Works by Zeggini, Eleftheria

Results: 120

Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals.

Published in:

2011

By:

Anderson, Carl A.;
Soranzo, Nicole;
Zeggini, Eleftheria;
Barrett, Jeffrey C.

Publication type:

Opinion

Population‐wide copy number variation calling using variant call format files from 6,898 individuals.

Published in:

Genetic Epidemiology, 2020, v. 44, n. 1, p. 79, doi. 10.1002/gepi.22260

By:

Png, Grace;
Suveges, Daniel;
Park, Young‐Chan;
Walter, Klaudia;
Kundu, Kousik;
Ntalla, Ioanna;
Tsafantakis, Emmanouil;
Karaleftheri, Maria;
Dedoussis, George;
Zeggini, Eleftheria;
Gilly, Arthur

Publication type:

Article

Cover Image.

Published in:

Genetic Epidemiology, 2020, v. 44, n. 1, p. i, doi. 10.1002/gepi.22219

By:

Png, Grace;
Suveges, Daniel;
Park, Young‐Chan;
Walter, Klaudia;
Kundu, Kousik;
Ntalla, Ioanna;
Tsafantakis, Emmanouil;
Karaleftheri, Maria;
Dedoussis, George;
Zeggini, Eleftheria;
Gilly, Arthur

Publication type:

Article

A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits.

Published in:

Genetic Epidemiology, 2015, v. 39, n. 8, p. 624, doi. 10.1002/gepi.21919

By:

Asimit, Jennifer L.;
Panoutsopoulou, Kalliope;
Wheeler, Eleanor;
Berndt, Sonja I.;
Cordell, Heather J.;
Morris, Andrew P.;
Zeggini, Eleftheria;
Barroso, Inês

Publication type:

Article

Estimating Genome-Wide Significance for Whole-Genome Sequencing Studies.

Published in:

Genetic Epidemiology, 2014, v. 38, n. 4, p. 281, doi. 10.1002/gepi.21797

By:

Xu, ChangJiang;
Tachmazidou, Ioanna;
Walter, Klaudia;
Ciampi, Antonio;
Zeggini, Eleftheria;
Greenwood, Celia M. T.

Publication type:

Article

Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases.

Published in:

Genetic Epidemiology, 2012, v. 36, n. 8, p. 785, doi. 10.1002/gepi.21675

By:

Mägi, Reedik;
Asimit, Jennifer L.;
Day-Williams, Aaron G.;
Zeggini, Eleftheria;
Morris, Andrew P.

Publication type:

Article

Defining the power limits of genome-wide association scan meta-analyses.

Published in:

Genetic Epidemiology, 2011, v. 35, n. 8, p. 781, doi. 10.1002/gepi.20627

By:

Chapman, Kay;
Ferreira, Teresa;
Morris, Andrew;
Asimit, Jennifer;
Zeggini, Eleftheria

Publication type:

Article

A powerful approach to sub-phenotype analysis in population-based genetic association studies.

Published in:

Genetic Epidemiology, 2010, v. 34, n. 4, p. 335, doi. 10.1002/gepi.20486

By:

Morris, Andrew P.;
Lindgren, Cecilia M.;
Zeggini, Eleftheria;
Timpson, Nicholas J.;
Frayling, Timothy M.;
Hattersley, Andrew T.;
McCarthy, Mark I.

Publication type:

Article

An evaluation of statistical approaches to rare variant analysis in genetic association studies.

Published in:

Genetic Epidemiology, 2010, v. 34, n. 2, p. 188, doi. 10.1002/gepi.20450

By:

Morris, Andrew P.;
Zeggini, Eleftheria

Publication type:

Article

Examining the statistical properties of fine-scale mapping in large-scale association studies.

Published in:

Genetic Epidemiology, 2008, v. 32, n. 3, p. 204, doi. 10.1002/gepi.20295

By:

Wiltshire, Steven;
Morris, Andrew P.;
Zeggini, Eleftheria

Publication type:

Article

Mendelian randomization study highlights the role of hematological traits on Type-2 diabetes mellitus in African ancestry individuals.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1436972

By:

Soremekun, Chisom;
Jjingo, Daudi;
Kateete, David;
Nash, Oyekanmi;
Nitsch, Dorothea;
Nyirenda, Moffat;
Gill, Dipender;
Zeggini, Eleftheria;
Grallert, Harald;
Peters, Annette;
Chikowore, Tinashe;
Batini, Chiara;
Soremekun, Opeyemi;
Fatumo, Segun

Publication type:

Article

Using population isolates in genetic association studies.

Published in:

Briefings in Functional Genomics, 2014, v. 13, n. 5, p. 371, doi. 10.1093/bfgp/elu022

By:

Hatzikotoulas, Konstantinos;
Gilly, Arthur;
Zeggini, Eleftheria

Publication type:

Article

Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study.

Published in:

Journal of Orthopaedic Research, 2017, v. 35, n. 10, p. 2323, doi. 10.1002/jor.23525

By:

Steinberg, Julia;
Shah, Karan M.;
Gartland, Alison;
Zeggini, Eleftheria;
Wilkinson, Jeremy Mark

Publication type:

Article

Functional genomics in osteoarthritis: Past, present, and future.

Published in:

Journal of Orthopaedic Research, 2016, v. 34, n. 7, p. 1105, doi. 10.1002/jor.23296

By:

Steinberg, Julia;
Zeggini, Eleftheria

Publication type:

Article

Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition.

Published in:

BMC Genetics, 2005, v. 6, p. 21, doi. 10.1186/1471-2156-6-21

By:

Zeggini, Eleftheria;
Barton, Anne;
Eyre, Stephen;
Ward, Daniel;
Ollier, William;
Worthington, Jane;
John, Sally

Publication type:

Article

Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure.

Published in:

BMC Genetics, 2003, v. 4, p. S26, doi. 10.1186/1471-2156-4-S1-S26

By:

Shephard, Neil;
Falcaro, Milena;
Zeggini, Eleftheria;
Chapman, Philip;
Hinks, Anne;
Barton, Anne;
Worthington, Jane;
Pickles, Andrew;
John, Sally

Publication type:

Article

Genetic architecture of human thinness compared to severe obesity.

Published in:

PLoS Genetics, 2019, v. 15, n. 1, p. 1, doi. 10.1371/journal.pgen.1007603

By:

Riveros-McKay, Fernando;
Mistry, Vanisha;
Bounds, Rebecca;
Hendricks, Audrey;
Keogh, Julia M.;
Thomas, Hannah;
Henning, Elana;
Corbin, Laura J.;
null, null;
O’Rahilly, Stephen;
Zeggini, Eleftheria;
Wheeler, Eleanor;
Barroso, Inês;
Farooqi, I. Sadaf

Publication type:

Article

ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.

Published in:

PLoS Genetics, 2018, v. 14, n. 10, p. 1, doi. 10.1371/journal.pgen.1007591

By:

Hendricks, Audrey E.;
Billups, Stephen C.;
Pike, Hamish N. C.;
Farooqi, I. Sadaf;
Zeggini, Eleftheria;
Santorico, Stephanie A.;
Barroso, Inês;
Dupuis, Josée

Publication type:

Article

Family-based analysis of vitamin D receptor gene polymorphisms and type 1 diabetes in the population of South Croatia.

Published in:

Journal of Human Genetics, 2008, v. 53, n. 3, p. 210, doi. 10.1007/s10038-007-0234-2

By:

Boraska, Vesna;
Škrabić, Veselin;
Zeggini, Eleftheria;
Groves, Christopher;
Buljubašić, Maja;
Peruzović, Marijana;
Zemunik, Tatijana

Publication type:

Article

Mapping the serum proteome to neurological diseases using whole genome sequencing.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27387-1

By:

Png, Grace;
Barysenka, Andrei;
Repetto, Linda;
Navarro, Pau;
Shen, Xia;
Pietzner, Maik;
Wheeler, Eleanor;
Wareham, Nicholas J.;
Langenberg, Claudia;
Tsafantakis, Emmanouil;
Karaleftheri, Maria;
Dedoussis, George;
Mälarstig, Anders;
Wilson, James F.;
Gilly, Arthur;
Zeggini, Eleftheria

Publication type:

Article

Do genome-wide association scans have potential for translation?

Published in:

Clinical Chemistry & Laboratory Medicine, 2012, v. 50, n. 2, p. 255, doi. 10.1515/cclm.2011.748

By:

Lopes, Margarida C.;
Zeggini, Eleftheria;
Panoutsopoulou, Kalliope

Publication type:

Article

Using ancestry-informative markers to identify fine structure across 15 populations of European origin.

Published in:

European Journal of Human Genetics, 2014, v. 22, n. 10, p. 1190, doi. 10.1038/ejhg.2014.1

By:

Huckins, Laura M;
Boraska, Vesna;
Franklin, Christopher S;
Floyd, James A B;
Southam, Lorraine;
Sullivan, Patrick F;
Bulik, Cynthia M;
Collier, David A;
Tyler-Smith, Chris;
Zeggini, Eleftheria;
Tachmazidou, Ioanna

Publication type:

Article

An evaluation of different meta-analysis approaches in the presence of allelic heterogeneity.

Published in:

European Journal of Human Genetics, 2012, v. 20, n. 6, p. 709, doi. 10.1038/ejhg.2011.274

By:

Asimit, Jennifer;
Day-Williams, Aaron;
Zgaga, Lina;
Rudan, Igor;
Boraska, Vesna;
Zeggini, Eleftheria

Publication type:

Article

The effect of genome-wide association scan quality control on imputation outcome for common variants.

Published in:

European Journal of Human Genetics, 2011, v. 19, n. 5, p. 610, doi. 10.1038/ejhg.2010.242

By:

Southam, Lorraine;
Panoutsopoulou, Kalliope;
Rayner, N. William;
Chapman, Kay;
Durrant, Caroline;
Ferreira, Teresa;
Arden, Nigel;
Carr, Andrew;
Deloukas, Panos;
Doherty, Michael;
Loughlin, John;
McCaskie, Andrew;
Ollier, William E. R.;
Ralston, Stuart;
Spector, Timothy D.;
Valdes, Ana M.;
Wallis, Gillian A.;
Wilkinson, J. Mark;
Marchini, Jonathan;
Zeggini, Eleftheria

Publication type:

Article

Reply to Dlouha et al.

Published in:

2010

By:

Tönjes, Anke;
Kovacs, Peter;
Elliott, Katherine;
Zeggini, Eleftheria;
McCarthy, Mark I.;
Stumvoll, Michael

Publication type:

Letter

Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany.

Published in:

European Journal of Human Genetics, 2010, v. 18, n. 1, p. 104, doi. 10.1038/ejhg.2009.107

By:

Tönjes, Anke;
Zeggini, Eleftheria;
Kovacs, Peter;
Böttcher, Yvonne;
Schleinitz, Dorit;
Dietrich, Kerstin;
Morris, Andrew P.;
Enigk, Beate;
Rayner, Nigel W.;
Koriath, Moritz;
Eszlinger, Markus;
Kemppinen, Anu;
Prokopenko, Inga;
Hoffmann, Katrin;
Teupser, Daniel;
Thiery, Joachim;
Krohn, Knut;
McCarthy, Mark I.;
Stumvoll, Michael

Publication type:

Article

Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.

Published in:

European Journal of Human Genetics, 2007, v. 15, n. 6, p. 679, doi. 10.1038/sj.ejhg.5201802

By:

Barber, Thomas M.;
Bennett, Amanda J.;
Gloyn, Anna L.;
Groves, Christopher J.;
Sovio, Ulla;
Ruokonen, Aimo;
Martikainen, Hannu;
Pouta, Anneli;
Taponen, Saara;
Weedon, Michael N.;
Hartikainen, Anna-Liisa;
Wass, John A. H.;
Järvelin, Marjo-Riitta;
Zeggini, Eleftheria;
Franks, Stephen;
McCarthy, Mark I.

Publication type:

Article

Identification of novel putative rheumatoid arthritis susceptibility genes via analysis of rare variants.

Published in:

BMC Proceedings, 2009, v. 3, p. 1, doi. 10.1186/1753-6561-3-S7-S131

By:

Morris, Andrew P.;
Zeggini, Eleftheria;
Lindgren, Cecilia M.

Publication type:

Article

Replication of Established Common Genetic Variants for Adult BMI and Childhood Obesity in Greek Adolescents: The TEENAGE Study.

Published in:

Annals of Human Genetics, 2013, v. 77, n. 3, p. 268, doi. 10.1111/ahg.12012

By:

Ntalla, Ioanna;
Panoutsopoulou, Kalliope;
Vlachou, Panagiota;
Southam, Lorraine;
William Rayner, Nigel;
Zeggini, Eleftheria;
Dedoussis, George V.

Publication type:

Article

Genome-Wide Association Scan Allowing for Epistasis in Type 2 Diabetes.

Published in:

Annals of Human Genetics, 2011, v. 75, n. 1, p. 10, doi. 10.1111/j.1469-1809.2010.00629.x

By:

Bell, Jordana T.;
Timpson, Nicholas J.;
Rayner, N. William;
Zeggini, Eleftheria;
Frayling, Timothy M.;
Hattersley, Andrew T.;
Morris, Andrew P.;
Mccarthy, Mark I.

Publication type:

Article

Genome-wide association studies in type 2 diabetes.

Published in:

Current Diabetes Reports, 2009, v. 9, n. 2, p. 164, doi. 10.1007/s11892-009-0027-4

By:

McCarthy, Mark;
Zeggini, Eleftheria

Publication type:

Article

Genetics of type 2 diabetes.

Published in:

Current Diabetes Reports, 2006, v. 6, n. 2, p. 147, doi. 10.1007/s11892-006-0026-7

By:

McCarthy, Mark;
Zeggini, Eleftheria

Publication type:

Article

Next-generation association studies for complex traits.

Published in:

Nature Genetics, 2011, v. 43, n. 4, p. 287, doi. 10.1038/ng0411-287

By:

Zeggini, Eleftheria

Publication type:

Article

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Published in:

2011

By:

Voight, Benjamin F.;
Scott, Laura J.;
Steinthorsdottir, Valgerdur;
Morris, Andrew P.;
Dina, Christian;
Welch, Ryan P.;
Zeggini, Eleftheria;
Huth, Cornelia;
Aulchenko, Yurii S.;
Thorleifsson, Gudmar;
McCulloch, Laura J.;
Ferreira, Teresa;
Grallert, Harald;
Amin, Najaf;
Wu, Guanming;
Willer, Cristen J.;
Raychaudhuri, Soumya;
McCarroll, Steve A.;
Langenberg, Claudia;
Hofmann, Oliver M.

Publication type:

Correction Notice

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Published in:

Nature Genetics, 2010, v. 42, n. 7, p. 579, doi. 10.1038/ng.609

By:

Voight, Benjamin F;
Scott, Laura J;
Steinthorsdottir, Valgerdur;
Morris, Andrew P;
Dina, Christian;
Welch, Ryan P;
Zeggini, Eleftheria;
Huth, Cornelia;
Aulchenko, Yurii S;
Thorleifsson, Gudmar;
McCulloch, Laura J;
Ferreira, Teresa;
Grallert, Harald;
Amin, Najaf;
Wu, Guanming;
Willer, Cristen J;
Raychaudhuri, Soumya;
McCarroll, Steve A;
Langenberg, Claudia;
Hofmann, Oliver M

Publication type:

Article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Published in:

Nature Genetics, 2008, v. 40, n. 5, p. 638, doi. 10.1038/ng.120

By:

Zeggini, Eleftheria;
Scott, Laura J.;
Saxena, Richa;
Voight, Benjamin F.

Publication type:

Article

A common variant of HMGA2 is associated with adult and childhood height in the general population.

Published in:

Nature Genetics, 2007, v. 39, n. 10, p. 1245, doi. 10.1038/ng2121

By:

Weedon, Michael N.;
Lettre, Guillaume;
Freathy, Rachel M.;
Lindgren, Cecilia M.;
Voight, Benjamin F.;
Perry, John R. B.;
Elliott, Katherine S.;
Hackett, Rachel;
Guiducci, Candace;
Shields, Beverley;
Zeggini, Eleftheria;
Lango, Hana;
Lyssenko, Valeriya;
Timpson, Nicholas J.;
Burtt, Noel P.;
Rayner, Nigel W.;
Saxena, Richa;
Ardlie, Kristin;
Tobias, Jonathan H.;
Ness, Andrew R.

Publication type:

Article

An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.

Published in:

Nature Genetics, 2005, v. 37, n. 12, p. 1320, doi. 10.1038/ng1670

By:

Zeggini, Eleftheria;
Rayner, William;
Morris, Andrew P.;
Hattersley, Andrew T.;
Walker, Mark;
Hitman, Graham A.;
Deloukas, Panos;
Cardon, Lon R.;
McCarthy, Mark I.

Publication type:

Article

Whole Exome Re-Sequencing Implicates <i>CCDC38</i> and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction.

Published in:

PLoS Genetics, 2014, v. 10, n. 5, p. 1, doi. 10.1371/journal.pgen.1004314

By:

Wain, Louise V.;
Sayers, Ian;
Soler Artigas, María;
Portelli, Michael A.;
Zeggini, Eleftheria;
Obeidat, Ma'en;
Sin, Don D.;
Bossé, Yohan;
Nickle, David;
Brandsma, Corry-Anke;
Malarstig, Anders;
Vangjeli, Ciara;
Jelinsky, Scott A.;
John, Sally;
Kilty, Iain;
McKeever, Tricia;
Shrine, Nick R. G.;
Cook, James P.;
Patel, Shrina;
Spector, Tim D.

Publication type:

Article

Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction.

Published in:

PLoS Medicine, 2006, v. 3, n. 10, p. 1877, doi. 10.1371/journal.pmed.0030374

By:

Weedon, Michael N.;
McCarthy, Mark I.;
Hitman, Graham;
Walker, Mark;
Groves, Christopher J.;
Zeggini, Eleftheria;
Rayner, N. William;
Shields, Beverley;
Owen, Katharine R.;
Hattersley, Andrew T.;
Frayling, Timothy M.

Publication type:

Article

Imputation of Rare Variants in Next-Generation Association Studies.

Published in:

Human Heredity, 2013, v. 74, n. 3/4, p. 196, doi. 10.1159/000345602

By:

Asimit, Jennifer L.;
Zeggini, Eleftheria

Publication type:

Article

Rare Variant Association Testing for Next-Generation Sequencing Data via Hierarchical Clustering.

Published in:

Human Heredity, 2013, v. 74, n. 3/4, p. 165, doi. 10.1159/000346022

By:

Tachmazidou, Ioanna;
Morris, Andrew;
Zeggini, Eleftheria

Publication type:

Article

ARIEL and AMELIA: Testing for an Accumulation of Rare Variants Using Next-Generation Sequencing Data.

Published in:

Human Heredity, 2012, v. 73, n. 2, p. 84, doi. 10.1159/000336982

By:

Asimit, Jennifer L.;
Day-Williams, Aaron G.;
Morris, Andrew P.;
Zeggini, Eleftheria

Publication type:

Article

A Combined Functional Annotation Score for Non-Synonymous Variants.

Published in:

Human Heredity, 2012, v. 73, n. 1, p. 47, doi. 10.1159/000334984

By:

Lopes, Margarida C.;
Joyce, Chris;
Ritchie, Graham R.S.;
John, Sally L.;
Cunningham, Fiona;
Asimit, Jennifer;
Zeggini, Eleftheria

Publication type:

Article

Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0052-4

By:

Hatzikotoulas, Konstantinos;
Roposch, Andreas;
Shah, Karan M.;
Clark, Matthew J.;
Bratherton, Selina;
Limbani, Vasanti;
Steinberg, Julia;
Zengini, Eleni;
Warsame, Kaltuun;
Ratnayake, Madhushika;
Tselepi, Maria;
Schwartzentruber, Jeremy;
Loughlin, John;
Eastwood, Deborah M.;
Zeggini, Eleftheria;
Wilkinson, J. Mark

Publication type:

Article

Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.

Published in:

Translational Psychiatry, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41398-018-0304-6

By:

Hackinger, Sophie;
Prins, Bram;
Mamakou, Vasiliki;
Zengini, Eleni;
Marouli, Eirini;
Brčić, Luka;
Serafetinidis, Ioannis;
Lamnissou, Klea;
Kontaxakis, Vassilis;
Dedoussis, George;
Gonidakis, Fragiskos;
Thanopoulou, Anastasia;
Tentolouris, Nikolaos;
Tsezou, Aspasia;
Zeggini, Eleftheria

Publication type:

Article

Insights into the molecular underpinning of type 2 diabetes complications.

Published in:

Human Molecular Genetics, 2025, v. 34, n. 6, p. 469, doi. 10.1093/hmg/ddae203

By:

Singh, Archit;
Bocher, Ozvan;
Zeggini, Eleftheria

Publication type:

Article

Epigenomic profiling of the infrapatellar fat pad in osteoarthritis.

Published in:

Human Molecular Genetics, 2024, v. 33, n. 6, p. 501, doi. 10.1093/hmg/ddad198

By:

Kreitmaier, Peter;
Park, Young-Chan;
Swift, Diane;
Gilly, Arthur;
Wilkinson, J Mark;
Zeggini, Eleftheria

Publication type:

Article

Identifying causal serum protein–cardiometabolic trait relationships using whole genome sequencing.

Published in:

Human Molecular Genetics, 2023, v. 32, n. 8, p. 1266, doi. 10.1093/hmg/ddac275

By:

Png, Grace;
Gerlini, Raffaele;
Hatzikotoulas, Konstantinos;
Barysenka, Andrei;
Rayner, N William;
Klarić, Lucija;
Rathkolb, Birgit;
Aguilar-Pimentel, Juan A;
Rozman, Jan;
Fuchs, Helmut;
Gailus-Durner, Valerie;
Tsafantakis, Emmanouil;
Karaleftheri, Maria;
Dedoussis, George;
Pietrzik, Claus;
Wilson, James F;
Angelis, Martin Hrabe de;
Becker-Pauly, Christoph;
Gilly, Arthur;
Zeggini, Eleftheria

Publication type:

Article

molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis.

Published in:

Human Molecular Genetics, 2022, v. 31, n. 12, p. 2090, doi. 10.1093/hmg/ddac017

By:

Katsoula, Georgia;
Steinberg, Julia;
Tuerlings, Margo;
Almeida, Rodrigo Coutinho de;
Southam, Lorraine;
Swift, Diane;
Meulenbelt, Ingrid;
Wilkinson, J Mark;
Zeggini, Eleftheria

Publication type:

Article