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The Impact of Chemical Modifications on the Interferon-Inducing and Antiproliferative Activity of Short Double-Stranded Immunostimulating RNA.
- Published in:
- Molecules, 2024, v. 29, n. 13, p. 1, doi. 10.3390/molecules29133225
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- Article
Tumor- and Fibroblast-Derived Cell-Free DNAs Differently Affect the Progression of B16 Melanoma In Vitro and In Vivo.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 10, p. 5304, doi. 10.3390/ijms25105304
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- Article
Cholesterol-Modified Anti-Il6 siRNA Reduces the Severity of Acute Lung Injury in Mice.
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- Cells (2073-4409), 2024, v. 13, n. 9, p. 767, doi. 10.3390/cells13090767
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- Article
Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification.
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- Molecules, 2024, v. 29, n. 4, p. 786, doi. 10.3390/molecules29040786
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- Article
The Nexus of Inflammation-Induced Epithelial-Mesenchymal Transition and Lung Cancer Progression: A Roadmap to Pentacyclic Triterpenoid-Based Therapies.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 24, p. 17325, doi. 10.3390/ijms242417325
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- Article
Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 22, p. 16042, doi. 10.3390/ijms242216042
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- Article
Soloxolone Methyl Reduces the Stimulatory Effect of Leptin on the Aggressive Phenotype of Murine Neuro2a Neuroblastoma Cells via the MAPK/ERK1/2 Pathway.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 10, p. 1369, doi. 10.3390/ph16101369
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- Article
Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA.
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- Pharmaceutics, 2023, v. 15, n. 9, p. 2184, doi. 10.3390/pharmaceutics15092184
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- Article
Effective Prognostic Model for Therapy Response Prediction in Acute Myeloid Leukemia Patients.
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- Journal of Personalized Medicine, 2023, v. 13, n. 8, p. 1234, doi. 10.3390/jpm13081234
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- Article
The Effect of Cell-Free DNA from Blood Serum of Mice with Metastatic Melanoma on Enhancement of Oncogenic Properties of Melanoma Cells.
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- Biochemistry (00062979), 2023, v. 88, n. 7, p. 995, doi. 10.1134/S0006297923070118
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- Article
Evaluation of the Antitumor Potential of Soloxolone Tryptamide against Glioblastoma Multiforme Using in silico, in vitro, and in vivo Approaches.
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- Biochemistry (00062979), 2023, v. 88, n. 7, p. 1008, doi. 10.1134/S000629792307012X
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- Article
Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7287, doi. 10.3390/ijms24087287
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- Article
Identification of Novel Core Genes Involved in Malignant Transformation of Inflamed Colon Tissue Using a Computational Biology Approach and Verification in Murine Models.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 5, p. 4311, doi. 10.3390/ijms24054311
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- Article
siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 2, p. 1641, doi. 10.3390/ijms24021641
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- Article
Pulmonary Fibrosis as a Result of Acute Lung Inflammation: Molecular Mechanisms, Relevant In Vivo Models, Prognostic and Therapeutic Approaches.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 14959, doi. 10.3390/ijms232314959
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- Article
Single Shot vs. Cocktail: A Comparison of Mono- and Combinative Application of miRNA-Targeted Mesyl Oligonucleotides for Efficient Antitumor Therapy.
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- Cancers, 2022, v. 14, n. 18, p. N.PAG, doi. 10.3390/cancers14184396
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- Article
Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 12, p. 6562, doi. 10.3390/ijms23126562
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- Article
Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 11, p. 6214, doi. 10.3390/ijms23116214
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- Article
Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo.
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- Pharmaceutics, 2022, v. 14, n. 6, p. 1173, doi. 10.3390/pharmaceutics14061173
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- Article
Asthma and Post-Asthmatic Fibrosis: A Search for New Promising Molecular Markers of Transition from Acute Inflammation to Pulmonary Fibrosis.
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- Biomedicines, 2022, v. 10, n. 5, p. 1017, doi. 10.3390/biomedicines10051017
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- Article
Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 5, p. 603, doi. 10.3390/ph15050603
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- Article
"Bind, cleave and leave": multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates.
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- Nucleic Acids Research, 2022, v. 50, n. 2, p. 651, doi. 10.1093/nar/gkab1273
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- Article
Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study.
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- PLoS ONE, 2021, v. 16, n. 11, p. 1, doi. 10.1371/journal.pone.0260450
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- Article
Antigen‐Specific Stimulation and Expansion of CAR‐T Cells Using Membrane Vesicles as Target Cell Surrogates.
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- Small, 2021, v. 17, n. 45, p. 1, doi. 10.1002/smll.202102643
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- Article
Human Recombinant DNase I (Pulmozyme ®) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 12074, doi. 10.3390/ijms222112074
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- Article
Tropism of Extracellular Vesicles and Cell-Derived Nanovesicles to Normal and Cancer Cells: New Perspectives in Tumor-Targeted Nucleic Acid Delivery.
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- Pharmaceutics, 2021, v. 13, n. 11, p. 1911, doi. 10.3390/pharmaceutics13111911
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- Article
Drug responsiveness of leukemic cells detected in vitro at diagnosis correlates with therapy response and survival in patients with acute myeloid leukemia.
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- Cancer Reports, 2021, v. 4, n. 4, p. 1, doi. 10.1002/cnr2.1362
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- Article
Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy.
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- Pharmaceutics, 2021, v. 13, n. 8, p. 1252, doi. 10.3390/pharmaceutics13081252
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- Article
Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences.
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- Molecules, 2021, v. 26, n. 6, p. 1732, doi. 10.3390/molecules26061732
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- Article
Novel Lipid-Oligonucleotide Conjugates Containing Long-Chain Sulfonyl Phosphoramidate Groups: Synthesis and Biological Properties.
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- Applied Sciences (2076-3417), 2021, v. 11, n. 3, p. 1174, doi. 10.3390/app11031174
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- Article
Cyano Enone-Bearing Triterpenoid Soloxolone Methyl Inhibits Epithelial-Mesenchymal Transition of Human Lung Adenocarcinoma Cells In Vitro and Metastasis of Murine Melanoma In Vivo.
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- Molecules, 2020, v. 25, n. 24, p. 5925, doi. 10.3390/molecules25245925
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- Article
Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates.
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- Nucleic Acids Research, 2020, v. 48, n. 19, p. 10662, doi. 10.1093/nar/gkaa780
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- Article
Antitumour Activity of the Ribonuclease Binase from Bacillus pumilus in the RLS 40 Tumour Model Is Associated with the Reorganisation of the miRNA Network and Reversion of Cancer-Related Cascades to Normal Functioning.
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- Biomolecules (2218-273X), 2020, v. 10, n. 11, p. 1509, doi. 10.3390/biom10111509
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- Article
Dual Effect of Soloxolone Methyl on LPS-Induced Inflammation In Vitro and In Vivo.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 7876, doi. 10.3390/ijms21217876
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- Article
Immunostimulating RNA Delivered by P1500 PEGylated Cationic Liposomes Limits Influenza Infection in C57Bl/6 Mice.
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- Pharmaceutics, 2020, v. 12, n. 9, p. 875, doi. 10.3390/pharmaceutics12090875
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- Article
Transport Oligonucleotides—A Novel System for Intracellular Delivery of Antisense Therapeutics.
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- Molecules, 2020, v. 25, n. 16, p. 3663, doi. 10.3390/molecules25163663
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- Article
Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 10, p. 3511, doi. 10.3390/ijms21103511
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- Article
Trioxolone Methyl, a Novel Cyano Enone-Bearing 18βH-Glycyrrhetinic Acid Derivative, Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice.
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- Molecules, 2020, v. 25, n. 10, p. 2406, doi. 10.3390/molecules25102406
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- Article
Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance.
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- Molecules, 2020, v. 25, n. 10, p. 2459, doi. 10.3390/molecules25102459
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- Article
Position of Disulfide Bond Determines the Properties of Novel Stimuli‐Responsive Cationic Lipids.
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- ChemistrySelect, 2020, v. 5, n. 15, p. 4509, doi. 10.1002/slct.201904879
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- Article
Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA.
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- Frontiers in Oncology, 2019, v. 9, p. 1, doi. 10.3389/fonc.2019.01454
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- Article
Cytochalasin-B-Inducible Nanovesicle Mimics of Natural Extracellular Vesicles That Are Capable of Nucleic Acid Transfer.
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- Micromachines, 2019, v. 10, n. 11, p. 750, doi. 10.3390/mi10110750
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- Article
Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model.
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- Frontiers in Pharmacology, 2019, p. 1, doi. 10.3389/fphar.2019.00879
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- Article
Novel Derivatives of Deoxycholic Acid Bearing Linear Aliphatic Diamine and Aminoalcohol Moieties and their Cyclic Analogs at the C3 Position: Synthesis and Evaluation of Their In Vitro Antitumor Potential.
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- Molecules, 2019, v. 24, n. 14, p. 2644, doi. 10.3390/molecules24142644
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- Article
Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected In Vitro on Treatment Response and Survival of Leukemia Patients.
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- Journal of Personalized Medicine, 2019, v. 9, n. 2, p. 24, doi. 10.3390/jpm9020024
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- Article
Novel PEGylated Liposomes Enhance Immunostimulating Activity of isRNA.
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- Molecules, 2018, v. 23, n. 12, p. 3101, doi. 10.3390/molecules23123101
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- Article
Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides.
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- Molecules, 2018, v. 23, n. 10, p. 2654, doi. 10.3390/molecules23102654
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- Article
A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]- 4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride.
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- Molbank, 2018, v. 2018, n. 1, p. m981, doi. 10.3390/M981
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- Article
Nuclease‐resistant 63‐bp trimeric siRNAs simultaneously silence three different genes in tumor cells.
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- FEBS Letters, 2018, v. 592, n. 1, p. 122, doi. 10.1002/1873-3468.12927
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- Article
Alteration of the exDNA profile in blood serum of LLC-bearing mice under the decrease of tumour invasion potential by bovine pancreatic DNase I treatment.
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- PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0171988
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- Article