Works by van Faassen, Henk

Results: 26

In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats.

Published in:

Fluids & Barriers of the CNS, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12987-024-00617-6

By:

Costain, Will J.;
Haqqani, Arsalan S.;
Hussack, Greg;
van Faassen, Henk;
Lessard, Etienne;
Ling, Binbing;
Brunette, Eric;
Ly, Dao;
Fang, Hung;
Bultinck, Jennyfer;
Geysens, Steven;
Pynaert, Gwenda;
Piens, Kathleen;
Ryckaert, Stefan;
Fudalej, Franck;
Vervecken, Wouter;
Stanimirovic, Danica

Publication type:

Article

Structure of a Therapeutic Antibody in Complex with MUC16 Reveals a Conformational Epitope Influenced by Antigen Glycosylation.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5166

By:

Brooks, Cory L.;
Aguilar, Eric N.;
White, Brandy;
van Faassen, Henk;
Michaud, Sarah;
Goodlett, David;
Brooks, Teresa;
Hussack, Greg;
Henry, Kevin;
Radhakrishnan, Prakash

Publication type:

Article

Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics.

Published in:

FASEB Journal, 2022, v. 36, n. 3, p. 1, doi. 10.1096/fj.202101644R

By:

Alata, Wael;
Yogi, Alvaro;
Brunette, Eric;
Delaney, Christie E.;
van Faassen, Henk;
Hussack, Greg;
Iqbal, Umar;
Kemmerich, Kristin;
Haqqani, Arsalan S.;
Moreno, Maria J.;
Stanimirovic, Danica B.

Publication type:

Article

Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2025, v. 81, n. 5, p. 223, doi. 10.1107/S2059798325002554

By:

Li, Wei;
Mandel, Ulla;
van Faassen, Henk;
Parker, Matthew J.;
Legg, Max S. G.;
Hussack, Greg;
Clausen, Henrik;
Evans, Stephen V.

Publication type:

Article

Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor.

Published in:

Pharmaceutics, 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/pharmaceutics14071452

By:

Yogi, Alvaro;
Hussack, Greg;
van Faassen, Henk;
Haqqani, Arsalan S.;
Delaney, Christie E.;
Brunette, Eric;
Sandhu, Jagdeep K.;
Hewitt, Melissa;
Sulea, Traian;
Kemmerich, Kristin;
Stanimirovic, Danica B.

Publication type:

Article

A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01406

By:

Hussack, Greg;
Baral, Toya Nath;
Baardsnes, Jason;
van Faassen, Henk;
Raphael, Shalini;
Henry, Kevin A.;
Jianbing Zhang;
MacKenzie, C. Roger

Publication type:

Article

A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies.

Published in:

PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0163113

By:

Henry, Kevin A.;
Sulea, Traian;
van Faassen, Henk;
Hussack, Greg;
Purisima, Enrico O.;
MacKenzie, C. Roger;
Arbabi-Ghahroudi, Mehdi

Publication type:

Article

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03866-z

By:

Rossotti, Martin A.;
van Faassen, Henk;
Tran, Anh T.;
Sheff, Joey;
Sandhu, Jagdeep K.;
Duque, Diana;
Hewitt, Melissa;
Wen, Xiaoxue;
Bavananthasivam, Jegarubee;
Beitari, Saina;
Matte, Kevin;
Laroche, Geneviève;
Giguère, Patrick M.;
Gervais, Christian;
Stuible, Matthew;
Guimond, Julie;
Perret, Sylvie;
Hussack, Greg;
Langlois, Marc-André;
Durocher, Yves

Publication type:

Article

Epitope mapping of a blood–brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction.

Published in:

Journal of Biochemistry, 2023, v. 173, n. 2, p. 95, doi. 10.1093/jb/mvac088

By:

Sheff, Joey;
Kelly, John;
Foss, Mary;
Brunette, Eric;
Kemmerich, Kristin;
Faassen, Henk van;
Raphael, Shalini;
Hussack, Greg;
Comamala, Gerard;
Rand, Kasper;
Stanimirovic, Danica B.

Publication type:

Article

Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0208978

By:

Hussack, Greg;
Ryan, Shannon;
van Faassen, Henk;
Rossotti, Martin;
MacKenzie, C. Roger;
Tanha, Jamshid

Publication type:

Article

Serum albumin‐binding VHHs with variable pH sensitivities enable tailored half‐life extension of biologics.

Published in:

FASEB Journal, 2020, v. 34, n. 6, p. 8155, doi. 10.1096/fj.201903231R

By:

van Faassen, Henk;
Ryan, Shannon;
Henry, Kevin A.;
Raphael, Shalini;
Yang, Qingling;
Rossotti, Martin A.;
Brunette, Eric;
Jiang, Susan;
Haqqani, Arsalan S.;
Sulea, Traian;
MacKenzie, C. Roger;
Tanha, Jamshid;
Hussack, Greg

Publication type:

Article

Isolation and characterization of a VHH targeting the Acinetobacter baumannii cell surface protein CsuA/B.

Published in:

Applied Microbiology & Biotechnology, 2023, v. 107, n. 14, p. 4567, doi. 10.1007/s00253-023-12594-1

By:

Lei, Eric K.;
Ryan, Shannon;
van Faassen, Henk;
Foss, Mary;
Robotham, Anna;
Baltat, Isabel;
Fulton, Kelly;
Henry, Kevin A.;
Chen, Wangxue;
Hussack, Greg

Publication type:

Article

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling.

Published in:

Biochemical Journal, 2019, v. 476, n. 1, p. 39, doi. 10.1042/BCJ20180795

By:

Rossotti, Martin A.;
Henry, Kevin A.;
van Faassen, Henk;
Tanha, Jamshid;
Callaghan, Deborah;
Hussack, Greg;
Arbabi-Ghahroudi, Mehdi;
MacKenzie, C. Roger

Publication type:

Article

A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models.

Published in:

Advanced Science, 2024, v. 11, n. 40, p. 1, doi. 10.1002/advs.202405432

By:

Martina, Marzia;
Banderali, Umberto;
Yogi, Alvaro;
Arbabi Ghahroudi, Mehdi;
Liu, Hong;
Sulea, Traian;
Durocher, Yves;
Hussack, Greg;
van Faassen, Henk;
Chakravarty, Balu;
Liu, Qing Yan;
Iqbal, Umar;
Ling, Binbing;
Lessard, Etienne;
Sheff, Joey;
Robotham, Anna;
Callaghan, Debbie;
Moreno, Maria;
Comas, Tanya;
Ly, Dao

Publication type:

Article

Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83198-w

By:

Sheff, Joey;
Wang, Ping;
Xu, Ping;
Arbour, Melanie;
Masson, Luke;
van Faassen, Henk;
Hussack, Greg;
Kemmerich, Kristin;
Brunette, Eric;
Stanimirovic, Danica;
Hill, Jennifer J.;
Kelly, John;
Ni, Feng

Publication type:

Article

Pentavalent Single-Domain Antibodies Reduce Campylobacter jejuni Motility and Colonization in Chickens.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083928

By:

Riazi, Ali;
Strong, Philippa C. R.;
Coleman, Russell;
Chen, Wangxue;
Hirama, Tomoko;
van Faassen, Henk;
Henry, Matthew;
Logan, Susan M.;
Szymanski, Christine M.;
MacKenzie, Roger;
Ghahroudi, Mehdi Arbabi

Publication type:

Article

Monoclonal Antibodies Recognizing the Surface Autolysin IspC of Listeria monocytogenes Serotype 4b: Epitope Localization, Kinetic Characterization, and Cross-Reaction Studies.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055098

By:

Ronholm, Jennifer;
van Faassen, Henk;
MacKenzie, Roger;
Zhang, Zhiyi;
Cao, Xudong;
Lin, Min

Publication type:

Article

Correction to: Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.

Published in:

2023

By:

Henry, Kevin A.;
van Faassen, Henk;
Harcus, Doreen;
Marcil, Anne;
Hill, Jennifer J.;
Muyldermans, Serge;
MacKenzie, C. Roger

Publication type:

Correction Notice

Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.

Published in:

Immunogenetics, 2019, v. 71, n. 4, p. 307, doi. 10.1007/s00251-018-01102-9

By:

Henry, Kevin A.;
van Faassen, Henk;
Harcus, Doreen;
Marcil, Anne;
Hill, Jennifer J.;
Muyldermans, Serge;
MacKenzie, C. Roger

Publication type:

Article

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor.

Published in:

Frontiers in Microbiology, 2023, v. 14, p. 1, doi. 10.3389/fmicb.2023.1110541

By:

Hussack, Greg;
Rossotti, Martin A.;
van Faassen, Henk;
Tomohiko Murase;
Eugenio, Luiz;
Schrag, Joseph D.;
Ng, Kenneth K.-S.;
Tanha, Jamshid

Publication type:

Article

Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility.

Published in:

PEDS: Protein Engineering, Design & Selection, 2014, v. 27, n. 6, p. 191, doi. 10.1093/protein/gzu011

By:

Hussack, Greg;
Riazi, Ali;
Ryan, Shannon;
van Faassen, Henk;
MacKenzie, Roger;
Tanha, Jamshid;
Arbabi-Ghahroudi, Mehdi

Publication type:

Article

Disulfide linkage engineering for improving biophysical properties of human VH domains 6.

Published in:

PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 10, p. 581, doi. 10.1093/protein/gzs055

By:

Kim, Dae Young;
Kandalaft, Hiba;
Ding, Wen;
Ryan, Shannon;
van Faassen, Henk;
Hirama, Tomoko;
Foote, Simon J.;
MacKenzie, Roger;
Tanha, Jamshid

Publication type:

Article

A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders †.

Published in:

PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 6, p. 313, doi. 10.1093/protein/gzs014

By:

Hussack, Greg;
Keklikian, Artine;
Alsughayyir, Jawaher;
Hanifi-Moghaddam, Pejman;
Arbabi-Ghahroudi, Mehdi;
van Faassen, Henk;
Hou, Sheng T.;
Sad, Subash;
MacKenzie, Roger;
Tanha, Jamshid

Publication type:

Article

Optimization of synthetic human VH affinity and solubility through in vitro affinity maturation and minimal camelization.

Published in:

Protein Science: A Publication of the Protein Society, 2025, v. 34, n. 5, p. 1, doi. 10.1002/pro.70114

By:

Bélanger, Kasandra;
Wu, Cunle;
Sulea, Traian;
van Faassen, Henk;
Callaghan, Deborah;
Aubry, Annie;
Sasseville, Marc;
Hussack, Greg;
Tanha, Jamshid

Publication type:

Article

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX.

Published in:

2021

By:

Sheff, Joey G.;
Kelly, John F.;
Robotham, Anna;
Sulea, Traian;
Malenfant, Félix;
L'Abbé, Denis;
Duchesne, Mélanie;
Pelletier, Alex;
Lefebvre, Jean;
Acel, Andrea;
Parat, Marie;
Gosselin, Mylene;
Wu, Cunle;
Fortin, Yves;
Baardsnes, Jason;
Van Faassen, Henk;
Awrey, Shannon;
Chafe, Shawn C.;
McDonald, Paul C.;
Dedhar, Shoukat

Publication type:

Report

Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.

Published in:

mAbs (1942-0862), 2014, v. 6, n. 1, p. 1, doi. 10.4161/mabs.26844

By:

Dae Young Kim;
To, Rebecca;
Kandalaft, Hiba;
Wen Ding;
van Faassen, Henk;
Yan Luo;
Schrag, Joseph D.;
St-Amant, Nadereh;
Hefford, Mary;
Tomoko Hirama;
Kelly, John F.;
MacKenzie, Roger;
Tanha, Jamshid

Publication type:

Article

Works by van Faassen, Henk

In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats.

Structure of a Therapeutic Antibody in Complex with MUC16 Reveals a Conformational Epitope Influenced by Antigen Glycosylation.

Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics.

Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope.

Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor.

A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display.

A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies.

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models.

Epitope mapping of a blood–brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction.

Neutralization of Clostridium difficile toxin B with V<sub>H</sub>H-Fc fusions targeting the delivery and CROPs domains.

Serum albumin‐binding V<sub>H</sub>Hs with variable pH sensitivities enable tailored half‐life extension of biologics.

Isolation and characterization of a VHH targeting the Acinetobacter baumannii cell surface protein CsuA/B.

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling.

A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models.

Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor.

Pentavalent Single-Domain Antibodies Reduce <i>Campylobacter jejuni</i> Motility and Colonization in Chickens.

Monoclonal Antibodies Recognizing the Surface Autolysin IspC of <i>Listeria monocytogenes</i> Serotype 4b: Epitope Localization, Kinetic Characterization, and Cross-Reaction Studies.

Correction to: Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.

Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor.

Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility.

Disulfide linkage engineering for improving biophysical properties of human VH domains 6.

A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders †.

Optimization of synthetic human V<sub>H</sub> affinity and solubility through in vitro affinity maturation and minimal camelization.

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX.

Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.