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ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
Published in:
PLoS ONE, 2020, v. 15, n. 9, p. 1, doi. 10.1371/journal.pone.0239595
By:
- Hanson, Amanda;
- Elpek, Kutlu;
- Duong, Ellen;
- Shallberg, Lindsey;
- Fan, Martin;
- Johnson, Calvin;
- Wallace, Matthew;
- Mabry, George R.;
- Sazinsky, Stephen;
- Pepper, Lauren;
- Shu, Chengyi J.;
- Sathyanarayanan, Sriram;
- Zuerndorfer, Sarah;
- Simpson, Tyler;
- Gostissa, Monica;
- Briskin, Michael;
- Law, Deborah;
- Michaelson, Jennifer;
- Harvey, Christopher J.
Publication type:
Article
Persistent antigen exposure via the eryptotic pathway drives terminal T cell dysfunction.
Published in:
Science Immunology, 2021, v. 6, n. 56, p. 1, doi. 10.1126/sciimmunol.abe1801
By:
- Watkins, Elyse A.;
- Antane, Jennifer T.;
- Roberts, Jaeda L.;
- Lorentz, Kristen M.;
- Zuerndorfer, Sarah;
- Dunaif, Anya C.;
- Bailey, Lucas J.;
- Tremain, Andrew C.;
- Nguyen, Mindy;
- De Loera, Roberto C.;
- Wallace, Rachel P.;
- Weathered, Rachel K.;
- Kontos, Stephan;
- Hubbell, Jeffrey A.
Publication type:
Article