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Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells.
Published in:
Journal of Biomedical Optics, 2011, v. 16, n. 1, p. 018001, doi. 10.1117/1.3533316
By:
- Joachim Vandepitte;
- Mieke Roelants;
- Ben Van Cleynenbreugel;
- Klaudia Hettinger;
- Evelyne Lerut;
- Hendrik Van Poppel;
- Peter A. M. de Witte
Publication type:
Article
Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.
Published in:
BJU International, 2007, v. 100, n. 5, p. 1176, doi. 10.1111/j.1464-410X.2007.07167.x
By:
- Huygens, Ann;
- Crnolatac, Ivo;
- Maes, Jan;
- Van Cleynenbreugel, Ben;
- Van Poppel, Hendrik;
- Roskams, Tania;
- de Witte, Peter A. M.
Publication type:
Article
From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin.
Published in:
Pharmaceuticals (14248247), 2022, v. 15, n. 2, p. 247, doi. 10.3390/ph15020247
By:
- Copmans, Daniëlle;
- Kildgaard, Sara;
- Roux, Emma;
- Partoens, Michèle;
- Steurs, Gert;
- Wang, Xinhui;
- De Borggraeve, Wim M.;
- Esguerra, Camila V.;
- Crawford, Alexander D.;
- Larsen, Thomas O.;
- de Witte, Peter A. M.
Publication type:
Article
Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis.
Published in:
Pharmaceuticals (14248247), 2021, v. 14, n. 6, p. 576, doi. 10.3390/ph14060576
By:
- Guarin, Marlly;
- Ny, Annelii;
- De Croze, Noémie;
- Maes, Jan;
- Léonard, Marc;
- Annaert, Pieter;
- de Witte, Peter A. M.
Publication type:
Article
Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11420, doi. 10.3390/ijms222111420
By:
- Kozioł, Ewelina;
- Jóźwiak, Krzysztof;
- Budzyńska, Barbara;
- de Witte, Peter A. M.;
- Copmans, Daniëlle;
- Skalicka-Woźniak, Krystyna
Publication type:
Article
An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8416, doi. 10.3390/ijms22168416
By:
- Martin, Parthena;
- Reeder, Thadd;
- Sourbron, Jo;
- de Witte, Peter A. M.;
- Gammaitoni, Arnold R.;
- Galer, Bradley S.
Publication type:
Article
Using Zebrafish as a Disease Model to Study Fibrotic Disease.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 12, p. 6404, doi. 10.3390/ijms22126404
By:
- Wang, Xixin;
- Copmans, Daniëlle;
- de Witte, Peter A. M.
Publication type:
Article
Liquid-phase synthesis of mixture-based bicyclic β-lactam libraries.
Published in:
Journal of Heterocyclic Chemistry, 2003, v. 40, n. 6, p. 951, doi. 10.1002/jhet.5570400601
By:
- Gedey, Szilvia;
- Fülöp, Ferenc;
- Vainiotalo, Pirjo;
- De Witte, Peter A. M.;
- Zupkó, Istvían
Publication type:
Article
Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles.
Published in:
Scientific Reports, 2016, p. 37145, doi. 10.1038/srep37145
By:
- Pham, Duc-Hung;
- De Roo, Bert;
- Nguyen, Xuan-Bac;
- Vervaele, Mattias;
- Kecskés, Angela;
- Ny, Annelii;
- Copmans, Daniëlle;
- Vriens, Hanne;
- Locquet, Jean-Pierre;
- Hoet, Peter;
- de Witte, Peter A. M.
Publication type:
Article
Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0125898
By:
- Zhang, Yifan;
- Kecskés, Angéla;
- Copmans, Daniëlle;
- Langlois, Mélanie;
- Crawford, Alexander D.;
- Ceulemans, Berten;
- Lagae, Lieven;
- de Witte, Peter A. M.;
- Esguerra, Camila V.
Publication type:
Article
A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling.
Published in:
PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083293
By:
- Gebruers, Evelien;
- Cordero-Maldonado, María Lorena;
- Gray, Alexander I.;
- Clements, Carol;
- Harvey, Alan L.;
- Edrada-Ebel, Ruangelie;
- de Witte, Peter A. M.;
- Crawford, Alexander D.;
- Esguerra, Camila V.
Publication type:
Article
Insights from Zebrafish and Mouse Models on the Activity and Safety of Ar-Turmerone as a Potential Drug Candidate for the Treatment of Epilepsy.
Published in:
PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0081634
By:
- Orellana-Paucar, Adriana Monserrath;
- Afrikanova, Tatiana;
- Thomas, Joice;
- Aibuldinov, Yelaman K.;
- Dehaen, Wim;
- de Witte, Peter A. M.;
- Esguerra, Camila V.
Publication type:
Article
Optimization and Pharmacological Validation of a Leukocyte Migration Assay in Zebrafish Larvae for the Rapid In Vivo Bioactivity Analysis of Anti-Inflammatory Secondary Metabolites.
Published in:
PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0075404
By:
- Cordero-Maldonado, María Lorena;
- Siverio-Mota, Dany;
- Vicet-Muro, Liliana;
- Wilches-Arizábala, Isabel María;
- Esguerra, Camila V.;
- de Witte, Peter A. M.;
- Crawford, Alexander D.
Publication type:
Article
Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064006
By:
- Bohni, Nadine;
- Cordero-Maldonado, María Lorena;
- Maes, Jan;
- Siverio-Mota, Dany;
- Marcourt, Laurence;
- Munck, Sebastian;
- Kamuhabwa, Appolinary R.;
- Moshi, Mainen J.;
- Esguerra, Camila V.;
- de Witte, Peter A. M.;
- Crawford, Alexander D.;
- Wolfender, Jean-Luc
Publication type:
Article
Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054166
By:
- Afrikanova, Tatiana;
- Serruys, Ann-Sophie K.;
- Buenafe, Olivia E. M.;
- Clinckers, Ralph;
- Smolders, Ilse;
- de Witte, Peter A. M.;
- Crawford, Alexander D.;
- Esguerra, Camila V.
Publication type:
Article
Evaluation of 14 Organic Solvents and Carriers for Screening Applications in Zebrafish Embryos and Larvae.
Published in:
PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0043850
By:
- Maes, Jan;
- Verlooy, Lien;
- Buenafe, Olivia E.;
- de Witte, Peter A. M.;
- Esguerra, Camila V.;
- Crawford, Alexander D.
Publication type:
Article
Zebrafish Bioassay-Guided Natural Product Discovery: Isolation of Angiogenesis Inhibitors from East African Medicinal Plant.
Published in:
PLoS ONE, 2011, v. 6, n. 2, p. 1, doi. 10.1371/journal.pone.0014694
By:
- Crawford, Alexander D.;
- Liekens, Sandra;
- Kamuhabwa, Appolinary R.;
- Maes, Jan;
- Munck, Sebastian;
- Busson, Roger;
- Rozenski, Jef;
- Esguerra, Camila V.;
- de Witte, Peter A. M.
Publication type:
Article
Transferrin-Conjugated Liposome Targeting of Photosensitizer AlPcS4 to Rat Bladder Carcinoma Cells.
Published in:
JNCI: Journal of the National Cancer Institute, 2004, v. 96, n. 21, p. 1620, doi. 10.1093/jnci/djh314
By:
- Derycke, Annelies S. L.;
- Kamuhabwa, Appolinary;
- Gijsens, Antoon;
- Roskams, Tania;
- De Vos, Dirk;
- Kasran, Ahmad;
- Huwyler, Jörg;
- Missiaen, Ludwig;
- de Witte, Peter A. M.
Publication type:
Article
Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B.
Published in:
Marine Drugs, 2019, v. 17, n. 11, p. 607, doi. 10.3390/md17110607
By:
- Copmans, Daniëlle;
- Kildgaard, Sara;
- Rasmussen, Silas A.;
- Ślęzak, Monika;
- Dirkx, Nina;
- Partoens, Michèle;
- Esguerra, Camila V.;
- Crawford, Alexander D.;
- Larsen, Thomas O.;
- de Witte, Peter A. M.
Publication type:
Article
Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery.
Published in:
Frontiers in Molecular Neuroscience, 2022, p. 1, doi. 10.3389/fnmol.2022.881933
By:
- Zhang, Yifan;
- Heylen, Lise;
- Partoens, Michèle;
- Mills, James D.;
- Kaminski, Rafal M.;
- Godard, Patrice;
- Gillard, Michel;
- de Witte, Peter A. M.;
- Siekierska, Aleksandra
Publication type:
Article
Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome.
Published in:
Neurochemical Research, 2021, v. 46, n. 9, p. 2249, doi. 10.1007/s11064-021-03358-2
By:
- Li, Jing;
- Nelis, Maxim;
- Sourbron, Jo;
- Copmans, Daniëlle;
- Lagae, Lieven;
- Cabooter, Deirdre;
- de Witte, Peter A. M.
Publication type:
Article
Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.
Published in:
Frontiers in Molecular Neuroscience, 2021, v. 14, p. 1, doi. 10.3389/fnmol.2021.753936
By:
- Heylen, Lise;
- Pham, Duc-Hung;
- De Meulemeester, Ann-Sofie;
- Samarut, Éric;
- Skiba, Adrianna;
- Copmans, Daniëlle;
- Kazwiny, Youcef;
- Vanden Berghe, Pieter;
- de Witte, Peter A. M.;
- Siekierska, Aleksandra
Publication type:
Article
Accumulation and Photocytotoxicity of Hypericin and Analogs in Two- and Three-Dimensional Cultures of Transitional Cell Carcinoma Cells.
Published in:
Photochemistry & Photobiology, 2003, v. 78, n. 6, p. 607, doi. 10.1562/0031-8655(2003)0780607AAPOHA2.0.CO2
By:
- Huygens, Ann;
- Huyghe, Dieter;
- Bormans, Guy;
- Verbruggen, Alfons;
- Kamuhabwa, Appolinary R.;
- Roskams, Tania;
- De Witte, Peter A. M.
Publication type:
Article
Potentiation of Photodynamic Therapy with Hypericin by Mitomycin C in the Radiation-induced Fibrosarcoma-1 Mouse Tumor Model.
Published in:
Photochemistry & Photobiology, 2003, v. 78, n. 3, p. 278, doi. 10.1562/0031-8655(2003)0780278POPTWH2.0.CO2
By:
- Chen, Bin;
- Ahmed, Bissan;
- Landuyt, Willy;
- Ni, Yicheng;
- Gaspar, Robert;
- Roskams, Tania;
- De Witte, Peter A. M.
Publication type:
Article
Cellular Photodestruction Induced by Hypericin in AY-27 Rat Bladder Carcinoma Cells.
Published in:
Photochemistry & Photobiology, 2001, v. 74, n. 2, p. 126, doi. 10.1562/0031-8655(2001)0740126CPIBHI2.0.CO2
By:
- Kamuhabwa, Appolinary R.;
- Agostinis, Patrizia M.;
- D'Hallewin, Marie-Ange;
- Baert, Luc;
- De Witte, Peter A. M.
Publication type:
Article

Found: 25

Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells.

Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.

From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin.

Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis.

Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish.

An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies.

Using Zebrafish as a Disease Model to Study Fibrotic Disease.

Liquid-phase synthesis of mixture-based bicyclic β-lactam libraries.

Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles.

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine.

A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling.

Insights from Zebrafish and Mouse Models on the Activity and Safety of Ar-Turmerone as a Potential Drug Candidate for the Treatment of Epilepsy.

Optimization and Pharmacological Validation of a Leukocyte Migration Assay in Zebrafish Larvae for the Rapid <i>In Vivo</i> Bioactivity Analysis of Anti-Inflammatory Secondary Metabolites.

Integration of Microfractionation, qNMR and Zebrafish Screening for the <i>In Vivo</i> Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products

Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs.

Evaluation of 14 Organic Solvents and Carriers for Screening Applications in Zebrafish Embryos and Larvae.

Zebrafish Bioassay-Guided Natural Product Discovery: Isolation of Angiogenesis Inhibitors from East African Medicinal Plant.

Transferrin-Conjugated Liposome Targeting of Photosensitizer AlPcS<sub>4</sub> to Rat Bladder Carcinoma Cells.

Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B.

Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery.

Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome.

Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.

Accumulation and Photocytotoxicity of Hypericin and Analogs in Two- and Three-Dimensional Cultures of Transitional Cell Carcinoma Cells.

Potentiation of Photodynamic Therapy with Hypericin by Mitomycin C in the Radiation-induced Fibrosarcoma-1 Mouse Tumor Model.

Cellular Photodestruction Induced by Hypericin in AY-27 Rat Bladder Carcinoma Cells.