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Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphoma.
Published in:
Blood Cancer Journal, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41408-024-01146-z
By:
- Özoğul, Ece;
- Montaner, Anna;
- Pol, Melina;
- Frigola, Gerard;
- Balagué, Olga;
- Syrykh, Charlotte;
- Bousquets-Muñoz, Pablo;
- Royo, Romina;
- Fontaine, Juliette;
- Traverse-Glehen, Alexandra;
- Bühler, Marco M.;
- Giudici, Luca;
- Roncador, Marco;
- Zenz, Thorsten;
- Carras, Sylvain;
- Valmary-Degano, Severine;
- de Leval, Laurence;
- Bosch-Schips, Jan;
- Climent, Fina;
- Salmeron-Villalobos, Julia
Publication type:
Article
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33739-2
By:
- Mangolini, Maurizio;
- Maiques-Diaz, Alba;
- Charalampopoulou, Stella;
- Gerhard-Hartmann, Elena;
- Bloehdorn, Johannes;
- Moore, Andrew;
- Giachetti, Giorgia;
- Lu, Junyan;
- Roamio Franklin, Valar Nila;
- Chilamakuri, Chandra Sekkar Reddy;
- Moutsopoulos, Ilias;
- Rosenwald, Andreas;
- Stilgenbauer, Stephan;
- Zenz, Thorsten;
- Mohorianu, Irina;
- D'Santos, Clive;
- Deaglio, Silvia;
- Hodson, Daniel J.;
- Martin-Subero, Jose I.;
- Ringshausen, Ingo
Publication type:
Article
Requirement for YAP1 signaling in myxoid liposarcoma.
Published in:
EMBO Molecular Medicine, 2019, v. 11, n. 5, p. 1, doi. 10.15252/emmm.201809889
By:
- Trautmann, Marcel;
- Cheng, Ya‐Yun;
- Jensen, Patrizia;
- Azoitei, Ninel;
- Brunner, Ines;
- Hüllein, Jennifer;
- Slabicki, Mikolaj;
- Isfort, Ilka;
- Cyra, Magdalene;
- Berthold, Ruth;
- Wardelmann, Eva;
- Huss, Sebastian;
- Altvater, Bianca;
- Rossig, Claudia;
- Hafner, Susanne;
- Simmet, Thomas;
- Ståhlberg, Anders;
- Åman, Pierre;
- Zenz, Thorsten;
- Lange, Undine
Publication type:
Article
BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia.
Published in:
2014
By:
- Yaktapour, Niuscha;
- Meiss, Frank;
- Mastroianni, Justin;
- Zenz, Thorsten;
- Andrlova, Hana;
- Mathew, Nimitha R;
- Claus, Rainer;
- Hutter, Barbara;
- Fröhling, Stefan;
- Brors, Benedikt;
- Pfeifer, Dietmar;
- Pantic, Milena;
- Bartsch, Ingrid;
- Spehl, Timo S;
- Meyer, Philipp T;
- Duyster, Justus;
- Zirlik, Katja;
- Brummer, Tilman;
- Zeiser, Robert
Publication type:
journal article
BRAF inhibitor--associated ERK activation drives development of chronic lymphocytic leukemia.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 11, p. 5074, doi. 10.1172/JCI76539
By:
- Yaktapour, Niuscha;
- Meiss, Frank;
- Mastroianni, Justin;
- Zenz, Thorsten;
- Andrlova, Hana;
- Mathew, Nimitha R.;
- Claus, Rainer;
- Hutter, Barbara;
- Fröhling, Stefan;
- Brors, Benedikt;
- Pfeifer, Dietmar;
- Pantic, Milena;
- Bartsch, Ingrid;
- Spehl, Timo S.;
- Meyer, Philipp T.;
- Duyster, Justus;
- Zirlik, Katja;
- Brummer, Tilman;
- Zeiser, Robert
Publication type:
Article
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23752-2
By:
- Ecker, Veronika;
- Stumpf, Martina;
- Brandmeier, Lisa;
- Neumayer, Tanja;
- Pfeuffer, Lisa;
- Engleitner, Thomas;
- Ringshausen, Ingo;
- Nelson, Nina;
- Jücker, Manfred;
- Wanninger, Stefan;
- Zenz, Thorsten;
- Wendtner, Clemens;
- Manske, Katrin;
- Steiger, Katja;
- Rad, Roland;
- Müschen, Markus;
- Ruland, Jürgen;
- Buchner, Maike
Publication type:
Article
B‐cell maturation antigen‐directed bispecific antibodies in plasmablastic lymphoma.
Published in:
British Journal of Haematology, 2024, v. 205, n. 2, p. 722, doi. 10.1111/bjh.19571
By:
- Hofer, Kevin D.;
- Wolfensberger, Nathan;
- Bachofner, Adrian;
- Schneidawind, Corina;
- Stühler, Claudia;
- Bühler, Marco M.;
- Abela, Irene A.;
- Müller, Nicolas J.;
- Zenz, Thorsten;
- Manz, Markus G.;
- Rösler, Wiebke;
- Khanna, Nina;
- Schneidawind, Dominik
Publication type:
Article
GOALs in relapsed DLBCL.
Published in:
British Journal of Haematology, 2022, v. 198, n. 3, p. 419, doi. 10.1111/bjh.18296
By:
- Rösler, Wiebke;
- Zenz, Thorsten
Publication type:
Article
MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.
Published in:
British Journal of Haematology, 2017, v. 179, n. 3, p. 421, doi. 10.1111/bjh.14869
By:
- Wu, Bian;
- Słabicki, Mikołaj;
- Sellner, Leopold;
- Dietrich, Sascha;
- Liu, Xiyang;
- Jethwa, Alexander;
- Hüllein, Jennifer;
- Walther, Tatjana;
- Wagner, Lena;
- Huang, Zhiqin;
- Zapatka, Marc;
- Zenz, Thorsten
Publication type:
Article
Assessment of TP53 functionality in chronic lymphocytic leukaemia by different assays; an ERIC-wide approach.
Published in:
British Journal of Haematology, 2014, v. 167, n. 4, p. 565, doi. 10.1111/bjh.13006
By:
- Raa, G. Doreen;
- Malčiková, Jitka;
- Mraz, Marek;
- Trbusek, Martin;
- Le Garff‐Tavernier, Magali;
- Merle‐Béral, Hélène;
- Greil, Rudolf;
- Merkel, Olaf;
- Pospíšilová, Sarka;
- Lin, Ke;
- Pettitt, Andrew R.;
- Stankovic, Tatjana;
- Oers, Marinus H.;
- Eldering, Eric;
- Stilgenbauer, Stephan;
- Zenz, Thorsten;
- Kater, Arnon P.
Publication type:
Article
Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia.
Published in:
British Journal of Haematology, 2013, v. 163, n. 4, p. 496, doi. 10.1111/bjh.12539
By:
- Jethwa, Alexander;
- Hüllein, Jennifer;
- Stolz, Tatjana;
- Blume, Carolin;
- Sellner, Leopold;
- Jauch, Anna;
- Sill, Martin;
- Kater, Arnon P.;
- te Raa, G. Doreen;
- Geisler, Christian;
- Oers, Marinus;
- Dietrich, Sascha;
- Dreger, Peter;
- Ho, Anthony D.;
- Paruzynski, Anna;
- Schmidt, Manfred;
- Kalle, Christof;
- Glimm, Hanno;
- Zenz, Thorsten
Publication type:
Article
BRAF inhibitor treatment of classical hairy cell leukemia allows successful vaccination against SARS-CoV-2.
Published in:
Annals of Hematology, 2023, v. 102, n. 2, p. 403, doi. 10.1007/s00277-022-05026-z
By:
- Konrat, Judith;
- Rösler, Wiebke;
- Roiss, Michael;
- Meier-Abt, Fabienne;
- Widmer, Corinne C.;
- Balabanov, Stefan;
- Manz, Markus G.;
- Zenz, Thorsten
Publication type:
Article
Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling.
Published in:
PLoS Computational Biology, 2022, v. 18, n. 8, p. 1, doi. 10.1371/journal.pcbi.1010438
By:
- Batzilla, Alina;
- Lu, Junyan;
- Kivioja, Jarno;
- Putzker, Kerstin;
- Lewis, Joe;
- Zenz, Thorsten;
- Huber, Wolfgang
Publication type:
Article
The Effect of SF3B1 Mutation on the DNA Damage Response and Nonsense-Mediated mRNA Decay in Cancer.
Published in:
Frontiers in Oncology, 2021, v. 11, p. N.PAG, doi. 10.3389/fonc.2020.609409
By:
- Leeksma, Alexander C.;
- Derks, Ingrid A. M.;
- Kasem, M. Haidar;
- Kilic, Emine;
- de Klein, Annelies;
- Jager, Martine J.;
- van de Loosdrecht, Arjan A.;
- Jansen, Joop H.;
- Navrkalova, Veronika;
- Faber, Laura M.;
- Zaborsky, Nadja;
- Egle, Alexander;
- Zenz, Thorsten;
- Pospisilova, Sarka;
- Abdel-Wahab, Omar;
- Kater, Arnon P.;
- Eldering, Eric
Publication type:
Article
Drug‐microenvironment perturbations reveal resistance mechanisms and prognostic subgroups in CLL.
Published in:
Molecular Systems Biology, 2022, v. 18, n. 8, p. 1, doi. 10.15252/msb.202110855
By:
- Bruch, Peter‐Martin;
- Giles, Holly AR;
- Kolb, Carolin;
- Herbst, Sophie A;
- Becirovic, Tina;
- Roider, Tobias;
- Lu, Junyan;
- Scheinost, Sebastian;
- Wagner, Lena;
- Huellein, Jennifer;
- Berest, Ivan;
- Kriegsmann, Mark;
- Kriegsmann, Katharina;
- Zgorzelski, Christiane;
- Dreger, Peter;
- Zaugg, Judith B;
- Müller‐Tidow, Carsten;
- Zenz, Thorsten;
- Huber, Wolfgang;
- Dietrich, Sascha
Publication type:
Article
Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets.
Published in:
Molecular Systems Biology, 2018, v. 14, n. 6, p. 1, doi. 10.15252/msb.20178124
By:
- Argelaguet, Ricard;
- Velten, Britta;
- Arnol, Damien;
- Dietrich, Sascha;
- Zenz, Thorsten;
- Marioni, John C.;
- Buettner, Florian;
- Huber, Wolfgang;
- Stegle, Oliver
Publication type:
Article
Tumor-derived exosomes modulate PD-L1 expression in monocytes.
Published in:
Science Immunology, 2017, v. 2, n. 13, p. 1, doi. 10.1126/sciimmunol.aah5509
By:
- Haderk, Franziska;
- Schulz, Ralph;
- Iskar, Murat;
- Cid, Laura Llaó;
- Worst, Thomas;
- Willmund, Karolin V.;
- Schulz, Angela;
- Warnken, Uwe;
- Seiler, Jana;
- Benner, Axel;
- Nessling, Michelle;
- Zenz, Thorsten;
- Göbel, Maria;
- Dürig, Jan;
- Diederichs, Sven;
- Paggetti, Jérôme;
- Moussay, Etienne;
- Stilgenbauer, Stephan;
- Zapatka, Marc;
- Lichter, Peter
Publication type:
Article
TP53 mutation and survival in aggressive B cell lymphoma.
Published in:
International Journal of Cancer, 2017, v. 141, n. 7, p. 1381, doi. 10.1002/ijc.30838
By:
- Zenz, Thorsten;
- Kreuz, Markus;
- Fuge, Maxi;
- Klapper, Wolfram;
- Horn, Heike;
- Staiger, Annette M.;
- Winter, Doris;
- Helfrich, Hanne;
- Huellein, Jennifer;
- Hansmann, Martin‐Leo;
- Stein, Harald;
- Feller, Alfred;
- Möller, Peter;
- Schmitz, Norbert;
- Trümper, Lorenz;
- Loeffler, Markus;
- Siebert, Reiner;
- Rosenwald, Andreas;
- Ott, German;
- Pfreundschuh, Michael
Publication type:
Article
Epigenetic silencing of miR-708 enhances NF-κB signaling in chronic lymphocytic leukemia.
Published in:
International Journal of Cancer, 2015, v. 137, n. 6, p. 1352, doi. 10.1002/ijc.29491
By:
- Baer, Constance;
- Oakes, Christopher C.;
- Ruppert, Amy S.;
- Claus, Rainer;
- Kim‐Wanner, Soo‐Zin;
- Mertens, Daniel;
- Zenz, Thorsten;
- Stilgenbauer, Stephan;
- Byrd, John C.;
- Plass, Christoph
Publication type:
Article
High-throughput detection of nuclear factor-kappaB activity using a sensitive oligo-based chemiluminescent enzyme-linked immunosorbent assay.
Published in:
International Journal of Cancer, 2010, v. 127, n. 2, p. 404, doi. 10.1002/ijc.25054
By:
- Bhattacharya, Nupur;
- Sarno, Antonio;
- Idler, Irina S.;
- Führer, Marita;
- Zenz, Thorsten;
- Döhner, Hartmut;
- Stilgenbauer, Stephan;
- Mertens, Daniel
Publication type:
Article
High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas.
Published in:
Genes, Chromosomes & Cancer, 2013, v. 52, n. 2, p. 150, doi. 10.1002/gcc.22014
By:
- Salaverria, Itziar;
- Martin‐Guerrero, Idoia;
- Burkhardt, Birgit;
- Kreuz, Markus;
- Zenz, Thorsten;
- Oschlies, Ilske;
- Arnold, Norbert;
- Baudis, Michael;
- Bens, Susanne;
- García‐Orad, Africa;
- Lisfeld, Jasmin;
- Schwaenen, Carsten;
- Szczepanowski, Monika;
- Wessendorf, Swen;
- Pfreundschuh, Michael;
- Trümper, Lorenz;
- Klapper, Wolfram;
- Siebert, Reiner
Publication type:
Article
How to integrate CD19 specific chimeric antigen receptor T cells with other CD19 targeting agents in diffuse large B‐cell lymphoma?
Published in:
Hematological Oncology, 2024, v. 42, n. 1, p. 1, doi. 10.1002/hon.3237
By:
- de Ramon Ortiz, Carmen;
- Wang, Sisi;
- Stathis, Anastasios;
- Bertoni, Francesco;
- Zenz, Thorsten;
- Novak, Urban;
- Simonetta, Federico
Publication type:
Article
P53 and microRNAs in chronic lymphocytic leukemia.
Published in:
Journal of Nucleic Acids Investigation, 2011, v. 2, n. 1-3, p. 43, doi. 10.4081/jnai.2011.2414
By:
- Bloehdorn, Johannes;
- Langer, Christian;
- Döhner, Hartmut;
- Zenz, Thorsten;
- Stilgenbauer, Stephan
Publication type:
Article
Rapid response of biallelic BRAF V600 E mutated hairy cell leukaemia to low dose vemurafenib.
Published in:
British Journal of Haematology, 2013, v. 161, n. 1, p. 150, doi. 10.1111/bjh.12201
By:
- Follows, George A.;
- Sims, Hannah;
- Bloxham, David M.;
- Zenz, Thorsten;
- Hopper, Melanie A.;
- Liu, Hongxiang;
- Bench, Anthony;
- Wright, Penny;
- van't Veer, Mars B.;
- Scott, Mike A.
Publication type:
Article
The gene expression signature associated with TP53 mutation/deletion in chronic lymphocytic leukaemia is dominated by the under-expression of TP53 and other genes on chromosome 17p.
Published in:
British Journal of Haematology, 2013, v. 160, n. 1, p. 53, doi. 10.1111/bjh.12092
By:
- Lin, Ke;
- Lane, Brian;
- Carter, Anthony;
- Johnson, Gillian G.;
- Onwuazor, Obiageli;
- Oates, Melanie;
- Zenz, Thorsten;
- Stilgenbauer, Stephan;
- Atherton, Mark;
- Douglas, Angela;
- Ebrahimi, Bahram;
- Sherrington, Paul D.;
- Pettitt, Andrew R.
Publication type:
Article
Nurse-like cells show deregulated expression of genes involved in immunocompetence.
Published in:
British Journal of Haematology, 2011, v. 154, n. 3, p. 349, doi. 10.1111/j.1365-2141.2011.08747.x
By:
- Bhattacharya, Nupur;
- Diener, Susanne;
- Idler, Irina S.;
- Rauen, Judith;
- Häbe, Sarah;
- Busch, Hauke;
- Habermann, Annett;
- Zenz, Thorsten;
- Döhner, Hartmut;
- Stilgenbauer, Stephan;
- Mertens, Daniel
Publication type:
Article
SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL).
Published in:
2010
By:
- Philippen, Angela;
- Diener, Susanne;
- Zenz, Thorsten;
- Döhner, Hartmut;
- Stilgenbauer, Stephan;
- Mertens, Daniel
Publication type:
Letter
Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17 T helper cells.
Published in:
2010
By:
- Idler, Irina;
- Giannopoulos, Krzysztof;
- Zenz, Thorsten;
- Bhattacharya, Nupur;
- Nothing, Maria;
- Döhner, Hartmut;
- Stilgenbauer, Stephan;
- Mertens, Daniel
Publication type:
Letter
Reduced-intensity conditioning followed by T-cell depleted allogeneic stem cell transplantation for patients with chronic myeloid leukaemia and minimal residual disease at the time of transplant: high risk of molecular relapse.
Published in:
British Journal of Haematology, 2007, v. 136, n. 1, p. 127, doi. 10.1111/j.1365-2141.2006.06404.x
By:
- Ringhoffer, Mark;
- Von Harsdorf, Stephanie;
- Schmitt, Michael;
- Wiesneth, Markus;
- Zenz, Thorsten;
- Stilgenbauer, Stephan;
- Greiner, Jochen;
- Döhner, Konstanze;
- Marx, Martin;
- Döhner, Hartmut;
- Bunjes, Donald
Publication type:
Article
<sup>188</sup>Re or <sup>90</sup>Y-labelled anti-CD66 antibody as part of a dose-reduced conditioning regimen for patients with acute leukaemia or myelodysplastic syndrome over the age of 55: results of a phase I–II study.
Published in:
British Journal of Haematology, 2005, v. 130, n. 4, p. 604, doi. 10.1111/j.1365-2141.2005.05663.x
By:
- Ringhoffer, Mark;
- Blumstein, Norbert;
- Neumaier, Bernd;
- Glatting, Gerhard;
- von Harsdorf, Stephanie;
- Buchmann, Inga;
- Wiesneth, Markus;
- Kotzerke, Jörg;
- Zenz, Thorsten;
- Buck, Andreas K.;
- Schauwecker, Peter;
- Stilgenbauer, Stephan;
- Döhner, Hartmut;
- Reske, Sven N.;
- Bunjes, Donald
Publication type:
Article
From pathogenesis to treatment of chronic lymphocytic leukaemia.
Published in:
2010
By:
- Zenz, Thorsten;
- Mertens, Daniel;
- Küppers, Ralf;
- Döhner, Hartmut;
- Stilgenbauer, Stephan;
- Küppers, Ralf;
- Döhner, Hartmut
Publication type:
journal article
IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17095-7
By:
- Nadeu, Ferran;
- Mas-de-les-Valls, Rut;
- Navarro, Alba;
- Royo, Romina;
- Martín, Silvia;
- Villamor, Neus;
- Suárez-Cisneros, Helena;
- Mares, Rosó;
- Lu, Junyan;
- Enjuanes, Anna;
- Rivas-Delgado, Alfredo;
- Aymerich, Marta;
- Baumann, Tycho;
- Colomer, Dolors;
- Delgado, Julio;
- Morin, Ryan D.;
- Zenz, Thorsten;
- Puente, Xose S.;
- Campbell, Peter J.;
- Beà, Sílvia
Publication type:
Article
Single-cell analysis based dissection of clonality in myelofibrosis.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13892-x
By:
- Mylonas, Elena;
- Yoshida, Kenichi;
- Frick, Mareike;
- Hoyer, Kaja;
- Christen, Friederike;
- Kaeda, Jaspal;
- Obenaus, Matthias;
- Noerenberg, Daniel;
- Hennch, Cornelius;
- Chan, Willy;
- Ochi, Yotaro;
- Shiraishi, Yuichi;
- Shiozawa, Yusuke;
- Zenz, Thorsten;
- Oakes, Christopher C.;
- Sawitzki, Birgit;
- Schwarz, Michaela;
- Bullinger, Lars;
- le Coutre, Philipp;
- Rose-Zerilli, Matthew J. J.
Publication type:
Article
Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL.
Published in:
Genome Medicine, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13073-020-00724-7
By:
- Wierzbinska, Justyna A.;
- Toth, Reka;
- Ishaque, Naveed;
- Rippe, Karsten;
- Mallm, Jan-Philipp;
- Klett, Lara C.;
- Mertens, Daniel;
- Zenz, Thorsten;
- Hielscher, Thomas;
- Seifert, Marc;
- Küppers, Ralf;
- Assenov, Yassen;
- Lutsik, Pavlo;
- Stilgenbauer, Stephan;
- Roessner, Philipp M.;
- Seiffert, Martina;
- Byrd, John;
- Oakes, Christopher C.;
- Plass, Christoph;
- Lipka, Daniel B.
Publication type:
Article
Can Prognostic Factors Be Used to Direct Therapy in Chronic Lymphocytic Leukemia?
Published in:
Current Hematologic Malignancy Reports, 2012, v. 7, n. 1, p. 3, doi. 10.1007/s11899-011-0110-1
By:
- Sellner, Leopold;
- Dietrich, Sascha;
- Dreger, Peter;
- Glimm, Hanno;
- Zenz, Thorsten
Publication type:
Article
Bone Marrow Transplantation Nephropathy after an Intensified Conditioning Regimen with Radioimmunotherapy and Allogeneic Stem Cell Transplantation.
Published in:
Journal of Nuclear Medicine, 2006, v. 47, n. 2, p. 278
By:
- Zenz, Thorsten;
- Schlenk, Richard F.;
- Glatting, Gerhard;
- Neumaier, Bernd;
- Blumstein, Norbert;
- Buchmann, Inga;
- von Harsdorf, Stephanie;
- Ringhoffer, Mark;
- Wiesneth, Markus;
- Keller, Frieder;
- Kotzerke, Jörg;
- Röttinger, Erwin;
- Stilgenbauer, Stephan;
- Döhner, Hartmut;
- Reske, Sven N.;
- Bunjes, Donald
Publication type:
Article

Found: 36