Works by Zhongcong Xie

Results: 90

Inhibition of unfolded protein response prevents post‐anesthesia neuronal hyperactivity and synapse loss in aged mice.

Published in:

Aging Cell, 2022, v. 21, n. 4, p. 1, doi. 10.1111/acel.13592

By:

Chen, Kai;
Hu, Qiuping;
Gupta, Riya;
Stephens, Jessie;
Xie, Zhongcong;
Yang, Guang

Publication type:

Article

Monocyte NLRP3‐IL‐1β Hyperactivation Mediates Neuronal and Synaptic Dysfunction in Perioperative Neurocognitive Disorder.

Published in:

Advanced Science, 2022, v. 9, n. 16, p. 1, doi. 10.1002/advs.202104106

By:

Chen, Kai;
Hu, Qiuping;
Xie, Zhongcong;
Yang, Guang

Publication type:

Article

Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA<sub>A</sub>R‐Dependent TRIM21 Modulation of Src Expression.

Published in:

Advanced Science, 2021, v. 8, n. 18, p. 1, doi. 10.1002/advs.202102079

By:

Liu, Qidong;
Sheng, Zhihao;
Cheng, Chun;
Zheng, Hui;
Lanuti, Michael;
Liu, Rong;
Wang, Ping;
Shen, Yuan;
Xie, Zhongcong

Publication type:

Article

Using the Chinese version of Memorial Delirium Assessment Scale to describe postoperative delirium after hip surgery.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00297

By:

Zhongyong Shi;
Yujie Wu;
Cheng Li;
Shukun Fu;
Guodong Li;
Yingbo Zhu;
Swain, Celeste A.;
Marcantonio, Edward R.;
Zhongcong Xie;
Yuan Shen

Publication type:

Article

Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00107

By:

Culley, Deborah J.;
Snayd, Mary;
Baxter, Mark G.;
Zhongcong Xie;
In Ho Lee;
Rudolph, James;
Inouye, Sharon K.;
Marcantonio, Edward R.;
Crosby, Gregory

Publication type:

Article

SYSTEMIC INFLAMMATION IMPAIRS ATTENTION AND COGNITIVE FLEXIBILITY BUT NOT ASSOCIATIVE LEARNING IN AGED RATS: Possible Implications for Delirium.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00107

By:

Culley, Deborah J.;
Snayd, Mary;
Baxter, Mark G.;
Xie, Zhongcong;
Lee, In Ho;
Rudolph, James;
Inouye, Sharon K.;
Marcantonio, Edward R.;
Crosby, Gregory

Publication type:

Article

Acute Fasting Does Not Induce Cognitive Impairment in Mice.

Published in:

Frontiers in Neuroscience, 2019, p. 1, doi. 10.3389/fnins.2019.00896

By:

Zheng, Hua;
Ton, Hoai;
Yang, Lei;
Liufu, Ning;
Dong, Yuanlin;
Zhang, Yiying;
Xie, Zhongcong

Publication type:

Article

Hippocampal Glutamate Level and Glutamate Aspartate Transporter (GLAST) are Up-Regulated in Senior Rat Associated with Isoflurane-Induced Spatial Learning/Memory Impairment.

Published in:

Neurochemical Research, 2013, v. 38, n. 1, p. 59, doi. 10.1007/s11064-012-0889-8

By:

Qu, Xiangdong;
Xu, Chengshi;
Wang, Hui;
Xu, Jie;
Liu, Weiran;
Wang, Yun;
Jia, Xingyuan;
Xie, Zhongcong;
Xu, Zhipeng;
Ji, Chao;
Wu, Anshi;
Yue, Yun

Publication type:

Article

Neuronal vulnerability to anesthesia neurotoxicity depends on age of neurons.

Published in:

Annals of Neurology, 2013, v. 73, n. 6, p. 686, doi. 10.1002/ana.23914

By:

Xie, Zhongcong

Publication type:

Article

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory.

Published in:

Annals of Neurology, 2012, v. 72, n. 4, p. 630, doi. 10.1002/ana.23683

By:

Zhang, Yiying;
Xie, Zhongcong

Publication type:

Article

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory.

Published in:

Annals of Neurology, 2012, v. 71, n. 5, p. 687, doi. 10.1002/ana.23536

By:

Zhang, Yiying;
Xu, Zhipeng;
Wang, Hui;
Dong, Yuanlin;
Shi, Hai Ning;
Culley, Deborah J.;
Crosby, Gregory;
Marcantonio, Edward R.;
Tanzi, Rudolph E.;
Xie, Zhongcong

Publication type:

Article

Isoflurane-Induced Apoptosis: A Potential Pathogenic Link Between Delirium and Dementia.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2006, v. 61, n. 12, p. 1300, doi. 10.1093/gerona/61.12.1300

By:

Zhongcong Xie;
Yuanlin Dong;
Uta Maeda;
Moir, Robert;
Inouye, Sharon K.;
Culley, Deborah J.;
Crosby, Gregory;
Tanzi, Rudolph E.

Publication type:

Article

Targeted metabolomics analysis of postoperative delirium.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-020-80412-z

By:

Tripp, Bridget A.;
Dillon, Simon T.;
Yuan, Min;
Asara, John M.;
Vasunilashorn, Sarinnapha M.;
Fong, Tamara G.;
Metzger, Eran D.;
Inouye, Sharon K.;
Xie, Zhongcong;
Ngo, Long H.;
Marcantonio, Edward R.;
Libermann, Towia A.;
Otu, Hasan H.

Publication type:

Article

Sevoflurane induces neuronal activation and behavioral hyperactivity in young mice.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66959-x

By:

Yang, Lei;
Ton, Hoai;
Zhao, Ruohe;
Geron, Erez;
Li, Mengzhu;
Dong, Yuanlin;
Zhang, Yiying;
Yu, Buwei;
Yang, Guang;
Xie, Zhongcong

Publication type:

Article

Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 01, doi. 10.3389/fimmu.2022.955581

By:

Liuyue Yang;
Weihua Ding;
Yuanlin Dong;
Cynthia Chen;
Yanru Zeng;
Zhangjie Jiang;
Shuyuan Gan;
Zerong You;
Yilin Zhao;
Yiying Zhang;
Xinghua Ren;
Shiyu Wang;
Jiajia Dai;
Zhong Chen;
Shengmei Zhu;
Lucy Chen;
Shiqian Shen;
Jianren Mao;
Zhongcong Xie

Publication type:

Article

Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex.

Published in:

Frontiers in Cellular Neuroscience, 2018, p. 1, doi. 10.3389/fncel.2018.00107

By:

Zhao, Ruohe;
Zhou, Hang;
Huang, Lianyan;
Xie, Zhongcong;
Wang, Jing;
Gan, Wen-Biao;
Yang, Guang

Publication type:

Article

Mild Hypothermia Attenuates the Anesthetic Isoflurane-Induced Cytotoxicity.

Published in:

Frontiers in Cellular Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fncel.2017.00015

By:

Cheng Li;
Yuanlin Dong;
Dan Chen;
Zhongcong Xie;
Yiying Zhang;
Jie Cui;
Huafeng WEi

Publication type:

Article

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo.

Published in:

2008

By:

Xie Z;
Culley DJ;
Dong Y;
Zhang G;
Zhang B;
Moir RD;
Frosch MP;
Crosby G;
Tanzi RE;
Xie, Zhongcong;
Culley, Deborah J;
Dong, Yuanlin;
Zhang, Guohua;
Zhang, Bin;
Moir, Robert D;
Frosch, Matthew P;
Crosby, Gregory;
Tanzi, Rudolph E

Publication type:

journal article

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid β-protein level in vivo.

Published in:

Annals of Neurology, 2008, v. 64, n. 6, p. 618, doi. 10.1002/ana.21548

By:

Xie, Zhongcong;
Culley, Deborah J.;
Dong, Yuanlin;
Zhang, Guohua;
Zhang, Bin;
Moir, Robert D.;
Frosch, Matthew P.;
Crosby, Gregory;
Tanzi, Rudolph E.

Publication type:

Article

Plasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study.

Published in:

2021

By:

Vasunilashorn, Sarinnapha M.;
Ngo, Long H.;
Dillon, Simon T.;
Fong, Tamara G.;
Carlyle, Becky C.;
Kivisäkk, Pia;
Trombetta, Bianca A.;
Vlassakov, Kamen V.;
Kunze, Lisa J.;
Arnold, Steven E.;
Xie, Zhongcong;
Inouye, Sharon K.;
Libermann, Towia A.;
Marcantonio, Edward R.;
RISE Study Group;
Arnold, Steven;
Dickerson, Bradford;
Fong, Tamara;
Jones, Richard;
Libermann, Towia

Publication type:

journal article

39 Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration.

Published in:

Journal of Clinical & Translational Science, 2025, v. 9, p. 13, doi. 10.1017/cts.2024.726

By:

Datta, Dibyadeep;
Perone, Isabella;
Wijegunawardana, Denethi;
Liang, Feng;
Morozov, Yury M.;
Arellano, Jon;
Duque, Alvaro;
Xie, Zhongcong;
van Dyck, Christopher H.;
Joyce, Mary Kate P.;
Arnsten, Amy F. T.

Publication type:

Article

Proteome-Wide Analysis Using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery.

Published in:

2022

By:

Vasunilashorn, Sarinnapha M;
Dillon, Simon T;
Chan, Noel Y;
Fong, Tamara G;
Joseph, Marie;
Tripp, Bridget;
Xie, Zhongcong;
Ngo, Long H;
Lee, Chun Geun;
Elias, Jack A;
Otu, Hasan H;
Inouye, Sharon K;
Marcantonio, Edward R;
Libermann, Towia A;
Inouye, Sharon

Publication type:

journal article

Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.

Published in:

2019

By:

Vasunilashorn, Sarinnapha M;
Ngo, Long H;
Chan, Noel Y;
Zhou, Wenxiao;
Dillon, Simon T;
Otu, Hasan H;
Inouye, Sharon K;
Wyrobnik, Iris;
Kuchel, George A;
McElhaney, Janet E;
Xie, Zhongcong;
Alsop, David C;
Jones, Richard N;
Libermann, Towia A;
Marcantonio, Edward R

Publication type:

journal article

The association between gut microbiota and postoperative delirium in patients.

Published in:

Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02450-1

By:

Zhang, Yiying;
Baldyga, Kathryn;
Dong, Yuanlin;
Song, Wenyu;
Villanueva, Mirella;
Deng, Hao;
Mueller, Ariel;
Houle, Timothy T.;
Marcantonio, Edward R.;
Xie, Zhongcong

Publication type:

Article

Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse Neurons.

Published in:

PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0159637

By:

Zimering, Jeffrey H.;
Dong, Yuanlin;
Fang, Fang;
Huang, Lining;
Zhang, Yiying;
Xie, Zhongcong

Publication type:

Article

Surgical Incision-Induced Nociception Causes Cognitive Impairment and Reduction in Synaptic NMDA Receptor 2B in Mice.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 45, p. 17737, doi. 10.1523/JNEUROSCI.2049-13.2013

By:

Xiaoqin Zhang;
Xin Xin;
Yuanlin Dong;
Yiying Zhang;
Buwei Yu;
Jianren Mao;
Zhongcong Xie

Publication type:

Article

Correlations of blood and brain NMR metabolomics with Alzheimer's disease mouse models.

Published in:

Translational Psychiatry, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41398-025-03293-8

By:

Knörnschild, Franz;
Zhang, Ella J.;
Ghosh Biswas, Rajshree;
Kobus, Marta;
Chen, Jiashang;
Zhou, Jonathan X.;
Rao, Angela;
Sun, Joseph;
Wang, Xiaoyu;
Li, Wei;
Muti, Isabella H.;
Habbel, Piet;
Nowak, Johannes;
Xie, Zhongcong;
Zhang, Yiying;
Cheng, Leo L.

Publication type:

Article

Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep03766

By:

Zhipeng Xu;
Yuanlin Dong;
Hui Wang;
Culley, Deborah J.;
Marcantonio, Edward R.;
Crosby, Gregory;
Tanzi, Rudolph E.;
Yiying Zhang;
Zhongcong Xie

Publication type:

Article

Sevoflurane increases locomotion activity in mice.

Published in:

PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0206649

By:

Ton, Hoai T.;
Yang, Lei;
Xie, Zhongcong

Publication type:

Article

Sevoflurane induces cognitive impairment in young mice via autophagy.

Published in:

PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0216372

By:

Wang, Xiaoning;
Dong, Yuanlin;
Zhang, Yiying;
Li, Tianzuo;
Xie, Zhongcong

Publication type:

Article

Microglia in the aged brain develop a hypoactive molecular phenotype after surgery.

Published in:

Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03307-0

By:

Yin, Zhuoran;
Leonard, Anna K.;
Porto, Carl M.;
Xie, Zhongcong;
Silveira, Sebastian;
Culley, Deborah J.;
Butovsky, Oleg;
Crosby, Gregory

Publication type:

Article

Janus Kinase Mediates Faster Recovery From Sevoflurane Anesthesia Than Isoflurane Anesthesia in the Migratory Locusts.

Published in:

Frontiers in Physiology, 2022, v. 13, p. 1, doi. 10.3389/fphys.2022.806746

By:

Ma, Zongyuan;
Zheng, Jialin C.;
Li, Tianzuo;
Xie, Zhongcong;
Kang, Le

Publication type:

Article

Hypocapnia Induces Caspase-3 Activation and Increases Aβ Production.

Published in:

Neurodegenerative Diseases, 2004, v. 1, n. 1, p. 29, doi. 10.1159/000076667

By:

Xie, Zhongcong;
Moir, Robert D.;
Romano, Donna M.;
Tesco, Giuseppina;
Kovacs, Dora M.;
Tanzi, Rudolph E.

Publication type:

Article

Mechanistic insight into sevoflurane-associated developmental neurotoxicity.

Published in:

Cell Biology & Toxicology, 2022, v. 38, n. 6, p. 927, doi. 10.1007/s10565-021-09677-y

By:

Sun, Mingyang;
Xie, Zhongcong;
Zhang, Jiaqiang;
Leng, Yufang

Publication type:

Article

Perioperative neurocognitive and cardiovascular disease.

Published in:

Heart & Mind, 2024, v. 8, n. 2, p. 59, doi. 10.4103/hm.HM-D-24-00010

By:

Xie, Zhongcong

Publication type:

Article

Hyperhomocysteinemia is key for increased susceptibility to PND in aged mice.

Published in:

Annals of Clinical & Translational Neurology, 2019, v. 6, n. 8, p. 1435, doi. 10.1002/acn3.50838

By:

Zhao, Guangchao;
Deng, Jiao;
Shen, Yuan;
Zhang, Peng;
Dong, Hailong;
Xie, Zhongcong;
Xiong, Lize

Publication type:

Article

Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium.

Published in:

Annals of Clinical & Translational Neurology, 2014, v. 1, n. 5, p. 319, doi. 10.1002/acn3.58

By:

Xie, Zhongcong;
Swain, Celeste A.;
Ward, Sarah A. P.;
Zheng, Hui;
Dong, Yuanlin;
Sunder, Neelakantan;
Burke, Dennis W.;
Escobar, Diana;
Zhang, Yiying;
Marcantonio, Edward R.

Publication type:

Article

Isoflurane impairs oogenesis through germ cell apoptosis in C. elegans.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-93737-0

By:

Zhang, Tao;
Ni, Cheng;
Li, Cheng;
Lu, Pan;
Chen, Dan;
Dong, Yuanlin;
Whetstine, Johnathan R.;
Zhang, Yiying;
Xie, Zhongcong

Publication type:

Article

Preoperative homocysteine modifies the association between postoperative C-reactive protein and postoperative delirium.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.963421

By:

Xin Ma;
Xinchun Mei;
Tianyi Tang;
Meijuan Wang;
Xiaoyi Wei;
Hailin Zheng;
Jing Cao;
Hui Zheng;
Cody, Kathryn;
Lize Xiong;
Marcantonio, Edward R.;
Zhongcong Xie;
Yuan Shen

Publication type:

Article

The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer's Pathogenesis via Specific Pathways.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.912709

By:

Wu, Hongle;
Qiu, Wei;
Zhu, Xiaofang;
Li, Xiangfen;
Xie, Zhongcong;
Carreras, Isabel;
Dedeoglu, Alpaslan;
Van Dyke, Thomas;
Han, Yiping W.;
Karimbux, Nadeem;
Tu, Qisheng;
Cheng, Lei;
Chen, Jake

Publication type:

Article

Sevoflurane Induces a Cyclophilin D-Dependent Decrease of Neural Progenitor Cells Migration.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6746, doi. 10.3390/ijms24076746

By:

Lu, Pan;
Liang, Feng;
Dong, Yuanlin;
Xie, Zhongcong;
Zhang, Yiying

Publication type:

Article

Brief review: Anesthetic neurotoxicity in the elderly, cognitive dysfunction and Alzheimer's disease.

Published in:

Canadian Journal of Anaesthesia / Journal Canadien d'Anesthésie, 2011, v. 58, n. 2, p. 216, doi. 10.1007/s12630-010-9418-x

By:

Bittner, Edward;
Yue, Yun;
Xie, Zhongcong

Publication type:

Article

Artefactual effects of lipid-based cell transfection reagents on AβPP processing and Aβ production.

Published in:

Amyloid, 2006, v. 13, n. 2, p. 86, doi. 10.1080/13506120600722605

By:

Romano, Donna M.;
Dong, Yuanlin;
Hiltunen, Mikko;
Tanzi, Rudolph E.;
Xie, Zhongcong

Publication type:

Article

Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density.

Published in:

2010

By:

Zhang C;
Browne A;
Divito JR;
Stevenson JA;
Romano D;
Dong Y;
Xie Z;
Tanzi RE;
Zhang, Can;
Browne, Andrew;
Divito, Jason R;
Stevenson, Jesse A;
Romano, Donna;
Dong, Yuanlin;
Xie, Zhongcong;
Tanzi, Rudolph E

Publication type:

journal article

Amyloid-β Production Via Cleavage of Amyloid-β Protein Precursor is Modulated by Cell Density.

Published in:

Journal of Alzheimer's Disease, 2010, v. 22, n. 2, p. 683, doi. 10.3233/JAD-2010-100816

By:

Zhang, Can;
Browne, Andrew;
DiVito, Jason R.;
Stevenson, Jesse A.;
Romano, Donna;
Dong, Yuanlin;
Xie, Zhongcong;
Tanzi, Rudolph E.

Publication type:

Article

High Resolution Magic Angle Spinning Proton NMR Study of Alzheimer's Disease with Mouse Models.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 3, p. 253, doi. 10.3390/metabo12030253

By:

Füzesi, Mark V.;
Muti, Isabella H.;
Berker, Yannick;
Li, Wei;
Sun, Joseph;
Habbel, Piet;
Nowak, Johannes;
Xie, Zhongcong;
Cheng, Leo L.;
Zhang, Yiying

Publication type:

Article

Anesthesia and Surgery Impair Blood-Brain Barrier and Cognitive Function in Mice.

Published in:

Frontiers in Immunology, 2017, p. 1, doi. 10.3389/fimmu.2017.00902

By:

Siming Yang;
Changping Gu;
Mandeville, Emiri T.;
Yuanlin Dong;
Esposito, Elga;
Yiying Zhang;
Guang Yang;
Yuan Shen;
Xiaobing Fu;
Lo, Eng H.;
Zhongcong Xie

Publication type:

Article

WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice.

Published in:

Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.688587

By:

Lin, Jiefu;
Shen, Fuyi;
Lu, Jing;
Liang, Feng;
Zhang, Yiying;
Xie, Zhongcong;
Dong, Yuanlin

Publication type:

Article

Surgery impairs glymphatic activity and cognitive function in aged mice.

Published in:

Molecular Brain, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13041-025-01177-y

By:

Chen, Kai;
Du, Xingyu;
Chao, Melissa A.;
Xie, Zhongcong;
Yang, Guang

Publication type:

Article

Anesthetic Isoflurane or Desflurane Plus Surgery Differently Affects Cognitive Function in Alzheimer’s Disease Transgenic Mice.

Published in:

Molecular Neurobiology, 2018, v. 55, n. 7, p. 5623, doi. 10.1007/s12035-017-0787-9

By:

Miao, Huihui;
Dong, Yuanlin;
Zhang, Yiying;
Zheng, Hui;
Shen, Yuan;
Crosby, Gregory;
Culley, Deborah J.;
Marcantonio, Edward R.;
Xie, Zhongcong

Publication type:

Article