Works by van den Akker, Emile

Results: 33

Human serum albumin or polyvinyl alcohol can only partially replace human plasma during in vitro red cell production from PBMC.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-024-81341-x

By:

Claessen, Marie-José A. G.;
Yagci, Nurcan;
van Mierlo, Gerard;
Kersten, Marie José;
von Lindern, Marieke;
van den Akker, Emile

Publication type:

Article

Expansion and differentiation of ex vivo cultured erythroblasts in scalable stirred bioreactors.

Published in:

Biotechnology & Bioengineering, 2022, v. 119, n. 11, p. 3096, doi. 10.1002/bit.28193

By:

Gallego‐Murillo, Joan Sebastián;
Iacono, Giulia;
van der Wielen, Luuk A. M.;
van den Akker, Emile;
von Lindern, Marieke;
Wahl, Sebastian Aljoscha

Publication type:

Article

Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer.

Published in:

American Journal of Hematology, 2022, v. 97, n. 5, p. E180, doi. 10.1002/ajh.26509

By:

Flormann, Daniel;
Qiao, Min;
Murciano, Nicoletta;
Iacono, Giulia;
Darras, Alexis;
Hof, Sebastian;
Recktenwald, Steffen M.;
Rotordam, Maria Giustina;
Becker, Nadine;
Geisel, Jürgen;
Wagner, Christian;
von Lindern, Marieke;
van den Akker, Emile;
Kaestner, Lars

Publication type:

Article

Reduced myeloid commitment and increased uptake by macrophages of stem cell-derived HPS2 neutrophils.

Published in:

Life Science Alliance, 2024, v. 7, n. 4, p. 1, doi. 10.26508/lsa.202302263

By:

Webbers, Steven D. S.;
Aarts, Cathelijn E. M.;
Klein, Bart;
Koops, Dané;
Geissler, Judy;
Tool, Anton T. J.;
van Bruggen, Robin;
van den Akker, Emile;
Kuijpers, Taco W.

Publication type:

Article

Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-81746-8

By:

Iacono, Giulia;
Abay, Asena;
Murillo, Joan S. Gallego;
Aglialoro, Francesca;
Yagci, Nurcan;
Varga, Eszter;
Bijlsma, Tieme;
Sohler, Justine;
Fu, Kerly;
Reisz, Julie A.;
Argabright, Amy;
D'Alessandro, Angelo;
Svendsen, Arthur F.;
von Lindern, Marieke;
van den Akker, Emile

Publication type:

Article

Human‐induced pluripotent stem cell‐derived blood products: state of the art and future directions.

Published in:

FEBS Letters, 2019, v. 593, n. 23, p. 3288, doi. 10.1002/1873-3468.13599

By:

Hansen, Marten;
von Lindern, Marieke;
van den Akker, Emile;
Varga, Eszter

Publication type:

Article

A cellular reporter system to evaluate endogenous fetal hemoglobin induction and screen for therapeutic compounds.

Published in:

HemaSphere, 2024, v. 8, n. 8, p. 1, doi. 10.1002/hem3.139

By:

Verheul, Thijs C. J.;
Gillemans, Nynke;
Putzker, Kerstin;
Majied, Rezin;
Li, Tingyue;
Vasiliou, Memnia;
Eussen, Bert;
de Klein, Annelies;
van IJcken, Wilfred F. J.;
van den Akker, Emile;
von Lindern, Marieke;
Lewis, Joe;
Uhrig, Ulrike;
Nakamura, Yukio;
van Dijk, Thamar;
Philipsen, Sjaak

Publication type:

Article

S277: IPSC DISEASE MODELS TO STUDY AND TREAT DIAMOND‐BLACKFAN ANEMIA SYNDROME (DBAS)

Published in:

HemaSphere, 2023, v. 7, p. 1, doi. 10.1097/01.HS9.0000968020.21669.d5

By:

Clark, Chantal;
Bartels, Marije;
Varga, Ester;
von Lindern, Marieke;
van den Akker, Emile

Publication type:

Article

Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-32706-1

By:

Gallego-Murillo, Joan Sebastián;
Yağcı, Nurcan;
Pinho, Eduardo Machado;
Wahl, Sebastian Aljoscha;
van den Akker, Emile;
von Lindern, Marieke

Publication type:

Article

SMIM1 underlies the Vel blood group and influences red blood cell traits.

Published in:

Nature Genetics, 2013, v. 45, n. 5, p. 542, doi. 10.1038/ng.2603

By:

Cvejic, Ana;
Haer-Wigman, Lonneke;
Stephens, Jonathan C;
Kostadima, Myrto;
Smethurst, Peter A;
Frontini, Mattia;
van den Akker, Emile;
Bertone, Paul;
Bielczyk-Maczyńska, Ewa;
Farrow, Samantha;
Fehrmann, Rudolf S N;
Gray, Alan;
de Haas, Masja;
Haver, Vincent G;
Jordan, Gregory;
Karjalainen, Juha;
Kerstens, Hindrik H D;
Kiddle, Graham;
Lloyd-Jones, Heather;
Needs, Malcolm

Publication type:

Article

The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 3, p. 1416, doi. 10.3390/ijms25031416

By:

Petkova-Kirova, Polina;
Murciano, Nicoletta;
Iacono, Giulia;
Jansen, Julia;
Simionato, Greta;
Qiao, Min;
van der Zwaan, Carmen;
Rotordam, Maria Giustina;
John, Thomas;
Hertz, Laura;
Hoogendijk, Arjan J.;
Becker, Nadine;
Wagner, Christian;
von Lindern, Marieke;
Egee, Stephane;
van den Akker, Emile;
Kaestner, Lars

Publication type:

Article

Mechanical Stress Induces Ca 2+ -Dependent Signal Transduction in Erythroblasts and Modulates Erythropoiesis.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 2, p. 955, doi. 10.3390/ijms22020955

By:

Aglialoro, Francesca;
Abay, Asena;
Yagci, Nurcan;
Rab, Minke A. E.;
Kaestner, Lars;
van Wijk, Richard;
von Lindern, Marieke;
van den Akker, Emile

Publication type:

Article

The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 3, p. 967, doi. 10.3390/ijms21030967

By:

Hansen, Marten;
Zeddies, Sabrina;
Meinders, Marjolein;
di Summa, Franca;
Rollmann, Ewa;
van Alphen, Floris P.J.;
Hoogendijk, Arjan J.;
Moore, Kat S.;
Halbach, Melanie;
Gutiérrez, Laura;
van den Biggelaar, Maartje;
Thijssen-Timmer, Daphne C.;
Auburger, Georg W.J.;
van den Akker, Emile;
von Lindern, Marieke

Publication type:

Article

Identification of a novel single-nucleotide mutation in SMIM1 gene that results in low Vel antigen expression.

Published in:

2019

By:

Rijst, Marea V.E.;
Voorn, Lesley;
Veldhuisen, Barbera;
Jongerius, John M.;
Akker, Emile;
Schoot, C. Ellen;
van der Rijst, Marea V E;
van den Akker, Emile;
van der Schoot, C Ellen

Publication type:

journal article

Development of a recombinant anti-Vel immunoglobulin M to identify Vel-negative donors.

Published in:

2019

By:

van der Rijst, Marea V.E.;
Lissenberg‐Thunnissen, Suzanne N.;
Ligthart, Peter C.;
Visser, Remco;
Jongerius, John M.;
Voorn, Lesley;
Veldhuisen, Barbera;
Vidarsson, Gestur;
van den Akker, Emile;
van der Schoot, C. Ellen;
Lissenberg-Thunnissen, Suzanne N

Publication type:

journal article

A variant RhAG protein encoded by the RHAG*572A allele causes serological weak D expression while maintaining normal RhCE phenotypes.

Published in:

2019

By:

Wen, Jizhi;
Verhagen, Onno J.H.M.;
Jia, Shuangshuang;
Liang, Qianni;
Wang, Zhen;
Wei, Ling;
Luo, Hong;
Luo, Guangping;
Vidarsson, Gestur;
Akker, Emile;
Ji, Yanli;
Schoot, C. Ellen;
van den Akker, Emile;
van der Schoot, C Ellen

Publication type:

journal article

GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06090-z

By:

Venhuizen, Jeron;
van Bergen, Maaike G. J. M.;
Bergevoet, Saskia M.;
Gilissen, Daan;
Spruijt, Cornelia G.;
Wingens, Laura;
van den Akker, Emile;
Vermeulen, Michiel;
Jansen, Joop H.;
Martens, Joost H. A.;
van der Reijden, Bert A.

Publication type:

Article

Thrombocytopenia after meta-iodobenzylguanidine (MIBG) therapy in neuroblastoma patients may be caused by selective MIBG uptake via the serotonin transporter located on megakaryocytes.

Published in:

EJNMMI Research, 2021, v. 11, n. 1, p. 1, doi. 10.1186/s13550-021-00823-5

By:

Blom, Thomas;
Meinsma, Rutger;
di Summa, Franca;
van den Akker, Emile;
van Kuilenburg, André B. P.;
Hansen, Marten;
Tytgat, Godelieve A. M.

Publication type:

Article

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific.

Published in:

Nucleic Acids Research, 2018, v. 46, n. 16, p. 8168, doi. 10.1093/nar/gky721

By:

Nicolet, Benoit P;
Engels, Sander;
Aglialoro, Francesca;
van den Akker, Emile;
von Lindern, Marieke;
Wolkers, Monika C

Publication type:

Article

Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts.

Published in:

Frontiers in Physiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.00958

By:

Aglialoro, Francesca;
Hofsink, Naomi;
Hofman, Menno;
Brandhorst, Nicole;
van den Akker, Emile

Publication type:

Article

Glutaraldehyde – A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells.

Published in:

Frontiers in Physiology, 2019, p. N.PAG, doi. 10.3389/fphys.2019.00514

By:

Abay, Asena;
Simionato, Greta;
Chachanidze, Revaz;
Bogdanova, Anna;
Hertz, Laura;
Bianchi, Paola;
van den Akker, Emile;
von Lindern, Marieke;
Leonetti, Marc;
Minetti, Giampaolo;
Wagner, Christian;
Kaestner, Lars

Publication type:

Article

Rapid, Sensitive, and Specific Severe Acute Respiratory Syndrome Coronavirus 2 Detection: A Multicenter Comparison Between Standard Quantitative Reverse-Transcriptase Polymerase Chain Reaction and CRISPR-Based DETECTR.

Published in:

2021

By:

Brandsma, Eelke;
Verhagen, Han J M P;
Laar, Thijs J W van de;
Claas, Eric C J;
Cornelissen, Marion;
van den Akker, Emile;
van de Laar, Thijs J W

Publication type:

Journal Article

CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-81060-7

By:

Heshusius, Steven;
Heideveld, Esther;
von Lindern, Marieke;
van den Akker, Emile

Publication type:

Article

Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts.

Published in:

Frontiers in Neurology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.00958

By:

Aglialoro, Francesca;
Hofsink, Naomi;
Hofman, Menno;
Brandhorst, Nicole;
van den Akker, Emile

Publication type:

Article

Grsf1-Induced Translation of the SNARE Protein Use1 Is Required for Expansion of the Erythroid Compartment.

Published in:

PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0104631

By:

Nieradka, Andrzej;
Ufer, Christoph;
Thiadens, Klaske;
Grech, Godfrey;
Horos, Rastislav;
van Coevorden-Hameete, Marleen;
van den Akker, Emile;
Sofi, Sajad;
Kuhn, Hartmut;
von Lindern, Marieke

Publication type:

Article

Differential Proteomic Analysis of Human Erythroblasts Undergoing Apoptosis Induced by Epo-Withdrawal.

Published in:

PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038356

By:

Pellegrin, Stéphanie;
Heesom, Kate J.;
Satchwell, Timothy J.;
Hawley, Bethan R.;
Daniels, Geoff;
Den Akker, Emile van;
Toye, Ashley M.

Publication type:

Article

Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-021-04126-6

By:

Heshusius, Steven;
Grech, Laura;
Gillemans, Nynke;
Brouwer, Rutger W. W.;
den Dekker, Xander T.;
van IJcken, Wilfred F. J.;
Nota, Benjamin;
Felice, Alex E.;
van Dijk, Thamar B.;
von Lindern, Marieke;
Borg, Joseph;
van den Akker, Emile;
Philipsen, Sjaak

Publication type:

Article

Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97149-y

By:

Eernstman, Jesse;
Veldhuisen, Barbera;
Ligthart, Peter;
von Lindern, Marieke;
van der Schoot, C. Ellen;
van den Akker, Emile

Publication type:

Article

Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95291-1

By:

Mattebo, Alexander;
Sen, Taha;
Jassinskaja, Maria;
Pimková, Kristýna;
Prieto González-Albo, Isabel;
Alattar, Abdul Ghani;
Ramakrishnan, Ramprasad;
Lang, Stefan;
Järås, Marcus;
Hansson, Jenny;
Soneji, Shamit;
Singbrant, Sofie;
van den Akker, Emile;
Flygare, Johan

Publication type:

Article

Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 23, p. 4689, doi. 10.1093/hmg/ddx351

By:

Theil, Arjan F.;
Mandemaker, Imke K.;
van den Akker, Emile;
Swagemakers, Sigrid M. A.;
Raams, Anja;
Wüst, Tatjana;
Marteijn, Jurgen A.;
Giltay, Jacques C.;
Colombijn, Richard M.;
Moog, Ute;
Kotzaeridou, Urania;
Ghazvini, Mehrnaz;
von Lindern, Marieke;
Hoeijmakers, Jan H. J.;
Jaspers, Nicolaas G. J.;
van der Spek, Peter J.;
Vermeulen, Wim

Publication type:

Article

Genetic programming of macrophages generates an in vitro model for the human erythroid island niche.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08705-0

By:

Lopez-Yrigoyen, Martha;
Yang, Cheng-Tao;
Fidanza, Antonella;
Cassetta, Luca;
Taylor, A. Helen;
McCahill, Angela;
Sellink, Erica;
von Lindern, Marieke;
van den Akker, Emile;
Mountford, Joanne C.;
Pollard, Jeffrey W.;
Forrester, Lesley M.

Publication type:

Article

The Shape Shifting Story of Reticulocyte Maturation.

Published in:

Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.00829

By:

Ovchynnikova, Elina;
Aglialoro, Francesca;
von Lindern, Marieke;
van den Akker, Emile

Publication type:

Article

The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity.

Published in:

Biological Chemistry, 2004, v. 385, n. 5, p. 409, doi. 10.1515/BC.2004.045

By:

Van den Akker, Emile;
Van Dijk, Thamar B.;
Schmidt, Uwe;
Felida, Lamberto;
Beug, Hartmut;
Löwenberg, Bob;
Von Lindern, Marieke

Publication type:

Article