OpenURL Connection Search

Select item for more details and to access through your institution.

Targeting development of incretin-producing cells increases insulin secretion.
Published in:
Journal of Clinical Investigation, 2015, v. 125, n. 1, p. 379, doi. 10.1172/JCI75838
By:
- Petersen, Natalia;
- Reimann, Frank;
- van Es, Johan H.;
- van den Berg, Bernard M.;
- Kroone, Chantal;
- Pais, Ramona;
- Jansen, Erik;
- Clevers, Hans;
- Gribble, Fiona M.;
- de Koning, Eelco J. P.
Publication type:
Article
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
Published in:
EMBO Reports, 2008, v. 9, n. 4, p. 377, doi. 10.1038/embor.2008.7
By:
- Riccio, Orbicia;
- van Gijn, Marielle E;
- Bezdek, April C;
- Pellegrinet, Luca;
- van Es, Johan H;
- Zimber-Strobl, Ursula;
- Strobl, Lothar J;
- Honjo, Tasuku;
- Clevers, Hans;
- Radtke, Freddy
Publication type:
Article
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.
Published in:
Nature Genetics, 2008, v. 40, n. 11, p. 1291, doi. 10.1038/ng.239
By:
- Jaks, Viljar;
- Barker, Nick;
- Kasper, Maria;
- van Es, Johan H;
- Snippert, Hugo J;
- Clevers, Hans;
- Toftgård, Rune
Publication type:
Article
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.
Published in:
Nature Methods, 2014, v. 11, n. 1, p. 106, doi. 10.1038/nmeth.2737
By:
- Yin, Xiaolei;
- Farin, Henner F;
- van Es, Johan H;
- Clevers, Hans;
- Langer, Robert;
- Karp, Jeffrey M
Publication type:
Article
Controlled gene expression in primary Lgr5 organoid cultures.
Published in:
Nature Methods, 2012, v. 9, n. 1, p. 81, doi. 10.1038/nmeth.1802
By:
- Koo, Bon-Kyoung;
- Stange, Daniel E;
- Sato, Toshiro;
- Karthaus, Wouter;
- Farin, Henner F;
- Huch, Meritxell;
- van Es, Johan H;
- Clevers, Hans
Publication type:
Article
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40701-3
By:
- Geurts, Maarten H.;
- Gandhi, Shashank;
- Boretto, Matteo G.;
- Akkerman, Ninouk;
- Derks, Lucca L. M.;
- van Son, Gijs;
- Celotti, Martina;
- Harshuk-Shabso, Sarina;
- Peci, Flavia;
- Begthel, Harry;
- Hendriks, Delilah;
- Schürmann, Paul;
- Andersson-Rolf, Amanda;
- Chuva de Sousa Lopes, Susana M.;
- van Es, Johan H.;
- van Boxtel, Ruben;
- Clevers, Hans
Publication type:
Article
Retromer Dependent Recycling of the Wnt Secretion Factor Wls Is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium.
Published in:
PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076971
By:
- de Groot, Reinoud E. A.;
- Farin, Henner F.;
- Macůrková, Marie;
- van Es, Johan H.;
- Clevers, Hans C.;
- Korswagen, Hendrik C.
Publication type:
Article
The BMP Antagonist Follistatin-Like 1 Is Required for Skeletal and Lung Organogenesis.
Published in:
PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0022616
By:
- Sylva, Marc;
- Li, Vivian S. W.;
- Buffing, Anita A. A.;
- van Es, Johan H.;
- den Born, Maaike van;
- Velden, Saskia van der;
- Gunst, Quinn;
- Koolstra, Jan Harm;
- Moorman, Antoon F. M.;
- Clevers, Hans;
- van den Hoff, Maurice J. B.
Publication type:
Article
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
Published in:
EMBO Journal, 2013, v. 32, n. 20, p. 2708, doi. 10.1038/emboj.2013.204
By:
- Huch, Meritxell;
- Bonfanti, Paola;
- Boj, Sylvia F;
- Sato, Toshiro;
- Loomans, Cindy J M;
- van de Wetering, Marc;
- Sojoodi, Mozhdeh;
- Li, Vivian S W;
- Schuijers, Jurian;
- Gracanin, Ana;
- Ringnalda, Femke;
- Begthel, Harry;
- Hamer, Karien;
- Mulder, Joyce;
- van Es, Johan H;
- de Koning, Eelco;
- Vries, Robert G J;
- Heimberg, Harry;
- Clevers, Hans
Publication type:
Article
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
Published in:
EMBO Journal, 2012, v. 31, n. 14, p. 3079, doi. 10.1038/emboj.2012.166
By:
- Muñoz, Javier;
- Stange, Daniel E;
- Schepers, Arnout G;
- van de Wetering, Marc;
- Koo, Bon-Kyoung;
- Itzkovitz, Shalev;
- Volckmann, Richard;
- Kung, Kevin S;
- Koster, Jan;
- Radulescu, Sorina;
- Myant, Kevin;
- Versteeg, Rogier;
- Sansom, Owen J;
- van Es, Johan H;
- Barker, Nick;
- van Oudenaarden, Alexander;
- Mohammed, Shabaz;
- Heck, Albert J R;
- Clevers, Hans
Publication type:
Article
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Published in:
Nature, 2011, v. 469, n. 7330, p. 415, doi. 10.1038/nature09637
By:
- Sato, Toshiro;
- van Es, Johan H.;
- Snippert, Hugo J.;
- Stange, Daniel E.;
- Vries, Robert G.;
- van den Born, Maaike;
- Barker, Nick;
- Shroyer, Noah F.;
- van de Wetering, Marc;
- Clevers, Hans
Publication type:
Article
Single Lgr5 stem cells build crypt?villus structures in vitro without a mesenchymal niche.
Published in:
Nature, 2009, v. 459, n. 7244, p. 262, doi. 10.1038/nature07935
By:
- Sato, Toshiro;
- Vries, Robert G.;
- Snippert, Hugo J.;
- van de Wetering, Marc;
- Barker, Nick;
- Stange, Daniel E.;
- van Es, Johan H.;
- Abo, Arie;
- Kujala, Pekka;
- Peters, Peter J.;
- Clevers, Hans
Publication type:
Article
Crypt stem cells as the cells-of-origin of intestinal cancer.
Published in:
Nature, 2009, v. 457, n. 7229, p. 608, doi. 10.1038/nature07602
By:
- Barker, Nick;
- Ridgway, Rachel A.;
- van Es, Johan H.;
- van de Wetering, Marc;
- Begthel, Harry;
- van den Born, Maaike;
- Danenberg, Esther;
- Clarke, Alan R.;
- Sansom, Owen J.;
- Clevers, Hans
Publication type:
Article
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Published in:
Nature, 2007, v. 449, n. 7165, p. 1003, doi. 10.1038/nature06196
By:
- Barker, Nick;
- van Es, Johan H.;
- Kuipers, Jeroen;
- Kujala, Pekka;
- van den Born, Maaike;
- Cozijnsen, Miranda;
- Haegebarth, Andrea;
- Korving, Jeroen;
- Begthel, Harry;
- Peters, Peter J.;
- Clevers, Hans
Publication type:
Article
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.
Published in:
Nature Cell Biology, 2012, v. 14, n. 10, p. 1099, doi. 10.1038/ncb2581
By:
- van Es, Johan H.;
- Sato, Toshiro;
- van de Wetering, Marc;
- Lyubimova, Anna;
- Yee Nee, Annie Ng;
- Gregorieff, Alex;
- Sasaki, Nobuo;
- Zeinstra, Laura;
- van den Born, Maaike;
- Korving, Jeroen;
- Martens, Anton C. M.;
- Barker, Nick;
- van Oudenaarden, Alexander;
- Clevers, Hans
Publication type:
Article
Wnt signalling induces maturation of Paneth cells in intestinal crypts.
Published in:
2005
By:
- van Es, Johan H.;
- Jay, Philippe;
- Gregorieff, Alex;
- van Gijn, Marielle E.;
- Jonkheer, Suzanne;
- Hatzis, Pantelis;
- Thiele, Andrea;
- van den Born, Maaike;
- Begthel, Harry;
- Brabletz, Thomas;
- Taketo, Makoto M.;
- Clevers, Hans
Publication type:
Letter
Mutations in the APC tumour suppressor gene cause chromosomal instability.
Published in:
Nature Cell Biology, 2001, v. 3, n. 4, p. 433, doi. 10.1038/35070129
By:
- Fodde, Riccardo;
- Kuipers, Jeroen;
- Rosenberg, Carla;
- Smits, Ron;
- Kielman, Menno;
- Gaspar, Claudia;
- van Es, Johan H.;
- Breukel, Cor;
- Wiegant, Joop;
- Giles, Rachel H.;
- Clevers, Hans
Publication type:
Article
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.
Published in:
Nature Communications, 2016, v. 7, n. 3, p. 10883, doi. 10.1038/ncomms10883
By:
- Zhao, Chuntao;
- Deng, Yaqi;
- Liu, Lei;
- Yu, Kun;
- Zhang, Liguo;
- Wang, Haibo;
- He, Xuelian;
- Wang, Jincheng;
- Lu, Changqing;
- Wu, Laiman N;
- Weng, Qinjie;
- Mao, Meng;
- Li, Jianrong;
- van Es, Johan H;
- Xin, Mei;
- Parry, Lee;
- Goldman, Steven A;
- Clevers, Hans;
- Lu, Q. Richard
Publication type:
Article
A20 controls intestinal homeostasis through cell-specific activities.
Published in:
Nature Communications, 2014, v. 5, n. 9, p. 5103, doi. 10.1038/ncomms6103
By:
- Vereecke, Lars;
- Vieira-Silva, Sara;
- Billiet, Thomas;
- van Es, Johan H.;
- Mc Guire, Conor;
- Slowicka, Karolina;
- Sze, Mozes;
- van den Born, Maaike;
- De Hertogh, Gert;
- Clevers, Hans;
- Raes, Jeroen;
- Rutgeerts, Paul;
- Vermeire, Severine;
- Beyaert, Rudi;
- van Loo, Geert
Publication type:
Article
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.
Published in:
Genome Biology, 2013, v. 14, n. 5, p. 1, doi. 10.1186/gb-2013-14-5-r50
By:
- Kaaij, Lucas T. J.;
- van de Wetering, Marc;
- Fang, Fang;
- Decato, Benjamin;
- Molaro, Antoine;
- van de Werken, Harmen J. G.;
- van Es, Johan H.;
- Schuijers, Jurian;
- de Wit, Elzo;
- de Laat, Wouter;
- Hannon, Gregory J.;
- Clevers, Hans C.;
- Smith, Andrew D.;
- Ketting, René F.
Publication type:
Article
NOTCH1 Signaling as a Therapeutic Target in Sézary Syndrome.
Published in:
Journal of Investigative Dermatology, 2012, v. 132, n. 12, p. 2810, doi. 10.1038/jid.2012.203
By:
- van der Fits, Leslie;
- Qin, Yongjun;
- Out-Luiting, Jacoba J;
- Vermeer, Kim G;
- Whittaker, Sean;
- van Es, Johan H;
- Tensen, Cornelis P;
- Vermeer, Maarten H
Publication type:
Article
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Published in:
Nature, 2005, v. 435, n. 7044, p. 959, doi. 10.1038/nature03659
By:
- van Es, Johan H.;
- van Gijn, Marielle E.;
- Riccio, Orbicia;
- van den Born, Maaike;
- Vooijs, Marc;
- Begthel, Harry;
- Cozijnsen, Miranda;
- Robine, Sylvie;
- Winton, Doug J.;
- Radtke, Freddy;
- Clevers, Hans
Publication type:
Article
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
Published in:
Journal of Cell Biology, 2011, v. 192, n. 5, p. 767, doi. 10.1083/jcb.201010127
By:
- Gerbe, François;
- van Es, Johan H.;
- Makrini, Leila;
- Brulin, Bénédicte;
- Mellitzer, Georg;
- Robine, Sylvie;
- Romagnolo, Béatrice;
- Shroyer, Noah F.;
- Bourgaux, Jean-François;
- Pignodel, Christine;
- Clevers, Hans;
- Jay, Philippe
Publication type:
Article
Urine-derived bladder cancer organoids (urinoids) as a tool for cancer longitudinal response monitoring and therapy adaptation.
Published in:
British Journal of Cancer, 2024, v. 130, n. 3, p. 369, doi. 10.1038/s41416-023-02494-6
By:
- Viergever, Bastiaan J.;
- Raats, Daniëlle A. E.;
- Geurts, Veerle;
- Mullenders, Jasper;
- Jonges, Trudy N.;
- van der Heijden, Michiel S.;
- van Es, Johan H.;
- Kranenburg, Onno;
- Meijer, Richard P.
Publication type:
Article
A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta.
Published in:
PLoS Biology, 2013, v. 11, n. 4, p. 1, doi. 10.1371/journal.pbio.1001536
By:
- Jinhua Lu;
- Shuang Zhang;
- Nakano, Haruo;
- Simmons, David G.;
- Shumin Wang;
- Shuangbo Kong;
- Qiang Wang;
- Lianju Shen;
- Zhaowei Tu;
- Weixiang Wang;
- Bingyan Wang;
- Hongmei Wang;
- Yanling Wang;
- van Es, Johan H.;
- Clevers, Hans;
- Leone, Gustavo;
- Cross, James C.;
- Haibin Wang
Publication type:
Article
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Published in:
Nature, 2013, v. 494, n. 7436, p. 247, doi. 10.1038/nature11826
By:
- Huch, Meritxell;
- Dorrell, Craig;
- Boj, Sylvia F.;
- van Es, Johan H.;
- Li, Vivian S. W.;
- van de Wetering, Marc;
- Sato, Toshiro;
- Hamer, Karien;
- Sasaki, Nobuo;
- Finegold, Milton J.;
- Haft, Annelise;
- Vries, Robert G.;
- Grompe, Markus;
- Clevers, Hans
Publication type:
Article
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.
Published in:
Nature, 2012, v. 488, n. 7413, p. 665, doi. 10.1038/nature11308
By:
- Koo, Bon-Kyoung;
- Spit, Maureen;
- Jordens, Ingrid;
- Low, Teck Y.;
- Stange, Daniel E.;
- van de Wetering, Marc;
- van Es, Johan H.;
- Mohammed, Shabaz;
- Heck, Albert J. R.;
- Maurice, Madelon M.;
- Clevers, Hans
Publication type:
Article
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction.
Published in:
Nature Neuroscience, 2009, v. 12, n. 7, p. 829, doi. 10.1038/nn.2333
By:
- Feng Ye;
- Ying Chen;
- ThaoNguyen Hoang;
- Montgomery, Rusty L.;
- Xian-hui Zhao;
- Hong Bu;
- Tom Hu;
- Taketo, Makoto M.;
- van Es, Johan H.;
- Clevers, Hans;
- Hsieh, Jenny;
- Bassel-Duby, Rhonda;
- Olson, Eric N.;
- Lu, Q. Richard
Publication type:
Article
High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.
Published in:
European Journal of Immunology, 1992, v. 22, n. 10, p. 2761, doi. 10.1002/eji.1830221046
By:
- Van Es, Johan H.;
- Meyling, Frits H. J. Gmeli;
- Logtenberg, Ton
Publication type:
Article
Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16432-0
By:
- Lõhmussaar, Kadi;
- Kopper, Oded;
- Korving, Jeroen;
- Begthel, Harry;
- Vreuls, Celien P. H.;
- van Es, Johan H.;
- Clevers, Hans
Publication type:
Article

Found: 30

Targeting development of incretin-producing cells increases insulin secretion.

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27<sup>Kip1</sup> and p57<sup>Kip2</sup>.

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

Niche-independent high-purity cultures of Lgr5<sup>+</sup> intestinal stem cells and their progeny.

Controlled gene expression in primary Lgr5 organoid cultures.

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids.

Retromer Dependent Recycling of the Wnt Secretion Factor Wls Is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium.

The BMP Antagonist Follistatin-Like 1 Is Required for Skeletal and Lung Organogenesis.

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Single Lgr5 stem cells build crypt?villus structures in vitro without a mesenchymal niche.

Crypt stem cells as the cells-of-origin of intestinal cancer.

Identification of stem cells in small intestine and colon by marker gene Lgr5.

Dll1<sup>+</sup> secretory progenitor cells revert to stem cells upon crypt damage.

Wnt signalling induces maturation of Paneth cells in intestinal crypts.

Mutations in the APC tumour suppressor gene cause chromosomal instability.

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

A20 controls intestinal homeostasis through cell-specific activities.

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus.

NOTCH1 Signaling as a Therapeutic Target in Sézary Syndrome.

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.

Urine-derived bladder cancer organoids (urinoids) as a tool for cancer longitudinal response monitoring and therapy adaptation.

A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta.

In vitro expansion of single Lgr5<sup>+</sup> liver stem cells induced by Wnt-driven regeneration.

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction.

High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.

Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids.