Works by Zuccato, Cristina

Results: 37

A β-Thalassemia Cell Biobank: Updates, Further Validation in Genetic and Therapeutic Research and Opportunities During (and After) the COVID-19 Pandemic.

Published in:

Journal of Clinical Medicine, 2025, v. 14, n. 1, p. 289, doi. 10.3390/jcm14010289

By:

Gambari, Roberto;
Gamberini, Maria Rita;
Cosenza, Lucia Carmela;
Zuccato, Cristina;
Finotti, Alessia

Publication type:

Article

Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin).

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 9, p. 2479, doi. 10.3390/jcm13092479

By:

Zurlo, Matteo;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Gamberini, Maria Rita;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study.

Published in:

2023

By:

Gamberini, Maria Rita;
Zuccato, Cristina;
Zurlo, Matteo;
Cosenza, Lucia Carmela;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Case Study

Recent trends in the gene therapy of β-thalassemia.

Published in:

Journal of Blood Medicine, 2015, v. 6, p. 69, doi. 10.2147/JBM.S46256

By:

Finotti, Alessia;
Bianchi, Nicoletta;
Zuccato, Cristina;
Gambari, Roberto;
Breda, Laura;
Rivella, Stefano;
Lederer, Carsten W.;
Kleanthous, Marina

Publication type:

Article

Effects of rapamycin on accumulation of α-, β- and γ-globin mRNAs in erythroid precursor cells from β-thalassaemia patients.

Published in:

European Journal of Haematology, 2006, v. 77, n. 5, p. 437, doi. 10.1111/j.1600-0609.2006.00731.x

By:

Fibach, Eitan;
Bianchi, Nicoletta;
Borgatti, Monica;
Zuccato, Cristina;
Finotti, Alessia;
Lampronti, Ilaria;
Prus, Eugenia;
Mischiati, Carlo;
Gambari, Roberto

Publication type:

Article

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike sequences.

Published in:

PLoS ONE, 2022, v. 17, n. 4, p. 1, doi. 10.1371/journal.pone.0266419

By:

Gasparello, Jessica;
Papi, Chiara;
Zurlo, Matteo;
Cosenza, Lucia Carmela;
Breveglieri, Giulia;
Zuccato, Cristina;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs.

Published in:

2009

By:

Lampronti, Ilaria;
Bianchi, Nicoletta;
Zuccato, Cristina;
Dall’Acqua, Francesco;
Vedaldi, Daniela;
Viola, Giampietro;
Potenza, Rocco;
Chiavilli, Francesco;
Breveglieri, Giulia;
Borgatti, Monica;
Finotti, Alessia;
Feriotto, Giordana;
Salvatori, Francesca;
Gambari, Roberto;
Dall'acqua, Francesco

Publication type:

journal article

Production of β-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous β039 thalassemia patients.

Published in:

American Journal of Hematology, 2009, v. 84, n. 11, p. 720, doi. 10.1002/ajh.21539

By:

Salvatori, Francesca;
Breveglieri, Giulia;
Zuccato, Cristina;
Finotti, Alessia;
Bianchi, Nicoletta;
Borgatti, Monica;
Feriotto, Giordana;
Destro, Federica;
Canella, Alessandro;
Brognara, Eleonora;
Lampronti, Ilaria;
Breda, Laura;
Rivella, Stefano;
Gambari, Roberto

Publication type:

Article

5613398 A DRUG REPOSITIONING PROJECT FOR Β-THALASSEMIA: SIROLIMUS AND CINCHONA ALKALOIDS.

Published in:

2023

By:

Michele Lipucci Di Paola, M.L.P.;
Cristina Zuccato, C.Z.;
Lucia Carmela Cosenza, L.C.C.;
Matteo Zurlo, M.Z.;
Monica Borgatti, M.B.;
Ilaria Lampronti, I.L.;
Chris Sotirelis, C.T.S.;
Marco Prosdocimi, M.P.;
Roberto Gambari, R.G.;
Alessia Finotti, A.F.

Publication type:

Abstract

5613417 CO-TREATMENT OF ERYTHROID CELLS ISOLATED FROM Β039-THALASSEMIA PATIENTS WITH CRISPR-CAS9 GENE EDITING AND FETAL HEMOGLOBIN INDUCTION.

Published in:

2023

By:

Lipucci di Paola, M.L.P.;
Lucia Carmela Cosenza, L.C.C.;
Cristina Zuccato, C.Z.;
Matteo Zurlo, M.Z.;
Roberto Gambari, R.G.;
Alessia Finotti, A.F.

Publication type:

Abstract

5613423 TREATMENT OF ERYTHROID PRECURSOR CELLS FROM β-THALASSEMIC PATIENTS WITH ISOXAZOLE DERIVATIVES: POTENT INDUCTION OF FETAL HEMOGLOBIN.

Published in:

2023

By:

Cristina Zuccato, C.Z.;
Lucia Carmela Cosenza, L.C.C.;
Gianni Sacchetti, G.S.;
Riccardo Rondanin, R.R.;
Daniele Simoni, D.S.;
Marco Prosdocimi, M.P.;
Lipucci di Paola, M.L.P.;
Alessia Finotti, A.F.;
Roberto Gambari, R.G.;
Ilaria Lampronti, I.L.

Publication type:

Abstract

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy.

Published in:

Genes, 2023, v. 14, n. 3, p. 556, doi. 10.3390/genes14030556

By:

Zurlo, Matteo;
Gasparello, Jessica;
Cosenza, Lucia Carmela;
Breveglieri, Giulia;
Papi, Chiara;
Zuccato, Cristina;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β 0 39-Globin Gene Editing and Induction of Fetal Hemoglobin.

Published in:

Genes, 2022, v. 13, n. 10, p. N.PAG, doi. 10.3390/genes13101727

By:

Cosenza, Lucia Carmela;
Zuccato, Cristina;
Zurlo, Matteo;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 20, p. 15049, doi. 10.3390/ijms242015049

By:

Zurlo, Matteo;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Gasparello, Jessica;
Gamberini, Maria Rita;
Stievano, Alice;
Fortini, Monica;
Prosdocimi, Marco;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 1, p. 776, doi. 10.3390/ijms24010776

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Breveglieri, Giulia;
Bianchi, Nicoletta;
Lampronti, Ilaria;
Gasparello, Jessica;
Scapoli, Chiara;
Borgatti, Monica;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 24, p. 13433, doi. 10.3390/ijms222413433

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Lampronti, Ilaria;
Borgatti, Monica;
Scapoli, Chiara;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7426, doi. 10.3390/ijms21197426

By:

Breveglieri, Giulia;
Pacifico, Salvatore;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Sultan, Shaiq;
D'Aversa, Elisabetta;
Gambari, Roberto;
Preti, Delia;
Trapella, Claudio;
Guerrini, Remo;
Borgatti, Monica

Publication type:

Article

BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 12, p. 2530, doi. 10.3390/ijms18122530

By:

Gasparello, Jessica;
Fabbri, Enrica;
Bianchi, Nicoletta;
Breveglieri, Giulia;
Zuccato, Cristina;
Borgatti, Monica;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Development of K562 cell clones expressing β-globin mRNA carrying the β039 thalassaemia mutation for the screening of correctors of stop-codon mutations.

Published in:

Biotechnology & Applied Biochemistry, 2009, v. 54, n. 1, p. 41, doi. 10.1042/BA20080266

By:

Francesca Salvatori;
Vera Cantale;
Giulia Breveglieri;
Cristina Zuccato;
Alessia Finotti;
Nicoletta Bianchi;
Monica Borgatti;
Giordana Feriotto;
Federica Destro;
Alessandro Canella;
Laura Breda;
Stefano Rivella

Publication type:

Article

A validated cellular biobank for β-thalassemia.

Published in:

2016

By:

Cosenza, Lucia Carmela;
Breda, Laura;
Breveglieri, Giulia;
Zuccato, Cristina;
Finotti, Alessia;
Lampronti, Ilaria;
Borgatti, Monica;
Chiavilli, Francesco;
Gamberini, Maria Rita;
Satta, Stefania;
Manunza, Laura;
De Martis, Franca Rosa;
Moi, Paolo;
Rivella, Stefano;
Gambari, Roberto;
Bianchi, Nicoletta

Publication type:

journal article

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies.

Published in:

Biology (2079-7737), 2023, v. 12, n. 9, p. 1202, doi. 10.3390/biology12091202

By:

Gambari, Roberto;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Gasparello, Jessica;
Finotti, Alessia;
Gamberini, Maria Rita;
Prosdocimi, Marco

Publication type:

Article

Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV-A Irradiation of 5-Methoxypsoralen.

Published in:

ChemMedChem, 2010, v. 5, n. 9, p. 1506, doi. 10.1002/cmdc.201000204

By:

Salvador, Alessia;
Dall'Acqua, Stefano;
Sardo, Manlio Sutera;
Caffieri, Sergio;
Vedaldi, Daniela;
Dall'Acqua, Francesco;
Borgatti, Monica;
Zuccato, Cristina;
Bianchi, Nicoletta;
Gambari, Roberto

Publication type:

Article

Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β-Thalassemia Families with High Fetal Hemoglobin Levels.

Published in:

Molecular Diagnosis & Therapy, 2016, v. 20, n. 2, p. 161, doi. 10.1007/s40291-016-0187-2

By:

Bianchi, Nicoletta;
Cosenza, Lucia;
Lampronti, Ilaria;
Finotti, Alessia;
Breveglieri, Giulia;
Zuccato, Cristina;
Fabbri, Enrica;
Marzaro, Giovanni;
Chilin, Adriana;
Angelis, Gioia;
Borgatti, Monica;
Gallucci, Cristiano;
Alfieri, Cecilia;
Ribersani, Michela;
Isgrò, Antonella;
Marziali, Marco;
Gaziev, Javid;
Morrone, Aldo;
Sodani, Pietro;
Lucarelli, Guido

Publication type:

Article

Differentiation and Apoptosis in UVA-Irradiated Cells Treated with Furocoumarin Derivatives.

Published in:

Annals of the New York Academy of Sciences, 2009, v. 1171, p. 334, doi. 10.1111/j.1749-6632.2009.04894.x

By:

Viola, Giampietro;
Salvador, Alessia;
Vedaldi, Daniela;
Dall'Acqua, Francesco;
Bianchi, Nicoletta;
Zuccato, Cristina;
Borgatti, Monica;
Lampronti, Ilaria;
Gambari, Roberto

Publication type:

Article

A Novel Frameshift Mutation (+A) at Codon 18 of the β-Globin Gene Associated with High Persistence of Fetal Hemoglobin Phenotype and δβ-Thalassemia.

Published in:

Acta Haematologica, 2008, v. 119, n. 1, p. 28, doi. 10.1159/000114204

By:

Feriotto, Giordana;
Salvatori, Francesca;
Finotti, Alessia;
Breveglieri, Giulia;
Venturi, Marina;
Zuccato, Cristina;
Bianchi, Nicoletta;
Borgatti, Monica;
Lampronti, Ilaria;
Mancini, Irene;
Massei, Francesco;
Favre, Claudio;
Gambari, Roberto

Publication type:

Article

Everolimus Is a Potent Inducer of Erythroid Differentiation and γ-Globin Gene Expression in Human Erythroid Cells.

Published in:

Acta Haematologica, 2007, v. 117, n. 3, p. 168, doi. 10.1159/000097465

By:

Zuccato, Cristina;
Bianchi, Nicoletta;
Borgatti, Monica;
Lampronti, Ilaria;
Massei, Francesco;
Favre, Claudio;
Gambari, Roberto

Publication type:

Article

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

Published in:

BioMed Research International, 2015, v. 2015, p. 1, doi. 10.1155/2015/687635

By:

Breveglieri, Giulia;
Mancini, Irene;
Bianchi, Nicoletta;
Lampronti, Ilaria;
Salvatori, Francesca;
Fabbri, Enrica;
Zuccato, Cristina;
Cosenza, Lucia C.;
Montagner, Giulia;
Borgatti, Monica;
Altruda, Fiorella;
Fagoonee, Sharmila;
Carandina, Gianni;
Rubini, Michele;
Aiello, Vincenzo;
Breda, Laura;
Rivella, Stefano;
Gambari, Roberto;
Finotti, Alessia

Publication type:

Article

Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells.

Published in:

PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0121567

By:

Bianchi, Nicoletta;
Finotti, Alessia;
Ferracin, Manuela;
Lampronti, Ilaria;
Zuccato, Cristina;
Breveglieri, Giulia;
Brognara, Eleonora;
Fabbri, Enrica;
Borgatti, Monica;
Negrini, Massimo;
Gambari, Roberto

Publication type:

Article

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin).

Published in:

Therapeutic Advances in Hematology, 2022, v. 13, p. 1, doi. 10.1177/20406207221100648

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Zurlo, Matteo;
Gasparello, Jessica;
Papi, Chiara;
D'Aversa, Elisabetta;
Breveglieri, Giulia;
Lampronti, Ilaria;
Finotti, Alessia;
Borgatti, Monica;
Scapoli, Chiara;
Stievano, Alice;
Fortini, Monica;
Ramazzotti, Eric;
Marchetti, Nicola;
Prosdocimi, Marco;
Gamberini, Maria Rita;
Gambari, Roberto

Publication type:

Article

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences.

Published in:

Genes, 2023, v. 14, n. 10, p. 1927, doi. 10.3390/genes14101927

By:

Finotti, Alessia;
Gasparello, Jessica;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Fabbri, Enrica;
Bianchi, Nicoletta;
Gambari, Roberto

Publication type:

Article

Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia.

Published in:

Analytical & Bioanalytical Chemistry, 2019, v. 411, n. 29, p. 7699, doi. 10.1007/s00216-019-01987-9

By:

Gemmo, Chiara;
Breveglieri, Giulia;
Marzaro, Giovanni;
Lampronti, Ilaria;
Cosenza, Lucia Carmela;
Gasparello, Jessica;
Zuccato, Cristina;
Fabbri, Enrica;
Borgatti, Monica;
Chilin, Adriana;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.

Published in:

Analytical & Bioanalytical Chemistry, 2019, v. 411, n. 29, p. 7669, doi. 10.1007/s00216-019-01959-z

By:

Breveglieri, Giulia;
Salvatori, Francesca;
Finotti, Alessia;
Cosenza, Lucia Carmela;
Zuccato, Cristina;
Bianchi, Nicoletta;
Breda, Laura;
Rivella, Stefano;
Bresciani, Alberto;
Bisbocci, Monica;
Borgatti, Monica;
Gambari, Roberto

Publication type:

Article

New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from β-Thalassemic Patients.

Published in:

Molecules, 2024, v. 29, n. 1, p. 8, doi. 10.3390/molecules29010008

By:

Zuccato, Cristina;
Cosenza, Lucia Carmela;
Tupini, Chiara;
Finotti, Alessia;
Sacchetti, Gianni;
Simoni, Daniele;
Gambari, Roberto;
Lampronti, Ilaria

Publication type:

Article

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells.

Published in:

Journal of Cellular & Molecular Medicine, 2023, v. 27, n. 3, p. 353, doi. 10.1111/jcmm.17655

By:

Zurlo, Matteo;
Nicoli, Francesco;
Proietto, Davide;
Dallan, Beatrice;
Zuccato, Cristina;
Cosenza, Lucia Carmela;
Gasparello, Jessica;
Papi, Chiara;
d'Aversa, Elisabetta;
Borgatti, Monica;
Scapoli, Chiara;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.

Published in:

2012

By:

Zuccato C;
Breda L;
Salvatori F;
Breveglieri G;
Gardenghi S;
Bianchi N;
Brognara E;
Lampronti I;
Borgatti M;
Rivella S;
Gambari R;
Zuccato, Cristina;
Breda, Laura;
Salvatori, Francesca;
Breveglieri, Giulia;
Gardenghi, Sara;
Bianchi, Nicoletta;
Brognara, Eleonora;
Lampronti, Ilaria;
Borgatti, Monica

Publication type:

journal article

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.

Published in:

Annals of Hematology, 2012, v. 91, n. 8, p. 1201, doi. 10.1007/s00277-012-1430-5

By:

Zuccato, Cristina;
Breda, Laura;
Salvatori, Francesca;
Breveglieri, Giulia;
Gardenghi, Sara;
Bianchi, Nicoletta;
Brognara, Eleonora;
Lampronti, Ilaria;
Borgatti, Monica;
Rivella, Stefano;
Gambari, Roberto

Publication type:

Article

An Aγ-globin G->A gene polymorphism associated with β039 thalassemia globin gene and high fetal hemoglobin production.

Published in:

BMC Medical Genetics, 2017, v. 18, p. 1, doi. 10.1186/s12881-017-0450-3

By:

Breveglieri, Giulia;
Bianchi, Nicoletta;
Cosenza, Lucia Carmela;
Gamberini, Maria Rita;
Chiavilli, Francesco;
Zuccato, Cristina;
Montagner, Giulia;
Borgatti, Monica;
Lampronti, Ilaria;
Finotti, Alessia;
Gambari, Roberto

Publication type:

Article

Works by Zuccato, Cristina

A β-Thalassemia Cell Biobank: Updates, Further Validation in Genetic and Therapeutic Research and Opportunities During (and After) the COVID-19 Pandemic.

Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from β-Thalassemia Patients Treated with Sirolimus (Rapamycin).

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study.

Recent trends in the gene therapy of β-thalassemia.

Effects of rapamycin on accumulation of α-, β- and γ-globin mRNAs in erythroid precursor cells from β-thalassaemia patients.

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike sequences.

Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs.

Production of β-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous β<sup>0</sup>39 thalassemia patients.

5613398 A DRUG REPOSITIONING PROJECT FOR Β-THALASSEMIA: SIROLIMUS AND CINCHONA ALKALOIDS.

5613417 CO-TREATMENT OF ERYTHROID CELLS ISOLATED FROM Β039-THALASSEMIA PATIENTS WITH CRISPR-CAS9 GENE EDITING AND FETAL HEMOGLOBIN INDUCTION.

5613423 TREATMENT OF ERYTHROID PRECURSOR CELLS FROM β-THALASSEMIC PATIENTS WITH ISOXAZOLE DERIVATIVES: POTENT INDUCTION OF FETAL HEMOGLOBIN.

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy.

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β 0 39-Globin Gene Editing and Induction of Fetal Hemoglobin.

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus.

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers.

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production.

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.

BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression.

Development of K562 cell clones expressing β-globin mRNA carrying the β039 thalassaemia mutation for the screening of correctors of stop-codon mutations.

A validated cellular biobank for β-thalassemia.

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies.

Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV-A Irradiation of 5-Methoxypsoralen.

Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β-Thalassemia Families with High Fetal Hemoglobin Levels.

Differentiation and Apoptosis in UVA-Irradiated Cells Treated with Furocoumarin Derivatives.

A Novel Frameshift Mutation (+A) at Codon 18 of the β-Globin Gene Associated with High Persistence of Fetal Hemoglobin Phenotype and δβ-Thalassemia.

Everolimus Is a Potent Inducer of Erythroid Differentiation and γ-Globin Gene Expression in Human Erythroid Cells.

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells.

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin).

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences.

Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia.

Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and β-globin gene promoters.

New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from β-Thalassemic Patients.

Effects of Sirolimus treatment on patients with β‐Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells.

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.

An Aγ-globin G->A gene polymorphism associated with β<sup>0</sup>39 thalassemia globin gene and high fetal hemoglobin production.