Works matching AU van Boxtel, Ruben

Results: 32
    1

    Direct detection of 8-oxo-dG using nanopore sequencing.

    Published in:
    Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60391-3
    By:
    • Pagès-Gallego, Marc;
    • van Soest, Daan M. K.;
    • Besselink, Nicolle J. M.;
    • Straver, Roy;
    • Keijer, Janneke P.;
    • Vermeulen, Carlo;
    • Marcozzi, Alessio;
    • van Roosmalen, Markus J.;
    • van Boxtel, Ruben;
    • Burgering, Boudewijn M. T.;
    • Dansen, Tobias B.;
    • de Ridder, Jeroen
    Publication type:
    Article
    2

    Precancerous liver diseases do not cause increased mutagenesis in liver stem cells.

    Published in:
    Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02839-y
    By:
    • Nguyen, Luan;
    • Jager, Myrthe;
    • Lieshout, Ruby;
    • de Ruiter, Petra E.;
    • Locati, Mauro D.;
    • Besselink, Nicolle;
    • van der Roest, Bastiaan;
    • Janssen, Roel;
    • Boymans, Sander;
    • de Jonge, Jeroen;
    • IJzermans, Jan N. M.;
    • Doukas, Michail;
    • Verstegen, Monique M. A.;
    • van Boxtel, Ruben;
    • van der Laan, Luc J. W.;
    • Cuppen, Edwin;
    • Kuijk, Ewart
    Publication type:
    Article
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    Sequential cancer mutations in cultured human intestinal stem cells.

    Published in:
    Nature, 2015, v. 521, n. 7550, p. 43, doi. 10.1038/nature14415
    By:
    • Drost, Jarno;
    • van Jaarsveld, Richard H.;
    • Ponsioen, Bas;
    • Zimberlin, Cheryl;
    • van Boxtel, Ruben;
    • Buijs, Arjan;
    • Sachs, Norman;
    • Overmeer, René M.;
    • Offerhaus, G. Johan;
    • Begthel, Harry;
    • Korving, Jeroen;
    • van de Wetering, Marc;
    • Schwank, Gerald;
    • Logtenberg, Meike;
    • Cuppen, Edwin;
    • Snippert, Hugo J.;
    • Medema, Jan Paul;
    • Kops, Geert J. P. L.;
    • Clevers, Hans
    Publication type:
    Article
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    Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34519-8
    By:
    • Heijink, Anne Margriet;
    • Stok, Colin;
    • Porubsky, David;
    • Manolika, Eleni Maria;
    • de Kanter, Jurrian K.;
    • Kok, Yannick P.;
    • Everts, Marieke;
    • de Boer, H. Rudolf;
    • Audrey, Anastasia;
    • Bakker, Femke J.;
    • Wierenga, Elles;
    • Tijsterman, Marcel;
    • Guryev, Victor;
    • Spierings, Diana C. J.;
    • Knipscheer, Puck;
    • van Boxtel, Ruben;
    • Ray Chaudhuri, Arnab;
    • Lansdorp, Peter M.;
    • van Vugt, Marcel A. T. M.
    Publication type:
    Article
    9

    Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51.

    Published in:
    Nature Communications, 2022, v. 13, p. 1, doi. 10.1038/s41467-022-34519-8
    By:
    • Heijink, Anne Margriet;
    • Stok, Colin;
    • Porubsky, David;
    • Manolika, Eleni Maria;
    • de Kanter, Jurrian K.;
    • Kok, Yannick P.;
    • Everts, Marieke;
    • de Boer, H. Rudolf;
    • Audrey, Anastasia;
    • Bakker, Femke J.;
    • Wierenga, Elles;
    • Tijsterman, Marcel;
    • Guryev, Victor;
    • Spierings, Diana C. J.;
    • Knipscheer, Puck;
    • van Boxtel, Ruben;
    • Ray Chaudhuri, Arnab;
    • Lansdorp, Peter M.;
    • van Vugt, Marcel A. T. M.
    Publication type:
    Article
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    Prime editing for functional repair in patient-derived disease models.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19136-7
    By:
    • Schene, Imre F.;
    • Joore, Indi P.;
    • Oka, Rurika;
    • Mokry, Michal;
    • van Vugt, Anke H. M.;
    • van Boxtel, Ruben;
    • van der Doef, Hubert P. J.;
    • van der Laan, Luc J. W.;
    • Verstegen, Monique M. A.;
    • van Hasselt, Peter M.;
    • Nieuwenhuis, Edward E. S.;
    • Fuchs, Sabine A.
    Publication type:
    Article
    14
    15

    The mutational impact of culturing human pluripotent and adult stem cells.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16323-4
    By:
    • Kuijk, Ewart;
    • Jager, Myrthe;
    • van der Roest, Bastiaan;
    • Locati, Mauro D.;
    • Van Hoeck, Arne;
    • Korzelius, Jerome;
    • Janssen, Roel;
    • Besselink, Nicolle;
    • Boymans, Sander;
    • van Boxtel, Ruben;
    • Cuppen, Edwin
    Publication type:
    Article
    16

    Genomic landscape of rat strain and substrain variation.

    Published in:
    BMC Genomics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12864-015-1594-1
    By:
    • Hermsen, Roel;
    • de Ligt, Joep;
    • Spee, Wim;
    • Blokzijl, Francis;
    • Schäfer, Sebastian;
    • Adami, Eleonora;
    • Boymans, Sander;
    • Flink, Stephen;
    • van Boxtel, Ruben;
    • van der Weide, Robin H.;
    • Aitman, Tim;
    • Hübner, Norbert;
    • Simonis, Marieke;
    • Tabakoff, Boris;
    • Guryev, Victor;
    • Cuppen, Edwin
    Publication type:
    Article
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    Polyketide synthase positive Escherichia coli one‐time measurement in stool is not informative of colorectal cancer risk in a screening setting.

    Published in:
    Journal of Pathology, 2024, v. 263, n. 2, p. 217, doi. 10.1002/path.6276
    By:
    • de Klaver, Willemijn;
    • de Wit, Meike;
    • Bolijn, Anne;
    • Tijssen, Marianne;
    • Delis‐van Diemen, Pien;
    • Lemmens, Margriet;
    • Spaander, Manon CW;
    • Dekker, Evelien;
    • van Leerdam, Monique E;
    • Coupé, Veerle MH;
    • van Boxtel, Ruben;
    • Clevers, Hans;
    • Carvalho, Beatriz;
    • Meijer, Gerrit A
    Publication type:
    Article
    23
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    Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50384-z
    By:
    • Bertrums, Eline J. M.;
    • de Kanter, Jurrian K.;
    • Derks, Lucca L. M.;
    • Verheul, Mark;
    • Trabut, Laurianne;
    • van Roosmalen, Markus J.;
    • Hasle, Henrik;
    • Antoniou, Evangelia;
    • Reinhardt, Dirk;
    • Dworzak, Michael N.;
    • Mühlegger, Nora;
    • van den Heuvel-Eibrink, Marry M.;
    • Zwaan, C. Michel;
    • Goemans, Bianca F.;
    • van Boxtel, Ruben
    Publication type:
    Article
    25
    26

    One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids.

    Published in:
    Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40701-3
    By:
    • Geurts, Maarten H.;
    • Gandhi, Shashank;
    • Boretto, Matteo G.;
    • Akkerman, Ninouk;
    • Derks, Lucca L. M.;
    • van Son, Gijs;
    • Celotti, Martina;
    • Harshuk-Shabso, Sarina;
    • Peci, Flavia;
    • Begthel, Harry;
    • Hendriks, Delilah;
    • Schürmann, Paul;
    • Andersson-Rolf, Amanda;
    • Chuva de Sousa Lopes, Susana M.;
    • van Es, Johan H.;
    • van Boxtel, Ruben;
    • Clevers, Hans
    Publication type:
    Article
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    Genome sequencing of normal cells reveals developmental lineages and mutational processes.

    Published in:
    Nature, 2014, v. 513, n. 7518, p. 422, doi. 10.1038/nature13448
    By:
    • Behjati, Sam;
    • Huch, Meritxell;
    • van Boxtel, Ruben;
    • Karthaus, Wouter;
    • Wedge, David C.;
    • Martincorena, Iñigo;
    • Petljak, Mia;
    • Alexandrov, Ludmil B.;
    • Gundem, Gunes;
    • Tarpey, Patrick S.;
    • Roerink, Sophie;
    • Maddison, Mark;
    • Mudie, Laura;
    • Robinson, Ben;
    • Campbell, Peter;
    • Stratton, Michael R.;
    • Tamuri, Asif U.;
    • Goldman, Nick;
    • Blokker, Joyce;
    • van de Wetering, Marc
    Publication type:
    Article
    30

    Different responses to DNA damage determine ageing differences between organs.

    Published in:
    Aging Cell, 2022, v. 21, n. 4, p. 1, doi. 10.1111/acel.13562
    By:
    • Vougioukalaki, Maria;
    • Demmers, Joris;
    • Vermeij, Wilbert P.;
    • Baar, Marjolein;
    • Bruens, Serena;
    • Magaraki, Aristea;
    • Kuijk, Ewart;
    • Jager, Myrthe;
    • Merzouk, Sarra;
    • Brandt, Renata M.C.;
    • Kouwenberg, Janneke;
    • van Boxtel, Ruben;
    • Cuppen, Edwin;
    • Pothof, Joris;
    • Hoeijmakers, Jan H. J.
    Publication type:
    Article
    31

    Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

    Published in:
    Nature Cell Biology, 2012, v. 14, n. 8, p. 829, doi. 10.1038/ncb2536
    By:
    • van der Vos, Kristan E.;
    • Eliasson, Pernilla;
    • Proikas-Cezanne, Tassula;
    • Vervoort, Stephin J.;
    • van Boxtel, Ruben;
    • Putker, Marrit;
    • van Zutphen, Iris J.;
    • Mauthe, Mario;
    • Zellmer, Sebastian;
    • Pals, Cornelieke;
    • Verhagen, Liesbeth P.;
    • Groot Koerkamp, Marian J. A.;
    • Braat, A. Koen;
    • Dansen, Tobias B.;
    • Holstege, Frank C.;
    • Gebhardt, Rolf;
    • Burgering, Boudewijn M.;
    • Coffer, Paul J.
    Publication type:
    Article
    32

    Tubuloids derived from human adult kidney and urine for personalized disease modeling.

    Published in:
    Nature Biotechnology, 2019, v. 37, n. 3, p. 303, doi. 10.1038/s41587-019-0048-8
    By:
    • Schutgens, Frans;
    • Rookmaaker, Maarten B;
    • Margaritis, Thanasis;
    • Rios, Anne;
    • Ammerlaan, Carola;
    • Jansen, Jitske;
    • Gijzen, Linda;
    • Vormann, Marianne;
    • Vonk, Annelotte;
    • Viveen, Marco;
    • Yengej, Fjodor Yousef;
    • Derakhshan, Sepide;
    • de Winter-de Groot, Karin M.;
    • Artegiani, Benedetta;
    • van Boxtel, Ruben;
    • Cuppen, Edwin;
    • Hendrickx, Antoni P. A.;
    • van den Heuvel-Eibrink, Marry M.;
    • Heitzer, Ellen;
    • Lanz, Henriette
    Publication type:
    Article