Works by van Aalten, Daan M. F.

Results: 40

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor.

Published in:

PLoS Biology, 2009, v. 7, n. 6, p. 1, doi. 10.1371/journal.pbio.1000126

By:

Zeqiraj, Elton;
Filippi, Beatrice Maria;
Goldie, Simon;
Navratilova, Iva;
Boudeau, Jérôme;
Deak, Maria;
Alessi, Dario R.;
van Aalten, Daan M. F.

Publication type:

Article

Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91269

By:

Haibin Yu;
Dandan Liu;
Yaowen Zhang;
Ruijun Tang;
Xunan Fan;
Song Mao;
Lu Lv;
Fang Chen;
Hongtao Qin;
Zhuohua Zhang;
van Aalten, Daan M. F.;
Bing Yang;
Kai Yuan

Publication type:

Article

Essential dynamics of DNA containing a cis.syn cyclobutane thymine dimer lesion.

Published in:

Nucleic Acids Research, 1998, v. 26, n. 8, p. 1939, doi. 10.1093/nar/26.8.1939

By:

Yamaguchi, Hiroshi;
van Aalten, Daan M. F.;
Pinak, Miroslav;
Furukawa, Akira;
Osman, Roman

Publication type:

Article

Protein O-GlcNAcylation Is Required for Fibroblast Growth Factor Signaling in Drosophila.

Published in:

Science Signaling, 2011, v. 4, n. 204, p. 1, doi. 10.1126/scisignal.2002335

By:

Mariappa, Daniel;
Sauert, Kathrin;
Mariño, Karina;
Turnock, Daniel;
Webster, Ryan;
van Aalten, Daan M. F.;
Ferguson, Michael A. J.;
Müller, H.-Arno J.

Publication type:

Article

A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription.

Published in:

EMBO Journal, 2013, v. 32, n. 5, p. 612, doi. 10.1038/emboj.2013.26

By:

Mariappa, Daniel;
Pathak, Shalini;
van Aalten, Daan M F

Publication type:

Article

Structural insights into mechanism and specificity of O-GlcNAc transferase.

Published in:

EMBO Journal, 2008, v. 27, n. 20, p. 2780, doi. 10.1038/emboj.2008.186

By:

Clarke, Andrew J.;
Hurtado-Guerrero, Ramon;
Pathak, Shalini;
Schüttelkopf, Alexander W.;
Borodkin, Vladimir;
Shepherd, Sharon M.;
Ibrahim, Adel F. M.;
van Aalten, Daan M. F.

Publication type:

Article

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.

Published in:

EMBO Journal, 2006, v. 25, n. 7, p. 1569, doi. 10.1038/sj.emboj.7601026

By:

Rao, Francesco V.;
Dorfmueller, Helge C.;
Villa, Fabrizio;
Allwood, Matthew;
Eggleston, Ian M.;
van Aalten, Daan M. F.

Publication type:

Article

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

Published in:

EMBO Journal, 2004, v. 23, n. 20, p. 3918, doi. 10.1038/sj.emboj.7600379

By:

Komander, David;
Fairservice, Alison;
Deak, Maria;
Kular, Gursant S;
Prescott, Alan R;
Peter Downes, C;
Safrany, Stephen T;
Alessi, Dario R;
M F van Aalten, Daan

Publication type:

Article

The active site of O-GlcNAc transferase imposes constraints on substrate sequence.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 9, p. 744, doi. 10.1038/nsmb.3063

By:

Pathak, Shalini;
Alonso, Jana;
Schimpl, Marianne;
Rafie, Karim;
Blair, David E;
Borodkin, Vladimir S;
Schüttelkopf, Alexander W;
Albarbarawi, Osama;
van Aalten, Daan M F

Publication type:

Article

Evolution of the Aldose Reductase-Related Gecko Eye Lens Protein ρB-Crystallin: A Sheep in Wolf's Clothing.

Published in:

Journal of Molecular Evolution, 2001, v. 52, n. 3, p. 239, doi. 10.1007/s002390010152

By:

van Boekel, Martinus A. M.;
van Aalten, Daan M. F.;
Caspers, Gert-Jan;
Röll, Beate;
de Jong, Wilfried W.

Publication type:

Article

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Published in:

Nature, 2010, v. 464, n. 7289, p. 728, doi. 10.1038/nature08893

By:

Frearson, Julie A.;
Brand, Stephen;
McElroy, Stuart P.;
Cleghorn, Laura A. T.;
Smid, Ondrej;
Stojanovski, Laste;
Price, Helen P.;
Guther, M. Lucia S.;
Torrie, Leah S.;
Robinson, David A.;
Hallyburton, Irene;
Mpamhanga, Chidochangu P.;
Brannigan, James A.;
Wilkinson, Anthony J.;
Hodgkinson, Michael;
Hui, Raymond;
Wei Qiu;
Raimi, Olawale G.;
van Aalten, Daan M. F.;
Brenk, Ruth

Publication type:

Article

Structural insights into the recognition of substrates and activators by the OSR1 kinase.

Published in:

EMBO Reports, 2007, v. 8, n. 9, p. 839, doi. 10.1038/sj.embor.7401048

By:

Villa, Fabrizio;
Goebel, Jürgen;
Rafiqi, Fatema H;
Deak, Maria;
Thastrup, Jacob;
Alessi, Dario R;
van Aalten, Daan M F

Publication type:

Article

Inhibitors against Fungal Cell Wall Remodeling Enzymes.

Published in:

ChemMedChem, 2018, v. 13, n. 2, p. 128, doi. 10.1002/cmdc.201700720

By:

Delso, Ignacio;
Valero‐Gonzalez, Jessika;
Gomollón‐Bel, Fernando;
Castro‐López, Jorge;
Fang, Wenxia;
Navratilova, Iva;
van Aalten, Daan M. F.;
Tejero, Tomás;
Merino, Pedro;
Hurtado‐Guerrero, Ramon

Publication type:

Article

Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 6, p. 2492, doi. 10.1523/JNEUROSCI.4248-14.2015

By:

Ning Zhang;
Gordon, Sarah L.;
Fritsch, Maximilian J.;
Esoof, Noor;
Campbell, David G.;
Gourlay, Robert;
Velupillai, Srikannathasan;
Macartney, Thomas;
Peggie, Mark;
van Aalten, Daan M. F.;
Cousin, Michael A.;
Alessi, Dario R.

Publication type:

Article

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09674-0

By:

Fang, Wenxia;
Sanz, Ana Belén;
Bartual, Sergio Galan;
Wang, Bin;
Ferenbach, Andrew T.;
Farkaš, Vladimír;
Hurtado-Guerrero, Ramon;
Arroyo, Javier;
van Aalten, Daan M. F.

Publication type:

Article

O-GlcNAc transferase inhibitors: current tools and future challenges.

Published in:

Biochemical Society Transactions, 2016, v. 44, n. 1, p. 88, doi. 10.1042/BST20150189

By:

Trapannone, Riccardo;
Rafie, Karim;
van Aalten, Daan M. F.

Publication type:

Article

Gfa1 (glutamine fructose-6-phosphate aminotransferase) is essential for Aspergillus fumigatus growth and virulence.

Published in:

BMC Biology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12915-025-02184-0

By:

Qin, Qijian;
Wei, Pingzhen;
Usman, Sayed;
Ahamefule, Chukwuemeka Samson;
Jin, Cheng;
Wang, Bin;
Yan, Kaizhou;
van Aalten, Daan M. F.;
Fang, Wenxia

Publication type:

Article

Evidence for substrate-assisted catalysis in N-acetylphosphoglucosamine mutase.

Published in:

Biochemical Journal, 2018, v. 475, n. 15, p. 2547, doi. 10.1042/BCJ20180172

By:

Raimi, Olawale G.;
Hurtado-Guerrero, Ramon;
van Aalten, Daan M. F.

Publication type:

Article

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins.

Published in:

Biochemical Journal, 2016, v. 473, n. 12, p. 1693, doi. 10.1042/BCJ20160092

By:

Trapannone, Riccardo;
Mariappa, Daniel;
Ferenbach, Andrew T.;
van Aalten, Daan M. F.

Publication type:

Article

A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development.

Published in:

Biochemical Journal, 2015, v. 470, n. 2, p. 255, doi. 10.1042/BJ20150610

By:

Mariappa, Daniel;
Selvan, Nithya;
Borodkin, Vladimir S.;
Alonso, Jana;
Ferenbach, Andrew T.;
Shepherd, Claire;
Navratilova, Iva Hopkins;
van Aalten, Daan M. F.

Publication type:

Article

Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors.

Published in:

Biochemical Journal, 2014, v. 457, n. 3, p. 497, doi. 10.1042/BJ20131272

By:

BORODKIN, Vladimir S.;
SCHIMPL, Marianne;
GUNDOGDU, Mehmet;
RAFIE, Karim;
DORFMUELLER, Helge C.;
ROBINSON, David A.;
VAN AALTEN, Daan M. F.

Publication type:

Article

REVIEW ARTICLE Chemical tools to probe cellular O-GlcNAc signalling.

Published in:

Biochemical Journal, 2013, v. 456, n. 1, p. 1, doi. 10.1042/BJ20131081

By:

OSTROWSKI, Adam;
VAN AALTEN, Daan M. F.

Publication type:

Article

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila.

Published in:

PLoS Genetics, 2022, v. 18, n. 5, p. 1, doi. 10.1371/journal.pgen.1010159

By:

Fenckova, Michaela;
Muha, Villo;
Mariappa, Daniel;
Catinozzi, Marica;
Czajewski, Ignacy;
Blok, Laura E. R.;
Ferenbach, Andrew T.;
Storkebaum, Erik;
Schenck, Annette;
van Aalten, Daan M. F.

Publication type:

Article

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.

Published in:

Biochemical Journal, 2012, v. 446, n. 1, p. 149, doi. 10.1042/BJ20120377

By:

SCHIMPL, Marianne;
RUSH, Christina L.;
BETOU, Marie;
EGGLESTON, Ian M.;
RECKLIES, Anneliese D.;
VAN AALTEN, Daan M. F.

Publication type:

Article

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target.

Published in:

Bioscience Reports, 2013, v. 33, n. 5, p. 689, doi. 10.1042/BSR20130053

By:

Wenxia FANG;
Ting DU;
RAIMI, Olawale G.;
HURTADO-GUERRERO, Ram'on;
MARIÑO, Karina;
IBRAHIM, Adel F. M.;
ALBARBARAWI, Osama;
FERGUSON, Michael A. J.;
Cheng JIN;
VAN AALTEN, Daan M. F.

Publication type:

Article

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.

Published in:

Nature Communications, 2015, v. 6, n. 7, p. 7807, doi. 10.1038/ncomms8807

By:

Jank, Thomas;
Eckerle, Stephanie;
Steinemann, Marcus;
Trillhaase, Christoph;
Schimpl, Marianne;
Wiese, Sebastian;
van Aalten, Daan M. F.;
Driever, Wolfgang;
Aktories, Klaus

Publication type:

Article

The Vibrio cholerae Colonization Factor GbpA Possesses a Modular Structure that Governs Binding to Different Host Surfaces.

Published in:

PLoS Pathogens, 2012, v. 8, n. 1, p. 1, doi. 10.1371/journal.ppat.1002373

By:

Wong, Edmond;
Vaaje-Kolstad, Gustav;
Ghosh, Avishek;
Hurtado-Guerrero, Ramon;
Konarev, Peter V.;
Ibrahim, Adel F. M.;
Svergun, Dmitri I.;
Eijsink, Vincent G. H.;
Chatterjee, Nabendu S.;
van Aalten, Daan M. F.

Publication type:

Article

Charge-Surrounded Pockets and Electrostatic Interactions with Small Ions Modulate the Activity of Retroviral Fusion Proteins.

Published in:

PLoS Pathogens, 2011, v. 7, n. 2, p. 1, doi. 10.1371/journal.ppat.1001268

By:

Lamb, Daniel;
Schüttelkopf, Alexander W.;
van Aalten, Daan M. F.;
Brighty, David W.

Publication type:

Article

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.90376

By:

Czajewski, Ignacy;
Swain, Bijayalaxmi;
Jiawei Xu;
McDowall, Laurin;
Ferenbach, Andrew T.;
van Aalten, Daan M. F.

Publication type:

Article

Structure of the OSR1 kinase, a hypertension drug target.

Published in:

Proteins, 2008, v. 73, n. 4, p. 1082, doi. 10.1002/prot.22238

By:

Villa, Fabrizio;
Deak, Maria;
Alessi, Dario R.;
van Aalten, Daan M. F.

Publication type:

Article

UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 28, p. 7264, doi. 10.1002/chem.201801083

By:

Ghirardello, Mattia;
Perrone, Daniela;
Chinaglia, Nicola;
Sádaba, David;
Delso, Ignacio;
Tejero, Tomas;
Marchesi, Elena;
Fogagnolo, Marco;
Rafie, Karim;
van Aalten, Daan M. F.;
Merino, Pedro

Publication type:

Article

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.29985

By:

Kumar, Atul;
Tamjar, Jevgenia;
Waddell, Andrew D.;
Woodroof, Helen I.;
Raimi, Olawale G.;
Shaw, Andrew M.;
Peggie, Mark;
Muqit, Miratul M. K.;
van Aalten, Daan M. F.

Publication type:

Article

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis.

Published in:

Nature Chemical Biology, 2012, v. 8, n. 12, p. 969, doi. 10.1038/nchembio.1108

By:

Schimpl, Marianne;
Zheng, Xiaowei;
Borodkin, Vladimir S;
Blair, David E;
Ferenbach, Andrew T;
Schüttelkopf, Alexander W;
Navratilova, Iva;
Aristotelous, Tonia;
Albarbarawi, Osama;
Robinson, David A;
Macnaughtan, Megan A;
van Aalten, Daan M F

Publication type:

Article

Molecular recognition: O-GlcNAc transfer: size matters.

Published in:

Nature Chemical Biology, 2011, v. 7, n. 3, p. 134, doi. 10.1038/nchembio.529

By:

Gay, Laurie M.;
Xiaowei Zheng;
van Aalten, Daan M. F.

Publication type:

Article

Comparative structural analysis of retroviral fusion proteins identifies regions that modulate membrane fusion: a potential retroviral achilles heal?

Published in:

2011

By:

Lamb, Daniel;
Schüttelkopf, Alexander W.;
van Aalten, Daan M. F.;
Brighty, David W.

Publication type:

Abstract

Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope.

Published in:

Retrovirology, 2008, v. 5, p. 1, doi. 10.1186/1742-4690-5-70

By:

Lamb, Daniel;
Schüttelkopf, Alexander W.;
van Aalten, Daan M. F.;
Brighty, David W.

Publication type:

Article

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance.

Published in:

Molecular & Cellular Biology, 2008, v. 28, n. 10, p. 15, doi. 10.1128/MCB.02032-07

By:

Bayascas, Jose R.;
Wullschleger, Stephan;
Sakamoto, Kei;
García-Martínez, Juan M.;
Clacher, Carol;
Komander, David;
Van Aalten, Daan M. F.;
Boini, Krishna M.;
Lang, Florian;
Lipina, Christopher;
Logie, Lisa;
Sutherland, Calum;
Chudek, John A.;
Van Diepen, Janna A.;
Voshol, Peter J.;
Lucocq, John M.;
Alessi, Dario R.

Publication type:

Article

Exploiting O-GlcNAc transferase promiscuity to dissect site-specific O-GlcNAcylation.

Published in:

Glycobiology, 2023, v. 33, n. 12, p. 1172, doi. 10.1093/glycob/cwad086

By:

Mitchell, Conor W;
Bartual, Sergio Galan;
Ferenbach, Andrew T;
Scavenius, Carsten;
Aalten, Daan M F van

Publication type:

Article

First Synthesis of Argadin: A Nanomolar Inhibitor of Family-18 Chitinases.

Published in:

European Journal of Organic Chemistry, 2006, v. 2006, n. 22, p. 5002, doi. 10.1002/ejoc.200600599

By:

Mark J. Dixon;
Ole A. Andersen;
Daan M. F. van Aalten;
Ian M. Eggleston

Publication type:

Article

Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi.

Published in:

Protein Science: A Publication of the Protein Society, 2009, v. 18, n. 6, p. 1197, doi. 10.1002/pro.128

By:

Urch, Jonathan E.;
Hurtado-Guerrero, Ramon;
Brosson, Damien;
Liu, Zhanliang;
Eijsink, Vincent G. H.;
Texier, Catherine;
van Aalten, Daan M. F.

Publication type:

Article