Works by Zelcer, Noam

Results: 26

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET.
Published in:
Scientific Reports, 2025, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-84217-2
By:
- Ruffilli, Camilla;
- Röth, Sascha;
- Zelcer, Noam;
- Moreau, Kevin
Publication type:
Article
A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion.
Published in:
Cardiovascular Research, 2024, v. 120, n. 11, p. 1253, doi. 10.1093/cvr/cvae121
By:
- Meurs, Amber;
- Ndoj, Klevis;
- van den Berg, Marlene;
- Marinković, Goran;
- Tantucci, Matteo;
- Veenendaal, Tineke;
- Kuivenhoven, Jan Albert;
- Klumperman, Judith;
- Zelcer, Noam
Publication type:
Article
A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy.
Published in:
Human Molecular Genetics, 2012, v. 21, n. 2, p. 358, doi. 10.1093/hmg/ddr471
By:
- Weterman, Marian A.J.;
- Sorrentino, Vincenzo;
- Kasher, Paul R.;
- Jakobs, Marja E.;
- van Engelen, Baziel G.M.;
- Fluiter, Kees;
- de Wissel, Marit B.;
- Sizarov, Aleksander;
- Nürnberg, Gudrun;
- Nürnberg, Peter;
- Zelcer, Noam;
- Schelhaas, H. Jurgen;
- Baas, Frank
Publication type:
Article
RETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. N.PAG, doi. 10.1038/s41467-017-00508-5
By:
- Alioui, Anthony;
- Dufour, Julie;
- Leoni, Valerio;
- Loregger, Anke;
- Moeton, Martina;
- Iuliano, Luigi;
- Zerbinati, Chiara;
- Septier, Amandine;
- Val, Pierre;
- Fouache, Allan;
- Russo, Vincenzo;
- Volle, David H.;
- Lobaccaro, Jean-Marc A.;
- Zelcer, Noam;
- Baron, Silvère
Publication type:
Article
SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P.
Published in:
Molecular & Cellular Biology, 2024, v. 44, n. 4, p. 123, doi. 10.1080/10985549.2024.2348711
By:
- Hendrix, Sebastian;
- Tan, Josephine M. E.;
- Ndoj, Klevis;
- Kingma, Jenina;
- Valiloo, Masoud;
- Zijlstra, Lobke F.;
- Ottenhoff, Roelof;
- Seidah, Nabil G.;
- Loregger, Anke;
- Kober, Daniel L.;
- Zelcer, Noam
Publication type:
Article
A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
Published in:
Molecular & Cellular Biology, 2016, v. 36, n. 2, p. 285, doi. 10.1128/MCB.00890-15
By:
- Loregger, Anke;
- Cook, Emma Claire Laura;
- Nelson, Jessica Kristin;
- Moeton, Martina;
- Sharpe, Laura Jane;
- Engberg, Susanna;
- Karimova, Madina;
- Lambert, Gilles;
- Brown, Andrew John;
- Zelcer, Noam
Publication type:
Article
LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis.
Published in:
Molecular & Cellular Biology, 2015, v. 35, n. 1, p. 52, doi. 10.1128/MCB.00525-14
By:
- Kurakula, Kondababu;
- Sommer, Daniela;
- Sokolovic, Milka;
- Moerland, Perry D.;
- Scheij, Saskia;
- van Loenen, Pieter B.;
- Koenis, Duco S.;
- Zelcer, Noam;
- van Tiel, Claudia M.;
- de Vries, Carlie J. M.
Publication type:
Article
Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04653-3
By:
- Alioui, Anthony;
- Dufour, Julie;
- Leoni, Valerio;
- Loregger, Anke;
- Moeton, Martina;
- Iuliano, Luigi;
- Zerbinati, Chiara;
- Septier, Amandine;
- Val, Pierre;
- Fouache, Allan;
- Russo, Vincenzo;
- Volle, David H.;
- Lobaccaro, Jean-Marc A.;
- Zelcer, Noam;
- Baron, Silvère
Publication type:
Article
One E3 ligase targets two key control points in cholesterol synthesis (605.5).
Published in:
FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.605.5
By:
- Brown, Andrew;
- Sharpe, Laura;
- Loregger, Anke;
- Cook, Emma;
- Phan, Lisa;
- Stevenson, Julian;
- Zelcer, Noam
Publication type:
Article
Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40943-1
By:
- Hendrix, Sebastian;
- Kingma, Jenina;
- Ottenhoff, Roelof;
- Valiloo, Masoud;
- Svecla, Monika;
- Zijlstra, Lobke F.;
- Sachdev, Vinay;
- Kovac, Kristina;
- Levels, Johannes H. M.;
- Jongejan, Aldo;
- de Boer, Jan F.;
- Kuipers, Folkert;
- Rimbert, Antoine;
- Norata, Giuseppe D.;
- Loregger, Anke;
- Zelcer, Noam
Publication type:
Article
Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene.
Published in:
PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0172721
By:
- Cook, Emma C. L.;
- Nelson, Jessica K.;
- Sorrentino, Vincenzo;
- Koenis, Duco;
- Moeton, Martina;
- Scheij, Saskia;
- Ottenhoff, Roelof;
- Bleijlevens, Boris;
- Loregger, Anke;
- Zelcer, Noam
Publication type:
Article
Glutamine sensing licenses cholesterol synthesis.
Published in:
EMBO Journal, 2024, v. 43, n. 23, p. 5837, doi. 10.1038/s44318-024-00269-0
By:
- Garcia, Bruna Martins;
- Melchinger, Philipp;
- Medeiros, Tania;
- Hendrix, Sebastian;
- Prabhu, Kavan;
- Corrado, Mauro;
- Kingma, Jenina;
- Gorbatenko, Andrej;
- Deshwal, Soni;
- Veronese, Matteo;
- Scorrano, Luca;
- Pearce, Erika;
- Giavalisco, Patrick;
- Zelcer, Noam;
- Pernas, Lena
Publication type:
Article
SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50068-8
By:
- Hendrix, Sebastian;
- Dartigue, Vincent;
- Hall, Hailee;
- Bawaria, Shrankhla;
- Kingma, Jenina;
- Bajaj, Bilkish;
- Zelcer, Noam;
- Kober, Daniel L.
Publication type:
Article
Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.
Published in:
European Heart Journal, 2013, v. 34, n. 17, p. 1292, doi. 10.1093/eurheartj/ehs472
By:
- Sorrentino, Vincenzo;
- Fouchier, Sigrid W.;
- Motazacker, Mohammad M.;
- Nelson, Jessica K.;
- Defesche, Joep C.;
- Dallinga-Thie, Geesje M.;
- Kastelein, John J.P.;
- Kees Hovingh, G.;
- Zelcer, Noam
Publication type:
Article
Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia.
Published in:
European Heart Journal, 2012, v. 33, n. 11, p. 1360, doi. 10.1093/eurheartj/ehs010
By:
- Motazacker, Mohammad Mahdi;
- Pirruccello, James;
- Huijgen, Roeland;
- Do, Ron;
- Gabriel, Stacey;
- Peter, Jorge;
- Kuivenhoven, Jan Albert;
- Defesche, Joep C.;
- Kastelein, John J.P.;
- Hovingh, G. Kees;
- Zelcer, Noam;
- Kathiresan, Sekar;
- Fouchier, Sigrid W.
Publication type:
Article
LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P.
Published in:
Human Molecular Genetics, 2017, v. 26, n. 11, p. 2034, doi. 10.1093/hmg/ddx089
By:
- Hakonen, Johanna E.;
- Sorrentino, Vincenzo;
- Trezza, Rossella Avagliano;
- de Wissel, Marit B.;
- van den Berg, Marlene;
- Bleijlevens, Boris;
- van Ruissen, Fred;
- Distel, Ben;
- Baas, Frank;
- Zelcer, Noam;
- Weterman, Marian A. J.
Publication type:
Article
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Published in:
Nature Communications, 2020, v. 11, p. 1, doi. 10.1038/s41467-020-14811-1
By:
- Loregger, Anke;
- Raaben, Matthijs;
- Nieuwenhuis, Joppe;
- Tan, Josephine M. E.;
- Jae, Lucas T.;
- van den Hengel, Lisa G.;
- Hendrix, Sebastian;
- van den Berg, Marlene;
- Scheij, Saskia;
- Ji-Ying Song;
- Huijbers, Ivo J.;
- Kroese, Lona J.;
- Ottenhoff, Roelof;
- van Weeghel, Michel;
- van de Sluis, Bart;
- Brummelkamp, Thijn;
- Zelcer, Noam
Publication type:
Article
The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.
Published in:
2011
By:
- Weissglas-Volkov, Daphna;
- Calkin, Anna C.;
- Tusie-Luna, Teresa;
- Sinsheimer, Janet S.;
- Zelcer, Noam;
- Riba, Laura;
- Vargas Tino, Ana Maria;
- Ordoñez-Sánchez, Maria Luisa;
- Cruz-Bautista, Ivette;
- Aguilar-Salinas, Carlos A.;
- Tontonoz, Peter;
- Pajukanta, Päivi;
- Tino, Ana Maria Vargas
Publication type:
journal article
Liver X receptors as integrators of metabolic and inflammatory signaling.
Published in:
2006
By:
- Zelcer, Noam;
- Tontonoz, Peter
Publication type:
journal article
Hyperlipidaemia elicits an atypical, T helper 1–like CD4<sup>+</sup> T-cell response: a key role for very low-density lipoprotein.
Published in:
European Heart Journal Open, 2023, v. 3, n. 2, p. 1, doi. 10.1093/ehjopen/oead013
By:
- Os, Bram W van;
- Vos, Winnie G;
- Bosmans, Laura A;
- Tiel, Claudia M van;
- Lith, Sanne C;
- Toom, Myrthe S den;
- Beckers, Linda;
- Levels, Johannes H M;
- Wouw, Suzanne A E van;
- Zelcer, Noam;
- Zaal, Esther A;
- Berkers, Celia R;
- Lest, Chris H A van der;
- Helms, J Bernd;
- Weber, Christian;
- Atzler, Dorothee;
- Winther, Menno P J de;
- Baardman, Jeroen;
- Lutgens, Esther
Publication type:
Article
Liver X receptor α suppresses SNAI2 ensuring blood‐brain barrier function.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073228
By:
- Vacondio, Davide;
- Coenen, Loet;
- Mulder, Inge;
- Fontijn, Ruud;
- Hof, Bert;
- Fung, Wing Ka;
- Kooij, Gijs;
- Rozemuller, Annemieke J.M.;
- Zelcer, Noam;
- Vries, Helga E;
- Wit, Nienke M
Publication type:
Article
Liver X receptor α suppresses SNAI2 ensuring blood‐brain barrier function.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073228
By:
- Vacondio, Davide;
- Coenen, Loet;
- Mulder, Inge;
- Fontijn, Ruud;
- Hof, Bert;
- Fung, Wing Ka;
- Kooij, Gijs;
- Rozemuller, Annemieke J.M.;
- Zelcer, Noam;
- Vries, Helga E;
- Wit, Nienke M
Publication type:
Article
Industrial Trans Fatty Acids Stimulate SREBP2‐Mediated Cholesterogenesis and Promote Non‐Alcoholic Fatty Liver Disease.
Published in:
Molecular Nutrition & Food Research, 2019, v. 63, n. 19, p. N.PAG, doi. 10.1002/mnfr.201900385
By:
- Oteng, Antwi‐Boasiako;
- Loregger, Anke;
- Weeghel, Michel;
- Zelcer, Noam;
- Kersten, Sander
Publication type:
Article
A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.
Published in:
2016
By:
- Tol, Marc J.;
- Ottenhoff, Roelof;
- van Eijk, Marco;
- Zelcer, Noam;
- Aten, Jan;
- Houten, Sander M.;
- Geerts, Dirk;
- van Roomen, Cindy;
- Bierlaagh, Marlou C.;
- Scheij, Saskia;
- Hoeksema, Marten A.;
- Aerts, Johannes M.;
- Bogan, Jonathan S.;
- Dorn 2nd, Gerald W.;
- Argmann, Carmen A.;
- Verhoeven, Arthur J.;
- Dorn, Gerald W 2nd
Publication type:
journal article
The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway.
Published in:
Molecular & Cellular Biology, 2014, v. 34, n. 7, p. 1262, doi. 10.1128/MCB.01140-13
By:
- Zelcer, Noam;
- Sharpe, Laura J.;
- Loregger, Anke;
- Kristiana, Ika;
- Cook, Emma C. L.;
- Phan, Lisa;
- Stevenson, Julian;
- Brown, Andrew J.
Publication type:
Article
Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists.
Published in:
Molecular & Cellular Biology, 2011, v. 31, n. 9, p. 1885, doi. 10.1128/MCB.01469-10
By:
- Scotti, Elena;
- Hong, Cynthia;
- Yoshinaga, Yuko;
- Yiping Tu;
- Yan Hu;
- Zelcer, Noam;
- Boyadjian, Rima;
- de Jong, Pieter J.;
- Young, Stephen G.;
- Fong, Loren G.;
- Tontonoz, Peter
Publication type:
Article