Works by Zhong, Zifu

Results: 25

Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pK<sub>a</sub> of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 28, p. 1, doi. 10.1002/anie.202506954

By:

Chen, Yong;
De Lombaerde, Emily;
Bugler‐Lamb, Aimée;
Zhong, Zifu;
Schuijs, Martijn J.;
Gomez, Claudia M. Brenis;
De Baere, Jamie;
Gontsarik, Mark;
Lauwers, Heleen;
Deswarte, Kim;
Sanders, Niek N.;
Lambrecht, Bart N.;
Guilliams, Martin;
De Geest, Bruno G.

Publication type:

Article

Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pK<sub>a</sub> of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo.

Published in:

Angewandte Chemie, 2025, v. 137, n. 28, p. 1, doi. 10.1002/ange.202506954

By:

Chen, Yong;
De Lombaerde, Emily;
Bugler‐Lamb, Aimée;
Zhong, Zifu;
Schuijs, Martijn J.;
Gomez, Claudia M. Brenis;
De Baere, Jamie;
Gontsarik, Mark;
Lauwers, Heleen;
Deswarte, Kim;
Sanders, Niek N.;
Lambrecht, Bart N.;
Guilliams, Martin;
De Geest, Bruno G.

Publication type:

Article

Visible Light Conjugation with Triazolinediones as a Route to Degradable Poly(ethylene glycol)–Lipids for mRNA Lipid Nanoparticle Formulation.

Published in:

Angewandte Chemie, 2023, v. 135, n. 23, p. 1, doi. 10.1002/ange.202301102

By:

Golba, Bianka;
Soete, Matthieu;
Zhong, Zifu;
Sanders, Niek;
Du Prez, Filip E.;
Houck, Hannes A.;
De Geest, Bruno G.

Publication type:

Article

Berichtigung: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie, 2021, v. 133, n. 31, p. 16878, doi. 10.1002/ange.202105635

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie, 2021, v. 133, n. 17, p. 9553, doi. 10.1002/ange.202015362

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Current Status of COVID‐19 (Pre)Clinical Vaccine Development.

Published in:

Angewandte Chemie, 2020, v. 132, n. 43, p. 19045, doi. 10.1002/ange.202008319

By:

Ye, Tingting;
Zhong, Zifu;
García‐Sastre, Adolfo;
Schotsaert, Michael;
De Geest, Bruno G.

Publication type:

Article

Amphiphile Polymer‐Lipidkonjugate zur potenten lymphatischen Anreicherung von TLR7/8‐Agonisten ermöglichen eine örtlich begrenzte Aktivierung des angeborenen Immunsystems.

Published in:

Angewandte Chemie, 2019, v. 131, n. 43, p. 15535, doi. 10.1002/ange.201905687

By:

De Vrieze, Jana;
Louage, Benoit;
Deswarte, Kim;
Zhong, Zifu;
De Coen, Ruben;
Van Herck, Simon;
Nuhn, Lutz;
Kaas Frich, Camilla;
Zelikin, Alexander N.;
Lienenklaus, Stefan;
Sanders, Niek N.;
Lambrecht, Bart N.;
David, Sunil A.;
De Geest, Bruno G.

Publication type:

Article

Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine.

Published in:

Vaccines, 2019, v. 7, n. 3, p. 96, doi. 10.3390/vaccines7030096

By:

Zhong, Zifu;
Portela Catani, João Paulo;
Mc Cafferty, Séan;
Couck, Liesbeth;
Van Den Broeck, Wim;
Gorlé, Nina;
Vandenbroucke, Roosmarijn E.;
Devriendt, Bert;
Ulbert, Sebastian;
Cnops, Lieselotte;
Michels, Johan;
Ariën, Kevin K.;
Sanders, Niek N.

Publication type:

Article

Visible Light Conjugation with Triazolinediones as a Route to Degradable Poly(ethylene glycol)–Lipids for mRNA Lipid Nanoparticle Formulation.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 23, p. 1, doi. 10.1002/anie.202301102

By:

Golba, Bianka;
Soete, Matthieu;
Zhong, Zifu;
Sanders, Niek;
Du Prez, Filip E.;
Houck, Hannes A.;
De Geest, Bruno G.

Publication type:

Article

Corrigendum: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 31, p. 16741, doi. 10.1002/anie.202105635

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 17, p. 9467, doi. 10.1002/anie.202015362

By:

Jangra, Sonia;
De Vrieze, Jana;
Choi, Angela;
Rathnasinghe, Raveen;
Laghlali, Gabriel;
Uvyn, Annemiek;
Van Herck, Simon;
Nuhn, Lutz;
Deswarte, Kim;
Zhong, Zifu;
Sanders, Niek N.;
Lienenklaus, Stefan;
David, Sunil A.;
Strohmeier, Shirin;
Amanat, Fatima;
Krammer, Florian;
Hammad, Hamida;
Lambrecht, Bart N.;
Coughlan, Lynda;
García‐Sastre, Adolfo

Publication type:

Article

Current Status of COVID‐19 (Pre)Clinical Vaccine Development.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 43, p. 18885, doi. 10.1002/anie.202008319

By:

Ye, Tingting;
Zhong, Zifu;
García‐Sastre, Adolfo;
Schotsaert, Michael;
De Geest, Bruno G.

Publication type:

Article

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 43, p. 15390, doi. 10.1002/anie.201905687

By:

De Vrieze, Jana;
Louage, Benoit;
Deswarte, Kim;
Zhong, Zifu;
De Coen, Ruben;
Van Herck, Simon;
Nuhn, Lutz;
Kaas Frich, Camilla;
Zelikin, Alexander N.;
Lienenklaus, Stefan;
Sanders, Niek N.;
Lambrecht, Bart N.;
David, Sunil A.;
De Geest, Bruno G.

Publication type:

Article

A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity.

Published in:

Angewandte Chemie, 2025, v. 137, n. 7, p. 1, doi. 10.1002/ange.202419031

By:

Zhong, Zifu;
Deventer, Marie H.;
Chen, Yong;
Vanhee, Stijn;
Lammens, Inés;
Deswarte, Kim;
Huang, Yi;
Ye, Tingting;
Wang, Haixiu;
Nuhn, Lutz;
Vandeputte, Marthe M.;
Gontsarik, Mark;
Cui, Xiaole;
Sanders, Niek N.;
Lienenklaus, Stefan;
N. Lambrecht, Bart;
Baptista, Antonio P.;
Stove, Christophe P.;
G. De Geest, Bruno

Publication type:

Article

Nanoparticle‐Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses.

Published in:

Advanced Materials, 2018, v. 30, n. 45, p. N.PAG, doi. 10.1002/adma.201803397

By:

Nuhn, Lutz;
De Koker, Stefaan;
Van Lint, Sandra;
Zhong, Zifu;
Catani, João Portela;
Combes, Francis;
Deswarte, Kim;
Li, Yupeng;
Lambrecht, Bart N.;
Lienenklaus, Stefan;
Sanders, Niek N.;
David, Sunil A.;
Tavernier, Jan;
De Geest, Bruno G.

Publication type:

Article

Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza.

Published in:

NPJ Vaccines, 2024, v. 9, n. 1, p. 1, doi. 10.1038/s41541-024-00932-x

By:

Cui, Xiaole;
Vervaeke, Pieter;
Gao, Ya;
Opsomer, Lisa;
Sun, Qing;
Snoeck, Janne;
Devriendt, Bert;
Zhong, Zifu;
Sanders, Niek N.

Publication type:

Article

A Genetically Encoded Endogenous Antibody Recruitment Strategy for Innate Immune‐Mediated Killing of Cancer Cells.

Published in:

Advanced Materials, 2025, v. 37, n. 11, p. 1, doi. 10.1002/adma.202415468

By:

Aelvoet, Justine;
Zhong, Zifu;
Gomez, Claudia M. Brenis;
Aegerter, Helena;
Louage, Benoit;
Lambrecht, Bart N.;
De Geest, Bruno G.;
Schuijs, Martijn J.

Publication type:

Article

PH‐Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2‐Propionic‐3‐Methyl‐maleic Anhydrides with Cholesteryl End Groups.

Published in:

Advanced Healthcare Materials, 2024, v. 13, n. 32, p. 1, doi. 10.1002/adhm.202402875

By:

Heck, Alina G.;
Medina‐Montano, Carolina;
Zhong, Zifu;
Deswarte, Kim;
Eigen, Katharina;
Stickdorn, Judith;
Kockelmann, Johannes;
Scherger, Maximilian;
Sanders, Niek N.;
Lienenklaus, Stefan;
Lambrecht, Bart N.;
Grabbe, Stephan;
De Geest, Bruno G.;
Nuhn, Lutz

Publication type:

Article

Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue.

Published in:

Advanced Healthcare Materials, 2023, v. 12, n. 32, p. 1, doi. 10.1002/adhm.202301687

By:

Zhong, Zifu;
Chen, Yong;
Deswarte, Kim;
Lauwers, Heleen;
De Lombaerde, Emily;
Cui, Xiaole;
Van Herck, Simon;
Ye, Tingting;
Gontsarik, Mark;
Lienenklaus, Stefan;
Sanders, Niek N.;
Lambrecht, Bart N.;
De Koker, Stefaan;
De Geest, Bruno G.

Publication type:

Article

Heat-Stable Enterotoxins of Enterotoxigenic Escherichia coli and Their Impact on Host Immunity.

Published in:

Toxins, 2019, v. 11, n. 1, p. 24, doi. 10.3390/toxins11010024

By:

Wang, Haixiu;
Zhong, Zifu;
Luo, Yu;
Cox, Eric;
Devriendt, Bert

Publication type:

Article

Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery.

Published in:

Advanced Functional Materials, 2024, v. 34, n. 21, p. 1, doi. 10.1002/adfm.202310623

By:

De Lombaerde, Emily;
Chen, Yong;
Ye, Tingting;
Deckers, Julie;
Mencarelli, Giulia;
De Swarte, Kim;
Lauwers, Heleen;
De Coen, Ruben;
Kasmi, Sabah;
Bevers, Sanne;
Kuchmiy, Anna;
Bogaert, Bram;
Baekens, Lies;
Zhong, Zifu;
Lamoot, Alexander;
Sanders, Niek N.;
Lambrecht, Bart N.;
Baptista, Antonio P.;
De Koker, Stefaan;
De Geest, Bruno G.

Publication type:

Article

Transient Lymph Node Immune Activation by Hydrolysable Polycarbonate Nanogels.

Published in:

Advanced Functional Materials, 2022, v. 32, n. 35, p. 1, doi. 10.1002/adfm.202203490

By:

Czysch, Christian;
Medina‐Montano, Carolina;
Zhong, Zifu;
Fuchs, Alexander;
Stickdorn, Judith;
Winterwerber, Pia;
Schmitt, Sascha;
Deswarte, Kim;
Raabe, Marco;
Scherger, Maximilian;
Combes, Francis;
De Vrieze, Jana;
Kasmi, Sabah;
Sandners, Niek N.;
Lienenklaus, Stefan;
Koynov, Kaloian;
Räder, Hans‐Joachim;
Lambrecht, Bart N.;
David, Sunil A.;
Bros, Matthias

Publication type:

Article

Introducing Degradable Cationic Nanogels Carrying TLR9 Stimulating Oligonucleotides.

Published in:

Small, 2025, v. 21, n. 4, p. 1, doi. 10.1002/smll.202406082

By:

Fuchs, Alexander;
Czysch, Christian;
Maxeiner, Konrad;
Winterwerber, Pia;
Schmitt, Sascha;
Stickdorn, Judith;
Zhong, Zifu;
Medina‐Montano, Carolina;
Räder, Hans‐Joachim;
Bros, Matthias;
De Geest, Bruno G.;
Koynov, Kaloian;
Grabbe, Stephan;
Nuhn, Lutz

Publication type:

Article

Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity.

Published in:

Small, 2024, p. 1, doi. 10.1002/smll.202306892

By:

Lamoot, Alexander;
Jangra, Sonia;
Laghlali, Gabriel;
Warang, Prajakta;
Singh, Gagandeep;
Chang, Lauren A.;
Park, Seok‐Chan;
De Swarte, Kim;
Zhong, Zifu;
Louage, Benoit;
De Lombaerde, Emily;
Ye, Tingting;
Chen, Yong;
Cuadrado‐Castano, Sara;
Lienenklaus, Stefan;
Sanders, Niek N.;
Lambrecht, Bart N.;
García‐Sastre, Adolfo;
Schotsaert, Michael;
De Geest, Bruno G.

Publication type:

Article

A Fentanyl Hapten‐Displaying Lipid Nanoparticle Vaccine that Non‐Covalently Encapsulates a TLR7/8 Agonist and T‐Helper Epitope Induces Protective Anti‐Fentanyl Immunity.

Published in:

Angewandte Chemie International Edition, 2025, v. 64, n. 7, p. 1, doi. 10.1002/anie.202419031

By:

Zhong, Zifu;
Deventer, Marie H.;
Chen, Yong;
Vanhee, Stijn;
Lammens, Inés;
Deswarte, Kim;
Huang, Yi;
Ye, Tingting;
Wang, Haixiu;
Nuhn, Lutz;
Vandeputte, Marthe M.;
Gontsarik, Mark;
Cui, Xiaole;
Sanders, Niek N.;
Lienenklaus, Stefan;
N. Lambrecht, Bart;
Baptista, Antonio P.;
Stove, Christophe P.;
G. De Geest, Bruno

Publication type:

Article