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Pyrimidine salvage in Toxoplasma gondii as a target for new treatment.
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- Frontiers in Cellular & Infection Microbiology, 2023, p. 1, doi. 10.3389/fcimb.2023.1320160
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- Article
Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines.
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- Parasitology Research, 2023, v. 122, n. 12, p. 2751, doi. 10.1007/s00436-023-07993-2
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- Article
Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei.
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- Frontiers in Cellular & Infection Microbiology, 2023, p. 1, doi. 10.3389/fcimb.2023.1204707
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- Article
Arylimidamides Have Potential for Chemoprophylaxis against Blood-Transmitted Chagas Disease.
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- Pathogens, 2023, v. 12, n. 5, p. 701, doi. 10.3390/pathogens12050701
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- Article
Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 4, p. 3144, doi. 10.3390/ijms24043144
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- Article
The Activity of Red Nigerian Propolis and Some of Its Components against Trypanosoma brucei and Trypanosoma congolense.
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- Molecules, 2023, v. 28, n. 2, p. 622, doi. 10.3390/molecules28020622
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- Article
The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues.
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- Molecules, 2022, v. 27, n. 22, p. 0, doi. 10.3390/molecules27228045
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- Article
Phenotypic Evaluation of Nucleoside Analogues against Trypanosoma cruzi Infection: In Vitro and In Vivo Approaches.
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- Molecules, 2022, v. 27, n. 22, p. 8087, doi. 10.3390/molecules27228087
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- Article
Nucleoside Transport and Nucleobase Uptake Null Mutants in Leishmania mexicana for the Routine Expression and Characterization of Purine and Pyrimidine Transporters.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8139, doi. 10.3390/ijms23158139
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- Article
Differences in Transporters Rather than Drug Targets Are the Principal Determinants of the Different Innate Sensitivities of Trypanosoma congolense and Trypanozoon Subgenus Trypanosomes to Diamidines and Melaminophenyl Arsenicals.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 5, p. 2844, doi. 10.3390/ijms23052844
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- Article
The Antiprotozoal Activity of Papua New Guinea Propolis and Its Triterpenes.
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- Molecules, 2022, v. 27, n. 5, p. 1622, doi. 10.3390/molecules27051622
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- Article
A Toxoplasma gondii Oxopurine Transporter Binds Nucleobases and Nucleosides Using Different Binding Modes.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 2, p. 710, doi. 10.3390/ijms23020710
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- Article
Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter.
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- Molecular Microbiology, 2021, v. 116, n. 6, p. 1489, doi. 10.1111/mmi.14840
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- Article
Direct, Late‐Stage Mono‐N‐arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine‐Resistant Parasites.
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- ChemMedChem, 2021, v. 16, n. 22, p. 3396, doi. 10.1002/cmdc.202100509
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- Article
Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential.
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- Molecular Microbiology, 2021, v. 116, n. 2, p. 564, doi. 10.1111/mmi.14733
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- Article
Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.
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- PLoS Pathogens, 2021, v. 17, n. 7, p. 1, doi. 10.1371/journal.ppat.1009734
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- Article
Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana.
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- Molecules, 2021, v. 26, n. 13, p. 3912, doi. 10.3390/molecules26133912
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- Article
Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium.
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- Pathogens, 2021, v. 10, n. 2, p. 175, doi. 10.3390/pathogens10020175
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- Article
The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets.
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- Molecules, 2020, v. 25, n. 21, p. 5155, doi. 10.3390/molecules25215155
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- Article
Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.
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- PLoS Neglected Tropical Diseases, 2020, v. 14, n. 7, p. 1, doi. 10.1371/journal.pntd.0008447
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- Article
Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.
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- PLoS Neglected Tropical Diseases, 2020, v. 14, n. 7, p. 1, doi. 10.1371/journal.pntd.0008458
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- Article
Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi.
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- 2020
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- Publication type:
- journal article
Docking Studies and Antiprotozoal Activity of Secondary Metabolites Isolated from Scrophularia syriaca Benth. Growing in Saudi Arabia.
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- Records of Natural Products, 2020, v. 14, n. 1, p. 23, doi. 10.25135/rnp.19.03.1224
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- Article
Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness.
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- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13522-6
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- Article
Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.
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- Molecules, 2019, v. 24, n. 19, p. 3433, doi. 10.3390/molecules24193433
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- Article
European propolis is highly active against trypanosomatids including Crithidia fasciculata.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47840-y
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- Article
Synthesis, antimicrobial activities and GAPDH docking of novel 1, 2, 3-triazole derivatives.
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- Tropical Journal of Pharmaceutical Research, 2019, v. 18, n. 5, p. 1101, doi. 10.4314/tjpr.v18i5.27
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- Article
Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds.
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- Drug Design, Development & Therapy, 2019, v. 13, p. 1179, doi. 10.2147/DDDT.S204733
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- Article
Front Cover: Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei (ChemMedChem 6/2019).
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- ChemMedChem, 2019, v. 14, n. 6, p. 613, doi. 10.1002/cmdc.201900135
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- Article
Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)‐Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.
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- ChemMedChem, 2019, v. 14, n. 6, p. 621, doi. 10.1002/cmdc.201800790
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- Publication type:
- Article
Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan Propolis.
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- Molecules, 2019, v. 24, n. 6, p. 1041, doi. 10.3390/molecules24061041
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- Article
Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs.
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- Molecules, 2019, v. 24, n. 2, p. 268, doi. 10.3390/molecules24020268
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- Article
Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.
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- Nucleic Acids Research, 2017, v. 45, n. 14, p. 8378, doi. 10.1093/nar/gkx521
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- Article
Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F<sub>1</sub>F<sub>o</sub>-ATPase.
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- PLoS Neglected Tropical Diseases, 2016, v. 10, n. 8, p. 1, doi. 10.1371/journal.pntd.0004791
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- Article
Chemical and Antimicrobial Profiling of Propolis from Different Regions within Libya.
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- PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0155355
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- Article
Seroepidemiology and molecular diversity of Leishmania donovani complex in Georgia.
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- Parasites & Vectors, 2016, v. 9, p. 1, doi. 10.1186/s13071-016-1558-6
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- Article
Chemical characterisation of Nigerian red propolis and its biological activity against Trypanosoma Brucei.
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- Phytochemical Analysis, 2016, v. 27, n. 2, p. 107, doi. 10.1002/pca.2605
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- Article
The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!
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- Frontiers in Pharmacology, 2015, p. 1, doi. 10.3389/fphar.2015.00185
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- Article
Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.
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- PLoS Pathogens, 2015, v. 11, n. 6, p. 1, doi. 10.1371/journal.ppat.1004942
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- Article
Functional analysis of drug resistance-associated mutations in the T rypanosoma brucei adenosine transporter 1 ( TbAT1) and the proposal of a structural model for the protein.
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- Molecular Microbiology, 2015, v. 96, n. 4, p. 887, doi. 10.1111/mmi.12979
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- Article
Transport proteins determine drug sensitivity and resistance in a protozoan parasite,Trypanosoma brucei.
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- Frontiers in Pharmacology, 2015, v. 6, p. 1, doi. 10.3389/fphar.2015.00032
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- Publication type:
- Article
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
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- Nucleic Acids Research, 2015, v. 43, n. D1, p. D637, doi. 10.1093/nar/gku944
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- Article
Design and Synthesis of a Series of Truncated Neplanocin Fleximers.
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- Molecules, 2014, v. 19, n. 12, p. 21200, doi. 10.3390/molecules191221200
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- Article
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.
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- Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00231
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- Publication type:
- Article
Epidemiology of Visceral Leishmaniasis in Georgia.
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- PLoS Neglected Tropical Diseases, 2014, v. 8, n. 3, p. 1, doi. 10.1371/journal.pntd.0002725
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- Publication type:
- Article
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
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- Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 3, p. 651, doi. 10.1093/jac/dkt442
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- Article
Epidemiology of Visceral Leishmaniasis in Georgia.
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- PLoS Neglected Tropical Diseases, 2014, v. 8, n. 3, p. 1, doi. 10.1371/journal.pntd.0002725
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- Publication type:
- Article
Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol.
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- PLoS Neglected Tropical Diseases, 2013, v. 7, n. 10, p. 1, doi. 10.1371/journal.pntd.0002475
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- Article
Aquaporin 2 Mutations in <i>Trypanosoma brucei gambiense</i> Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol.
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- PLoS Neglected Tropical Diseases, 2013, v. 7, n. 10, p. 1, doi. 10.1371/journal.pntd.0002475
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- Article
Pyrimidine Biosynthesis Is Not an Essential Function for <i>Trypanosoma brucei</i> Bloodstream Forms.
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- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058034
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- Article