Works by van IJcken, Wilfred F. J.


Results: 98
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    Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease.

    Published in:
    Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-05881-6
    By:
    • Dheedene, Wouter;
    • Verhulst, Stefaan;
    • Demuynck, Louise;
    • Callewaert, Bram;
    • de Haan, Willeke;
    • Vinckier, Stefan;
    • Van Wauwe, Jore;
    • Vandervoort, Petra;
    • Lox, Marleen;
    • Stroobants, Mathias;
    • Lavend'homme, Renaud;
    • van IJcken, Wilfred F. J.;
    • Jones, Elizabeth A. V.;
    • Zwijsen, An;
    • Jacquemin, Marc;
    • van Grunsven, Leo A.;
    • Martinod, Kimberly;
    • Huylebroeck, Danny;
    • Mulugeta, Eskeatnaf;
    • Luttun, Aernout
    Publication type:
    Article
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    Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length.

    Published in:
    Frontiers in Genetics, 2020, v. 11, p. 1, doi. 10.3389/fgene.2020.00337
    By:
    • van der Spek, Ashley;
    • Warner, Sophie C.;
    • Broer, Linda;
    • Nelson, Christopher P.;
    • Vojinovic, Dina;
    • Ahmad, Shahzad;
    • Arp, Pascal P.;
    • Brouwer, Rutger W. W.;
    • Denniff, Matthew;
    • van den Hout, Mirjam C. G. N.;
    • van Rooij, Jeroen G. J.;
    • Kraaij, Robert;
    • van IJcken, Wilfred F. J.;
    • Samani, Nilesh J.;
    • Ikram, M. Arfan;
    • Uitterlinden, André G.;
    • Codd, Veryan;
    • Amin, Najaf;
    • van Duijn, Cornelia M.
    Publication type:
    Article
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    Circulating TP53 mutations are associated with early tumor progression and poor survival in pancreatic cancer patients treated with FOLFIRINOX.

    Published in:
    Therapeutic Advances in Medical Oncology, 2021, p. 1, doi. 10.1177/17588359211033704
    By:
    • van der Sijde, Fleur;
    • Azmani, Zakia;
    • Besselink, Marc G.;
    • Bonsing, Bert A.;
    • de Groot, Jan Willem B.;
    • Groot Koerkamp, Bas;
    • Haberkorn, Brigitte C. M.;
    • Homs, Marjolein Y. V.;
    • van IJcken, Wilfred F. J.;
    • Janssen, Quisette P.;
    • Lolkema, Martijn P.;
    • Luelmo, Saskia A. C.;
    • Mekenkamp, Leonie J. M.;
    • Mustafa, Dana A. M.;
    • van Schaik, Ron H. N.;
    • Wilmink, Johanna W.;
    • Vietsch, Eveline E.;
    • van Eijck, Casper H. J.
    Publication type:
    Article
    6

    Circulating TP53 mutations are associated with early tumor progression and poor survival in pancreatic cancer patients treated with FOLFIRINOX.

    Published in:
    Therapeutic Advances in Medical Oncology, 2021, p. 1, doi. 10.1177/17588359211033704
    By:
    • van der Sijde, Fleur;
    • Azmani, Zakia;
    • Besselink, Marc G.;
    • Bonsing, Bert A.;
    • de Groot, Jan Willem B.;
    • Groot Koerkamp, Bas;
    • Haberkorn, Brigitte C. M.;
    • Homs, Marjolein Y. V.;
    • van IJcken, Wilfred F. J.;
    • Janssen, Quisette P.;
    • Lolkema, Martijn P.;
    • Luelmo, Saskia A. C.;
    • Mekenkamp, Leonie J. M.;
    • Mustafa, Dana A. M.;
    • van Schaik, Ron H. N.;
    • Wilmink, Johanna W.;
    • Vietsch, Eveline E.;
    • van Eijck, Casper H. J.
    Publication type:
    Article
    7

    Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics.

    Published in:
    Molecular Oncology, 2025, v. 19, n. 6, p. 1797, doi. 10.1002/1878-0261.13812
    By:
    • Froyen, Guy;
    • Volders, Pieter‐Jan;
    • Geerdens, Ellen;
    • Berden, Severine;
    • Van der Meulen, Joni;
    • De Cock, Aaron;
    • Vermeire, Stefanie;
    • Van Huysse, Jacques;
    • de Barsy, Marie;
    • Beniuga, Gabriela;
    • de Leng, Wendy W. J.;
    • Jansen, Anne M. L.;
    • Demers, Imke;
    • Ozgur, Zeliha;
    • Dubbink, Hendrikus Jan;
    • Speel, Ernst‐Jan M.;
    • van IJcken, Wilfred F. J.;
    • Maes, Brigitte
    Publication type:
    Article
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    SPEN is required for Xist upregulation during initiation of X chromosome inactivation.

    Published in:
    Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27294-5
    By:
    • Robert-Finestra, Teresa;
    • Tan, Beatrice F.;
    • Mira-Bontenbal, Hegias;
    • Timmers, Erika;
    • Gontan, Cristina;
    • Merzouk, Sarra;
    • Giaimo, Benedetto Daniele;
    • Dossin, François;
    • van IJcken, Wilfred F. J.;
    • Martens, John W. M.;
    • Borggrefe, Tilman;
    • Heard, Edith;
    • Gribnau, Joost
    Publication type:
    Article
    13

    Enhancer-associated H3K4 methylation safeguards in vitro germline competence.

    Published in:
    Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26065-6
    By:
    • Bleckwehl, Tore;
    • Crispatzu, Giuliano;
    • Schaaf, Kaitlin;
    • Respuela, Patricia;
    • Bartusel, Michaela;
    • Benson, Laura;
    • Clark, Stephen J.;
    • Dorighi, Kristel M.;
    • Barral, Antonio;
    • Laugsch, Magdalena;
    • van IJcken, Wilfred F. J.;
    • Manzanares, Miguel;
    • Wysocka, Joanna;
    • Reik, Wolf;
    • Rada-Iglesias, Álvaro
    Publication type:
    Article
    14

    Time since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue.

    Published in:
    PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003522
    By:
    • van de Weg, Cornelia A. M.;
    • van den Ham, Henk-Jan;
    • Bijl, Maarten A.;
    • Anfasa, Fatih;
    • Zaaraoui-Boutahar, Fatiha;
    • Dewi, Beti E.;
    • Nainggolan, Leonard;
    • van IJcken, Wilfred F. J.;
    • Osterhaus, Albert D. M. E.;
    • Martina, Byron E. E.;
    • van Gorp, Eric C. M.;
    • Andeweg, Arno C.
    Publication type:
    Article
    15

    Time since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue.

    Published in:
    PLoS Neglected Tropical Diseases, 2015, v. 9, n. 3, p. 1, doi. 10.1371/journal.pntd.0003522
    By:
    • van de Weg, Cornelia A. M.;
    • van den Ham, Henk-Jan;
    • Bijl, Maarten A.;
    • Anfasa, Fatih;
    • Zaaraoui-Boutahar, Fatiha;
    • Dewi, Beti E.;
    • Nainggolan, Leonard;
    • van IJcken, Wilfred F. J.;
    • Osterhaus, Albert D. M. E.;
    • Martina, Byron E. E.;
    • van Gorp, Eric C. M.;
    • Andeweg, Arno C.
    Publication type:
    Article
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    MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma.

    Published in:
    PLoS ONE, 2020, v. 15, n. 1, p. 1, doi. 10.1371/journal.pone.0228014
    By:
    • Vos, Melissa;
    • Boers, Ruben;
    • Vriends, Anne L. M.;
    • Boers, Joachim;
    • van Kuijk, Patricia F.;
    • van Houdt, Winan J.;
    • van Leenders, Geert J. L. H.;
    • Wagrodzki, Michal;
    • van IJcken, Wilfred F. J.;
    • Gribnau, Joost;
    • Grünhagen, Dirk J.;
    • Verhoef, Cornelis;
    • Sleijfer, Stefan;
    • Wiemer, Erik A. C.
    Publication type:
    Article
    18

    Kidney Organoids Are Capable of Forming Tumors, but Not Teratomas.

    Published in:
    Stem Cells, 2022, v. 40, n. 6, p. 577, doi. 10.1093/stmcls/sxac009
    By:
    • Shankar, Anusha S;
    • Du, Zhaoyu;
    • Mora, Hector Tejeda;
    • Boers, Ruben;
    • Cao, Wanlu;
    • Bosch, Thierry P P van den;
    • Korevaar, Sander S;
    • Boers, Joachim;
    • IJcken, Wilfred F J van;
    • Bindels, Eric M J;
    • Eussen, Bert;
    • Klein, Annelies de;
    • Pan, Qiuwei;
    • Oudijk, Lindsey;
    • Groningen, Marian C Clahsen-van;
    • Hoorn, Ewout J;
    • Baan, Carla C;
    • Gribnau, Joost;
    • Hoogduijn, Martin J
    Publication type:
    Article
    19

    Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells.

    Published in:
    Stem Cells, 2017, v. 35, n. 3, p. 611, doi. 10.1002/stem.2521
    By:
    • Stryjewska, Agata;
    • Dries, Ruben;
    • Pieters, Tim;
    • Verstappen, Griet;
    • Conidi, Andrea;
    • Coddens, Kathleen;
    • Francis, Annick;
    • Umans, Lieve;
    • van IJcken, Wilfred F. J.;
    • Berx, Geert;
    • van Grunsven, Leo A.;
    • Grosveld, Frank G.;
    • Goossens, Steven;
    • Haigh, Jody J.;
    • Huylebroeck, Danny
    Publication type:
    Article
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    BMP4 and Temozolomide Synergize in the Majority of Patient-Derived Glioblastoma Cultures.

    Published in:
    International Journal of Molecular Sciences, 2024, v. 25, n. 18, p. 10176, doi. 10.3390/ijms251810176
    By:
    • Verploegh, Iris S. C.;
    • Conidi, Andrea;
    • El Hassnaoui, Hoesna;
    • Verhoeven, Floor A. M.;
    • Korporaal, Anne L.;
    • Ntafoulis, Ioannis;
    • van den Hout, Mirjam C. G. N.;
    • Brouwer, Rutger W. W.;
    • Lamfers, Martine L. M.;
    • van IJcken, Wilfred F. J.;
    • Huylebroeck, Danny;
    • Leenstra, Sieger
    Publication type:
    Article
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    Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic Disease.

    Published in:
    International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 438, doi. 10.3390/ijms23010438
    By:
    • Verhagen, Judith M. A.;
    • Burger, Joyce;
    • Bekkers, Jos A.;
    • den Dekker, Alexander T.;
    • von der Thüsen, Jan H.;
    • Zajec, Marina;
    • Brüggenwirth, Hennie T.;
    • van der Sterre, Marianne L. T.;
    • van den Born, Myrthe;
    • Luider, Theo M.;
    • van IJcken, Wilfred F. J.;
    • Wessels, Marja W.;
    • Essers, Jeroen;
    • Roos-Hesselink, Jolien W.;
    • van der Pluijm, Ingrid;
    • van de Laar, Ingrid M. B. H.;
    • Brosens, Erwin
    Publication type:
    Article
    31

    The Somatic Mutation Paradigm in Congenital Malformations: Hirschsprung Disease as a Model.

    Published in:
    International Journal of Molecular Sciences, 2021, v. 22, n. 22, p. 12354, doi. 10.3390/ijms222212354
    By:
    • MacKenzie, Katherine C.;
    • Garritsen, Rhiana;
    • Chauhan, Rajendra K.;
    • Sribudiani, Yunia;
    • de Graaf, Bianca M.;
    • Rugenbrink, Tim;
    • Brouwer, Rutger;
    • van Ijcken, Wilfred F. J.;
    • de Blaauw, Ivo;
    • Brooks, Alice S.;
    • Sloots, Cornelius E. J.;
    • Meeuwsen, Conny J. H. M.;
    • Wijnen, René M.;
    • Newgreen, Donald F.;
    • Burns, Alan J.;
    • Hofstra, Robert M. W.;
    • Alves, Maria M.;
    • Brosens, Erwin
    Publication type:
    Article
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    Genome-wide analysis toward the epigenetic aetiology of myelodysplastic syndrome disease progression and pharmacoepigenomic basis of hypomethylating agents drug treatment response.

    Published in:
    Human Genomics, 2023, v. 17, n. 1, p. 1, doi. 10.1186/s40246-023-00483-7
    By:
    • Siamoglou, Stavroula;
    • Boers, Ruben;
    • Koromina, Maria;
    • Boers, Joachim;
    • Tsironi, Anna;
    • Chatzilygeroudi, Theodora;
    • Lazaris, Vasileios;
    • Verigou, Evgenia;
    • Kourakli, Alexandra;
    • van IJcken, Wilfred F. J.;
    • Gribnau, Joost;
    • Symeonidis, Argiris;
    • Patrinos, George P.
    Publication type:
    Article
    34

    CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue.

    Published in:
    Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03249-4
    By:
    • van Riet, Job;
    • Saha, Chinmoy;
    • Strepis, Nikolaos;
    • Brouwer, Rutger W. W.;
    • Martens-Uzunova, Elena S.;
    • van de Geer, Wesley S.;
    • Swagemakers, Sigrid M. A.;
    • Stubbs, Andrew;
    • Halimi, Yassir;
    • Voogd, Sanne;
    • Tanmoy, Arif Mohammad;
    • Komor, Malgorzata A.;
    • Hoogstrate, Youri;
    • Janssen, Bart;
    • Fijneman, Remond J. A.;
    • Niknafs, Yashar S.;
    • Chinnaiyan, Arul M.;
    • van IJcken, Wilfred F. J.;
    • van der Spek, Peter J.;
    • Jenster, Guido
    Publication type:
    Article
    35

    Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus.

    Published in:
    Frontiers in Microbiology, 2017, p. 1, doi. 10.3389/fmicb.2017.01556
    By:
    • Lim, Stephanie M.;
    • van den Ham, Henk-Jan;
    • Oduber, Minoushka;
    • Martina, Eurydice;
    • Zaaraoui-Boutahar, Fatiha;
    • Roose, Jeroen M.;
    • van IJcken, Wilfred F. J.;
    • Osterhaus, Albert D. M. E.;
    • Andeweg, Arno C.;
    • Koraka, Penelope;
    • Martina, Byron E. E.
    Publication type:
    Article
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    Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-44913-z
    By:
    • Gonzalez Galofre, Zaniah N.;
    • Kilpatrick, Alastair M.;
    • Marques, Madalena;
    • Sá da Bandeira, Diana;
    • Ventura, Telma;
    • Gomez Salazar, Mario;
    • Bouilleau, Léa;
    • Marc, Yvan;
    • Barbosa, Ana B.;
    • Rossi, Fiona;
    • Beltran, Mariana;
    • van de Werken, Harmen J. G.;
    • van IJcken, Wilfred F. J.;
    • Henderson, Neil C.;
    • Forbes, Stuart J.;
    • Crisan, Mihaela
    Publication type:
    Article
    40

    Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-44913-z
    By:
    • Gonzalez Galofre, Zaniah N.;
    • Kilpatrick, Alastair M.;
    • Marques, Madalena;
    • Sá da Bandeira, Diana;
    • Ventura, Telma;
    • Gomez Salazar, Mario;
    • Bouilleau, Léa;
    • Marc, Yvan;
    • Barbosa, Ana B.;
    • Rossi, Fiona;
    • Beltran, Mariana;
    • van de Werken, Harmen J. G.;
    • van IJcken, Wilfred F. J.;
    • Henderson, Neil C.;
    • Forbes, Stuart J.;
    • Crisan, Mihaela
    Publication type:
    Article
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    Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis.

    Published in:
    2016
    By:
    • Korpershoek, Esther;
    • Koffy, Djamailys;
    • Eussen, Bert H;
    • Oudijk, Lindsey;
    • Papathomas, Thomas G;
    • van Nederveen, Francien H;
    • Belt, Eric J T;
    • Franssen, Gaston J H;
    • Restuccia, David F J;
    • Krol, Niels M G;
    • van der Luijt, Rob B;
    • Feelders, Richard A;
    • Oldenburg, Rogier A;
    • van Ijcken, Wilfred F J;
    • de Klein, Annelies;
    • de Herder, Wouter W;
    • de Krijger, Ronald R;
    • Dinjens, Winand N M
    Publication type:
    journal article
    44

    Physiological Thyroid Hormone Levels Regulate Numerous Skeletal Muscle Transcripts.

    Published in:
    Journal of Clinical Endocrinology & Metabolism, 2009, v. 94, n. 9, p. 3487, doi. 10.1210/jc.2009-0782
    By:
    • Visser, W. Edward;
    • Heemstra, Karen A.;
    • Swagemakers, Sigrid M. A.;
    • Özgür, Zeliha;
    • Corssmit, Eleonora P.;
    • Burggraaf, Jacobus;
    • van Ijcken, Wilfred F. J.;
    • van der Spek, Peter J.;
    • Smit, Johannes W. A.;
    • Visser, Theo J.
    Publication type:
    Article
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    High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments.

    Published in:
    Clinical Epigenetics, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13148-021-01177-4
    By:
    • Deger, Teoman;
    • Boers, Ruben G.;
    • de Weerd, Vanja;
    • Angus, Lindsay;
    • van der Put, Marjolijn M. J.;
    • Boers, Joachim B.;
    • Azmani, Z.;
    • van IJcken, Wilfred F. J.;
    • Grünhagen, Dirk J.;
    • van Dessel, Lisanne F.;
    • Lolkema, Martijn P. J. K.;
    • Verhoef, Cornelis;
    • Sleijfer, Stefan;
    • Martens, John W. M.;
    • Gribnau, Joost;
    • Wilting, Saskia M.
    Publication type:
    Article
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