan, Fenxia;
Park, Chaiwoo;
Yang, Xiaoman;
Sun, Chuqing;
Yan, Jin;
Chen, Weihua;
Liu, Zhi;
Almeida, Adelaide;
Fernández, Lucía

Publication type:

Article

A chemical genetic screen uncovers a small molecule enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis.

Published in:

Scientific Reports, 2017, p. 41121, doi. 10.1038/srep41121

By:

Khan, Bibi Rafeiza;
Faure, Lionel;
Chapman, Kent D.;
Blancaflor, Elison B.

Publication type:

Article

Plant chemical genetics.

Published in:

New Phytologist, 2010, v. 185, n. 1, p. 15, doi. 10.1111/j.1469-8137.2009.03045.x

By:

McCourt, Peter;
Desveaux, Darrell

Publication type:

Article

HTSplotter: An end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening.

Published in:

PLoS ONE, 2024, v. 19, n. 1, p. 1, doi. 10.1371/journal.pone.0296322

By:

Nunes, Carolina;
Anckaert, Jasper;
De Vloed, Fanny;
De Wyn, Jolien;
Durinck, Kaat;
Vandesompele, Jo;
Speleman, Frank;
Vermeirssen, Vanessa

Publication type:

Article

A chemical-genetic approach to elucidate protein kinase function inÂ planta.

Published in:

Plant Molecular Biology, 2007, v. 65, n. 6, p. 817

By:

Tina Romeis

Publication type:

Article

Inference of Protein Complex Activities from Chemical- Genetic Profile and Its Applications: Predicting Drug- Target Pathways.

Published in:

PLoS Computational Biology, 2008, v. 4, n. 8, p. 1, doi. 10.1371/journal.pcbi.1000162

By:

Han, Sangjo;
Dongsup Kim

Publication type:

Article

A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.

Published in:

Molecular Systems Biology, 2015, v. 11, n. 12, p. n/a, doi. 10.15252/msb.20156400

By:

Breinig, Marco;
Klein, Felix A;
Huber, Wolfgang;
Boutros, Michael

Publication type:

Article

Genetic structure, major chemical component contents and agronomic characters of the principal cultivars of the kelp Saccharina japonica in the largest kelp production province in China.

Published in:

Journal of Applied Phycology, 2023, v. 35, n. 2, p. 763, doi. 10.1007/s10811-023-02905-4

By:

Li, Xiao Dong;
Zhong, Chen Hui;
Jin, Zhen Hui;
Lin, Qi;
Shan, Ti Feng;
Pang, Shao Jun

Publication type:

Article