Works by van Faassen, Henk

Results: 24

In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats.
Published in:
Fluids & Barriers of the CNS, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12987-024-00617-6
By:
- Costain, Will J.;
- Haqqani, Arsalan S.;
- Hussack, Greg;
- van Faassen, Henk;
- Lessard, Etienne;
- Ling, Binbing;
- Brunette, Eric;
- Ly, Dao;
- Fang, Hung;
- Bultinck, Jennyfer;
- Geysens, Steven;
- Pynaert, Gwenda;
- Piens, Kathleen;
- Ryckaert, Stefan;
- Fudalej, Franck;
- Vervecken, Wouter;
- Stanimirovic, Danica
Publication type:
Article
A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display.
Published in:
Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.01406
By:
- Hussack, Greg;
- Baral, Toya Nath;
- Baardsnes, Jason;
- van Faassen, Henk;
- Raphael, Shalini;
- Henry, Kevin A.;
- Jianbing Zhang;
- MacKenzie, C. Roger
Publication type:
Article
A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models.
Published in:
Advanced Science, 2024, v. 11, n. 40, p. 1, doi. 10.1002/advs.202405432
By:
- Martina, Marzia;
- Banderali, Umberto;
- Yogi, Alvaro;
- Arbabi Ghahroudi, Mehdi;
- Liu, Hong;
- Sulea, Traian;
- Durocher, Yves;
- Hussack, Greg;
- van Faassen, Henk;
- Chakravarty, Balu;
- Liu, Qing Yan;
- Iqbal, Umar;
- Ling, Binbing;
- Lessard, Etienne;
- Sheff, Joey;
- Robotham, Anna;
- Callaghan, Debbie;
- Moreno, Maria;
- Comas, Tanya;
- Ly, Dao
Publication type:
Article
Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling.
Published in:
Biochemical Journal, 2019, v. 476, n. 1, p. 39, doi. 10.1042/BCJ20180795
By:
- Rossotti, Martin A.;
- Henry, Kevin A.;
- van Faassen, Henk;
- Tanha, Jamshid;
- Callaghan, Deborah;
- Hussack, Greg;
- Arbabi-Ghahroudi, Mehdi;
- MacKenzie, C. Roger
Publication type:
Article
Correction to: Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.
Published in:
2023
By:
- Henry, Kevin A.;
- van Faassen, Henk;
- Harcus, Doreen;
- Marcil, Anne;
- Hill, Jennifer J.;
- Muyldermans, Serge;
- MacKenzie, C. Roger
Publication type:
Correction Notice
Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.
Published in:
Immunogenetics, 2019, v. 71, n. 4, p. 307, doi. 10.1007/s00251-018-01102-9
By:
- Henry, Kevin A.;
- van Faassen, Henk;
- Harcus, Doreen;
- Marcil, Anne;
- Hill, Jennifer J.;
- Muyldermans, Serge;
- MacKenzie, C. Roger
Publication type:
Article
Epitope mapping of a blood–brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction.
Published in:
Journal of Biochemistry, 2023, v. 173, n. 2, p. 95, doi. 10.1093/jb/mvac088
By:
- Sheff, Joey;
- Kelly, John;
- Foss, Mary;
- Brunette, Eric;
- Kemmerich, Kristin;
- Faassen, Henk van;
- Raphael, Shalini;
- Hussack, Greg;
- Comamala, Gerard;
- Rand, Kasper;
- Stanimirovic, Danica B.
Publication type:
Article
Structure of a Therapeutic Antibody in Complex with MUC16 Reveals a Conformational Epitope Influenced by Antigen Glycosylation.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5166
By:
- Brooks, Cory L.;
- Aguilar, Eric N.;
- White, Brandy;
- van Faassen, Henk;
- Michaud, Sarah;
- Goodlett, David;
- Brooks, Teresa;
- Hussack, Greg;
- Henry, Kevin;
- Radhakrishnan, Prakash
Publication type:
Article
Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics.
Published in:
FASEB Journal, 2022, v. 36, n. 3, p. 1, doi. 10.1096/fj.202101644R
By:
- Alata, Wael;
- Yogi, Alvaro;
- Brunette, Eric;
- Delaney, Christie E.;
- van Faassen, Henk;
- Hussack, Greg;
- Iqbal, Umar;
- Kemmerich, Kristin;
- Haqqani, Arsalan S.;
- Moreno, Maria J.;
- Stanimirovic, Danica B.
Publication type:
Article
Serum albumin‐binding VHHs with variable pH sensitivities enable tailored half‐life extension of biologics.
Published in:
FASEB Journal, 2020, v. 34, n. 6, p. 8155, doi. 10.1096/fj.201903231R
By:
- van Faassen, Henk;
- Ryan, Shannon;
- Henry, Kevin A.;
- Raphael, Shalini;
- Yang, Qingling;
- Rossotti, Martin A.;
- Brunette, Eric;
- Jiang, Susan;
- Haqqani, Arsalan S.;
- Sulea, Traian;
- MacKenzie, C. Roger;
- Tanha, Jamshid;
- Hussack, Greg
Publication type:
Article
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03866-z
By:
- Rossotti, Martin A.;
- van Faassen, Henk;
- Tran, Anh T.;
- Sheff, Joey;
- Sandhu, Jagdeep K.;
- Duque, Diana;
- Hewitt, Melissa;
- Wen, Xiaoxue;
- Bavananthasivam, Jegarubee;
- Beitari, Saina;
- Matte, Kevin;
- Laroche, Geneviève;
- Giguère, Patrick M.;
- Gervais, Christian;
- Stuible, Matthew;
- Guimond, Julie;
- Perret, Sylvie;
- Hussack, Greg;
- Langlois, Marc-André;
- Durocher, Yves
Publication type:
Article
Structure-guided design of a potent Clostridioides difficile toxin A inhibitor.
Published in:
Frontiers in Microbiology, 2023, v. 14, p. 1, doi. 10.3389/fmicb.2023.1110541
By:
- Hussack, Greg;
- Rossotti, Martin A.;
- van Faassen, Henk;
- Tomohiko Murase;
- Eugenio, Luiz;
- Schrag, Joseph D.;
- Ng, Kenneth K.-S.;
- Tanha, Jamshid
Publication type:
Article
A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies.
Published in:
PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0163113
By:
- Henry, Kevin A.;
- Sulea, Traian;
- van Faassen, Henk;
- Hussack, Greg;
- Purisima, Enrico O.;
- MacKenzie, C. Roger;
- Arbabi-Ghahroudi, Mehdi
Publication type:
Article
Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor.
Published in:
Pharmaceutics, 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/pharmaceutics14071452
By:
- Yogi, Alvaro;
- Hussack, Greg;
- van Faassen, Henk;
- Haqqani, Arsalan S.;
- Delaney, Christie E.;
- Brunette, Eric;
- Sandhu, Jagdeep K.;
- Hewitt, Melissa;
- Sulea, Traian;
- Kemmerich, Kristin;
- Stanimirovic, Danica B.
Publication type:
Article
Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility.
Published in:
PEDS: Protein Engineering, Design & Selection, 2014, v. 27, n. 6, p. 191, doi. 10.1093/protein/gzu011
By:
- Hussack, Greg;
- Riazi, Ali;
- Ryan, Shannon;
- van Faassen, Henk;
- MacKenzie, Roger;
- Tanha, Jamshid;
- Arbabi-Ghahroudi, Mehdi
Publication type:
Article
Disulfide linkage engineering for improving biophysical properties of human VH domains 6.
Published in:
PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 10, p. 581, doi. 10.1093/protein/gzs055
By:
- Kim, Dae Young;
- Kandalaft, Hiba;
- Ding, Wen;
- Ryan, Shannon;
- van Faassen, Henk;
- Hirama, Tomoko;
- Foote, Simon J.;
- MacKenzie, Roger;
- Tanha, Jamshid
Publication type:
Article
A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders †.
Published in:
PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 6, p. 313, doi. 10.1093/protein/gzs014
By:
- Hussack, Greg;
- Keklikian, Artine;
- Alsughayyir, Jawaher;
- Hanifi-Moghaddam, Pejman;
- Arbabi-Ghahroudi, Mehdi;
- van Faassen, Henk;
- Hou, Sheng T.;
- Sad, Subash;
- MacKenzie, Roger;
- Tanha, Jamshid
Publication type:
Article
Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-83198-w
By:
- Sheff, Joey;
- Wang, Ping;
- Xu, Ping;
- Arbour, Melanie;
- Masson, Luke;
- van Faassen, Henk;
- Hussack, Greg;
- Kemmerich, Kristin;
- Brunette, Eric;
- Stanimirovic, Danica;
- Hill, Jennifer J.;
- Kelly, John;
- Ni, Feng
Publication type:
Article
Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains.
Published in:
PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0208978
By:
- Hussack, Greg;
- Ryan, Shannon;
- van Faassen, Henk;
- Rossotti, Martin;
- MacKenzie, C. Roger;
- Tanha, Jamshid
Publication type:
Article
Isolation and characterization of a VHH targeting the Acinetobacter baumannii cell surface protein CsuA/B.
Published in:
Applied Microbiology & Biotechnology, 2023, v. 107, n. 14, p. 4567, doi. 10.1007/s00253-023-12594-1
By:
- Lei, Eric K.;
- Ryan, Shannon;
- van Faassen, Henk;
- Foss, Mary;
- Robotham, Anna;
- Baltat, Isabel;
- Fulton, Kelly;
- Henry, Kevin A.;
- Chen, Wangxue;
- Hussack, Greg
Publication type:
Article
Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX.
Published in:
2021
By:
- Sheff, Joey G.;
- Kelly, John F.;
- Robotham, Anna;
- Sulea, Traian;
- Malenfant, Félix;
- L'Abbé, Denis;
- Duchesne, Mélanie;
- Pelletier, Alex;
- Lefebvre, Jean;
- Acel, Andrea;
- Parat, Marie;
- Gosselin, Mylene;
- Wu, Cunle;
- Fortin, Yves;
- Baardsnes, Jason;
- Van Faassen, Henk;
- Awrey, Shannon;
- Chafe, Shawn C.;
- McDonald, Paul C.;
- Dedhar, Shoukat
Publication type:
Report
Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.
Published in:
mAbs, 2014, v. 6, n. 1, p. 1, doi. 10.4161/mabs.26844
By:
- Dae Young Kim;
- To, Rebecca;
- Kandalaft, Hiba;
- Wen Ding;
- van Faassen, Henk;
- Yan Luo;
- Schrag, Joseph D.;
- St-Amant, Nadereh;
- Hefford, Mary;
- Tomoko Hirama;
- Kelly, John F.;
- MacKenzie, Roger;
- Tanha, Jamshid
Publication type:
Article
Pentavalent Single-Domain Antibodies Reduce Campylobacter jejuni Motility and Colonization in Chickens.
Published in:
PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083928
By:
- Riazi, Ali;
- Strong, Philippa C. R.;
- Coleman, Russell;
- Chen, Wangxue;
- Hirama, Tomoko;
- van Faassen, Henk;
- Henry, Matthew;
- Logan, Susan M.;
- Szymanski, Christine M.;
- MacKenzie, Roger;
- Ghahroudi, Mehdi Arbabi
Publication type:
Article
Monoclonal Antibodies Recognizing the Surface Autolysin IspC of Listeria monocytogenes Serotype 4b: Epitope Localization, Kinetic Characterization, and Cross-Reaction Studies.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055098
By:
- Ronholm, Jennifer;
- van Faassen, Henk;
- MacKenzie, Roger;
- Zhang, Zhiyi;
- Cao, Xudong;
- Lin, Min
Publication type:
Article

Works by van Faassen, Henk

In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats.

A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display.

A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models.

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling.

Correction to: Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.

Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct.

Epitope mapping of a blood–brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction.

Structure of a Therapeutic Antibody in Complex with MUC16 Reveals a Conformational Epitope Influenced by Antigen Glycosylation.

Targeting insulin‐like growth factor‐1 receptor (IGF1R) for brain delivery of biologics.

Serum albumin‐binding V<sub>H</sub>Hs with variable pH sensitivities enable tailored half‐life extension of biologics.

Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models.

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor.

A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies.

Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor.

Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility.

Disulfide linkage engineering for improving biophysical properties of human VH domains 6.

A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders †.

Defining the epitope of a blood–brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor.

Neutralization of Clostridium difficile toxin B with V<sub>H</sub>H-Fc fusions targeting the delivery and CROPs domains.

Isolation and characterization of a VHH targeting the Acinetobacter baumannii cell surface protein CsuA/B.

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX.

Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.

Pentavalent Single-Domain Antibodies Reduce <i>Campylobacter jejuni</i> Motility and Colonization in Chickens.

Monoclonal Antibodies Recognizing the Surface Autolysin IspC of <i>Listeria monocytogenes</i> Serotype 4b: Epitope Localization, Kinetic Characterization, and Cross-Reaction Studies.