Found: 38
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Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice.
- Published in:
- Diabetologia, 2022, v. 65, n. 10, p. 1687, doi. 10.1007/s00125-022-05756-9
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- Publication type:
- Article
Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro.
- Published in:
- Diabetologia, 2020, v. 63, n. 11, p. 2385, doi. 10.1007/s00125-020-05232-2
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- Publication type:
- Article
Neprilysin inhibition: a new therapeutic option for type 2 diabetes?
- Published in:
- Diabetologia, 2019, v. 62, n. 7, p. 1113, doi. 10.1007/s00125-019-4889-y
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- Publication type:
- Article
Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels.
- Published in:
- Diabetologia, 2017, v. 60, n. 4, p. 701, doi. 10.1007/s00125-016-4172-4
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- Publication type:
- Article
The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets.
- Published in:
- Diabetologia, 2016, v. 59, n. 10, p. 2166, doi. 10.1007/s00125-016-4045-x
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- Publication type:
- Article
Loss of perlecan heparan sulfate glycosaminoglycans lowers body weight and decreases islet amyloid deposition in human islet amyloid polypeptide transgenic mice.
- Published in:
- PEDS: Protein Engineering, Design & Selection, 2019, v. 32, n. 2, p. 95, doi. 10.1093/protein/gzz041
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- Publication type:
- Article
Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice.
- Published in:
- Endocrinology, 2024, v. 165, n. 8, p. 1, doi. 10.1210/endocr/bqae080
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- Publication type:
- Article
The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner.
- Published in:
- Frontiers in Endocrinology, 2024, p. 1, doi. 10.3389/fendo.2024.1432928
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- Publication type:
- Article
130-OR: Statin Exposure Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets: A Novel Mechanism for ß-Cell Dysfunction and Increased Diabetes Risk?
- Published in:
- Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-130-OR
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- Publication type:
- Article
1797-P: Effect of LCZ696 and Its Components Sacubitril and Valsartan on Insulin Secretion and Glucose Homeostasis in Mice.
- Published in:
- Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-1797-P
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- Publication type:
- Article
154-OR: Neprilysin Inhibition Increases Glucagon Levels with Possible Implications for Hepatic Amino Acid Metabolism.
- Published in:
- Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-154-OR
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- Publication type:
- Article
2042-P: Loss of Apoptosis Repressor with Caspase Recruitment Domain Promotes High-Fat Diet Induced Hyperglycemia In Vivo.
- Published in:
- Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-2042-P
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- Publication type:
- Article
2040-P: Chronic Activation of CREB by Islet Amyloid Increases Star (Steroidogenic Acute Regulatory Protein) Expression in Islets.
- Published in:
- Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-2040-P
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- Publication type:
- Article
2039-P: Plasmin-Mediated Cleavage of Human Islet Amyloid Polypeptide (hIAPP) Protects ß-Cells from Amyloid-Induced Toxicity.
- Published in:
- Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-2039-P
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- Publication type:
- Article
1829-P: Acute Inhibition of Intestinal Neprilysin Enhances Glucose-Stimulated Insulin Secretion in Mice.
- Published in:
- Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1829-P
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- Publication type:
- Article
2125-P: Increased StAR (Steroidogenic Acute Regulatory Protein) Is Detrimental to ß Cells and Promotes Mitochondrial Dysfunction.
- Published in:
- Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-2125-P
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- Publication type:
- Article
2126-P: Physiological Concentrations of IL-1 Beta Promote Islet Amyloid Deposition by Increasing Beta-Cell Secretion of Human Islet Amyloid Polypeptide.
- Published in:
- Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-2126-P
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- Publication type:
- Article
2124-P: The Tissue Plasminogen Activator (tPA)/Plasmin System Reduces Amyloid Formation by Cleaving Human Islet Amyloid Polypeptide (hIAPP).
- Published in:
- Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-2124-P
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- Publication type:
- Article
Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.
- Published in:
- 2017
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- Publication type:
- journal article
Neprilysin Is Required for Angiotensin-(1-7)'s Ability to Enhance Insulin Secretion via Its Proteolytic Activity to Generate Angiotensin-(1-2).
- Published in:
- 2017
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- Publication type:
- journal article
Neprilysin deficiency protects against fat-induced insulin secretory dysfunction by maintaining calcium influx.
- Published in:
- 2013
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- Publication type:
- journal article
Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx.
- Published in:
- Diabetes, 2013, v. 62, n. 5, p. 1593, doi. 10.2337/db11-1593
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- Publication type:
- Article
Amyloid Formation in Isolated Islets Is Not Associated with Endoplasmic Reticulum (ER) Stress.
- Published in:
- Diabetes, 2007, v. 56, p. A435
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- Publication type:
- Article
Amyloid-Induced Oxidative Stress Contributes to Reduced Islet Cell Viability But Does Not Impact Insulin Secretion.
- Published in:
- Diabetes, 2007, v. 56, p. A436
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- Publication type:
- Article
Inhibition of the Amyloid-Degrading Enzyme, Neprilysin, Results in Increased Amyloid in Islets from Human Islet Amyloid Polypeptide (hIAPP) Transgenic Mice.
- Published in:
- Diabetes, 2007, v. 56, p. A436
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- Publication type:
- Article
Polymorphisms in Genes Encoding the Transcription Factor 7-Like 2 (TCF7L2) and the Pancreatic β-Cell ATP-Sensitive Potassium Channel Subunit Kir6.2 (KCNJ11) Are Not Associated with Diabetes in Japanese Americans.
- Published in:
- Diabetes, 2007, v. 56, p. A293
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- Publication type:
- Article
Impaired Glucose Tolerance Is a More Important Risk Factor for the Development of Diabetes than Impaired Fasting Glucose in Japanese Americans.
- Published in:
- Diabetes, 2007, v. 56, p. A248
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- Publication type:
- Article
Identification of the Amyloid-Degrading Enzyme Neprilysin in Mouse Islets and Potential Role in Islet Amyloidogenesis.
- Published in:
- Diabetes, 2007, v. 56, n. 2, p. 304, doi. 10.2337/db06-0430
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- Publication type:
- Article
Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes.
- Published in:
- Diabetes, 2006, v. 55, n. 12, p. 3529, doi. 10.2337/db06-0577
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- Publication type:
- Article
Long-Term Treatment With Rosiglitazone and Metformin Reduces the Extent of, but Does Not Prevent, Islet Amyloid Deposition in Mice Expressing the Gene for Human Islet Amyloid Polypeptide.
- Published in:
- Diabetes, 2005, v. 54, n. 7, p. 2235, doi. 10.2337/diabetes.54.7.2235
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- Publication type:
- Article
Insulinotropic Effects of Neprilysin and/or Angiotensin Receptor Inhibition in Mice.
- Published in:
- Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.888867
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- Publication type:
- Article
Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution.
- Published in:
- 2009
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- Publication type:
- journal article
Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice.
- Published in:
- Diabetologia, 2014, v. 57, n. 9, p. 1884, doi. 10.1007/s00125-014-3304-y
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- Publication type:
- Article
The β Cell in Diabetes: Integrating Biomarkers With Functional Measures.
- Published in:
- Endocrine Reviews, 2021, v. 42, n. 5, p. 528, doi. 10.1210/endrev/bnab021
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- Publication type:
- Article
Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism.
- Published in:
- Journal of the Endocrine Society, 2021, v. 5, n. 9, p. 1, doi. 10.1210/jendso/bvab084
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- Publication type:
- Article
A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes.
- Published in:
- Journal of Diabetes Research, 2018, p. 1, doi. 10.1155/2018/6106051
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- Publication type:
- Article
Neprilysin Deficiency Is Associated With Expansion of Islet β-Cell Mass in High Fat-Fed Mice.
- Published in:
- Journal of Histochemistry & Cytochemistry, 2018, v. 66, n. 7, p. 523, doi. 10.1369/0022155418765164
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- Publication type:
- Article
Relationship of Liver Enzymes to Insulin Sensitivity and Intra-Abdominal Fat.
- Published in:
- Diabetes Care, 2007, v. 30, n. 10, p. 2673, doi. 10.2337/dc06-1758
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- Publication type:
- Article