Works matching Cech, Thomas R.

Results: 71

Thomas R. Cech.

Published in:

Nature Medicine, 2001, v. 7, n. 2, p. 140, doi. 10.1038/84561

By:

Birmingham, Karen

Publication type:

Article

The Tetrahymena ribozyme acts like an RNA restriction endonuclease.

Published in:

Nature, 1986, v. 324, n. 6096, p. 429, doi. 10.1038/324429a0

By:

Zaug, Arthur J.;
Been, Michael D.;
Cech, Thomas R.

Publication type:

Article

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA.

Published in:

Nature, 1984, v. 308, n. 5962, p. 820, doi. 10.1038/308820a0

By:

Bass, Brenda L.;
Cech, Thomas R.

Publication type:

Article

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers.

Published in:

Molecular Oncology, 2020, v. 14, n. 10, p. 2358, doi. 10.1002/1878-0261.12786

By:

Rowland, Teisha J.;
Bonham, Andrew J.;
Cech, Thomas R.

Publication type:

Article

Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.

Published in:

EMBO Journal, 2000, v. 19, n. 22, p. 6230, doi. 10.1093/emboj/19.22.6230

By:

Aigner, Stefan;
Lingner, Joachinm;
Goodrich, Karen J.;
Grosshans, Cheryl A.;
Shevchenko, Andrej;
Mann, Matthias;
Cech, Thomas R.

Publication type:

Article

Self-splicing of the Tetrahymena intron from mRNA in mammalian cells.

Published in:

EMBO Journal, 1999, v. 18, n. 22, p. 6491, doi. 10.1093/emboj/18.22.6491

By:

Hagen, Moira;
Cech, Thomas R.

Publication type:

Article

The POT1–TPP1 telomere complex is a telomerase processivity factor.

Published in:

Nature, 2007, v. 445, n. 7127, p. 506, doi. 10.1038/nature05454

By:

Feng Wang;
Podell, Elaine R.;
Zaug, Arthur J.;
Yuting Yang;
Baciu, Paul;
Cech, Thomas R.;
Ming Lei

Publication type:

Article

RNA finds a simpler way.

Published in:

Nature, 2004, v. 428, n. 6980, p. 263, doi. 10.1038/428263a

By:

Cech, Thomas R.

Publication type:

Article

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.

Published in:

Nature, 2003, v. 426, n. 6963, p. 198, doi. 10.1038/nature02092

By:

Lei, Ming;
Podell, Elaine R.;
Baumann, Peter;
Cech, Thomas R.

Publication type:

Article

DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 1, p. 235, doi. 10.1093/nar/gkr721

By:

Nandakumar, Jayakrishnan;
Cech, Thomas R.

Publication type:

Article

Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.

Published in:

Nucleic Acids Research, 2009, v. 37, n. 2, p. 354, doi. 10.1093/nar/gkn830

By:

Zappulla, David C.;
Roberts, Jennifer N.;
Goodrich, Karen J.;
Cech, Thomas R.;
Wuttke, Deborah S.

Publication type:

Article

Yeast telomerase is specialized for C/A‐rich RNA templates.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 6, p. 1646, doi. 10.1093/nar/gkg261

By:

Förstemann, Klaus;
Zaug, Arthur J.;
Cech, Thomas R.;
Lingner, Joachim

Publication type:

Article

Publisher Correction: Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention.

Published in:

2021

By:

Dumbović, Gabrijela;
Braunschweig, Ulrich;
Langner, Heera K.;
Smallegan, Michael;
Biayna, Josep;
Hass, Evan P.;
Jastrzebska, Katarzyna;
Blencowe, Benjamin;
Cech, Thomas R.;
Caruthers, Marvin H.;
Rinn, John L.

Publication type:

Correction Notice

Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23221-w

By:

Dumbović, Gabrijela;
Braunschweig, Ulrich;
Langner, Heera K.;
Smallegan, Michael;
Biayna, Josep;
Hass, Evan P.;
Jastrzebska, Katarzyna;
Blencowe, Benjamin;
Cech, Thomas R.;
Caruthers, Marvin H.;
Rinn, John L.

Publication type:

Article

On the occasion of the 25<sup>th</sup> anniversary of the discovery of catalytic RNA.

Published in:

Biological Chemistry, 2007, v. 388, n. 7, p. 661, doi. 10.1515/BC.2007.084

By:

Cech, Thomas R.

Publication type:

Article

Fostering Innovation and Discovery in Biomedical Research.

Published in:

2005

By:

Cech, Thomas R.

Publication type:

Editorial

How a Chemist Looks at RNA.

Published in:

Angewandte Chemie International Edition, 2013, v. 52, n. 1, p. 75, doi. 10.1002/anie.201205427

By:

Cech, Thomas R.

Publication type:

Article

Self-splicing RNA and an RNA Enzyme in Tetruhymena<sup>1</sup>.

Published in:

Journal of Eukaryotic Microbiology, 1987, v. 34, n. 4, p. 416, doi. 10.1111/j.1550-7408.1987.tb03204.x

By:

ZAUG, ARTHUR J.;
CECH, THOMAS R.

Publication type:

Article

G-strings at chromosome ends.

Published in:

Nature, 1988, v. 332, n. 6167, p. 777, doi. 10.1038/332777a0

By:

Cech, Thomas R.

Publication type:

Article

The Tetrahymena ribozyme acts like an RNA restriction endonuclease.

Published in:

Nature, 1987, v. 325, n. 6105, p. 646, doi. 10.1038/325646a0

By:

Zaug, Arthur J.;
Been, Michael D.;
Cech, Thomas R.

Publication type:

Article

Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.

Published in:

Protein Science: A Publication of the Protein Society, 2005, v. 14, n. 8, p. 2051, doi. 10.1110/ps.051532105

By:

Jacobs, Steven A.;
Podell, Elaine R.;
Wuttke, Deborah S.;
Cech, Thomas R.

Publication type:

Article

dGTP-dependent processivity and possible template switching of Euplotes telomerase.

Published in:

Nucleic Acids Research, 1997, v. 25, n. 18, p. 3698, doi. 10.1093/nar/25.18.3698

By:

Hammond, Philip W.;
Cech, Thomas R.

Publication type:

Article

Conserved Thermochemistry of Guanosine Nucleophile Binding for Structurally Distinct Group I Ribozymes.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 19, p. 3722, doi. 10.1093/nar/24.19.3722

By:

Kuo, Louis Y.;
Cech, Thomas R.

Publication type:

Article

Method for determining RNA 34 ends and application to human telomerase RNA.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 3, p. 532, doi. 10.1093/nar/24.3.532

By:

Zaug, Arthur J.;
Lingner, Joachim;
Cech, Thomas R.

Publication type:

Article

Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 20, p. 17, doi. 10.1128/MCB.00827-10

By:

Berman, Andrea J.;
Gooding, Anne R.;
Cech, Thomas R.

Publication type:

Article

Multiple Yeast Genes, Including Paf1 Complex Genes, Affect Telomere Length via Telomerase RNA Abundance.

Published in:

2008

By:

Mozdy, Amy D.;
Podell, Elaine R.;
Cech, Thomas R.

Publication type:

Abstract

Peptide bond formation by in vitro selected ribozymes.

Published in:

Nature, 1997, v. 390, n. 6655, p. 96, doi. 10.1038/36375

By:

Zhang, Biliang;
Cech, Thomas R.

Publication type:

Article

Hammerhead nailed down.

Published in:

Nature, 1994, v. 372, n. 6501, p. 38, doi. 10.1038/372039a0

By:

Cech, Thomas R.;
Uhlenbeck, Olke C.

Publication type:

Article

Ribozyme-mediated repair of defective mRNA by targeted trans-splicing.

Published in:

Nature, 1994, v. 371, n. 6498, p. 619, doi. 10.1038/371619a0

By:

Sullenger, Bruce A.;
Cech, Thomas R.

Publication type:

Article

Fishing for fresh catalysts.

Published in:

Nature, 1993, v. 365, n. 6443, p. 204, doi. 10.1038/365204a0

By:

Cech, Thomas R.

Publication type:

Article

Life at the End of the Chromosome: Telomeres and Telomerase.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 1, p. 34, doi. 10.1002/(SICI)1521-3773(20000103)39:1<34::AID-ANIE34>3.0.CO;2-N

By:

Cech, Thomas R.

Publication type:

Article

Evolution of Tetrahymena ribozyme mutants with increased structural stability.

Published in:

Nature Structural Biology, 2002, v. 9, n. 11, p. 855

By:

Guo, Feng;
Cech, Thomas R.

Publication type:

Article

Die RNA aus der Sicht eines Chemikers.

Published in:

Angewandte Chemie, 2013, v. 125, n. 1, p. 78, doi. 10.1002/ange.201205427

By:

Cech, Thomas R.

Publication type:

Article

Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 5, p. 1, doi. 10.1093/nar/gkaf177

By:

Wu, Guanhui;
Taylor, Erin;
Youmans, Daniel T;
Arnoult, Nausica;
Cech, Thomas R

Publication type:

Article

CST does not evict elongating telomerase but prevents initiation by ssDNA binding.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 20, p. 11653, doi. 10.1093/nar/gkab942

By:

Zaug, Arthur J;
Lim, Ci Ji;
Olson, Conner L;
Carilli, Maria T;
Goodrich, Karen J;
Wuttke, Deborah S;
Cech, Thomas R

Publication type:

Article

Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 6, p. 2969, doi. 10.1093/nar/gkaa073

By:

Heenan, Patrick R;
Wang, Xueyin;
Gooding, Anne R;
Cech, Thomas R;
Perkins, Thomas T

Publication type:

Article

Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 17, p. 8865, doi. 10.1093/nar/gky605

By:

Greenwood, Jessica;
Patel, Harshil;
Cech, Thomas R;
Cooper, Julia Promisel

Publication type:

Article

Nucleic acid-binding specificity of human FUS protein.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 15, p. 7535, doi. 10.1093/nar/gkv679

By:

Xueyin Wang;
Schwartz, Jacob C.;
Cech, Thomas R.

Publication type:

Article

A dimeric state for PRC2.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 14, p. 9236, doi. 10.1093/nar/gku540

By:

Davidovich, Chen;
Goodrich, Karen J.;
Gooding, Anne R.;
Cech, Thomas R.

Publication type:

Article

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 13, p. 8565, doi. 10.1093/nar/gku560

By:

Xi, Linghe;
Cech, Thomas R.

Publication type:

Article

Many disease-associated variants of hTERT retain high telomerase enzymatic activity.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 19, p. 8969, doi. 10.1093/nar/gkt653

By:

Zaug, Arthur J.;
Crary, Sharon M.;
Jesse Fioravanti, Matthew;
Campbell, Kristina;
Cech, Thomas R.

Publication type:

Article

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01313-w

By:

Ci Ji Lim;
Zaug, Arthur J.;
Hee Jin Kim;
Cech, Thomas R.

Publication type:

Article

A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.

Published in:

Genome Biology, 2015, v. 16, p. 1, doi. 10.1186/s13059-015-0791-1

By:

Linghe Xi;
Schmidt, Jens C.;
Zaug, Arthur J.;
Ascarrunz, Dante R.;
Cech, Thomas R.

Publication type:

Article

Self-splicing and Enzymatic Activity of an Intervening Sequence RNA from Tetrahymena (Nobel Lecture).

Published in:

Angewandte Chemie International Edition, 1990, v. 29, n. 7, p. 759, doi. 10.1002/anie.199007591

By:

Cech, Thomas R.

Publication type:

Article

POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.

Published in:

EMBO Journal, 2010, v. 29, n. 5, p. 924, doi. 10.1038/emboj.2009.409

By:

Latrick, Chrysa M.;
Cech, Thomas R.

Publication type:

Article

3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.

Published in:

BMC Molecular Biology, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2199-14-23

By:

Goldfarb, Katherine C.;
Cech, Thomas R.

Publication type:

Article

Promiscuous RNA binding by Polycomb repressive complex 2.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 11, p. 1250, doi. 10.1038/nsmb.2679

By:

Davidovich, Chen;
Zheng, Leon;
Goodrich, Karen J;
Cech, Thomas R

Publication type:

Article

The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 12, p. 1371, doi. 10.1038/nsmb.2174

By:

Berman, Andrea J;
Akiyama, Benjamin M;
Stone, Michael D;
Cech, Thomas R

Publication type:

Article

Mutation in TERT separates processivity from anchor-site function.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 8, p. 870, doi. 10.1038/nsmb.1462

By:

Zaug, Arthur J.;
Podell, Elaine R.;
Cech, Thomas R.

Publication type:

Article

Triple-helix structure in telomerase RNA contributes to catalysis.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 6, p. 634, doi. 10.1038/nsmb.1420

By:

Feng Qiao;
Cech, Thomas R.

Publication type:

Article