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ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
Published in:
Virchows Archiv: European Journal of Pathology, 2021, v. 479, n. 1, p. 3, doi. 10.1007/s00428-020-03005-1
By:
- de la Fouchardiere, Arnaud;
- Blokx, Willeke;
- van Kempen, Léon C.;
- Luzar, Boštjan;
- Piperno-Neumann, Sophie;
- Puig, Susana;
- Alos, Llucia;
- Calonje, Eduardo;
- Massi, Daniela
Publication type:
Article
Recommendations for the clinical interpretation and reporting of copy number gains using gene panel NGS analysis in routine diagnostics.
Published in:
2019
By:
- Eijkelenboom, Astrid;
- Tops, Bastiaan B. J.;
- van den Berg, Anke;
- van den Brule, Adrianus J. C.;
- Dinjens, Winand N. M.;
- Dubbink, Hendrikus J.;
- ter Elst, Arja;
- Geurts-Giele, Willemina R. R.;
- Groenen, Patricia J. T. A.;
- Groenendijk, Floris H.;
- Heideman, Daniëlle A. M.;
- Huibers, Manon M. H.;
- Huijsmans, Cornelis J. J.;
- Jeuken, Judith W. M.;
- van Kempen, Léon C.;
- Korpershoek, Esther;
- Kroeze, Leonie I.;
- de Leng, Wendy W. J.;
- van Noesel, Carel J. M.;
- Speel, Ernst-Jan M.
Publication type:
journal article
Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23695-8
By:
- Allahyar, Amin;
- Pieterse, Mark;
- Swennenhuis, Joost;
- Los-de Vries, G. Tjitske;
- Yilmaz, Mehmet;
- Leguit, Roos;
- Meijers, Ruud W. J.;
- van der Geize, Robert;
- Vermaat, Joost;
- Cleven, Arjen;
- van Wezel, Tom;
- Diepstra, Arjan;
- van Kempen, Léon C.;
- Hijmering, Nathalie J.;
- Stathi, Phylicia;
- Sharma, Milan;
- Melquiond, Adrien S. J.;
- de Vree, Paula J. P.;
- Verstegen, Marjon J. A. M.;
- Krijger, Peter H. L.
Publication type:
Article
A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland.
Published in:
Genes, Chromosomes & Cancer, 2023, v. 62, n. 5, p. 297, doi. 10.1002/gcc.23122
By:
- de Jager, Vincent D.;
- de Visscher, Sebastiaan A. H. J.;
- Schuuring, Ed;
- Doff, Jan J.;
- van Kempen, Léon C.
Publication type:
Article
Actionability of on-target ALK Resistance Mutations in Patients With Non-Small Cell Lung Cancer: Local Experience and Review of the Literature.
Published in:
Clinical Lung Cancer, 2022, v. 23, n. 2, p. e104, doi. 10.1016/j.cllc.2021.06.011
By:
- Koopman, Bart;
- Groen, Harry J.M.;
- Schuuring, Ed;
- Hiltermann, T. Jeroen N.;
- Timens, Wim;
- den Dunnen, Wilfred F.A.;
- van den Berg, Anke;
- ter Elst, Arja;
- van Kruchten, Michel;
- Kluiver, Joost L.;
- Hiddinga, Birgitta I.;
- Hijmering-Kappelle, Lucie B.M.;
- Groves, Matthew R.;
- Vilacha, Juliana F.;
- van Kempen, Léon C.;
- van der Wekken, Anthonie J.
Publication type:
Article
Rare Oncogenic Fusions in Pediatric Central Nervous System Tumors: A Case Series and Literature Review.
Published in:
Cancers, 2024, v. 16, n. 19, p. 3344, doi. 10.3390/cancers16193344
By:
- Ahmed, Melek;
- Sieben, Anne;
- Van Genechten, Toon;
- Libbrecht, Sasha;
- Gilis, Nathalie;
- De Praeter, Mania;
- Fricx, Christophe;
- Calò, Pierluigi;
- Van Campenhout, Claude;
- D'Haene, Nicky;
- Witte, Olivier De;
- Kempen, Léon C. Van;
- Lammens, Martin;
- Salmon, Isabelle;
- Lebrun, Laetitia
Publication type:
Article
Unmet Needs and Perspectives in Oral Cancer Prevention.
Published in:
Cancers, 2022, v. 14, n. 7, p. 1815, doi. 10.3390/cancers14071815
By:
- Bouaoud, Jebrane;
- Bossi, Paolo;
- Elkabets, Moshe;
- Schmitz, Sandra;
- van Kempen, Léon C.;
- Martinez, Pierre;
- Jagadeeshan, Sankar;
- Breuskin, Ingrid;
- Puppels, Gerwin J.;
- Hoffmann, Caroline;
- Hunter, Keith D.;
- Simon, Christian;
- Machiels, Jean-Pascal;
- Grégoire, Vincent;
- Bertolus, Chloé;
- Brakenhoff, Ruud H.;
- Koljenović, Senada;
- Saintigny, Pierre
Publication type:
Article
A Nationwide Study on the Impact of Routine Testing for EGFR Mutations in Advanced NSCLC Reveals Distinct Survival Patterns Based on EGFR Mutation Subclasses.
Published in:
Cancers, 2021, v. 13, n. 14, p. 3641, doi. 10.3390/cancers13143641
By:
- Koopman, Bart;
- Cajiao Garcia, Betzabel N.;
- Kuijpers, Chantal C. H. J.;
- Damhuis, Ronald A. M.;
- van der Wekken, Anthonie J.;
- Groen, Harry J. M.;
- Schuuring, Ed;
- Willems, Stefan M.;
- van Kempen, Léon C.
Publication type:
Article
Comparison of Circulating Cell-Free DNA Extraction Methods for Downstream Analysis in Cancer Patients.
Published in:
Cancers, 2020, v. 12, n. 5, p. 1222, doi. 10.3390/cancers12051222
By:
- van der Leest, Paul;
- Boonstra, Pieter A.;
- ter Elst, Arja;
- van Kempen, Léon C.;
- Tibbesma, Marco;
- Koopmans, Jill;
- Miedema, Anneke;
- Tamminga, Menno;
- Groen, Harry J. M.;
- Reyners, Anna K. L.;
- Schuuring, Ed
Publication type:
Article
Mutational Evolution in Relapsed Diffuse Large B-Cell Lymphoma.
Published in:
Cancers, 2018, v. 10, n. 11, p. 459, doi. 10.3390/cancers10110459
By:
- Nijland, Marcel;
- Seitz, Annika;
- Terpstra, Martijn;
- van Imhoff, Gustaaf W.;
- Kluin, Philip M;
- van Meerten, Tom;
- Atayar, Çiğdem;
- van Kempen, Léon C.;
- Diepstra, Arjan;
- Kok, Klaas;
- van den Berg, Anke
Publication type:
Article
Circulating tumor DNA as a biomarker for monitoring early treatment responses of patients with advanced lung adenocarcinoma receiving immune checkpoint inhibitors.
Published in:
Molecular Oncology, 2021, v. 15, n. 11, p. 2910, doi. 10.1002/1878-0261.13090
By:
- van der Leest, Paul;
- Hiddinga, Birgitta;
- Miedema, Anneke;
- Aguirre Azpurua, Maria L.;
- Rifaela, Naomi;
- ter Elst, Arja;
- Timens, Wim;
- Groen, Harry J. M.;
- van Kempen, Léon C.;
- Hiltermann, T. Jeroen N.;
- Schuuring, Ed
Publication type:
Article
Increased Interferon Signaling in Vaginal Tissue of Patients With Primary Sjögren Syndrome.
Published in:
Journal of Rheumatology, 2024, v. 51, n. 7, p. 687, doi. 10.3899/jrheum.2023-1068
By:
- Visser, Annie;
- van Nimwegen, Jolien F.;
- Wilbrink, Rick;
- Liefers, Silvia C.;
- van der Tuuk, Karin;
- Mourits, Marian J. E.;
- Diercks, Gilles F. H.;
- Bart, Joost;
- van der Vegt, Bert;
- van Kempen, Léon C.;
- Bootsma, Hendrika;
- Kroese, Frans G. M.;
- Verstappen, Gwenny M.
Publication type:
Article
External Quality Assessment on Molecular Tumor Profiling with Circulating Tumor DNA-Based Methodologies Routinely Used in Clinical Pathology within the COIN Consortium.
Published in:
Clinical Chemistry, 2024, v. 70, n. 5, p. 759, doi. 10.1093/clinchem/hvae014
By:
- van der Leest, Paul;
- Rozendal, Pim;
- Hinrichs, John;
- Noesel, Carel J M van;
- Zwaenepoel, Karen;
- Deiman, Birgit;
- Huijsmans, Cornelis J J;
- Eijk, Ronald van;
- Speel, Ernst Jan M;
- Haastert, Rick J van;
- Ligtenberg, Marjolijn J L;
- Schaik, Ron H N van;
- Jansen, Maurice P H M;
- Dubbink, Hendrikus J;
- Leng, Wendy W de;
- Leers, Mathie P G;
- Tamminga, Menno;
- van den Broek, Daan;
- Kempen, Léon C van;
- Schuuring, Ed
Publication type:
Article
Dutch National Round Robin Trial on Plasma-Derived Circulating Cell-Free DNA Extraction Methods Routinely Used in Clinical Pathology for Molecular Tumor Profiling.
Published in:
Clinical Chemistry, 2022, v. 68, n. 7, p. 963, doi. 10.1093/clinchem/hvac069
By:
- van der Leest, Paul;
- Ketelaar, Emma M.;
- van Noesel, Carel J. M.;
- van den Broek, Daan;
- van Boerdonk, Robert A. A.;
- Deiman, Birgit;
- Rifaela, Naomi;
- van der Geize, Robert;
- Huijsmans, Cornelis J. J.;
- Speel, Ernst Jan M.;
- Geerlings, Maartje J.;
- van Schaik, Ron H. N.;
- Jansen, Maurice P. H. M.;
- Dane-Vogelaar, Ria;
- Driehuis, Else;
- Leers, Mathie P. G.;
- Sidorenkov, Grigory;
- Tamminga, Menno;
- van Kempen, Léon C.;
- Schuuring, Ed
Publication type:
Article
Unraveling the MicroRNA tapestry: exploring the molecular dynamics of locoregional recurrent rectal cancer.
Published in:
Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1407217
By:
- Meyer, N. Helge;
- Kotnik, Nika;
- Nzeteu, Gaetan Aime Noubissi;
- van Kempen, Léon C.;
- Mastik, Mirjam;
- Bockhorn, Maximilian;
- Troja, Achim
Publication type:
Article
The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
Published in:
Science Translational Medicine, 2016, v. 8, n. 369, p. 1, doi. 10.1126/scitranslmed.aai9188
By:
- van Kempen, Léon C. L.;
- Redpath, Margaret;
- Elchebly, Mounib;
- Klein, Kathleen Oros;
- Papadakis, Andreas I.;
- Wilmott, James S.;
- Scolyer, Richard A.;
- Edqvist, Per-Henrik;
- Pontén, Fredrik;
- Schadendorf, Dirk;
- van Rijk, Anke F.;
- Michiels, Stefan;
- Dumay, Anne;
- Helbling-Leclerc, Anne;
- Dessen, Philippe;
- Wouters, Jasper;
- Stass, Marguerite;
- Greenwood, Celia M. T.;
- Ghanem, Ghanem E.;
- van den Oord, Joost
Publication type:
Article
Modulation of Activated Leukocyte Cell Adhesion Molecule-Mediated Invasion Triggers an Innate Immune Gene Response in Melanoma.
Published in:
Journal of Investigative Dermatology, 2012, v. 132, n. 5, p. 1462, doi. 10.1038/jid.2011.487
By:
- van Kilsdonk, Jeroen W J;
- Takahashi, Nozomi;
- Weidle, Ulrich;
- Burtscher, Helmut;
- Jarry, Jonathan;
- Daha, Mohamed R;
- Swart, Guido W M;
- van Kempen, Léon C L T
Publication type:
Article
Hemoglobin level predicts outcome for vulvar cancer patients independent of GLUT-1 and CA-IX expression in tumor tissue.
Published in:
2010
By:
- Nieuwenhof, Hedwig;
- Hullu, Joanne;
- Kaanders, Johannes;
- Bulten, Johan;
- Massuger, Leon;
- Kempen, Léon;
- van de Nieuwenhof, Hedwig P;
- de Hullu, Joanne A;
- Kaanders, Johannes H A M;
- Massuger, Leon F A G;
- van Kempen, Léon C L T
Publication type:
journal article
Utility and Micro-Costing Framework for TERT Promoter Mutation Analysis in Melanocytic Lesions of Uncertain Malignant Potential: A Retrospective Study in Dutch Local Clinical Practice.
Published in:
Diagnostics (2075-4418), 2024, v. 14, n. 15, p. 1665, doi. 10.3390/diagnostics14151665
By:
- Barrutia, Leire;
- Schuuring, Ed;
- Rácz, Emõke;
- Diercks, Gilles F. H.;
- van Kempen, Léon C.
Publication type:
Article
Detection of NTRK Fusions and TRK Expression and Performance of pan-TRK Immunohistochemistry in Routine Diagnostics: Results from a Nationwide Community-Based Cohort.
Published in:
Diagnostics (2075-4418), 2022, v. 12, n. 3, p. 668, doi. 10.3390/diagnostics12030668
By:
- Koopman, Bart;
- Kuijpers, Chantal C. H. J.;
- Groen, Harry J. M.;
- Timens, Wim;
- Schuuring, Ed;
- Willems, Stefan M.;
- van Kempen, Léon C.
Publication type:
Article
Detection and Monitoring of Tumor-Derived Mutations in Circulating Tumor DNA Using the UltraSEEK Lung Panel on the MassARRAY System in Metastatic Non-Small Cell Lung Cancer Patients.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13390, doi. 10.3390/ijms241713390
By:
- Leest, Paul van der;
- Janning, Melanie;
- Rifaela, Naomi;
- Azpurua, Maria L. Aguirre;
- Kropidlowski, Jolanthe;
- Loges, Sonja;
- Lozano, Nicolas;
- Sartori, Alexander;
- Irwin, Darryl;
- Lamy, Pierre-Jean;
- Hiltermann, T. Jeroen N.;
- Groen, Harry J. M.;
- Pantel, Klaus;
- Kempen, Léon C. van;
- Wikman, Harriet;
- Schuuring, Ed
Publication type:
Article
L1CAM in early-stage type I endometrial cancer: results of a large multicenter evaluation.
Published in:
2013
By:
- Zeimet, Alain G;
- Reimer, Daniel;
- Huszar, Monica;
- Winterhoff, Boris;
- Puistola, Ulla;
- Azim, Samira Abdel;
- Müller-Holzner, Elisabeth;
- Ben-Arie, Alon;
- van Kempen, Léon C;
- Petru, Edgar;
- Jahn, Stephan;
- Geels, Yvette P;
- Massuger, Leon F;
- Amant, Frédéric;
- Polterauer, Stephan;
- Lappi-Blanco, Elisa;
- Bulten, Johan;
- Meuter, Alexandra;
- Tanouye, Staci;
- Oppelt, Peter
Publication type:
Journal Article
Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-21365-3
By:
- Lutz, Pierre-Eric;
- Chay, Marc-Aurèle;
- Pacis, Alain;
- Chen, Gary G.;
- Aouabed, Zahia;
- Maffioletti, Elisabetta;
- Théroux, Jean-François;
- Grenier, Jean-Christophe;
- Yang, Jennie;
- Aguirre, Maria;
- Ernst, Carl;
- Redensek, Adriana;
- van Kempen, Léon C.;
- Yalcin, Ipek;
- Kwan, Tony;
- Mechawar, Naguib;
- Pastinen, Tomi;
- Turecki, Gustavo
Publication type:
Article
From biomarker development towards implementation of multidimensional biomarker panels in a clinical setting.
Published in:
2014
By:
- van Kempen, Léon C.;
- Spatz, Alan
Publication type:
Editorial

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