Works by Zappalà, Maria

Results: 35

Synthesis and Combination Studies of Novel Dipeptide Nitriles with Curcumin for a Potent Synergistic Action Against Rhodesain, Cysteine Protease of Trypanosoma brucei rhodesiense.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 6, p. 847, doi. 10.3390/ph18060847

By:

Di Chio, Carla;
Starvaggi, Josè;
Previti, Santo;
De Luca, Fabiola;
Natale, Benito;
Cosconati, Sandro;
Schirmeister, Tanja;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)‐1‐(4‐aminophenyl)‐7,8‐methylenedioxy‐1,2,3,5‐tetrahydro‐4H‐2,3‐benzodiazepin‐4‐oneCrystallographic data for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Centre (CCDC 189745).

Published in:

Chirality, 2007, v. 19, n. 1, p. 16

By:

Maria Luisa Calabrò;
Daniela Raneri;
Paola Ficarra;
Guido Ferreri;
Giovambattista De Sarro;
Giuseppe Bruno;
Maria Zappalà;
Nicola Micale;
Silvana Grasso

Publication type:

Article

Exploring the SARS-CoV-2 Proteome in the Search of Potential Inhibitors via Structure-Based Pharmacophore Modeling/Docking Approach.

Published in:

Computation, 2020, v. 8, n. 3, p. 77, doi. 10.3390/computation8030077

By:

Culletta, Giulia;
Gulotta, Maria Rita;
Perricone, Ugo;
Zappalà, Maria;
Almerico, Anna Maria;
Tutone, Marco

Publication type:

Article

Evaluation of curcumin irreversibility.

Published in:

2020

By:

Ettari, Roberta;
Previti, Santo;
Maiorana, Santina;
Allegra, Alessandro;
Schirmeister, Tanja;
Grasso, Silvana;
Zappalà, Maria

Publication type:

Letter

Drug combination studies of curcumin and genistein against rhodesain of Trypanosoma brucei rhodesiense.

Published in:

Natural Product Research, 2019, v. 33, n. 24, p. 3577, doi. 10.1080/14786419.2018.1483927

By:

Ettari, Roberta;
Previti, Santo;
Maiorana, Santina;
Allegra, Alessandro;
Schirmeister, Tanja;
Grasso, Silvana;
Zappalà, Maria

Publication type:

Article

Drug combination studies of PS-1 and quercetin against rhodesain of Trypanosoma brucei rhodesiense.

Published in:

Natural Product Research, 2022, v. 36, n. 16, p. 4282, doi. 10.1080/14786419.2021.1978993

By:

Di Chio, Carla;
Previti, Santo;
De Luca, Fabiola;
Allegra, Alessandro;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2019, v. 34, n. 1, p. 1307, doi. 10.1080/14756366.2019.1594802

By:

Ettari, Roberta;
Pallio, Giovanni;
Pizzino, Gabriele;
Irrera, Natasha;
Zappalà, Maria;
Maiorana, Santina;
Di Chio, Carla;
Altavilla, Domenica;
Squadrito, Francesco;
Bitto, Alessandra

Publication type:

Article

Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 6, p. 1184, doi. 10.3109/14756366.2015.1108972

By:

Ettari, Roberta;
Previti, Santo;
Cosconati, Sandro;
Kesselring, Jochen;
Schirmeister, Tanja;
Grasso, Silvana;
Zappalà, Maria

Publication type:

Article

Drug Combination Studies of Isoquinolinone AM12 with Curcumin or Quercetin: A New Combination Strategy to Synergistically Inhibit 20S Proteasome.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 19, p. 10708, doi. 10.3390/ijms251910708

By:

Di Chio, Carla;
Previti, Santo;
Starvaggi, Josè;
De Luca, Fabiola;
Calabrò, Maria Luisa;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 8, p. 4410, doi. 10.3390/ijms25084410

By:

Di Chio, Carla;
Starvaggi, Josè;
Totaro, Noemi;
Previti, Santo;
Natale, Benito;
Cosconati, Sandro;
Bogacz, Marta;
Schirmeister, Tanja;
Legac, Jenny;
Rosenthal, Philip J.;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 8, p. 4376, doi. 10.3390/ijms25084376

By:

Starvaggi, Josè;
Previti, Santo;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Blunting Neuroinflammation by Targeting the Immunoproteasome with Novel Amide Derivatives.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10732, doi. 10.3390/ijms241310732

By:

Imbesi, Chiara;
Ettari, Roberta;
Irrera, Natasha;
Zappalà, Maria;
Pallio, Giovanni;
Bitto, Alessandra;
Mannino, Federica

Publication type:

Article

Virtual Screening Strategy and In Vitro Tests to Identify New Inhibitors of the Immunoproteasome.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10504, doi. 10.3390/ijms241310504

By:

Culletta, Giulia;
Tutone, Marco;
Ettari, Roberta;
Perricone, Ugo;
Di Chio, Carla;
Almerico, Anna Maria;
Zappalà, Maria

Publication type:

Article

Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 10, p. 8477, doi. 10.3390/ijms24108477

By:

Di Chio, Carla;
Previti, Santo;
Totaro, Noemi;
De Luca, Fabiola;
Allegra, Alessandro;
Schirmeister, Tanja;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Monoclonal Antibodies: The Greatest Resource to Treat Multiple Myeloma.

Published in:

2023

By:

De Luca, Fabiola;
Allegra, Alessandro;
Di Chio, Carla;
Previti, Santo;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Literature Review

Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 22, p. 14470, doi. 10.3390/ijms232214470

By:

Di Chio, Carla;
Previti, Santo;
De Luca, Fabiola;
Bogacz, Marta;
Zimmer, Collin;
Wagner, Annika;
Schirmeister, Tanja;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF‐CEM and Multidrug‐Resistant CEM/ADR5000 Leukemia Cells.

Published in:

Chemistry & Biodiversity, 2022, v. 19, n. 2, p. 1, doi. 10.1002/cbdv.202100451

By:

Di Chio, Carla;
Zhou, Min;
Efferth, Thomas;
Schirmeister, Tanja;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Development of Novel Benzodiazepine‐Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense.

Published in:

ChemMedChem, 2020, v. 15, n. 11, p. 995, doi. 10.1002/cmdc.202000158

By:

Di Chio, Carla;
Previti, Santo;
Amendola, Giorgio;
Cosconati, Sandro;
Schirmeister, Tanja;
Zappalà, Maria;
Ettari, Roberta

Publication type:

Article

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes.

Published in:

ChemMedChem, 2019, v. 14, n. 8, p. 842, doi. 10.1002/cmdc.201900028

By:

Ettari, Roberta;
Cerchia, Carmen;
Maiorana, Santina;
Guccione, Manuela;
Novellino, Ettore;
Bitto, Alessandra;
Grasso, Silvana;
Lavecchia, Antonio;
Zappalà, Maria

Publication type:

Article

Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents.

Published in:

ChemMedChem, 2014, v. 9, n. 8, p. 1801, doi. 10.1002/cmdc.201402075

By:

Scarbaci, Kety;
Troiano, Valeria;
Ettari, Roberta;
Pinto, Andrea;
Micale, Nicola;
Di Giovanni, Carmen;
Cerchia, Carmen;
Schirmeister, Tanja;
Novellino, Ettore;
Lavecchia, Antonio;
Zappalà, Maria;
Grasso, Silvana

Publication type:

Article

Synthesis and Biological Evaluation of Papain-Family Cathepsin L-Like Cysteine Protease Inhibitors Containing a 1,4-Benzodiazepine Scaffold as Antiprotozoal Agents.

Published in:

ChemMedChem, 2014, v. 9, n. 8, p. 1817, doi. 10.1002/cmdc.201402079

By:

Ettari, Roberta;
Pinto, Andrea;
Tamborini, Lucia;
Angelo, Ilenia C.;
Grasso, Silvana;
Zappalà, Maria;
Capodicasa, Natale;
Yzeiraj, Laura;
Gruber, Esther;
Aminake, Makoah N.;
Pradel, Gabriele;
Schirmeister, Tanja;
De Micheli, Carlo;
Conti, Paola

Publication type:

Article

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors.

Published in:

ChemMedChem, 2012, v. 7, n. 9, p. 1594, doi. 10.1002/cmdc.201200274

By:

Ettari, Roberta;
Micale, Nicola;
Grazioso, Giovanni;
Bova, Floriana;
Schirmeister, Tanja;
Grasso, Silvana;
Zappalà, Maria

Publication type:

Article

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors.

Published in:

ChemMedChem, 2011, v. 6, n. 7, p. 1228, doi. 10.1002/cmdc.201100093

By:

Ettari, Roberta;
Bonaccorso, Cinzia;
Micale, Nicola;
Heindl, Cornelia;
Schirmeister, Tanja;
Calabrò, Maria Luisa;
Grasso, Silvana;
Zappalà, Maria

Publication type:

Article

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist.

Published in:

ChemMedChem, 2009, v. 4, n. 3, p. 415, doi. 10.1002/cmdc.200800341

By:

Calabrò, Maria Luisa;
Raneri, Daniela;
Ficarra, Paola;
Mennini, Tiziana;
Colleoni, Simona;
Grazioso, Giovanni;
Micale, Nicola;
Zappalà, Maria;
Grasso, Silvana

Publication type:

Article

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain-2 Inhibitors.

Published in:

ChemMedChem, 2008, v. 3, n. 7, p. 1030, doi. 10.1002/cmdc.200800050

By:

Ettari, Roberta;
Nizi, Emanuela;
Di Francesco, Maria Emilia;
Micale, Nicola;
Grasso, Silvana;
Zappalà, Maria;
Vičík, Radim;
Schirmeister, Tanja

Publication type:

Article

Synthesis and stereochemistry of novel [1,2,4]oxadiazolo[4,5- a][1,5]benzodiazepine derivatives.

Published in:

Journal of Heterocyclic Chemistry, 1990, v. 27, n. 2, p. 371, doi. 10.1002/jhet.5570270250

By:

Chimirri, Alba;
Grasso, Silvana;
Ottanà, Rosaria;
Romeo, Giovanni;
Zappalà, Maria

Publication type:

Article

Peptide-Based Proteasome Inhibitors in Anticancer Drug Design.

Published in:

Medicinal Research Reviews, 2014, v. 34, n. 5, p. 1001, doi. 10.1002/med.21312

By:

Micale, Nicola;
Scarbaci, Kety;
Troiano, Valeria;
Ettari, Roberta;
Grasso, Silvana;
Zappalà, Maria

Publication type:

Article

Falcipain-2 inhibitors.

Published in:

Medicinal Research Reviews, 2010, v. 30, n. 1, p. 136, doi. 10.1002/med.20163

By:

Ettari, Roberta;
Bova, Floriana;
Zappalà, Maria;
Grasso, Silvana;
Micale, Nicola

Publication type:

Article

Synthesis of Novel 3-(Alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3 H-quinazolin-4-ones as Anticonvulsant Agents.

Published in:

Chemistry & Biodiversity, 2006, v. 3, n. 3, p. 304, doi. 10.1002/cbdv.200690033

By:

Micale, Nicola;
Postorino, Giovanna;
Grasso, Silvana;
Zappalà, Maria;
Zuccalà, Giuseppe;
Ferreri, Guido;
De Sarro, Giovambattista

Publication type:

Article

Ethnobotanical studies on the Tyrrhenian side of the Aspromonte Massif (Calabria, Southern Italy).

Published in:

Plant Biosystems, 2024, v. 158, n. 3, p. 545, doi. 10.1080/11263504.2024.2336601

By:

Patti, Miriam;
Musarella, Carmelo Maria;
Postiglione, Serena Maria;
Papalia, Fabiana;
Falcone, Maria Consuelo;
Mammone, Giuseppe;
Zappalà, Maria Angela;
Laface, Valentina Lucia Astrid;
Spampinato, Giovanni

Publication type:

Article

Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment.

Published in:

ChemMedChem, 2020, v. 15, n. 16, p. 1552, doi. 10.1002/cmdc.202000360

By:

Maiorana, Santina;
Ettari, Roberta;
Previti, Santo;
Amendola, Giorgio;
Wagner, Annika;
Cosconati, Sandro;
Hellmich, Ute A.;
Schirmeister, Tanja;
Zappalà, Maria

Publication type:

Article

Synthesis and Antitumour Activity of 1 H,3 H-Thiazolo[3,4- a]benzimidazole Derivatives.

Published in:

Archiv der Pharmazie, 2001, v. 334, n. 6, p. 203, doi. 10.1002/1521-4184(200106)334:6<203::AID-ARDP203>3.0.CO;2-L

By:

Chimirri, Alba;
Monforte, Pietro;
Musumeci, Laura;
Rao, Angela;
Zappalà, Maria;
Monforte, Anna-Maria

Publication type:

Article

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis.

Published in:

Molecules, 2022, v. 27, n. 12, p. 3765, doi. 10.3390/molecules27123765

By:

Previti, Santo;
Ettari, Roberta;
Di Chio, Carla;
Ravichandran, Rahul;
Bogacz, Marta;
Hellmich, Ute A.;
Schirmeister, Tanja;
Cosconati, Sandro;
Zappalà, Maria

Publication type:

Article

Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods.

Published in:

Molecules, 2021, v. 26, n. 13, p. 4046, doi. 10.3390/molecules26134046

By:

Culletta, Giulia;
Zappalà, Maria;
Ettari, Roberta;
Almerico, Anna Maria;
Tutone, Marco

Publication type:

Article

A SIMPLE AND EFFICIENT SYNTHESIS OF GYKI 52466 AND GYKI 52895.

Published in:

Synthetic Communications, 2002, v. 32, n. 4, p. 527, doi. 10.1081/SCC-120002397

By:

Zappalà, Maria;
Grasso, Silvana;
Micale, Nicola;
Polimeni, Santina;
De Micheli, Carlo

Publication type:

Article