Works by van Zundert, Brigitte

Results: 31

Restoring endogenous Dlg4/PSD95 expression by an artificial transcription factor ameliorates cognitive and motor learning deficits in the R6/2 mouse model of Huntington's disease.

Published in:

Clinical Epigenetics, 2025, v. 17, n. 1, p. 1, doi. 10.1186/s13148-025-01903-2

By:

Fernández, Germán;
Leiva, Kevin;
Bustos, Fernando J.;
van Zundert, Brigitte

Publication type:

Article

Variable transcriptional responsiveness of the P2X3 receptor gene during CFA‐induced inflammatory hyperalgesia.

Published in:

Journal of Cellular Biochemistry, 2018, v. 119, n. 5, p. 3922, doi. 10.1002/jcb.26534

By:

Nuñez‐Badinez, Paulina;
Sepúlveda, Hugo;
Diaz, Emilio;
Greffrath, Wolfgang;
Treede, Rolf‐Detlef;
Stehberg, Jimmy;
Montecino, Martin;
van Zundert, Brigitte

Publication type:

Article

Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis.

Published in:

Journal of Cellular Biochemistry, 2012, v. 113, n. 11, p. 3301, doi. 10.1002/jcb.24234

By:

van Zundert, Brigitte;
Izaurieta, Pamela;
Fritz, Elsa;
Alvarez, Francisco J.

Publication type:

Article

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.

Published in:

Molecular Medicine, 2024, v. 30, n. 1, p. 1, doi. 10.1186/s10020-024-00942-4

By:

Martínez, Pablo;
Silva, Mónica;
Abarzúa, Sebastián;
Tevy, María Florencia;
Jaimovich, Enrique;
Constantine-Paton, Martha;
Bustos, Fernando J.;
van Zundert, Brigitte

Publication type:

Article

Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model.

Published in:

Arthritis & Rheumatology, 2015, v. 67, n. 6, p. 1598, doi. 10.1002/art.39081

By:

Segovia‐Miranda, Fabián;
Serrano, Felipe;
Dyrda, Agnieszka;
Ampuero, Estibaliz;
Retamal, Claudio;
Bravo‐Zehnder, Marcela;
Parodi, Jorge;
Zamorano, Pedro;
Valenzuela, David;
Massardo, Loreto;
van Zundert, Brigitte;
Inestrosa, Nibaldo C.;
González, Alfonso

Publication type:

Article

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094037

By:

Bustos, Fernando J.;
Varela-Nallar, Lorena;
Campos, Matias;
Henriquez, Berta;
Phillips, Marnie;
Opazo, Carlos;
Aguayo, Luis G.;
Montecino, Martin;
Constantine-Paton, Martha;
Inestrosa, Nibaldo C.;
van Zundert, Brigitte

Publication type:

Article

Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala.

Published in:

FASEB Journal, 2022, v. 36, n. 2, p. 1, doi. 10.1096/fj.202100798RR

By:

Linsambarth, Sergio;
Carvajal, Francisco J.;
Moraga‐Amaro, Rodrigo;
Mendez, Luis;
Tamburini, Giovanni;
Jimenez, Ivanka;
Verdugo, Daniel Antonio;
Gómez, Gonzalo I.;
Jury, Nur;
Martínez, Pablo;
van Zundert, Brigitte;
Varela‐Nallar, Lorena;
Retamal, Mauricio A.;
Martin, Claire;
Altenberg, Guillermo A.;
Fiori, Mariana C.;
Cerpa, Waldo;
Orellana, Juan A.;
Stehberg, Jimmy

Publication type:

Article

The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 16, p. 2913, doi. 10.1093/hmg/ddy204

By:

Gonzalez, David;
Rebolledo, Daniela L;
Correa, Lina M;
Court, Felipe A;
Cerpa, Waldo;
Lipson, Kenneth E;
Zundert, Brigitte van;
Brandan, Enrique

Publication type:

Article

A Myosin Va Mutant Mouse with Disruptions in Glutamate Synaptic Development and Mature Plasticity in Visual Cortex.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 19, p. 8472, doi. 10.1523/JNEUROSCI.4585-12.2013

By:

Yoshii, Akira;
Zhao, Jian-Ping;
Pandian, Swarna;
van Zundert, Brigitte;
Constantine-Paton, Martha

Publication type:

Article

Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-022-02677-7

By:

Pérez-Núñez, Ramón;
Chamorro, Alejandro;
González, María Fernanda;
Contreras, Pamela;
Artigas, Rocío;
Corvalán, Alejandro H.;
van Zundert, Brigitte;
Reyes, Christopher;
Moya, Pablo R.;
Avalos, Ana María;
Schneider, Pascal;
Quest, Andrew F. G.;
Leyton, Lisette

Publication type:

Article

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers.

Published in:

PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177649

By:

Gonzalez, David;
Contreras, Osvaldo;
Rebolledo, Daniela L.;
Espinoza, Juan Pablo;
van Zundert, Brigitte;
Brandan, Enrique

Publication type:

Article

Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPβ factors.

Published in:

Journal of Cellular Physiology, 2013, v. 228, n. 4, p. 860, doi. 10.1002/jcp.24236

By:

Ugarte, Giorgia D.;
Diaz, Emilio;
Biscaia, Miguel;
Stehberg, Jimmy;
Montecino, Martin;
van Zundert, Brigitte

Publication type:

Article

Runx1 and C/EBPβ transcription factors directly up-regulate P2X3 gene transcription.

Published in:

Journal of Cellular Physiology, 2012, v. 227, n. 4, p. 1645, doi. 10.1002/jcp.22882

By:

Ugarte, Giorgia D.;
Opazo, Tatiana;
Leisewitz, Francisco;
van Zundert, Brigitte;
Montecino, Martin

Publication type:

Article

1α,25-dihydroxy vitamin D3 induces nuclear matrix association of the 1α,25-dihydroxy vitamin D3 receptor in osteoblasts independently of its ability to bind DNA.

Published in:

Journal of Cellular Physiology, 2010, v. 222, n. 2, p. 336, doi. 10.1002/jcp.21958

By:

ARRIAGADA, GLORIA;
PAREDES, ROBERTO;
WIJNEN, ANDRE J. VAN;
LIAN, JANE B.;
ZUNDERT, BRIGITTE VAN;
STEIN, GARY S.;
STEIN, JANET L.;
MONTECINO, MARTIN

Publication type:

Article

BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.

Published in:

Clinical Epigenetics, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13148-021-01039-z

By:

Quezada, Esteban;
Cappelli, Claudio;
Diaz, Iván;
Jury, Nur;
Wightman, Nicholas;
Brown, Robert H.;
Montecino, Martín;
van Zundert, Brigitte

Publication type:

Article

Alterations in the motor neuron-renshaw cell circuit in the Sod1 G93A mouse model.

Published in:

Journal of Comparative Neurology, 2013, v. 521, n. 7, p. Spc1, doi. 10.1002/cne.23266

By:

Wootz, Hanna;
FitzSimons‐Kantamneni, Eileen;
Larhammar, Martin;
Rotterman, Travis M.;
Enjin, Anders;
Patra, Kalicharan;
André, Elodie;
Van Zundert, Brigitte;
Kullander, Klas;
Alvarez, Francisco J.

Publication type:

Article

Alterations in the motor neuron-renshaw cell circuit in the Sod1 G93A mouse model.

Published in:

Journal of Comparative Neurology, 2013, v. 521, n. 7, p. 1449, doi. 10.1002/cne.23266

By:

Wootz, Hanna;
FitzSimons‐Kantamneni, Eileen;
Larhammar, Martin;
Rotterman, Travis M.;
Enjin, Anders;
Patra, Kalicharan;
André, Elodie;
Van Zundert, Brigitte;
Kullander, Klas;
Alvarez, Francisco J.

Publication type:

Article

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.

Published in:

Autophagy, 2013, v. 9, n. 9, p. 1308, doi. 10.4161/auto.25188

By:

Castillo, Karen;
Nassif, Melissa;
Valenzuela, Vicente;
Rojas, Fabiola;
Matus, Soledad;
Mercado, Gabriela;
Court, Felipe A.;
Van Zundert, Brigitte;
Hetz, Claudio

Publication type:

Article

Synaptic drive at developing synapses: Transient upregulation of kainate receptors.

Published in:

Developmental Neurobiology (19328451), 2010, v. 70, n. 11, p. 737, doi. 10.1002/dneu.20807

By:

van Zundert, Brigitte;
Zhao, Jiang-Ping;
Constantine-Paton, Martha

Publication type:

Article

Epigenetic Changes and Chromatin Reorganization in Brain Function: Lessons from Fear Memory Ensemble and Alzheimer's Disease.

Published in:

2022

By:

van Zundert, Brigitte;
Montecino, Martin

Publication type:

Literature Review

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1924, doi. 10.3390/ijms22041924

By:

Harcha, Paloma A.;
Garcés, Polett;
Arredondo, Cristian;
Fernández, Germán;
Sáez, Juan C.;
van Zundert, Brigitte;
Scorziello, Antonella

Publication type:

Article

Downregulation of the Polycomb-Associated Methyltransferase Ezh2 during Maturation of Hippocampal Neurons Is Mediated by MicroRNAs Let-7 and miR-124.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8472, doi. 10.3390/ijms21228472

By:

Guajardo, Laura;
Aguilar, Rodrigo;
Bustos, Fernando J.;
Nardocci, Gino;
Gutiérrez, Rodrigo A.;
van Zundert, Brigitte;
Montecino, Martin

Publication type:

Article

NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac.

Published in:

Journal of Cellular Physiology, 2017, v. 232, n. 12, p. 3677, doi. 10.1002/jcp.25843

By:

Bustos, Fernando J.;
Jury, Nur;
Martinez, Pablo;
Ampuero, Estibaliz;
Campos, Matias;
Abarzúa, Sebastian;
Jaramillo, Karen;
Ibing, Susanne;
Mardones, Muriel D.;
Haensgen, Henny;
Kzhyshkowska, Julia;
Tevy, Maria Florencia;
Neve, Rachael;
Sanhueza, Magdalena;
Varela-Nallar, Lorena;
Montecino, Martín;
van Zundert, Brigitte

Publication type:

Article

Chronic infusion of SOD1G93A astrocyte-secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats.

Published in:

Journal of Cellular Physiology, 2017, v. 232, n. 10, p. 2610, doi. 10.1002/jcp.25827

By:

Ramírez‐Jarquín, Uri N.;
Rojas, Fabiola;
van Zundert, Brigitte;
Tapia, Ricardo

Publication type:

Article

Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells.

Published in:

Journal of Cellular Physiology, 2017, v. 232, n. 9, p. 2519, doi. 10.1002/jcp.25627

By:

Sepulveda, Hugo;
Aguilar, Rodrigo;
Prieto, Catalina P.;
Bustos, Francisco;
Aedo, Sócrates;
Lattus, José;
van Zundert, Brigitte;
Palma, Veronica;
Montecino, Martin

Publication type:

Article

Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons.

Published in:

Journal of Cellular Physiology, 2017, v. 232, n. 5, p. 1187, doi. 10.1002/jcp.25605

By:

Ampuero, Estibaliz;
Jury, Nur;
Härtel, Steffen;
Marzolo, María‐Paz;
van Zundert, Brigitte

Publication type:

Article

Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD.

Published in:

Biochemical Society Transactions, 2024, v. 52, n. 1, p. 123, doi. 10.1042/BST20230257

By:

Garcés, Polett;
Amaro, Armando;
Montecino, Martin;
van Zundert, Brigitte

Publication type:

Article

αVβ3 Integrin regulates astrocyte reactivity.

Published in:

2017

By:

Lagos-Cabré, Raúl;
Alvarez, Alvaro;
Kong, Milene;
Burgos-Bravo, Francesca;
Cárdenas, Areli;
Rojas-Mancilla, Edgardo;
Pérez-Nuñez, Ramón;
Herrera-Molina, Rodrigo;
Rojas, Fabiola;
Schneider, Pascal;
Herrera-Marschitz, Mario;
Quest, Andrew F. G.;
van Zundert, Brigitte;
Leyton, Lisette

Publication type:

journal article

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.

Published in:

Antioxidants, 2023, v. 12, n. 11, p. 2007, doi. 10.3390/antiox12112007

By:

Martinez, Alexis;
Lamaizon, Cristian M.;
Valls, Cristian;
Llambi, Fabien;
Leal, Nancy;
Fitzgerald, Patrick;
Guy, Cliff;
Kamiński, Marcin M.;
Inestrosa, Nibaldo C.;
van Zundert, Brigitte;
Cancino, Gonzalo I.;
Dulcey, Andrés E.;
Zanlungo, Silvana;
Marugan, Juan J.;
Hetz, Claudio;
Green, Douglas R.;
Alvarez, Alejandra R.

Publication type:

Article

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice.

Published in:

Clinical Epigenetics, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13148-020-0816-9

By:

Jury, Nur;
Abarzua, Sebastian;
Diaz, Ivan;
Guerra, Miguel V.;
Ampuero, Estibaliz;
Cubillos, Paula;
Martinez, Pablo;
Herrera-Soto, Andrea;
Arredondo, Cristian;
Rojas, Fabiola;
Manterola, Marcia;
Rojas, Adriana;
Montecino, Martín;
Varela-Nallar, Lorena;
van Zundert, Brigitte

Publication type:

Article

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 43, p. 10864, doi. 10.1523/JNEUROSCI.1340-08.2008

By:

van Zundert, Brigitte;
Peuscher, Marieke H.;
Hynynen, Meri;
Chen, Adam;
Neve, Rachael L.;
Brown Jr., Robert H.;
Constantine-Paton, Martha;
Bellingham, Mark C.

Publication type:

Article

Works by van Zundert, Brigitte

Restoring endogenous Dlg4/PSD95 expression by an artificial transcription factor ameliorates cognitive and motor learning deficits in the R6/2 mouse model of Huntington's disease.

Variable transcriptional responsiveness of the P2X3 receptor gene during CFA‐induced inflammatory hyperalgesia.

Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis.

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.

Pathogenicity of Lupus Anti-Ribosomal P Antibodies: Role of Cross-Reacting Neuronal Surface P Antigen in Glutamatergic Transmission and Plasticity in a Mouse Model.

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors.

Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala.

The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model.

A Myosin Va Mutant Mouse with Disruptions in Glutamate Synaptic Development and Mature Plasticity in Visual Cortex.

Protein kinase B (AKT) upregulation and Thy-1-α<sub>v</sub>β<sub>3</sub> integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis.

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers.

Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPβ factors.

Runx1 and C/EBPβ transcription factors directly up-regulate P2X3 gene transcription.

1α,25-dihydroxy vitamin D<sub>3</sub> induces nuclear matrix association of the 1α,25-dihydroxy vitamin D<sub>3</sub> receptor in osteoblasts independently of its ability to bind DNA.

BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model.

Alterations in the motor neuron-renshaw cell circuit in the Sod1<sup> G93A</sup> mouse model.

Alterations in the motor neuron-renshaw cell circuit in the Sod1<sup> G93A</sup> mouse model.

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.

Synaptic drive at developing synapses: Transient upregulation of kainate receptors.

Epigenetic Changes and Chromatin Reorganization in Brain Function: Lessons from Fear Memory Ensemble and Alzheimer's Disease.

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions.

Downregulation of the Polycomb-Associated Methyltransferase Ezh2 during Maturation of Hippocampal Neurons Is Mediated by MicroRNAs Let-7 and miR-124.

NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac.

Chronic infusion of SOD1<sup>G93A</sup> astrocyte-secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats.

Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells.

Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons.

Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD.

α<sub>V</sub>β<sub>3</sub> Integrin regulates astrocyte reactivity.

c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration.

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice.

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis.