Works by van Raamsdonk, Jeremy M.

Results: 32

Resistance to Stress Can Be Experimentally Dissociated From Longevity.

Published in:

2019

By:

Dues, Dylan J;
Andrews, Emily K;
Senchuk, Megan M;
Raamsdonk, Jeremy M Van;
Van Raamsdonk, Jeremy M

Publication type:

journal article

Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity.

Published in:

Antioxidants, 2023, v. 12, n. 4, p. 944, doi. 10.3390/antiox12040944

By:

AlOkda, Abdelrahman;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.

Published in:

Life Science Alliance, 2021, v. 4, n. 12, p. 1, doi. 10.26508/lsa.202101182

By:

Soo, Sonja K.;
Traa, Annika;
Rudich, Paige D.;
Mistry, Meeta;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Cognitive Dysfunction Precedes Neuropathology and Motor Abnormalities in the YAC128 Mouse Model of Huntington's Disease.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 16, p. 4169, doi. 10.1523/JNEUROSCI.0590-05.2005

By:

Van Raamsdonk, Jeremy M.;
Pearson, Jacqueline;
Slow, Elizabeth J.;
Hossain, Sazzad M.;
Leavitt, Blair R.;
Hayden, Michael R.

Publication type:

Article

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan.

Published in:

PLoS Genetics, 2015, v. 11, n. 2, p. 1, doi. 10.1371/journal.pgen.1004972

By:

Schaar, Claire E.;
Dues, Dylan J.;
Spielbauer, Katie K.;
Machiela, Emily;
Cooper, Jason F.;
Senchuk, Megan;
Hekimi, Siegfried;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans.

Published in:

PLoS Genetics, 2009, v. 5, n. 2, p. 1, doi. 10.1371/journal.pgen.1000361

By:

Van Raamsdonk, Jeremy M.;
Hekimi, Siegfried

Publication type:

Article

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13447, doi. 10.3390/ijms222413447

By:

Traa, Annika;
Machiela, Emily;
Rudich, Paige D.;
Soo, Sonja K.;
Senchuk, Megan M.;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants.

Published in:

Frontiers in Aging, 2023, p. 1, doi. 10.3389/fragi.2023.1145198

By:

Traa, Annika;
Shields, Hazel;
AlOkda, Abdelrahman;
Rudich, Zenith D.;
Bokang Ko;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Body weight is modulated by levels of full-length Huntingtin.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 9, p. 1513, doi. 10.1093/hmg/ddl072

By:

Van Raamsdonk, Jeremy M.;
Gibson, William T.;
Pearson, Jacqueline;
Murphy, Zoe;
Lu, Ge;
Leavitt, Blair R.;
Hayden, Michael R.

Publication type:

Article

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.

Published in:

Human Molecular Genetics, 2005, v. 14, n. 24, p. 3823, doi. 10.1093/hmg/ddi407

By:

Van Raamsdonk, Jeremy M.;
Murphy, Zoe;
Slow, Elizabeth J.;
Leavitt, Blair R.;
Hayden, Michael R.

Publication type:

Article

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.

Published in:

Human Molecular Genetics, 2005, v. 14, n. 10, p. 1379, doi. 10.1093/hmg/ddi147

By:

Van Raamsdonk, Jeremy M.;
Pearson, Jacqueline;
Rogers, Daniel A.;
Bissada, Nagat;
Vogl, A. Wayne;
Hayden, Michael R.;
Leavitt, Blair R.

Publication type:

Article

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease.

Published in:

Science Translational Medicine, 2016, v. 8, n. 368, p. 1, doi. 10.1126/scitranslmed.aag2210

By:

Ghosh, Anamitra;
Tyson, Trevor;
George, Sonia;
Hildebrandt, Erin N.;
Steiner, Jennifer A.;
Madaj, Zachary;
Schulz, Emily;
Machiela, Emily;
McDonald, William G.;
Escobar Galvis, Martha L.;
Kordower, Jeffrey H.;
Van Raamsdonk, Jeremy M.;
Colca, Jerry R.;
Brundin, Patrik

Publication type:

Article

HotSpots.

Published in:

Clinical Genetics, 2001, v. 60, n. 2, p. 99, doi. 10.1034/j.1399-0004.2001.6002021.x

By:

Devon, Rebecca S;
Chopra, Vikramjit;
van Raamsdonk, Jeremy M

Publication type:

Article

HotSpots.

Published in:

Clinical Genetics, 2001, v. 60, n. 2, p. 100, doi. 10.1034/j.1399-0004.2001.6002022.x

By:

Devon, Rebecca S;
Chopra, Vikramjit;
van Raamsdonk, Jeremy M

Publication type:

Article

HotSpots.

Published in:

Clinical Genetics, 2001, v. 60, n. 2, p. 102, doi. 10.1034/j.1399-0004.2001.6002023.x

By:

Devon, Rebecca S;
Chopra, Vikramjit;
van Raamsdonk, Jeremy M

Publication type:

Article

Huntingtin Decreases Susceptibility to a Spontaneous Seizure Disorder in FVN/B Mice.

Published in:

Aging & Disease, 2023, v. 14, n. 6, p. 2249, doi. 10.14336/AD.2023.0423

By:

Van Raamsdonk, Jeremy M.;
Al-Shekaili, Hilal H.;
Wagner, Laura;
Bredy, Tim W.;
Chan, Laura;
Pearson, Jacqueline;
Schwab, Claudia;
Murphy, Zoe;
Devon, Rebecca S.;
Ge Lu;
Kobor, Michael S.;
Hayden, Michael R.;
Leavitt, Blair R.

Publication type:

Article

Targeting Mitochondrial Network Disorganization is Protective in C. elegans Models of Huntington's Disease.

Published in:

Aging & Disease, 2021, v. 12, n. 7, p. 1753, doi. 10.14336/AD.2021.0404

By:

Machiela, Emily;
Rudich, Paige D.;
Traa, Annika;
Anglas, Ulrich;
Soo, Sonja K.;
Senchuk, Megan M.;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Published in:

BMC Biology, 2018, v. 16, n. 1, p. 1, doi. 10.1186/s12915-018-0615-3

By:

Wu, Ziyun;
Senchuk, Megan M.;
Dues, Dylan J.;
Johnson, Benjamin K.;
Cooper, Jason F.;
Lew, Leira;
Machiela, Emily;
Schaar, Claire E.;
DeJonge, Heather;
Blackwell, T. Keith;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant.

Published in:

GeroScience, 2025, v. 47, n. 1, p. 877, doi. 10.1007/s11357-024-01276-z

By:

Traa, Annika;
Tamez González, Aura A.;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity.

Published in:

Aging Cell, 2024, v. 23, n. 10, p. 1, doi. 10.1111/acel.14262

By:

Traa, Annika;
Keil, Allison;
AlOkda, Abdelrahman;
Jacob‐Tomas, Suleima;
Tamez González, Aura A.;
Zhu, Shusen;
Rudich, Zenith;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms.

Published in:

Aging Cell, 2023, v. 22, n. 3, p. 1, doi. 10.1111/acel.13762

By:

Traa, Annika;
Soo, Sonja K.;
AlOkda, Abdelrahman;
Ko, Bokang;
Rocheleau, Christian E.;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Genetic basis of enhanced stress resistance in long‐lived mutants highlights key role of innate immunity in determining longevity.

Published in:

Aging Cell, 2023, v. 22, n. 2, p. 1, doi. 10.1111/acel.13740

By:

Soo, Sonja K.;
Traa, Annika;
Rudich, Zenith D.;
Moldakozhayev, Alibek;
Mistry, Meeta;
Van Raamsdonk, Jeremy M.

Publication type:

Article

RNA Sequencing of Pooled Samples Effectively Identifies Differentially Expressed Genes.

Published in:

Biology (2079-7737), 2023, v. 12, n. 6, p. 812, doi. 10.3390/biology12060812

By:

Ko, Bokang;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

Published in:

BMC Neuroscience, 2006, v. 7, p. 80, doi. 10.1186/1471-2202-7-80

By:

Van Raamsdonk, Jeremy M.;
Pearson, Jacqueline;
Murphy, Zoe;
Hayden, Michael R.;
Leavitt, Blair R.

Publication type:

Article

The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan.

Published in:

PLoS Genetics, 2022, v. 18, n. 8, p. 1, doi. 10.1371/journal.pgen.1010328

By:

Meraş, İçten;
Chotard, Laëtitia;
Liontis, Thomas;
Ratemi, Zakaria;
Wiles, Benjamin;
Seo, Jung Hwa;
Van Raamsdonk, Jeremy M.;
Rocheleau, Christian E.

Publication type:

Article

Huntingtin inhibits caspase-3 activation.

Published in:

EMBO Journal, 2006, v. 25, n. 24, p. 5896, doi. 10.1038/sj.emboj.7601445

By:

Yu Zhang;
Leavitt, Blair R.;
van Raamsdonk, Jeremy M.;
Dragatsis, Ioannis;
Goldowitz, Dan;
MacDonald, Marcy E.;
Hayden, Michael R.;
Friedlander, Robert M.

Publication type:

Article

Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways.

Published in:

FASEB Journal, 2020, v. 34, n. 6, p. 8475, doi. 10.1096/fj.201903235R

By:

Machiela, Emily;
Liontis, Thomas;
Dues, Dylan J.;
Rudich, Paige D.;
Traa, Annika;
Wyman, Leslie;
Kaufman, Corah;
Cooper, Jason F.;
Lew, Leira;
Nadarajan, Saravanapriah;
Senchuk, Megan M.;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

Published in:

Journal of Neurochemistry, 2005, v. 95, n. 1, p. 210, doi. 10.1111/j.1471-4159.2005.03357.x

By:

van Raamsdonk, Jeremy M.;
Pearson, Jacqueline;
Bailey, Craig D. C.;
Rogers, Daniel A.;
Johnson, Gail V. W.;
Hayden, Michael R.;
Leavitt, Blair R.

Publication type:

Article

Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.

Published in:

Journal of Neurochemistry, 2005, v. 94, n. 4, p. 1087, doi. 10.1111/j.1471-4159.2005.03255.x

By:

Pinto, John T.;
van Raamsdonk, Jeremy M.;
Leavitt, Blair R.;
Hayden, Michael R.;
Jeitner, Thomas M.;
Thaler, Howard T.;
Krasnikov, Boris F.;
Cooper, Arthur J. L.

Publication type:

Article

Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

Published in:

PLoS Genetics, 2018, v. 14, n. 3, p. 1, doi. 10.1371/journal.pgen.1007268

By:

Senchuk, Megan M.;
Dues, Dylan J.;
Schaar, Claire E.;
Johnson, Benjamin K.;
Madaj, Zachary B.;
Bowman, Megan J.;
Winn, Mary E.;
Van Raamsdonk, Jeremy M.

Publication type:

Article

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling.

Published in:

EMBO Reports, 2021, v. 22, n. 12, p. 1, doi. 10.15252/embr.202152964

By:

Campos, Juliane C;
Wu, Ziyun;
Rudich, Paige D;
Soo, Sonja K;
Mistry, Meeta;
Ferreira, Julio CB;
Blackwell, T Keith;
Van Raamsdonk, Jeremy M

Publication type:

Article

Modeling Parkinson's Disease in C. elegans.

Published in:

Journal of Parkinson's Disease, 2018, v. 8, n. 1, p. 17, doi. 10.3233/JPD-171258

By:

Cooper, Jason F.;
Van Raamsdonk, Jeremy M.

Publication type:

Article