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Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.
Published in:
2016
By:
- Thomsen, Soren K.;
- Ceroni, Alessandro;
- de Bunt, Martijn van;
- Burrows, Carla;
- Barrett, Amy;
- Scharfmann, Raphael;
- Ebner, Daniel;
- McCarthy, Mark I.;
- Gloyn, Anna L.;
- van de Bunt, Martijn
Publication type:
journal article
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci.
Published in:
eLife, 2018, p. 1, doi. 10.7554/eLife.31977
By:
- Thurner, Matthias;
- van de Bunt, Martijn;
- Torres, Jason M.;
- Mahajan, Anubha;
- Nylander, Vibe;
- Bennett, Amanda J.;
- Gaulton, Kyle J.;
- Barrett, Amy;
- Burrows, Carla;
- Bell, Christopher G.;
- Lowe, Robert;
- Beck, Stephan;
- Rakyan, Vardhman K.;
- Gloyn, Anna L.;
- McCarthy, Mark I.
Publication type:
Article
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.
Published in:
Nature Genetics, 2014, v. 46, n. 2, p. 136, doi. 10.1038/ng.2870
By:
- Pasquali, Lorenzo;
- Gaulton, Kyle J;
- Rodríguez-Seguí, Santiago A;
- Mularoni, Loris;
- Miguel-Escalada, Irene;
- Akerman, İldem;
- Tena, Juan J;
- Morán, Ignasi;
- Gómez-Marín, Carlos;
- van de Bunt, Martijn;
- Ponsa-Cobas, Joan;
- Castro, Natalia;
- Nammo, Takao;
- Cebola, Inês;
- García-Hurtado, Javier;
- Maestro, Miguel Angel;
- Pattou, François;
- Piemonti, Lorenzo;
- Berney, Thierry;
- Gloyn, Anna L
Publication type:
Article
Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.
Published in:
Diabetologia, 2018, v. 61, n. 7, p. 1614, doi. 10.1007/s00125-018-4612-4
By:
- Perez-Alcantara, Marta;
- Honoré, Christian;
- Wesolowska-Andersen, Agata;
- Gloyn, Anna L.;
- McCarthy, Mark I.;
- Hansson, Mattias;
- Beer, Nicola L.;
- van de Bunt, Martijn
Publication type:
Article
The miRNA Profile of Human Pancreatic Islets and Beta- Cells and Relationship to Type 2 Diabetes Pathogenesis.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0055272
By:
- de Bunt, Martijn van;
- Gaulton, Kyle J.;
- Parts, Leopold;
- Moran, Ignasi;
- Johnson, Paul R.;
- Lindgren, Cecilia M.;
- Ferrer, Jorge;
- Gloyn, Anna L.;
- McCarthy, Mark I.
Publication type:
Article
Identification and Functional Characterisation of Novel Glucokinase Mutations Causing Maturity-Onset Diabetes of the Young in Slovakia.
Published in:
PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0034541
By:
- Valentínová, Lucia;
- Beer, Nicola L.;
- Staník, Juraj;
- Tribble, Nicholas D.;
- Bunt, Martijn van de;
- Hučková, Miroslava;
- Barrett, Amy;
- Klimeš, Iwar;
- Gašperíkova, Daniela;
- Gloyn, Anna L.
Publication type:
Article
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10189-x
By:
- Haythorne, Elizabeth;
- Rohm, Maria;
- van de Bunt, Martijn;
- Brereton, Melissa F.;
- Tarasov, Andrei I.;
- Blacker, Thomas S.;
- Sachse, Gregor;
- Silva dos Santos, Mariana;
- Terron Exposito, Raul;
- Davis, Simon;
- Baba, Otto;
- Fischer, Roman;
- Duchen, Michael R.;
- Rorsman, Patrik;
- MacRae, James I.;
- Ashcroft, Frances M.
Publication type:
Article
Semantic text mining in early drug discovery for type 2 diabetes.
Published in:
PLoS ONE, 2020, v. 15, n. 6, p. 1, doi. 10.1371/journal.pone.0233956
By:
- Hansson, Lena K.;
- Hansen, Rasmus Borup;
- Pletscher-Frankild, Sune;
- Berzins, Rudolfs;
- Hansen, Daniel Hvidberg;
- Madsen, Dennis;
- Christensen, Sten B.;
- Christiansen, Malene Revsbech;
- Boulund, Ulrika;
- Wolf, Xenia Asbæk;
- Kjærulff, Sonny Kim;
- van de Bunt, Martijn;
- Tulin, Søren;
- Jensen, Thomas Skøt;
- Wernersson, Rasmus;
- Jensen, Jan Nygaard
Publication type:
Article
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
Published in:
2015
By:
- Ferdaoussi, Mourad;
- Xiaoqing Dai;
- Jensen, Mette V.;
- Runsheng Wang;
- Peterson, Brett S.;
- Chao Huang;
- Ilkayeva, Olga;
- Smith, Nancy;
- Miller, Nathanael;
- Hajmrle, Catherine;
- Spigelman, Aliya F.;
- Wright, Robert C.;
- Plummer, Gregory;
- Kunimasa Suzuki;
- Mackay, James P.;
- van de Bunt, Martijn;
- Gloyn, Anna L.;
- Ryan, Terence E.;
- Norquay, Lisa D.;
- Brosnan, M. Julia
Publication type:
journal article
Deep learning reveals 3D atherosclerotic plaque distribution and composition.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-78632-4
By:
- Jurtz, Vanessa Isabell;
- Skovbjerg, Grethe;
- Salinas, Casper Gravesen;
- Roostalu, Urmas;
- Pedersen, Louise;
- Hecksher-Sørensen, Jacob;
- Rolin, Bidda;
- Nyberg, Michael;
- van de Bunt, Martijn;
- Ingvorsen, Camilla
Publication type:
Article
Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.
Published in:
Human Molecular Genetics, 2014, v. 23, n. 24, p. 6432
By:
- Raimondo, Anne;
- Chakera, Ali J.;
- Thomsen, Soren K.;
- Colclough, Kevin;
- Barrett, Amy;
- De Franco, Elisa;
- Chatelas, Alisson;
- Demirbilek, Huseyin;
- Akcay, Teoman;
- Alawneh, Hussein;
- Flanagan, Sarah E.;
- Van De Bunt, Martijn;
- Hattersley, Andrew T.;
- Gloyn, Anna L.;
- Ellard, Sian
Publication type:
Article
Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci.
Published in:
PLoS Genetics, 2015, v. 11, n. 9, p. 1, doi. 10.1371/journal.pgen.1005535
By:
- van de Bunt, Martijn;
- Cortes, Adrian;
- null, null;
- Brown, Matthew A.;
- Morris, Andrew P.;
- McCarthy, Mark I.
Publication type:
Article
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
Published in:
PLoS Genetics, 2015, v. 11, n. 7, p. 1, doi. 10.1371/journal.pgen.1005230
By:
- Horikoshi, Momoko;
- Mӓgi, Reedik;
- van de Bunt, Martijn;
- Surakka, Ida;
- Sarin, Antti-Pekka;
- Mahajan, Anubha;
- Marullo, Letizia;
- Thorleifsson, Gudmar;
- Hӓgg, Sara;
- Hottenga, Jouke-Jan;
- Ladenvall, Claes;
- Ried, Janina S.;
- Winkler, Thomas W.;
- Willems, Sara M.;
- Pervjakova, Natalia;
- Esko, Tõnu;
- Beekman, Marian;
- Nelson, Christopher P.;
- Willenborg, Christina;
- Wiltshire, Steven
Publication type:
Article
Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue.
Published in:
PLoS Genetics, 2012, v. 8, n. 5, p. 1, doi. 10.1371/journal.pgen.1002704
By:
- Parts, Leopold;
- Hedman, Åsa K.;
- Keildson, Sarah;
- Knights, Andrew J.;
- Abreu-Goodger, Cei;
- Van De Bunt, Martijn;
- Guerra-Assunção, José Afonso;
- Bartonicek, Nenad;
- van Dongen, Stijn;
- Mägi, Reedik;
- Nisbet, James;
- Barrett, Amy;
- Rantalainen, Mattias;
- Nica, Alexandra C.;
- Quail, Michael A.;
- Small, Kerrin S.;
- Glass, Daniel;
- Enright, Anton J.;
- Winn, John;
- Deloukas, Panos
Publication type:
Article
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34743-7
By:
- Hastoy, Benoît;
- Godazgar, Mahdieh;
- Clark, Anne;
- Nylander, Vibe;
- Spiliotis, Ioannis;
- van de Bunt, Martijn;
- Chibalina, Margarita V.;
- Barrett, Amy;
- Burrows, Carla;
- Tarasov, Andrei I.;
- Scharfmann, Raphael;
- Gloyn, Anna L.;
- Rorsman, Patrik
Publication type:
Article
Insights Into the Pathogenicity of Rare Missense GCK Variants From the Identification and Functional Characterization of Compound Heterozygous and Double Mutations Inherited in Cis.
Published in:
Diabetes Care, 2012, v. 35, n. 7, p. 1482, doi. 10.2337/dc11-2420
By:
- Beer, Nicola L.;
- Osbak, Kara K.;
- De Bunt, Martijn Van;
- Tribble, Nicholas D.;
- Steele, Anna M.;
- Wensley, Kirsty J.;
- Edghill, Emma L.;
- Colcough, Kevin;
- Barrett, Amy;
- Valentínová, Lucia;
- Rundle, Jana K.;
- Raimondo, Anne;
- Grimsby, Joseph;
- Ellard, Sian;
- Gloyn, Anna L.
Publication type:
Article
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18581-8
By:
- Viñuela, Ana;
- Varshney, Arushi;
- van de Bunt, Martijn;
- Prasad, Rashmi B.;
- Asplund, Olof;
- Bennett, Amanda;
- Boehnke, Michael;
- Brown, Andrew A.;
- Erdos, Michael R.;
- Fadista, João;
- Hansson, Ola;
- Hatem, Gad;
- Howald, Cédric;
- Iyengar, Apoorva K.;
- Johnson, Paul;
- Krus, Ulrika;
- MacDonald, Patrick E.;
- Mahajan, Anubha;
- Manning Fox, Jocelyn E.;
- Narisu, Narisu
Publication type:
Article
Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.
Published in:
Genome Medicine, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13073-019-0628-8
By:
- Fernández-Tajes, Juan;
- Gaulton, Kyle J.;
- van de Bunt, Martijn;
- Torres, Jason;
- Thurner, Matthias;
- Mahajan, Anubha;
- Gloyn, Anna L.;
- Lage, Kasper;
- McCarthy, Mark I.
Publication type:
Article
Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study.
Published in:
PLoS ONE, 2018, v. 13, n. 1, p. 1, doi. 10.1371/journal.pone.0189886
By:
- Gudmundsdottir, Valborg;
- Pedersen, Helle Krogh;
- Allebrandt, Karla Viviani;
- Brorsson, Caroline;
- van Leeuwen, Nienke;
- Banasik, Karina;
- Mahajan, Anubha;
- Groves, Christopher J.;
- van de Bunt, Martijn;
- Dawed, Adem Y.;
- Fritsche, Andreas;
- Staiger, Harald;
- Simonis-Bik, Annemarie M. C.;
- Deelen, Joris;
- Kramer, Mark H. H.;
- Dietrich, Axel;
- Hübschle, Thomas;
- Willemsen, Gonneke;
- Häring, Hans-Ulrich;
- de Geus, Eco J. C.
Publication type:
Article
Identification of a Novel β-Cell Glucokinase (GCK) Promoter Mutation (-71G>C) That Modulates GCK Gene Expression Through Loss of Allele-Specific Sp1 Binding Causing Mild Fasting Hyperglycemia in Humans.
Published in:
Diabetes, 2009, v. 58, n. 8, p. 1929, doi. 10.2337/db09-0070
By:
- Gašperíková, Daniela;
- Tribble, Nicolas D.;
- Staník, Juraj;
- Hučková, Miroslava;
- Mišovicová, Nadežda;
- van de Bunt, Martijn;
- Valentínová, Lucia;
- Barrow, Beryl A.;
- Barák, L'ubomir;
- Dobránsky, Radoslav;
- Bereczková, Eva;
- Michálek, Jozef;
- Wicks, Kate;
- Colclough, Kevin;
- Knight, Julian C.;
- Ellard, Sian;
- Klimeš, Iwar;
- Gloyn, Anna L.
Publication type:
Article
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
Published in:
PLoS Genetics, 2015, v. 11, n. 12, p. 1, doi. 10.1371/journal.pgen.1005694
By:
- van de Bunt, Martijn;
- Fox, Jocelyn E. Manning;
- Xiaoqing Dai;
- Barrett, Amy;
- Grey, Caleb;
- Lei Li;
- Bennett, Amanda J.;
- Johnson, Paul R.;
- Rajotte, Raymond V.;
- Gaulton, Kyle J.;
- Dermitzakis, Emmanouil T.;
- MacDonald, Patrick E.;
- McCarthy, Mark I.;
- Gloyn, Anna L.
Publication type:
Article

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