Works by van Wezel, Gilles P.

Results: 67

Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis.

Published in:

PLoS Biology, 2025, v. 23, n. 6, p. 1, doi. 10.1371/journal.pbio.3003183

By:

Augustijn, Hannah E.;
Reitz, Zachary L.;
Zhang, Le;
Boot, Jeanine A.;
Elsayed, Somayah S.;
Challis, Gregory L.;
Medema, Marnix H.;
van Wezel, Gilles P.

Publication type:

Article

Taxonomic and metabolic diversity of Actinomycetota isolated from faeces of a 28,000‐year‐old mammoth.

Published in:

Environmental Microbiology, 2024, v. 26, n. 2, p. 1, doi. 10.1111/1462-2920.16589

By:

van Bergeijk, Doris A.;
Augustijn, Hannah E.;
Elsayed, Somayah S.;
Willemse, Joost;
Carrión, Victor J.;
Du, Chao;
Urem, Mia;
Grigoreva, Lena V.;
Cheprasov, Maksim Y.;
Grigoriev, Semyon;
Jansen, Hans;
Wintermans, Bas;
Budding, Andries E.;
Spaink, Herman P.;
Medema, Marnix H.;
van Wezel, Gilles P.

Publication type:

Article

Volatile sensation: The chemical ecology of the earthy odorant geosmin.

Published in:

Environmental Microbiology, 2023, v. 25, n. 9, p. 1565, doi. 10.1111/1462-2920.16381

By:

Garbeva, Paolina;
Avalos, Mariana;
Ulanova, Dana;
van Wezel, Gilles P.;
Dickschat, Jeroen S.

Publication type:

Article

New approaches to achieve high level enzyme production in Streptomyces lividans.

Published in:

Microbial Cell Factories, 2016, v. 15, p. 1, doi. 10.1186/s12934-016-0425-7

By:

Sevillano, Laura;
Vijgenboom, Erik;
van Wezel, Gilles P.;
Díaz, Margarita;
Santamaría, Ramón I.

Publication type:

Article

A novel locus for mycelial aggregation forms a gateway to improved Streptomyces cell factories.

Published in:

Microbial Cell Factories, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12934-015-0224-6

By:

van Dissel, Dino;
Claessen, Dennis;
Roth, Martin;
van Wezel, Gilles P.

Publication type:

Article

Harnessing regulatory networks in Actinobacteria for natural product discovery.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2024, v. 51, p. 1, doi. 10.1093/jimb/kuae011

By:

Augustijn, Hannah E;
Roseboom, Anna M;
Medema, Marnix H;
Wezel, Gilles P van

Publication type:

Article

Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2019, v. 46, n. 3/4, p. 483, doi. 10.1007/s10295-019-02140-2

By:

Machushynets, Nataliia V.;
Wu, Changsheng;
Elsayed, Somayah S.;
Hankemeier, Thomas;
van Wezel, Gilles P.

Publication type:

Article

Prodiginines Postpone the Onset of Sporulation in Streptomyces coelicolor.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 12, p. 847, doi. 10.3390/antibiotics9120847

By:

Tenconi, Elodie;
Traxler, Matthew;
Tellatin, Déborah;
van Wezel, Gilles P.;
Rigali, Sébastien

Publication type:

Article

Discovery of actinomycin L, a new member of the actinomycin family of antibiotics.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06736-0

By:

Machushynets, Nataliia V.;
Elsayed, Somayah S.;
Du, Chao;
Siegler, Maxime A.;
de la Cruz, Mercedes;
Genilloud, Olga;
Hankemeier, Thomas;
van Wezel, Gilles P.

Publication type:

Article

Genome-Wide Analysis of In Vivo Binding of the Master Regulator DasR in Streptomyces coelicolor Identifies Novel Non-Canonical Targets.

Published in:

PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0122479

By:

Świątek-Połatyńska, Magdalena A.;
Bucca, Giselda;
Laing, Emma;
Gubbens, Jacob;
Titgemeyer, Fritz;
Smith, Colin P.;
Rigali, Sébastien;
van Wezel, Gilles P.

Publication type:

Article

Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041359

By:

Qingping Xu;
van Wezel, Gilles P.;
Hsiu-Ju Chiu;
Jaroszewski, Lukasz;
Klock, Heath E.;
Knuth, Mark W.;
Miller, Mitchell D.;
Lesley, Scott A.;
Godzik, Adam;
Elsliger, Marc-André;
Deacon, Ashley M.;
Wilson, Ian A.

Publication type:

Article

Imaging of Streptomyces coelicolor A3(2) with Reduced Autofluorescence Reveals a Novel Stage of FtsZ Localization.

Published in:

PLoS ONE, 2009, v. 4, n. 1, p. 1, doi. 10.1371/journal.pone.0004242

By:

Willemse, Joost;
van Wezel, Gilles P.

Publication type:

Article

Iso‐maleimycin, a Constitutional Isomer of Maleimycin, from Streptomyces sp. QL37.

Published in:

European Journal of Organic Chemistry, 2020, v. 2020, n. 32, p. 5145, doi. 10.1002/ejoc.202000767

By:

Uiterweerd, Michiel T.;
Santiago, Isabel Nuñez;
van der Heul, Helga;
van Wezel, Gilles P.;
Minnaard, Adriaan J.

Publication type:

Article

nanoRAPIDS as an analytical pipeline for the discovery of novel bioactive metabolites in complex culture extracts at the nanoscale.

Published in:

Communications Chemistry, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42004-024-01153-y

By:

Nuñez Santiago, Isabel;
Machushynets, Nataliia V.;
Mladic, Marija;
van Bergeijk, Doris A.;
Elsayed, Somayah S.;
Hankemeier, Thomas;
van Wezel, Gilles P.

Publication type:

Article

Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis.

Published in:

Communications Chemistry, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42004-023-01059-1

By:

Elsayed, Somayah S.;
van der Heul, Helga U.;
Xiao, Xiansha;
Nuutila, Aleksi;
Baars, Laura R.;
Wu, Changsheng;
Metsä-Ketelä, Mikko;
van Wezel, Gilles P.

Publication type:

Article

Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism.

Published in:

Bioengineered, 2012, v. 3, n. 5, p. 280, doi. 10.4161/bioe.21371

By:

Świątek, Magdalena A.;
Urem, Mia;
Tenconi, Elodie;
Rigali, Sebastien;
van Wezel, Gilles P.

Publication type:

Article

Cell division and DNA segregation in Streptomyces: how to build a septum in the middle of nowhere?

Published in:

Molecular Microbiology, 2012, v. 85, n. 3, p. 393, doi. 10.1111/j.1365-2958.2012.08107.x

By:

Jakimowicz, Dagmara;
van Wezel, Gilles P.

Publication type:

Article

The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control.

Published in:

Molecular Microbiology, 2010, v. 75, n. 5, p. 1133, doi. 10.1111/j.1365-2958.2009.07020.x

By:

Nothaft, Harald;
Rigali, Sébastien;
Boomsma, Bart;
Swiatek, Magdalena;
McDowall, Kenneth J.;
Van Wezel, Gilles P.;
Titgemeyer, Fritz

Publication type:

Article

Loss of the controlled localization of growth stage-specific cell-wall synthesis pleiotropically affects developmental gene expression in an ssgA mutant of Streptomyces coelicolor.

Published in:

Molecular Microbiology, 2007, v. 64, n. 5, p. 1244, doi. 10.1111/j.1365-2958.2007.05732.x

By:

Noens, Elke E.;
Mersinias, Vassili;
Willemse, Joost;
Traag, Bjørn A.;
Laing, Emma;
Chater, Keith F.;
Smith, Colin P.;
Koerten, Henk K.;
Van Wezel, Gilles P.

Publication type:

Article

MreB of Streptomyces coelicolor is not essential for vegetative growth but is required for the integrity of aerial hyphae and spores.

Published in:

Molecular Microbiology, 2006, v. 60, n. 4, p. 838, doi. 10.1111/j.1365-2958.2006.05134.x

By:

Mazza, Paola;
Noens, Elke E.;
Schirner, Kathrin;
Grantcharova, Nina;
Mommaas, A. Mieke;
Koerten, Henk K.;
Muth, Günther;
Flärdh, Klas;
van Wezel, Gilles P.;
Wohlleben, Wolfgang

Publication type:

Article

SsgA-like proteins determine the fate of peptidoglycan during sporulation of Streptomyces coelicolor.

Published in:

Molecular Microbiology, 2005, v. 58, n. 4, p. 929, doi. 10.1111/j.1365-2958.2005.04883.x

By:

Noens, Elke E. E.;
Mersinias, Vassilis;
Traag, Bjørn A.;
Smith, Colin P.;
Koerten, Henk K.;
van Wezel, Gilles P.

Publication type:

Article

GlcP constitutes the major glucose uptake system ofStreptomyces coelicolorA3(2).

Published in:

Molecular Microbiology, 2005, v. 55, n. 2, p. 624, doi. 10.1111/j.1365-2958.2004.04413.x

By:

van Wezel, Gilles P.;
Mahr, Kerstin;
König, Miriam;
Traag, Bjørn A.;
Pimentel-Schmitt, Elisângela F.;
Willimek, Andreas;
Titgemeyer, Fritz

Publication type:

Article

Transcription of the sporulation gene ssgA is activated by the IclR-type regulator SsgR in a whi-independent manner in Streptomyces coelicolor A3(2).

Published in:

Molecular Microbiology, 2004, v. 53, n. 3, p. 985, doi. 10.1111/j.1365-2958.2004.04186.x

By:

Traag, Bjørn A.;
Kelemen, Gabriella H.;
van Wezel, Gilles P.

Publication type:

Article

Endocytosis-like DNA uptake by cell wall-deficient bacteria.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33054-w

By:

Kapteijn, Renée;
Shitut, Shraddha;
Aschmann, Dennis;
Zhang, Le;
de Beer, Marit;
Daviran, Deniz;
Roverts, Rona;
Akiva, Anat;
van Wezel, Gilles P.;
Kros, Alexander;
Claessen, Dennis

Publication type:

Article

The tmRNA-tagging mechanism and the control of gene expression: a review.

Published in:

Wiley Interdisciplinary Reviews: RNA, 2011, v. 2, n. 2, p. 233, doi. 10.1002/wrna.48

By:

Barends, Sharief;
Barend, Kraal;
van Wezel, Gilles P.

Publication type:

Article

Dynamic effects of probiotic formula ecologic<sup>®</sup>825 on human small intestinal ileostoma microbiota: a network theory approach.

Published in:

Gut Microbes, 2023, v. 15, n. 1, p. 1, doi. 10.1080/19490976.2023.2232506

By:

Jansma, Jack;
Thome, Nicola U.;
Schwalbe, Markus;
Chatziioannou, Anastasia Chrysovalantou;
Elsayed, Somayah S.;
van Wezel, Gilles P.;
van den Abbeele, Pieter;
van Hemert, Saskia;
El Aidy, Sahar

Publication type:

Article

Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species.

Published in:

ISME Journal: Multidisciplinary Journal of Microbial Ecology, 2020, v. 14, n. 2, p. 569, doi. 10.1038/s41396-019-0537-2

By:

Avalos, Mariana;
Garbeva, Paolina;
Raaijmakers, Jos M.;
van Wezel, Gilles P.

Publication type:

Article

Aggregation of germlings is a major contributing factor towards mycelial heterogeneity of Streptomyces.

Published in:

Scientific Reports, 2016, p. 27045, doi. 10.1038/srep27045

By:

Zacchetti, Boris;
Willemse, Joost;
Recter, Brand;
van Dissel, Dino;
van Wezel, Gilles P.;
Wösten, H. A. B.;
Claessen, Dennis

Publication type:

Article

Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation.

Published in:

Scientific Reports, 2015, p. 10868, doi. 10.1038/srep10868

By:

Wu, Changsheng;
Zacchetti, Boris;
Ram, Arthur F.J.;
van Wezel, Gilles P.;
Claessen, Dennis;
Hae Choi, Young

Publication type:

Article

Structural and Proteomic Changes in Viable but Non-culturable Vibrio cholerae.

Published in:

Frontiers in Microbiology, 2019, p. N.PAG, doi. 10.3389/fmicb.2019.00793

By:

Brenzinger, Susanne;
van der Aart, Lizah T.;
van Wezel, Gilles P.;
Lacroix, Jean-Marie;
Glatter, Timo;
Briegel, Ariane

Publication type:

Article

Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07560-9

By:

Ramijan, Karina;
Ultee, Eveline;
Willemse, Joost;
Zheren Zhang;
Wondergem, Joeri A. J.;
van der Meij, Anne;
Heinrich, Doris;
Briegel, Ariane;
van Wezel, Gilles P.;
Claessen, Dennis

Publication type:

Article

Altered desferrioxamine-mediated iron utilization is a common trait of bald mutants of Streptomyces coelicolor.

Published in:

Metallomics, 2014, v. 6, n. 8, p. 1390, doi. 10.1039/c4mt00068d

By:

Lambert, Stéphany;
Traxler, Matthew F.;
Craig, Matthias;
Maciejewska, Marta;
Ongena, Marc;
van Wezel, Gilles P.;
Kolter, Roberto;
Rigali, Sébastien

Publication type:

Article

Unique Ligand-Based Oxidative DNA Cleavage by Zinc(II) Complexes of Hpyramol and Hpyrimol.

Published in:

Chemistry - A European Journal, 2007, v. 13, n. 18, p. 5213, doi. 10.1002/chem.200601525

By:

Maheswari, Palanisamy Uma;
Barends, Sharief;
Özalp-Yaman, Seniz;
de Hoog, Paul;
Casellas, Hélène;
Teat, Simon J.;
Massera, Chiara;
Lutz, Martin;
Spek, Anthony L.;
van Wezel, Gilles P.;
Gamez, Patrick;
Reedijk, Jan

Publication type:

Article

FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor.

Published in:

Antonie van Leeuwenhoek, 2023, v. 116, n. 1, p. 1, doi. 10.1007/s10482-022-01778-w

By:

Yagüe, Paula;
Willemse, Joost;
Xiao, Xiansha;
Zhang, Le;
Manteca, Angel;
van Wezel, Gilles P.

Publication type:

Article

Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration.

Published in:

Antonie van Leeuwenhoek, 2020, v. 113, n. 6, p. 825, doi. 10.1007/s10482-020-01393-7

By:

Ramijan, Karina;
Zhang, Zheren;
van Wezel, Gilles P.;
Claessen, Dennis

Publication type:

Article

Dispatches from the land of the morning calm: special issue papers from the 18th International Symposium on the Biology of Actinomycetes.

Published in:

Antonie van Leeuwenhoek, 2018, v. 111, n. 5, p. 639, doi. 10.1007/s10482-018-1077-x

By:

Hoskisson, Paul A.;
van Wezel, Gilles P.

Publication type:

Article

Inter- and intracellular colonization of <italic>Arabidopsis</italic> roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity.

Published in:

Antonie van Leeuwenhoek, 2018, v. 111, n. 5, p. 679, doi. 10.1007/s10482-018-1014-z

By:

van der Meij, Anne;
Willemse, Joost;
Schneijderberg, Martinus A.;
Geurts, René;
Raaijmakers, Jos M.;
van Wezel, Gilles P.

Publication type:

Article

Morphology-driven downscaling of <italic>Streptomyces lividans</italic> to micro-cultivation.

Published in:

Antonie van Leeuwenhoek, 2018, v. 111, n. 3, p. 457, doi. 10.1007/s10482-017-0967-7

By:

van Dissel, Dino;
van Wezel, Gilles P.

Publication type:

Article

SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures.

Published in:

Antonie van Leeuwenhoek, 2018, v. 111, n. 2, p. 171, doi. 10.1007/s10482-017-0939-y

By:

Willemse, Joost;
Büke, Ferhat;
van Dissel, Dino;
Grevink, Sanne;
Claessen, Dennis;
van Wezel, Gilles P.

Publication type:

Article

Transfer–messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces.

Published in:

EMBO Reports, 2010, v. 11, n. 2, p. 119, doi. 10.1038/embor.2009.255

By:

Barends, Sharief;
Zehl, Martin;
Bialek, Sylwia;
de Waal, Ellen;
Traag, Bjørn A;
Willemse, Joost;
Jensen, Ole Nørregaard;
Vijgenboom, Erik;
van Wezel, Gilles P

Publication type:

Article

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces.

Published in:

EMBO Reports, 2008, v. 9, n. 7, p. 670, doi. 10.1038/embor.2008.83

By:

Rigali, Sébastien;
Titgemeyer, Fritz;
Barends, Sharief;
Mulder, Suzanne;
Thomae, Andreas W;
Hopwood, David A;
van Wezel, Gilles P

Publication type:

Article

Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines.

Published in:

Frontiers in Bioengineering & Biotechnology, 2024, p. 01, doi. 10.3389/fbioe.2024.1363803

By:

Hulst, Mandy B.;
Le Zhang;
van der Heul, Helga U.;
Chao Du;
Elsayed, Somayah S.;
Koroleva, Arina;
Grocholski, Thadee;
Wander, Dennis P. A.;
Metsä-Ketelä, Mikko;
Neefjes, Jacques J. C.;
van Wezel, Gilles P.

Publication type:

Article

Diversity and functions of volatile organic compounds produced by Streptomyces from a disease-suppressive soil.

Published in:

Frontiers in Microbiology, 2015, v. 6, p. 1, doi. 10.3389/fmicb.2015.01081

By:

Cordovez, Viviane;
Carrion, Victor J.;
Etalo, Desalegn W.;
Mumm, Roland;
Hua Zhu;
van Wezel, Gilles P.;
Raaijmakers, Jos M.;
Tarkka, Mika Tapio

Publication type:

Article

Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics.

Published in:

Molecular Microbiology, 2017, v. 105, n. 1, p. 175, doi. 10.1111/mmi.13714

By:

Gubbens, Jacob;
Janus, Marleen M.;
Florea, Bogdan I.;
Overkleeft, Herman S.;
van Wezel, Gilles P.

Publication type:

Article

Intertwining nutrient-sensory networks and the control of antibiotic production in Streptomyces.

Published in:

Molecular Microbiology, 2016, v. 102, n. 2, p. 183, doi. 10.1111/mmi.13464

By:

Urem, Mia;
Świątek‐Połatyńska, Magdalena A.;
Rigali, Sébastien;
van Wezel, Gilles P.

Publication type:

Article

Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 7, p. 445, doi. 10.1038/ja.2015.14

By:

Wu, Changsheng;
van Wezel, Gilles P;
Hae Choi, Young

Publication type:

Article

Polyester degradation by soil bacteria: identification of conserved BHETase enzymes in Streptomyces.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-06414-z

By:

Verschoor, Jo-Anne;
Croese, Martijn R. J.;
Lakemeier, Sven E.;
Mugge, Annemiek;
Burgers, Charlotte M. C.;
Innocenti, Paolo;
Willemse, Joost;
Crooijmans, Marjolein E.;
van Wezel, Gilles P.;
Ram, Arthur F. J.;
de Winde, Johannes H.

Publication type:

Article

The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA.

Published in:

Molecular Microbiology, 2000, v. 37, n. 4, p. 811, doi. 10.1046/j.1365-2958.2000.02046.x

By:

Mingfu Liu;
Kirpekar, Finn;
van Wezel, Gilles P.;
Douthwaite, Stephen

Publication type:

Article

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lantibiotics.

Published in:

PLoS Biology, 2020, v. 18, n. 12, p. 1, doi. 10.1371/journal.pbio.3001026

By:

Kloosterman, Alexander M.;
Cimermancic, Peter;
Elsayed, Somayah S.;
Du, Chao;
Hadjithomas, Michalis;
Donia, Mohamed S.;
Fischbach, Michael A.;
van Wezel, Gilles P.;
Medema, Marnix H.

Publication type:

Article

Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline.

Published in:

Proteomics, 2018, v. 18, n. 18, p. 1, doi. 10.1002/pmic.201700332

By:

Du, Chao;
van Wezel, Gilles P.

Publication type:

Article