Found: 49
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Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
- Published in:
- 2016
- By:
- Publication type:
- journal article
A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions.
- Published in:
- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.914651
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- Publication type:
- Article
Derivatives of Salicylic Acid as Inhibitors of YopH in Yersinia pestis.
- Published in:
- Chemical Biology & Drug Design, 2010, v. 76, n. 2, p. 85, doi. 10.1111/j.1747-0285.2010.00996.x
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- Publication type:
- Article
A Target Enablement Package for the Inhibition of SHIP1 as a Therapeutic Strategy for the Treatment of Alzheimer's Disease.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.068781
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- Publication type:
- Article
Protein tyrosine phosphatases as potential therapeutic targets.
- Published in:
- Acta Pharmacologica Sinica, 2014, v. 35, n. 10, p. 1227, doi. 10.1038/aps.2014.80
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- Publication type:
- Article
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
- Published in:
- Journal of Clinical Investigation, 2014, v. 124, n. 8, p. 3295, doi. 10.1172/JCI71668
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- Publication type:
- Article
Targeting PTPs with small molecule inhibitors in cancer treatment.
- Published in:
- Cancer & Metastasis Reviews, 2008, v. 27, n. 2, p. 263, doi. 10.1007/s10555-008-9113-3
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- Publication type:
- Article
Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-36107-2
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- Publication type:
- Article
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26526-y
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- Publication type:
- Article
The tumor promoter-activated protein kinase Cs are a system for regulating filopodia.
- Published in:
- Cytoskeleton, 2017, v. 74, n. 8, p. 297, doi. 10.1002/cm.21373
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- Publication type:
- Article
Enantioselective Synthesis of ( S)-3-Carboxy-4-((carboxy)difluoromethyl)phenylalanine in Protected Form and Its Incorporation into a PTP-1B-Directed Tripeptide.
- Published in:
- Chemistry & Biodiversity, 2004, v. 1, n. 4, p. 626, doi. 10.1002/cbdv.200490053
- By:
- Publication type:
- Article
A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes.
- Published in:
- PLoS ONE, 2024, v. 19, n. 3, p. 1, doi. 10.1371/journal.pone.0299541
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- Publication type:
- Article
Drugging Protein Tyrosine Phosphatases through Targeted Protein Degradation.
- Published in:
- ChemMedChem, 2024, v. 19, n. 7, p. 1, doi. 10.1002/cmdc.202300669
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- Publication type:
- Article
PRL2/PTP4A2 Phosphatase Is Important for Hematopoietic Stem Cell Self-Renewal.
- Published in:
- Stem Cells, 2014, v. 32, n. 7, p. 1956, doi. 10.1002/stem.1672
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- Publication type:
- Article
PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours.
- Published in:
- EMBO Journal, 2020, v. 39, n. 2, p. N.PAG, doi. 10.15252/embj.2019103637
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- Publication type:
- Article
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice.
- Published in:
- 2024
- By:
- Publication type:
- Correction Notice
Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.
- Published in:
- Diabetologia, 2015, v. 58, n. 1, p. 122, doi. 10.1007/s00125-014-3413-7
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- Publication type:
- Article
Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis.
- Published in:
- Scientific Reports, 2016, p. 34211, doi. 10.1038/srep34211
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- Publication type:
- Article
Development and Characterization of an Endotoxemia Model in Zebra Fish.
- Published in:
- Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00607
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- Publication type:
- Article
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40170-8
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- Publication type:
- Article
SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop.
- Published in:
- Journal of Molecular Cell Biology, 2017, v. 9, n. 2, p. 144, doi. 10.1093/jmcb/mjw042
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- Publication type:
- Article
Small Molecule Inhibitors Target the Tissue Transglutaminase and Fibronectin Interaction.
- Published in:
- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0089285
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- Publication type:
- Article
Integrated Analysis of Global mRNA and Protein Expression Data in HEK293 Cells Overexpressing PRL-1.
- Published in:
- PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0072977
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- Publication type:
- Article
PTP‐MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
- Published in:
- EMBO Reports, 2021, v. 22, n. 5, p. 1, doi. 10.15252/embr.202052141
- By:
- Publication type:
- Article
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08115-8
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- Publication type:
- Article
Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors.
- Published in:
- Stem Cells, 2017, v. 35, n. 4, p. 1053, doi. 10.1002/stem.2559
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- Publication type:
- Article
Protein-tyrosine phosphatases: Structure, mechanism, and inhibitor discovery.
- Published in:
- Biopolymers, 1998, v. 47, n. 3, p. 225, doi. 10.1002/(SICI)1097-0282(1998)47:3<225::AID-BIP3>3.0.CO;2-O
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- Publication type:
- Article
Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity.
- Published in:
- Molecules, 2023, v. 28, n. 19, p. 6947, doi. 10.3390/molecules28196947
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- Publication type:
- Article
Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases.
- Published in:
- Immunological Reviews, 2016, v. 269, n. 1, p. 212, doi. 10.1111/imr.12381
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- Publication type:
- Article
Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis.
- Published in:
- Microorganisms, 2021, v. 9, n. 1, p. 14, doi. 10.3390/microorganisms9010014
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- Publication type:
- Article
Quinic Acid‐Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins.
- Published in:
- Small, 2018, v. 14, n. 50, p. 1, doi. 10.1002/smll.201803601
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- Publication type:
- Article
Small molecule tools for functional interrogation of protein tyrosine phosphatases.
- Published in:
- FEBS Journal, 2013, v. 280, n. 2, p. 731, doi. 10.1111/j.1742-4658.2012.08718.x
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- Publication type:
- Article
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.
- Published in:
- Angewandte Chemie, 2023, v. 135, n. 22, p. 1, doi. 10.1002/ange.202303818
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- Publication type:
- Article
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.
- Published in:
- Nature Communications, 2015, v. 6, n. 11, p. 8859, doi. 10.1038/ncomms9859
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- Publication type:
- Article
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.
- Published in:
- Angewandte Chemie International Edition, 2023, v. 62, n. 22, p. 1, doi. 10.1002/anie.202303818
- By:
- Publication type:
- Article
Design, Construction, and Intracellular Activation of an Intramolecularly Self-Silenced Signal Transduction InhibitorThis work was supported by NIH Grants DK68447 and CA095019, and the G. Harold and Leila Y. Mathers Charitable Foundation. Z.-Y.Z. is an Irma T. Hirschl Career Scientist.
- Published in:
- Angewandte Chemie, 2005, v. 117, n. 27, p. 4314, doi. 10.1002/ange.200462004
- By:
- Publication type:
- Article
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
- Published in:
- Journal of Cell Biology, 2008, v. 180, n. 5, p. 957, doi. 10.1083/jcb.200708048
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- Publication type:
- Article
Functional interrogation and therapeutic targeting of protein tyrosine phosphatases.
- Published in:
- Biochemical Society Transactions, 2021, v. 49, n. 4, p. 1723, doi. 10.1042/BST20201308
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- Publication type:
- Article
Role of PTP1B in Insulin Secretion.
- Published in:
- Diabetes, 2007, v. 56, p. A686
- By:
- Publication type:
- Article
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease.
- Published in:
- Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2023, v. 9, n. 4, p. 1, doi. 10.1002/trc2.12429
- By:
- Publication type:
- Article
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05768-3
- By:
- Publication type:
- Article
PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01168-1
- By:
- Publication type:
- Article
Design, Construction, and Intracellular Activation of an Intramolecularly Self-Silenced Signal Transduction InhibitorThis work was supported by NIH Grants DK68447 and CA095019, and the G. Harold and Leila Y. Mathers Charitable Foundation. Z.-Y.Z. is an Irma T. Hirschl Career Scientist.
- Published in:
- Angewandte Chemie International Edition, 2005, v. 44, n. 27, p. 4242, doi. 10.1002/anie.200462004
- By:
- Publication type:
- Article
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
- Published in:
- Human Molecular Genetics, 2009, v. 18, n. 3, p. 569
- By:
- Publication type:
- Article
A Facile Hydroxyindole Carboxylic Acid Based Focused Library Approach for Potent and Selective Inhibitors of Mycobacterium Protein Tyrosine Phosphatase B.
- Published in:
- ChemMedChem, 2013, v. 8, n. 6, p. 904, doi. 10.1002/cmdc.201300115
- By:
- Publication type:
- Article
Double Click Reaction for the Acquisition of a Highly Potent and Selective mPTPB Inhibitor.
- Published in:
- ChemMedChem, 2010, v. 5, n. 12, p. 2051, doi. 10.1002/cmdc.201000348
- By:
- Publication type:
- Article
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects.
- Published in:
- 2010
- By:
- Publication type:
- journal article
Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T-Cells of Type 1 Diabetic Subjects.
- Published in:
- Diabetes, 2010, v. 59, n. 2, p. 407, doi. 10.2337/db09-0694
- By:
- Publication type:
- Article