Works by de Sousa E. Melo, Felipe

Results: 12

Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer.

Published in:

Nature Communications, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41467-025-59588-3

By:

Qu, Xueping;
Hamidi, Habib;
Johnson, Radia M.;
Sokol, Ethan S.;
Lin, Eva;
Eng, Cathy;
Kim, Tae Won;
Bendell, Johanna;
Sivakumar, Smruthy;
Kaplan, Benjamin;
de Sousa e Melo, Felipe;
Mancini, Andrew;
Wongchenko, Matthew;
Shi, Yi;
Shames, David;
Yan, Yibing;
Ciardiello, Fortunato;
Bais, Carlos

Publication type:

Article

Axing Wnt signals.

Published in:

Cell Research, 2012, v. 22, n. 1, p. 9, doi. 10.1038/cr.2011.141

By:

De Sousa E Melo, Felipe;
Medema, Jan Paul

Publication type:

Article

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.

Published in:

Nature Cell Biology, 2010, v. 12, n. 5, p. 468, doi. 10.1038/ncb2048

By:

Vermeulen, Louis;
De Sousa E Melo, Felipe;
van der Heijden, Maartje;
Cameron, Kate;
de Jong, Joan H.;
Borovski, Tijana;
Tuynman, Jurriaan B.;
Todaro, Matilde;
Merz, Christian;
Rodermond, Hans;
Sprick, Martin R.;
Kemper, Kristel;
Richel, Dick J.;
Stassi, Giorgio;
Medema, Jan Paul

Publication type:

Article

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.

Published in:

EMBO Molecular Medicine, 2016, v. 8, n. 7, p. 745, doi. 10.15252/emmm.201606184

By:

Fessler, Evelyn;
Drost, Jarno;
Hooff, Sander R;
Linnekamp, Janneke F;
Wang, Xin;
Jansen, Marnix;
De Sousa E Melo, Felipe;
Prasetyanti, Pramudita R;
IJspeert, Joep EG;
Franitza, Marek;
Nürnberg, Peter;
Noesel, Carel JM;
Dekker, Evelien;
Vermeulen, Louis;
Clevers, Hans;
Medema, Jan Paul

Publication type:

Article

Cdk8 deletion in the Apc<sup>Min</sup> murine tumour model represses EZH2 activity and accelerates tumourigenesis.

Published in:

Journal of Pathology, 2015, v. 237, n. 4, p. 508, doi. 10.1002/path.4596

By:

McCleland, Mark L;
Soukup, Tim M;
Liu, Scot D;
Esensten, Jonathan H;
de Sousa e Melo, Felipe;
Yaylaoglu, Murat;
Warming, Soren;
Roose‐Girma, Merone;
Firestein, Ron

Publication type:

Article

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon.

Published in:

Molecular Cancer, 2013, v. 12, n. 1, p. 1, doi. 10.1186/1476-4598-12-126

By:

Prasetyanti, Pramudita Ramadhina;
Zimberlin, Cheryl Doreen;
Bots, Michael;
Vermeulen, Louis;
De Sousa E. Melo, Felipe;
Medema, Jan Paul

Publication type:

Article

Cancer heterogeneity-a multifaceted view.

Published in:

EMBO Reports, 2013, v. 14, n. 8, p. 686, doi. 10.1038/embor.2013.92

By:

Melo, Felipe De Sousa E;
Vermeulen, Louis;
Fessler, Evelyn;
Medema, Jan Paul

Publication type:

Article

Wnt Signaling in Cancer Stem Cell Biology.

Published in:

Cancers, 2016, v. 8, n. 7, p. 60, doi. 10.3390/cancers8070060

By:

de Sousa e Melo, Felipe;
Vermeulen, Louis

Publication type:

Article

The consensus molecular subtypes of colorectal cancer.

Published in:

Nature Medicine, 2015, v. 21, n. 11, p. 1350, doi. 10.1038/nm.3967

By:

Guinney, Justin;
Dienstmann, Rodrigo;
Wang, Xin;
de Reyniès, Aurélien;
Schlicker, Andreas;
Soneson, Charlotte;
Marisa, Laetitia;
Roepman, Paul;
Nyamundanda, Gift;
Angelino, Paolo;
Bot, Brian M;
Morris, Jeffrey S;
Simon, Iris M;
Gerster, Sarah;
Fessler, Evelyn;
De Sousa E Melo, Felipe;
Missiaglia, Edoardo;
Ramay, Hena;
Barras, David;
Homicsko, Krisztian

Publication type:

Article

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.

Published in:

Nature Medicine, 2013, v. 19, n. 5, p. 614, doi. 10.1038/nm.3174

By:

De Sousa E Melo, Felipe;
Wang, Xin;
Jansen, Marnix;
Fessler, Evelyn;
Trinh, Anne;
de Rooij, Laura P M H;
de Jong, Joan H;
de Boer, Onno J;
van Leersum, Ronald;
Bijlsma, Maarten F;
Rodermond, Hans;
van der Heijden, Maartje;
van Noesel, Carel J M;
Tuynman, Jurriaan B;
Dekker, Evelien;
Markowetz, Florian;
Medema, Jan Paul;
Vermeulen, Louis

Publication type:

Article

ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer.

Published in:

Nature Communications, 2022, v. 11, n. 1, p. 1, doi. 10.1038/s41467-022-33172-5

By:

Johnson, Radia M.;
Qu, Xueping;
Lin, Chu-Fang;
Huw, Ling-Yuh;
Venkatanarayan, Avinashnarayan;
Sokol, Ethan;
Ou, Fang-Shu;
Ihuegbu, Nnamdi;
Zill, Oliver A.;
Kabbarah, Omar;
Wang, Lisa;
Bourgon, Richard;
de Sousa e Melo, Felipe;
Bolen, Chris;
Daemen, Anneleen;
Venook, Alan P.;
Innocenti, Federico;
Lenz, Heinz-Josef;
Bais, Carlos

Publication type:

Article

Reconciliation of classification systems defining molecular subtypes of colorectal cancer.

Published in:

Cell Cycle, 2014, v. 13, n. 3, p. 353, doi. 10.4161/cc.27769

By:

Sadanandam, Anguraj;
Xin Wang;
de Sousa E. Melo, Felipe;
Gray, Joe W.;
Vermeulen, Louis;
Hanahan, Douglas;
Medema, Jan Paul

Publication type:

Article