Works matching AU Zelcer, Noam

Results: 26

Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40943-1

By:

Hendrix, Sebastian;
Kingma, Jenina;
Ottenhoff, Roelof;
Valiloo, Masoud;
Svecla, Monika;
Zijlstra, Lobke F.;
Sachdev, Vinay;
Kovac, Kristina;
Levels, Johannes H. M.;
Jongejan, Aldo;
de Boer, Jan F.;
Kuipers, Folkert;
Rimbert, Antoine;
Norata, Giuseppe D.;
Loregger, Anke;
Zelcer, Noam

Publication type:

Article

Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.

Published in:

European Heart Journal, 2013, v. 34, n. 17, p. 1292, doi. 10.1093/eurheartj/ehs472

By:

Sorrentino, Vincenzo;
Fouchier, Sigrid W.;
Motazacker, Mohammad M.;
Nelson, Jessica K.;
Defesche, Joep C.;
Dallinga-Thie, Geesje M.;
Kastelein, John J.P.;
Kees Hovingh, G.;
Zelcer, Noam

Publication type:

Article

Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia.

Published in:

European Heart Journal, 2012, v. 33, n. 11, p. 1360, doi. 10.1093/eurheartj/ehs010

By:

Motazacker, Mohammad Mahdi;
Pirruccello, James;
Huijgen, Roeland;
Do, Ron;
Gabriel, Stacey;
Peter, Jorge;
Kuivenhoven, Jan Albert;
Defesche, Joep C.;
Kastelein, John J.P.;
Hovingh, G. Kees;
Zelcer, Noam;
Kathiresan, Sekar;
Fouchier, Sigrid W.

Publication type:

Article

Industrial Trans Fatty Acids Stimulate SREBP2‐Mediated Cholesterogenesis and Promote Non‐Alcoholic Fatty Liver Disease.

Published in:

Molecular Nutrition & Food Research, 2019, v. 63, n. 19, p. N.PAG, doi. 10.1002/mnfr.201900385

By:

Oteng, Antwi‐Boasiako;
Loregger, Anke;
Weeghel, Michel;
Zelcer, Noam;
Kersten, Sander

Publication type:

Article

Retraction Note: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04653-3

By:

Alioui, Anthony;
Dufour, Julie;
Leoni, Valerio;
Loregger, Anke;
Moeton, Martina;
Iuliano, Luigi;
Zerbinati, Chiara;
Septier, Amandine;
Val, Pierre;
Fouache, Allan;
Russo, Vincenzo;
Volle, David H.;
Lobaccaro, Jean-Marc A.;
Zelcer, Noam;
Baron, Silvère

Publication type:

Article

RETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. N.PAG, doi. 10.1038/s41467-017-00508-5

By:

Alioui, Anthony;
Dufour, Julie;
Leoni, Valerio;
Loregger, Anke;
Moeton, Martina;
Iuliano, Luigi;
Zerbinati, Chiara;
Septier, Amandine;
Val, Pierre;
Fouache, Allan;
Russo, Vincenzo;
Volle, David H.;
Lobaccaro, Jean-Marc A.;
Zelcer, Noam;
Baron, Silvère

Publication type:

Article

A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion.

Published in:

Cardiovascular Research, 2024, v. 120, n. 11, p. 1253, doi. 10.1093/cvr/cvae121

By:

Meurs, Amber;
Ndoj, Klevis;
van den Berg, Marlene;
Marinković, Goran;
Tantucci, Matteo;
Veenendaal, Tineke;
Kuivenhoven, Jan Albert;
Klumperman, Judith;
Zelcer, Noam

Publication type:

Article

Glutamine sensing licenses cholesterol synthesis.

Published in:

EMBO Journal, 2024, v. 43, n. 23, p. 5837, doi. 10.1038/s44318-024-00269-0

By:

Garcia, Bruna Martins;
Melchinger, Philipp;
Medeiros, Tania;
Hendrix, Sebastian;
Prabhu, Kavan;
Corrado, Mauro;
Kingma, Jenina;
Gorbatenko, Andrej;
Deshwal, Soni;
Veronese, Matteo;
Scorrano, Luca;
Pearce, Erika;
Giavalisco, Patrick;
Zelcer, Noam;
Pernas, Lena

Publication type:

Article

SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50068-8

By:

Hendrix, Sebastian;
Dartigue, Vincent;
Hall, Hailee;
Bawaria, Shrankhla;
Kingma, Jenina;
Bajaj, Bilkish;
Zelcer, Noam;
Kober, Daniel L.

Publication type:

Article

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene.

Published in:

PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0172721

By:

Cook, Emma C. L.;
Nelson, Jessica K.;
Sorrentino, Vincenzo;
Koenis, Duco;
Moeton, Martina;
Scheij, Saskia;
Ottenhoff, Roelof;
Bleijlevens, Boris;
Loregger, Anke;
Zelcer, Noam

Publication type:

Article

A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.

Published in:

2016

By:

Tol, Marc J.;
Ottenhoff, Roelof;
van Eijk, Marco;
Zelcer, Noam;
Aten, Jan;
Houten, Sander M.;
Geerts, Dirk;
van Roomen, Cindy;
Bierlaagh, Marlou C.;
Scheij, Saskia;
Hoeksema, Marten A.;
Aerts, Johannes M.;
Bogan, Jonathan S.;
Dorn 2nd, Gerald W.;
Argmann, Carmen A.;
Verhoeven, Arthur J.;
Dorn, Gerald W 2nd

Publication type:

journal article

SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P.

Published in:

Molecular & Cellular Biology, 2024, v. 44, n. 4, p. 123, doi. 10.1080/10985549.2024.2348711

By:

Hendrix, Sebastian;
Tan, Josephine M. E.;
Ndoj, Klevis;
Kingma, Jenina;
Valiloo, Masoud;
Zijlstra, Lobke F.;
Ottenhoff, Roelof;
Seidah, Nabil G.;
Loregger, Anke;
Kober, Daniel L.;
Zelcer, Noam

Publication type:

Article

A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 2, p. 285, doi. 10.1128/MCB.00890-15

By:

Loregger, Anke;
Cook, Emma Claire Laura;
Nelson, Jessica Kristin;
Moeton, Martina;
Sharpe, Laura Jane;
Engberg, Susanna;
Karimova, Madina;
Lambert, Gilles;
Brown, Andrew John;
Zelcer, Noam

Publication type:

Article

LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 1, p. 52, doi. 10.1128/MCB.00525-14

By:

Kurakula, Kondababu;
Sommer, Daniela;
Sokolovic, Milka;
Moerland, Perry D.;
Scheij, Saskia;
van Loenen, Pieter B.;
Koenis, Duco S.;
Zelcer, Noam;
van Tiel, Claudia M.;
de Vries, Carlie J. M.

Publication type:

Article

Hyperlipidaemia elicits an atypical, T helper 1–like CD4<sup>+</sup> T-cell response: a key role for very low-density lipoprotein.

Published in:

European Heart Journal Open, 2023, v. 3, n. 2, p. 1, doi. 10.1093/ehjopen/oead013

By:

Os, Bram W van;
Vos, Winnie G;
Bosmans, Laura A;
Tiel, Claudia M van;
Lith, Sanne C;
Toom, Myrthe S den;
Beckers, Linda;
Levels, Johannes H M;
Wouw, Suzanne A E van;
Zelcer, Noam;
Zaal, Esther A;
Berkers, Celia R;
Lest, Chris H A van der;
Helms, J Bernd;
Weber, Christian;
Atzler, Dorothee;
Winther, Menno P J de;
Baardman, Jeroen;
Lutgens, Esther

Publication type:

Article

LRSAM1-mediated ubiquitylation is disrupted in axonal Charcot-Marie-Tooth disease 2P.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 11, p. 2034, doi. 10.1093/hmg/ddx089

By:

Hakonen, Johanna E.;
Sorrentino, Vincenzo;
Trezza, Rossella Avagliano;
de Wissel, Marit B.;
van den Berg, Marlene;
Bleijlevens, Boris;
van Ruissen, Fred;
Distel, Ben;
Baas, Frank;
Zelcer, Noam;
Weterman, Marian A. J.

Publication type:

Article

A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 2, p. 358, doi. 10.1093/hmg/ddr471

By:

Weterman, Marian A.J.;
Sorrentino, Vincenzo;
Kasher, Paul R.;
Jakobs, Marja E.;
van Engelen, Baziel G.M.;
Fluiter, Kees;
de Wissel, Marit B.;
Sizarov, Aleksander;
Nürnberg, Gudrun;
Nürnberg, Peter;
Zelcer, Noam;
Schelhaas, H. Jurgen;
Baas, Frank

Publication type:

Article

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.

Published in:

Nature Communications, 2020, v. 11, p. 1, doi. 10.1038/s41467-020-14811-1

By:

Loregger, Anke;
Raaben, Matthijs;
Nieuwenhuis, Joppe;
Tan, Josephine M. E.;
Jae, Lucas T.;
van den Hengel, Lisa G.;
Hendrix, Sebastian;
van den Berg, Marlene;
Scheij, Saskia;
Ji-Ying Song;
Huijbers, Ivo J.;
Kroese, Lona J.;
Ottenhoff, Roelof;
van Weeghel, Michel;
van de Sluis, Bart;
Brummelkamp, Thijn;
Zelcer, Noam

Publication type:

Article

Liver X receptor α suppresses SNAI2 ensuring blood‐brain barrier function.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073228

By:

Vacondio, Davide;
Coenen, Loet;
Mulder, Inge;
Fontijn, Ruud;
Hof, Bert;
Fung, Wing Ka;
Kooij, Gijs;
Rozemuller, Annemieke J.M.;
Zelcer, Noam;
Vries, Helga E;
Wit, Nienke M

Publication type:

Article

Liver X receptor α suppresses SNAI2 ensuring blood‐brain barrier function.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073228

By:

Vacondio, Davide;
Coenen, Loet;
Mulder, Inge;
Fontijn, Ruud;
Hof, Bert;
Fung, Wing Ka;
Kooij, Gijs;
Rozemuller, Annemieke J.M.;
Zelcer, Noam;
Vries, Helga E;
Wit, Nienke M

Publication type:

Article

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 7, p. 1262, doi. 10.1128/MCB.01140-13

By:

Zelcer, Noam;
Sharpe, Laura J.;
Loregger, Anke;
Kristiana, Ika;
Cook, Emma C. L.;
Phan, Lisa;
Stevenson, Julian;
Brown, Andrew J.

Publication type:

Article

Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists.

Published in:

Molecular & Cellular Biology, 2011, v. 31, n. 9, p. 1885, doi. 10.1128/MCB.01469-10

By:

Scotti, Elena;
Hong, Cynthia;
Yoshinaga, Yuko;
Yiping Tu;
Yan Hu;
Zelcer, Noam;
Boyadjian, Rima;
de Jong, Pieter J.;
Young, Stephen G.;
Fong, Loren G.;
Tontonoz, Peter

Publication type:

Article

Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET.

Published in:

Scientific Reports, 2025, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-84217-2

By:

Ruffilli, Camilla;
Röth, Sascha;
Zelcer, Noam;
Moreau, Kevin

Publication type:

Article

One E3 ligase targets two key control points in cholesterol synthesis (605.5).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.605.5

By:

Brown, Andrew;
Sharpe, Laura;
Loregger, Anke;
Cook, Emma;
Phan, Lisa;
Stevenson, Julian;
Zelcer, Noam

Publication type:

Article

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans.

Published in:

2011

By:

Weissglas-Volkov, Daphna;
Calkin, Anna C.;
Tusie-Luna, Teresa;
Sinsheimer, Janet S.;
Zelcer, Noam;
Riba, Laura;
Vargas Tino, Ana Maria;
Ordoñez-Sánchez, Maria Luisa;
Cruz-Bautista, Ivette;
Aguilar-Salinas, Carlos A.;
Tontonoz, Peter;
Pajukanta, Päivi;
Tino, Ana Maria Vargas

Publication type:

journal article

Liver X receptors as integrators of metabolic and inflammatory signaling.

Published in:

2006

By:

Zelcer, Noam;
Tontonoz, Peter

Publication type:

journal article